Ke loaʻa iā kākou kahi ʻoki a ʻeha paha ma kekahi wahi o ko kākou kino, he mea nui loa ke kāpili ʻana o ke koko e hoʻōki i ke kahe ʻana o ke koko . He ʻano pale ia o ko kākou kino. Akā, he aha ka mea e hana ʻia inā e hana ʻia nā kāpili koko i loko o nā kīʻaha koko i loko o ke kino me ke kumu ʻole? Hiki ke lilo i mea weliweli iki. I kēia lā, e kamaʻilio kākou e pili ana i kēlā ʻano maʻi hoʻoilina e hoʻonui ai i ka pilikia o ke kāpili ʻana o ke koko me ke kumu ʻole. ʻO ia ka Factor V Leiden thrombophilia .
I ka ʻōlelo maʻalahi, he aha ka Factor V Leiden?
ʻO ka Factor V Leiden thrombophilia kahi maʻi i hoʻokumu ʻia e kahi hoʻololi genetic i hoʻoilina ʻia mai ka hānau ʻana . ʻO kēia ka mea e ʻoi aku ai ka paʻa ʻana o kou koko ma mua o ka maʻamau. Ua haʻi ʻia ka inoa ʻo "factor five Leiden." ʻO V ke kū nei no ka helu Roma ʻelima.
ʻAʻole nā kānaka a pau me kēia maʻi e loaʻa i nā ʻūpā koko. Eia nō naʻe, ʻoi aku kou pilikia o ka loaʻa ʻana o nā ʻūpā koko i hoʻohālikelike ʻia me kekahi me ka ʻole o kēia ʻano hoʻoilina. Hiki i kēia ke alakaʻi i ʻelua mau kūlana weliweli nui:
- ʻO ka thrombosis aʻa hohonu ( DVT ): ʻO kēia ka wā e hana ʻia ai kahi ʻaʻa koko i loko o kahi kīʻaha koko hohonu i loko o ke kino. ʻO ka hapa pinepine, hana ʻia kēia mau mea i loko o nā aʻa koko o nā wāwae a i ʻole nā lima. Akā i kekahi manawa hiki iā lākou ke hana i loko o nā aʻa koko o ke akepaʻa , nā puʻupaʻa , ka lolo, a i ʻole nā maka.
- ʻO ka embolism pulmonary (PE): He mea weliweli iki kēia. ʻO ka mea e hana ʻia ma ʻaneʻi, ʻo ia ka haki ʻana o kahi ʻūpā koko i hana ʻia, hele pū me ke koko, a paʻa i loko o nā māmā .
ʻO ka mea nui, ʻaʻole pono ʻoe e hopohopo ke ʻike ʻoe he loaʻa iā ʻoe kēia maʻi. ʻEiwa o ka ʻumi poʻe (90%) me kēia maʻi ʻaʻole loa e loaʻa nā ʻūpā koko maʻamau ʻole. Akā he mea nui e makaʻala i nā pilikia.
He aha nā hōʻailona e hiki ai ke ʻike i kēia maʻi?
ʻO kaʻoiaʻiʻo, ʻaʻohe hōʻailona e pili ana i kēia hoʻololi ʻana o ka genetic. Hiki iā ʻoe ke ola i kou ola holoʻokoʻa me ka ʻike ʻole. Eia nō naʻe, inā hana ʻia kahi ʻūpā koko, e hoʻomaka ʻoe e ʻike i nā hōʻailona.
He mea nui loa: Inā ʻike ʻoe i kekahi o kēia mau hōʻailona o DVT a i ʻole PE, e hele i ka ʻOihana Pilikia (ETU) o ka haukapila a kāhea koke aku paha i kahi ambulance . ʻAʻole kēia he mea e hoʻopaneʻe ai.
| Kahi o ke koko koko | Nā hōʻailona hiki ke loaʻa |
|---|---|
| ʻO ka thrombosis aʻa hohonu (DVT) |
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| He ʻūpā koko i loko o ka māmā (PE) |
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No ke aha lā kēia e hana nei? He aha ke kumu o kēia?
Hoʻokumu ʻia ʻo Factor V Leiden e kahi hoʻololi genetic. E wehewehe iki kākou i kēia me ka maʻalahi.
Nui nā ʻano protein e kōkua i ko kākou hoʻopili koko. Ua kapa ʻia kēia mau mea ʻo 'coagulation factors'. ʻO "Coagulation factor V" kekahi o ia mau protein koʻikoʻi. Ua kuhikuhi ʻia ko kākou kino e hana i kēia protein e kahi gene i kapa ʻia ʻo 'F5`.
ʻO ka maʻamau, ua hānau ʻia mākou a pau me ʻelua kope olakino o kēia gene 'F5'. Eia nō naʻe, ʻo ke kanaka me ke kūlana Factor V Leiden he hoʻokahi a ʻelua paha kope o kēia gene 'F5' i hemahema. Ua ʻike mua ʻia kēia gene hemahema e kahi hui o nā kānaka noiʻi ma ke kūlanakauhale ʻo 'Leiden' ma Netherlands. ʻO ia ke kumu i loaʻa ai kona inoa.
Aia kahi loli iki i ke ʻano o ka protein Factor V, i hana ʻia e ke kino ma muli o nā kuhikuhi i loaʻa mai ka gene `F5` hemahema. Ma muli o kēia loli iki, ʻo nā protein ʻē aʻe i kapa ʻia ʻo `protein C` a me `protein S`, ka mea e kāohi ana i ke kāpili ʻana o ke koko, ʻo ia hoʻi, e hoʻōki i ke koko mai ke kāpili pono ʻole ʻana, ʻaʻole hiki ke kāohi i kēia protein Factor V i hoʻololi ʻia. Ua like ia me ke kaʻa me ka ʻole o nā paleki. No laila, hoʻomaka ke koko e kāpili ʻoiai i nā manawa pono ʻole.
He mea kēia i loaʻa mai nā hanauna mai?
ʻAe. Hiki iā ʻoe ke hoʻoilina i kēia mai kou makuahine, kou makuakāne, a i ʻole nā mea ʻelua. Ua hoʻoilina ʻia ma ke ʻano "autosomal dominant". ʻO ke ʻano kēia, hiki iā ʻoe ke hoʻoilina i kēia gene kīnā mai kou makuahine a i ʻole kou makuakāne.
- Hoʻoilina ka hapa nui o nā kānaka (heterozygous) i hoʻokahi kope wale nō o kēia gene kīnā (mai ka makuahine a i ʻole ka makuakāne).
- He mea kākaʻikahi loa, hiki i kahi kanaka (homozygous) ke hoʻoilina i nā kope ʻelua o kēia gene kīnā (mai ka makuahine a me ka makuakāne). ʻOi aku ka nui o ka pilikia o kēia poʻe i nā ʻōpū koko.
He aha nā mea e hoʻonui ai i ka pilikia o nā ʻūpā koko?
Inā loaʻa iā ʻoe ʻo Factor V Leiden, hiki i kēia mau mea ke hoʻonui i kou pilikia o ka loaʻa ʻana o kahi ʻūpā koko. No laila he mea nui e kūkākūkā i kēia me kāu kauka.
| Kumu pilikia | Wehewehena |
|---|---|
| Ka mana hoʻoilina | Ke hoʻoilina nei i ʻelua kope o ka gene F5 kīnā (homozygous). |
| Moʻolelo ʻohana | Ua loaʻa i kou ʻohana pili ka DVT a i ʻole PE. |
| Nā kūlana olakino ʻē aʻe | Loaʻa nā pilikia olakino ʻē aʻe e hoʻopilikia ai i ke kahe koko. |
| ʻoki kino | ʻOi aku ke kiʻekiʻe o ka pilikia no kekahi manawa ma hope o ke ʻoki kino nui. |
| Hāpai keiki | Hoʻonui ka pilikia i ka wā hāpai a ma hope o ka hānau ʻana. |
| Hoʻōla lāʻau hormone | ʻO ka lawe ʻana i nā pila hoʻomalu hānau a i ʻole nā lāʻau lapaʻau hormone ʻē aʻe i loaʻa ka hormone estrogen. |
| ʻAno nohona | Ka puhipaka, ka momona, a me ka noho ʻana ma ke kūlana hoʻokahi no ka lōʻihi loa. |
Pehea e ʻike ai nā kauka i kēia maʻi? He aha nā lāʻau lapaʻau?
Inā he moʻolelo kou o DVT a i ʻole PE, ʻoiai i ka wā ʻōpiopio, a inā he moʻolelo ko kekahi o kou ʻohana no kēia ʻano, kānalua paha kāu kauka iā Factor V Leiden.
Hana ʻia nā hoʻokolohua koko kūikawā (me nā hoʻokolohua genetic) e ʻike ai i kēia. Hiki i kēia ke haʻi pololei iā ʻoe inā loaʻa iā ʻoe kēia gene hewa, a inā pēlā, inā he hoʻokahi a ʻelua paha kope o ia mea.
Nā ʻano lapaʻau
No ka mea, he maʻi hoʻoilina kēia no ke ola holoʻokoʻa, ʻaʻohe lāʻau lapaʻau e hoʻololi i ka gene. Akā, hana nā lāʻau lapaʻau e hoʻoheheʻe i nā ʻōpū koko e kū nei a hōʻemi i ka pilikia o nā ʻōpū koko e hiki mai ana. No ka hana ʻana i kēia, hiki i kāu kauka ke ʻōlelo i kēia mau mea:
- Lāʻau anticoagulant: Ua kapa ʻia kēia mau mea he "mea hoʻokahe koko." Hoʻoheheʻe kēia mau lāʻau i nā ʻōpū koko a pale i ke kūkulu ʻana o nā ʻōpū koko hou. Na kāu kauka e hoʻoholo i ka lōʻihi o kou lawe ʻana i kēia mau lāʻau lapaʻau ma muli o kou pilikia.
- Nā kāmaʻa hoʻopaʻa: Kōkua kēia i ka hoʻomaikaʻi ʻana i ke kahe koko i nā wāwae a hōʻemi i ka pilikia o nā ʻūpā koko.
- Kānana Vena cava: He mea kānana liʻiliʻi kēia i hoʻokomo ʻia i loko o kahi aa koko nui i loko o ke kino e pale aku i nā ʻūpē koko i hana ʻia ma nā wāwae mai ka hele ʻana i nā māmā.
- ʻO ke ʻoki kino: I kekahi mau hihia, pono e wehe ʻia nā ʻūpā koko ma ke ʻoki kino.
Inā loaʻa iā ʻoe kēia ʻano, pono ʻoe e kamaʻilio me kāu kauka ma mua o ka hoʻohana ʻana i ka kaohi hānau, ka hoʻolālā ʻana e hāpai, a i ʻole ka hoʻomaka ʻana i kekahi lāʻau lapaʻau hormone.
Pehea e ola olakino ai me Factor V Leiden?
No ka hapa nui o ka poʻe me kēia maʻi, ʻaʻole i hoʻopilikia ʻia ka manaʻolana ola. ʻOiai inā e hana ʻia kahi ʻūpā koko, hiki i ka mālama mua ke pale i nā hopena koʻikoʻi. No laila, mai hopohopo. Eia nō naʻe, he mea nui loa ka mālama ʻana i kou nohona.
- E pale loa i ka puhipaka.
- Mai noho i ke kūlana hoʻokahi no ka lōʻihi loa. ʻOi aku hoʻi i nā lele lōʻihi, e ala a hele a puni a hoʻolōʻihi i kou mau wāwae ma ka liʻiliʻi hoʻokahi manawa i ka hola.
- E mālama i ke kaumaha o ke kino olakino.
- Mai hoʻohana i ka lāʻau lapaʻau hormone i loaʻa ka estrogen me ka ʻole o ke aʻo a kāu kauka.
He mea maʻamau ka makaʻu a me ka hopohopo ke ʻike ʻoe he Factor V Leiden thrombophilia kou. Akā e hoʻomanaʻo, hiki i ka hapa nui o ka poʻe me kēia maʻi ke ola i kahi ola maʻamau me ka ʻole o nā pilikia. ʻO ka mea nui loa, ʻo ia ka makaʻala i kou kūlana a hahai i ka ʻōlelo aʻo a kāu kauka.
Leka Lawe-Home
- ʻO ka Factor V Leiden thrombophilia kahi maʻi hoʻoilina i hoʻoili ʻia i nā hanauna. Hoʻonui kēia i ka pilikia o ke kāpili ʻana o ke koko.
- ʻAʻole nā kānaka a pau me kēia maʻi e loaʻa i nā ʻūpā koko. ʻEiwa o loko o ka ʻumi kānaka e loaʻa ʻole i kahi pilikia.
- Inā loaʻa iā ʻoe nā hōʻailona o DVT a i ʻole PE, e like me ka pehu ʻana o ka wāwae, ka ʻulaʻula, ka ʻeha o ka umauma, a me ka paʻakikī o ka hanu ʻana, e hele koke i ka Emergency Department (ETU) o ka haukapila.
- Inā ʻike ʻia kēia maʻi, hiki i nā lāʻau lapaʻau e like me nā lāʻau hoʻokahe koko ke kaohi i ka hoʻokumu ʻana o nā clot koko.
- E kūkākūkā mau me kāu kauka ma mua o ka hoʻomaka ʻana i kekahi lāʻau lapaʻau hormone a i ʻole ke ʻano kaohi hānau a ma mua o ka hāpai ʻana.
- He mea nui loa ia e hahai i kahi nohona olakino a pale i nā mea pilikia.
ʻO Factor V Leiden, ke kāpili ʻana o ke koko, DVT, Pulmonary Embolism, thrombophilia, nā maʻi genetic, nā ʻōpū koko i loko o nā kīʻaha koko, Sri Lanka
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