ʻAʻole anei he ʻeha ʻōpū wale nō kou ʻeha? E kamaʻilio kākou e pili ana i ka GIST (Gastrointestinal Stromal Tumor)!

Loaʻa iā ʻoe kekahi manawa ka ʻōpū ʻeha, a i ʻole ka ʻeha ʻōpū, a i ʻole ka manaʻo kaumaha? I kekahi manawa manaʻo mākou he mea ʻino ka meaʻai, "gastric upset", a i ʻole "flatulence" wale nō. Akā, e noʻonoʻo e pili ana i ia mea, i kekahi manawa aia kekahi moʻolelo koʻikoʻi ma hope o ia mau hōʻailona liʻiliʻi. ʻO kekahi o ia mau mea, ʻaʻole maʻamau, akā he mea nui loa e ʻike e pili ana i ke ʻano maʻi kanesa ʻo GIST, ʻo ia hoʻi ʻo Gastrointestinal Stromal Tumor . E kamaʻilio kākou e pili ana i kēia me nā kikoʻī hou aku, akā maʻalahi loa, ʻae?

He aha kēia ʻōpū stromal gastrointestinal (GIST)?

I ka ʻōlelo maʻalahi, ʻo nā GIST he mau puʻupuʻu kanesa e hana ʻia ana i loko o nā paia o kou ʻōnaehana hoʻoheheʻe - ʻo ia ka ʻāpana o kou kino kahi e hele ai ka meaʻai a me ka mea inu mai kou waha a i kou ʻōpū a laila ma o kou mau ʻōpū e hoʻoheheʻe ʻia. ʻO kēia mau puʻupuʻu, e pololei, hāʻule i loko o ka mea a nā kauka i kapa ai he 'sarcoma ʻiʻo palupalu .'

I kēia manawa, e noʻonoʻo e pili ana i ia mea, he liʻiliʻi loa kekahi mau puʻupuʻu GIST, e like me ka mea holoi penikala a i ʻole ka pī. Inā he puʻupuʻu liʻiliʻi loa ia, ʻaʻole paha ʻoe e ʻike a ʻeha paha. Eia nō naʻe, hoʻomaka kekahi mau puʻupuʻu e ulu i ka hala ʻana o ka manawa. ʻO ia ka manawa e hoʻomaka ai kēia mau GIST e hōʻike iā ʻoe i nā hōʻailona like ʻole a me nā pilikia olakino ʻē aʻe. ʻO ka hapa nui o ka manawa, mālama nā kauka i kēia kūlana GIST ma ka hana ʻana i ke ʻoki ʻana e wehe loa i ka puʻupuʻu a i ʻole nā ​​puʻupuʻu.

Pehea ka maʻamau o kēia kūlana i kapa ʻia ʻo GIST?

ʻO kaʻoiaʻiʻo, he ʻano maʻi kanesa kakaʻikahi loa ka GIST. ʻOiai ke hoʻohālikelike ʻia me nā ʻāina ʻē aʻe o ka honua, ua like nō ia. No ka laʻana, ma kahi ʻāina e like me ʻAmelika Hui Pū ʻIa, he 4,000 a 6,000 wale nō mau hihia hou o GIST i ʻike ʻia i kēlā me kēia makahiki. No laila hiki iā ʻoe ke noʻonoʻo i ka laha ʻole o kēia ʻano. No laila he mea nui e makaʻala iā ia, i hiki iā ʻoe ke ʻimi koke i ke kōkua lapaʻau inā ʻike ʻoe i nā hōʻailona.

He aha nā hōʻailona o ka GIST?

E like me kā mākou i ʻōlelo ai ma mua, inā he liʻiliʻi loa nā puʻupuʻu GIST, ʻaʻole paha ʻoe e ʻike i kekahi mau hōʻailona. ʻO ka hapa nui o ka manawa, ʻike ʻia kahi puʻupuʻu GIST ma ka hanana i ka wā o kahi hoʻāʻo, e like me ka scan ʻōpū, a i ʻole i ka wā o kekahi ʻoki kino ʻē aʻe.

Eia nō naʻe, i ka wā e nui ai ka puʻupuʻu, a i ʻole ma muli o kona wahi, e ʻike ʻia paha kekahi mau hōʻailona. Eia nā hōʻailona maʻamau:

• ʻEha a ʻoluʻolu ʻole paha ka ʻōpū . Hiki i kēia ke lilo i manaʻo piha a i ʻole kahi mea i paʻa i loko o kou ʻōpū.
• Ke koko i loko o kou ʻōpala a i ʻole ka ʻōpala i hoʻoluhi ʻia e ke koko. I kekahi manawa hiki ke ʻeleʻele ka ʻōpala, he hōʻailona hoʻi ia o ke kahe ʻana o ke koko i loko.
• ʻO ka paʻa ʻana o ka ʻōpū ke ʻano o ka ʻole o ka neʻe ʻana o ka ʻōpū no kekahi mau lā.
• Mau loaLuhi loa a me ka luhi . Me he mea lā ʻaʻohe ola i loko o ke kino.
• Ka hoʻemi kaumaha me ka ʻole o kou hoʻāʻo ʻana.
• ʻO Anorexia ke ʻano o ka makemake ʻole e ʻai.
• Ka luaʻi ʻana i ke koko . He hōʻailona koʻikoʻi kēia.

Inā ua loaʻa iā ʻoe kekahi a ʻoi aku paha o kēia mau hōʻailona no kekahi manawa, he mea naʻauao ke ʻike i ke kauka a nānā ʻia, ma mua o ka noʻonoʻo wale ʻana, "He aha kēlā?"

He aha nā kumu o GIST?

ʻO ka hapa nui o ka manawa, ulu ka GIST i ka wā e loaʻa ai kahi loli, a i ʻole ka mutation, i loko o kahi gene i kapa ʻia ʻo KIT i loko o ko mākou kino. E noʻonoʻo i kēia gene KIT e like me kahi ʻelele liʻiliʻi e haʻi ana i kekahi mau cell i loko o kā mākou ʻōnaehana digestive e "māhele a hoʻonui." No laila, i ka wā e loaʻa ai kahi kīnā i loko o kēia gene, hoʻomaka kēlā mau cell e māhele a hoʻonui me ka wikiwiki a me ka hiki ʻole ke kāohi. Hoʻokumu ʻia kēlā puʻupuʻu, a i ʻole GIST, i ka wā e ulu ai kēlā mau cell me ka hiki ʻole ke kāohi. ʻO ka maʻamau, hana ʻia kēia mutation gene ma hope o ko mākou hānau ʻana, i ko mākou ola ʻana. ʻAʻole ia he mea i hoʻoilina ʻia mai nā mākua a i nā keiki.

Ke haʻi aku nei kēia gene KIT i nā cell e hana i kahi protein i kapa ʻia ʻo KIT CD117 . Hoʻoulu kēia protein i ka mahele ʻana o nā cell i loko o ka ʻōnaehana hoʻoheheʻe. Ma GIST, hele hewa kēia kaʻina hana, e hoʻoulu ai i ka hoʻokumu ʻana o nā puʻupuʻu.

Eia nō naʻe, ʻoiai he mea kakaikahi loa, hiki i kekahi mau kūlana hoʻoilina ke hoʻonui iki i ka pilikia o ka loaʻa ʻana o GIST. ʻO kekahi o kēia mau kūlana:

• ʻO ka maʻi GIST Familial: He mea kākaʻikahi loa kēia. ʻO ka mea e hana ʻia ma ʻaneʻi, ʻo ia ka hoʻoilina ʻana o kahi kīnā i loko o ka gene KIT mai nā mākua a i nā keiki. Inā hana ʻia kēia, piʻi ka pilikia o ka loaʻa ʻana o GIST. Eia kekahi, hiki i ka GIST ke ulu i ka wā ʻōpio ma mua o ka maʻamau a hiki i nā ʻoi aku ma mua o hoʻokahi puʻupuʻu ke ulu.
• ʻAno Neurofibromatosis 1: He maʻi hoʻoilina nō hoʻi kēia. Hoʻoulu ia i kekahi mau ʻano o nā cell e ulu aʻe ma waho o ke kaohi a hana i nā puʻupuʻu ma nā wahi like ʻole o ke kino. ʻO GIST kekahi ʻano puʻupuʻu e hiki ke ulu ma kēia ʻano.
• ʻO ka maʻi Carney-Stratakis: He ʻano laha ʻole kēia, he ʻano hoʻoilina. ʻOi aku ka nui o ka pilikia o ka poʻe me kēia ʻano i ka loaʻa ʻana o ka GIST ma mua o nā poʻe ʻē aʻe.

Pehea e ʻike ʻia ai ka GIST?

Ke hele ʻoe e ʻike i ke kauka me nā hōʻailona i ʻōlelo ʻia ma luna, e nīnau mua ʻo ia iā ʻoe e pili ana i kāu mau hōʻailona, ​​pehea ka lōʻihi o ko lākou ʻike ʻana, a laila e hana ʻo ia i kahi hoʻokolokolo kino . ʻO ia hoʻi nā mea e like me ka hoʻopā ʻana i kou ʻōpū.

Eia kekahi, hiki i kāu kauka ke kauoha i kekahi mau hoʻokolohua ʻē aʻe e hōʻoia inā he GIST kou, kona nui, a inā ua pālahalaha. ʻO nā mea nui:

• ʻO ka endoscopy luna:ʻO kēia ke komo ʻana i kahi ʻōmole me kahi kāmela liʻiliʻi ma kou waha a me ka nānā ʻana i loko o kou puʻu, esophagus (paipu meaʻai), a me ka ʻōpū. Hiki iā ʻoe ke ʻike pololei inā he mea, e like me kahi puʻupuʻu.
• CT scan: Hoʻohana kēia i nā kukuna X e lawe i nā kiʻi kikoʻī o loko o kou ʻōpū. Hiki i kēia ke kōkua i ka hoʻoholo ʻana i ka nui a me kahi o ka puʻupuʻu.
• ʻO ke kiʻi ʻana o ka Positron emission tomography (PET): He ʻano kūikawā nō hoʻi kēia o ke kiʻi ʻana. Kōkua ia i ka ʻike ʻana i ke ʻano o ka hana ʻana o nā hunaola kanesa a inā ua laha lākou i nā ʻāpana ʻē aʻe o ke kino.
• Biopsy: ʻO kēia ka hoʻāʻo e hoʻohana ʻia e hōʻoia inā he GIST kou. Pili kēia i ka lawe ʻana i kahi ʻāpana liʻiliʻi loa o ka ʻiʻo mai ka puʻupuʻu a nānā ʻia ma lalo o kahi microscope e kahi pathologist . E kōkua kēia i ka hoʻoholo ʻana inā he GIST a i ʻole kekahi mea ʻē aʻe. I kekahi manawa hiki ke hana ʻia ka biopsy i ka manawa like me ka endoscopy.

Pehea e mālama ʻia ai ka GIST?

ʻO ke kanaka nui e mālama i ka GIST he oncologist . Hoʻomaʻamaʻa pinepine ʻia ʻo GIST me ke ʻoki ʻana e wehe i ka puʻupuʻu. Eia nō naʻe, ʻo ke ʻano o ka lāʻau kūpono iā ʻoe e hilinaʻi ʻia i nā mea i loaʻa i nā hoʻokolohua. ʻO ia hoʻi, e nānā nā kauka i nā mea e like me ka nui o ka puʻupuʻu, kahi i loaʻa ai, a inā ua laha (metastasized) mai kahi i hoʻomaka mua ai.

ʻo kahi laʻana:

• Inā liʻiliʻi loa ka puʻupuʻu, hiki paha i kāu kauka ʻokiʻoki oncology ke wehe loa iā ia me ke ʻoki ʻana. A laila, ʻaʻohe pono ʻē aʻe o kahi lāʻau lapaʻau.
• Akā inā nui loa ka puʻupuʻu a i ʻole ma kahi paʻakikī ke ʻoki ʻia, hiki i kāu kauka maʻi kanesa ke hoʻoholo e hāʻawi iā ʻoe i kahi ʻano lāʻau i kapa ʻia ʻo ka lāʻau lapaʻau i kuhikuhi ʻia e hoʻēmi i ka puʻupuʻu ma mua o ke ʻoki ʻana. Kuhi kēia mau lāʻau lapaʻau a hoʻouka i nā mea kikoʻī e kōkua i nā pūnaewele GIST e ulu. Hoʻēmi kēia i ka puʻupuʻu a maʻalahi ka hana ʻana. I kekahi manawa, hiki ke hoʻomau ʻia kēia mau lāʻau lapaʻau i kuhikuhi ʻia ma hope o ke ʻoki ʻana e pale i ka GIST mai ka hoʻi hou ʻana mai.

E hoʻomanaʻo, ʻaʻole loaʻa i nā maʻi GIST āpau ka lāʻau like. E kūkākūkā kāu hui lapaʻau me ʻoe i ka hoʻolālā lapaʻau maikaʻi loa no kou kūlana.

He aha nā hopena ʻaoʻao o ka lāʻau lapaʻau?

E like me kekahi lāʻau lapaʻau, hiki i ka lāʻau GIST ke hana i kekahi mau hopena ʻaoʻao.

ʻO kekahi mau hopena ʻaoʻao hiki ke loaʻa mai ka lāʻau lapaʻau i kuhikuhi ʻia:

• Ke ālai ʻia
• Ka maʻi ʻōpū (ʻeha ʻōpū)
• Luhi a me ka luhi
• ʻEhaʻeha o nā ʻiʻo
• Ka luaʻi (manaʻo e like me ka luaʻi ʻana)

Nā hopena ʻaoʻao maʻamau e hiki mai ana i ka wā o ke ʻoki ʻana:

• Nā hopena i ka anesthesia (e.g., dizziness, luaʻi)
• ʻEha ma kahi ʻoki kino
• Ke kahe ʻana o ke koko

ʻAʻole like kēia mau hopena ʻaoʻao i nā kānaka a pau. Hiki i kekahi poʻe ke loaʻa i kekahi o lākou, aʻo kekahi poʻe ʻaʻole paha e loaʻa i kekahi. Inā manaʻo ʻoe i kekahi ʻeha, e hōʻoia e haʻi i kāu kauka a kahu maʻi paha. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao.

He aha kaʻu e manaʻo ai ma hope inā loaʻa iaʻu kahi GIST?

ʻOiai ma hope o ka pau ʻana o ka lāʻau lapaʻau, e hoʻomau kāu kauka maʻi ʻaʻai i ka nānā ʻana iā ʻoe. ʻO ia hoʻi, e noi ʻia ʻoe e hele mai no nā manawa hoʻopaʻa maʻamau i nā manawa maʻamau e nānā i kou hoʻōla ʻana a me kou olakino holoʻokoʻa. ʻO ka maʻamau, hana ʻia kēia mau manawa i kēlā me kēia ʻekolu a ʻeono mahina.

I loko o kēia mau kipa ʻana, e nīnau kāu kauka iā ʻoe e pili ana i kāu mau hōʻailona, ​​e nānā iā ʻoe, a e hana paha i nā hoʻokolohua ʻē aʻe, e like me nā scans, e ʻike ai inā ua hoʻi mai ka GIST a i ʻole pehea e pane ai i ka lāʻau lapaʻau. ʻO nā hoʻokolohua maʻamau:

• Nā scan CT o ke akepaʻa a me ke pelvis.
• Nā kiʻi MRI (nā kiʻi kiʻi resonance Magnetic (MRI)) .
• Nā scan PET e ʻike i ka pane ʻana i nā lāʻau lapaʻau i hoʻopaʻa ʻia.

Na kāu kauka e hoʻoholo i ka pinepine o kāu hana ʻana i kēia mau hoʻokolohua, ma muli o kou kūlana.

He aha ka nui o ke ola me GIST?

He mea koʻikoʻi kēia. ʻOkoʻa ka nui o ke ola no kekahi me GIST mai kēlā kanaka a kēia kanaka. Aia kekahi mau mea e pili ana i ka hoʻoholo ʻana i kēia. No ka laʻana, ka nui o ka puʻupuʻu i ka wā e ʻike ʻia ai ka GIST, pehea kona hana, kou olakino holoʻokoʻa, a pehea ka pane ʻana o ka puʻupuʻu i ka lāʻau lapaʻau.

Wahi a ka ʻikepili i hōʻiliʻili ʻia mai nā ʻoihana e like me ka US National Cancer Institute (NCI) , ma kahi o 85% o ka poʻe me GIST e ola nei i ʻelima mau makahiki ma hope o ka ʻike ʻia ʻana o ka maʻi.

Eia nō naʻe, i kou ʻike ʻana i nā ʻikepili e like me kēia, pono ʻoe e hoʻomanaʻo i kekahi mau mea:

• He mau kuhi wale nō kēia: ua hoʻokumu ʻia lākou ma nā ʻike o nā poʻe he nui i loaʻa iā GIST ma mua. He ʻokoʻa loa paha kou kūlana. No ka laʻana, ʻo kou mau makahiki a inā he mau maʻi ʻē aʻe kāu e hiki ke hoʻopilikia i kēia mau helu.
• He mau helu mōʻaukala kēia: hōʻiliʻili ʻia ka ʻikepili ma kahi o kēlā me kēia ʻelima mau makahiki. No laila, ʻaʻole i hoʻokomo ʻia ka hopena o nā lāʻau lapaʻau hou loa i loko o kēia mau helu. Me nā lāʻau lapaʻau hou, hiki i kēia mau helu ke ʻoi aku ka maikaʻi.
• ʻElua mau mea like ʻole nā ​​helu ola a me ka manaʻolana ola: ʻAʻole haʻi ka helu ola iā ʻoe i ka lōʻihi o kou ola ʻana. He mea paʻakikī loa ka loaʻa ʻana o ka ʻikepili manaʻolana ola no ka poʻe me GIST.

No laila, mai hopohopo ʻoe i kēia mau helu. Inā he mau nīnau kāu, e nīnau i kāu kauka maʻi kanesa. E hiki iā ia ke wehewehe pehea e pili ai kēia mau helu i kou kūlana.

Pehea ʻoe e mālama ai iā ʻoe iho?

ʻO ka mālama ʻana i kou olakino holoʻokoʻa ka mea maikaʻi loa hiki iā ʻoe ke hana nou iho, i ka wā a ma hope o ka mālama ʻana no GIST.

• ʻAi maikaʻi: E hoʻāʻo e ʻai i kahi ʻai like ʻole i kiʻekiʻe i ka protein, haʻahaʻa i ka momona, a me ka nui o ka hiki. E hoʻokomo i nā greens, nā mea kanu, a me nā huaʻai i kāu papaʻai o kēlā me kēia lā. ʻO ka papaʻai kaulike e hāʻawi i kou kino i ka ikehu e hoʻōla koke.
• E hoʻoikaika kino: Hiki i ka maʻi ke lilo i mea hopohopo. ʻOiai ʻoe e hoʻōla ana mai ka lāʻau lapaʻau, hiki i ka hoʻoikaika kino māmā (e like me ka hele wāwae) ke kōkua iā ʻoe e hōʻemi i ke kaumaha. Eia nō naʻe, pono ʻoe e kamaʻilio mau me kāu kauka ma mua o ka hoʻomaka ʻana i kahi hana hoʻoikaika kino hou a i ʻole ma mua o kou hoʻomaka ʻana i kahi hana hoʻoikaika kino āu i hana ai.
• E pale loa i ka puhipaka: ʻO ka hoʻohana ʻana i kekahi ʻano huahana paka (me nā cigarette uila) e hoʻonui i ka pilikia o ka hoʻomohala ʻana i kahi maʻi kanesa hou, a me ka pilikia o ka hoʻi hou ʻana o kahi GIST.

ʻAʻole paha e hōʻike mua kahi maʻi e like me GIST i kekahi mau hōʻailona nui. Inā paha ʻoe e hana pēlā, manaʻo paha ʻoe he ʻōpū wale nō ia a i ʻole ka maʻi ʻōpū. No laila, ʻo ka ʻike ʻana he puʻupuʻu kanesa kakaʻikahi kou e like me kēia hiki ke lilo i mea hoʻohoka nui. Inā loaʻa iā ʻoe kēia maʻi, e hoʻokaʻawale i kekahi manawa e aʻo iā ʻoe iho e pili ana i kēia maʻi kakaʻikahi a me kāu mau koho lapaʻau. I nā hihia he nui, hiki i ka lāʻau lapaʻau ke hōʻoluʻolu i kāu mau hōʻailona a hoʻōla i ka GIST. He nui kāu mau nīnau. Aia kāu hui lapaʻau ma laila e pane iā lākou āpau a kākoʻo iā ʻoe.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

ʻOiai he mea e makaʻu ai ka GIST, he kūlana ia e hiki ke loaʻa nā hopena maikaʻi inā ʻoe e ʻike a loaʻa ka lāʻau lapaʻau i ka manawa kūpono.

• Mai hoʻowahāwahā: Inā loaʻa iā ʻoe kekahi ʻeha ʻōpū mau ʻole, nā hōʻailona o ke kahe ʻana o ke koko, a i ʻole ka pohō kaumaha i wehewehe ʻole ʻia, e ʻimi i ka ʻōlelo aʻo lapaʻau.
• He mea nui ka ʻike pololei: Pono nā hoʻokolohua kūikawā e ʻike ai i ka GIST. No laila, e ʻimi i ka manaʻo o kahi loea.
• Aia nā lāʻau lapaʻau: Aia nā lāʻau lapaʻau kūpono no GIST, e like me ke ʻoki kino a me ka lāʻau lapaʻau i hoʻolālā ʻia.
• ʻAʻole ʻoe hoʻokahi: e kōkua kāu hui lapaʻau, ʻohana, a me nā hoaaloha iā ʻoe ma kēia huakaʻi.

ʻO ka mea nui loa, ʻo ia ke noho ikaika a hahai i nā ʻōlelo aʻoaʻo a ke kauka.

ʻO ka puʻupuʻu stromal Gastrointestinal, GIST, maʻi ʻaʻai, ʻōnaehana hoʻoheheʻe, gene KIT, ʻoki kino, lāʻau lapaʻau i kuhikuhi ʻia