E aʻo kākou e pili ana i ka Human Growth Hormone (HGH) ma nā ʻōlelo maʻalahi.

Ke manaʻo nei ʻoe ʻaʻole e ulu ana kāu keiki e like me ka mea e pono ai? A i ʻole luhi a palaualelo mau ʻoe? Malia paha ke kumu o kēia he ʻelele kemika liʻiliʻi i loko o kou kino. ʻO kekahi hormone koʻikoʻi no ka ulu ʻana o ko mākou kino a me nā mea ʻē aʻe he nui i kapa ʻia ʻo ka hormone ulu kanaka . Kapa mākou iā ia ʻo HGH (Human Growth Hormone) no ka pōkole. Kapa pū kekahi iā ia ʻo somatotropin . No laila i kēia lā, e kamaʻilio kākou e pili ana i kēia HGH me nā kikoʻī, me ka maʻalahi loa.

He aha ka HGH? Pehea e hana ʻia ai i loko o ko kākou kino?

I ka ʻōlelo maʻalahi, he hormone kūlohelohe ka HGH a ko mākou kino e hana ai. Hana ʻia ia e kahi gland liʻiliʻi ma lalo pono o ko mākou lolo, e like me ka nui o ka iwi liʻiliʻi. Kāhea mākou iā ia ʻo ka pituitary gland . Hoʻopilikia kēia hormone HGH i nā ʻāpana he nui o ko mākou kino. He mea nui loa ia no ka ulu ʻana o nā keiki . Kōkua nui ka HGH i nā mea e like me ka hoʻonui ʻana i ke kiʻekiʻe o kāu keiki a me ka hoʻoikaika ʻana i ko lākou mau iwi.

Eia nō naʻe, i ka wā e ulu ai kākou, ʻo ia hoʻi, ma hope o ka pani ʻana o nā papa ulu i loko o ko kākou mau iwi (epiphyses), ʻaʻole e hoʻonui hou ka HGH iā kākou. Akā, ʻaʻole ia wale nō ka hana a ka HGH. ʻOiai ma hope o ko kākou ulu ʻana, kōkua ka HGH i ka mālama ʻana i ke ʻano maʻamau o ko kākou kino a mālama i ka holo pono ʻana o kā kākou metabolism . ʻO kēia metabolism ka mea e hoʻololi ai i ka meaʻai a kākou e ʻai ai i ikehu. Kōkua pū ka HGH i ka mālama ʻana i ko kākou pae kō koko (glucose) ma kahi pae.

He mau kemika nā hormones i loko o ko kākou kino. Hana lākou e like me nā ʻelele. Hele lākou ma ke koko a haʻi i ko kākou mau ʻōpū, nā ʻiʻo, a me nā ʻiʻo ʻē aʻe i ka mea e hana ai a me ka wā e hana ai. Aia ma mua o 50 o kēia mau hormones i loko o ko kākou kino!

Aia ka pituitary gland aʻu i ʻōlelo ai ma mua ma ke kumu o ka lolo, ma lalo o ka hypothalamus . Hoʻomalu kēia hypothalamus i nā mea he nui e like me ke koko, ka helu o ka puʻuwai, ka mahana o ke kino, a me ka ʻai ʻana. No laila, ʻo kēia hypothalamus ka mea e haʻi aku i ka pituitary gland e hoʻokuʻu i ka HGH. ʻO kahi hormone e kōkua ana i kēlā ua kapa ʻia ʻo GHRH (growth hormone-releasing hormone) . Eia kekahi, ʻo kekahi hormone (somatostatin) e hele mai ana mai ka hypothalamus e hoʻōki i ka hoʻokuʻu ʻana o ka HGH. Penei ke ʻano o ka hoʻomalu ʻia ʻana o ka HGH.

I kekahi manawa hoʻohana nā kauka i ka HGH synthetic e mālama i kekahi mau maʻi. Akā e hoʻomanaʻo, mai hoʻohana i ka HGH synthetic me ke kauoha ʻole a ke kauka.

He aha nā mea e hoʻopilikia ai i ka hoʻokuʻu ʻana o ka HGH?

Hoʻokuʻu pinepine kā mākou pituitary gland i ka HGH i nā ʻāpana liʻiliʻi i ka lā a pau, i kapa ʻia he pulses . Hoʻokele nui ʻia kēia e ʻelua mau hormones mai ka hypothalamus i kapa ʻia ʻo GHRH a me somatostatin.

ʻAʻole wale kēlā, akā pili pū kekahi mau hormones ʻē aʻe. Eia kekahi laʻana,Hoʻemi ka Insulin-like growth factor 1 (IGF-1) i ka hana ʻana o ka HGH, ʻoiai ʻo nā hormones e like me thyroxine , glucocorticoids , a me ghrelin e hoʻonui i ka hoʻokuʻu ʻana o ka HGH.

ʻO IGF-1, ka mea i hoʻokuʻu ʻia e ko kākou akepaʻa, he huahana nui ia o ka hana HGH. ʻO kēia IGF-1 ka mea e kāohi ana i ka hana nui ʻana o HGH. ʻO ia hoʻi, ʻo HGH ke kumu o ka hana ʻana o IGF-1, a ʻo ka IGF-1 i hana ʻia e hōʻemi hou i ka hana ʻana o HGH. Ua like ia me kahi pōʻaiapuni.

I ke kanaka olakino, ua kāohi ʻia ka hoʻokuʻu ʻana o HGH e nā pae kō koko kiʻekiʻe (hyperglycemia) . Eia kekahi, ua hoʻoulu ʻia ka hoʻokuʻu ʻana o HGH e nā mea e like me ka hiamoe, ke kaumaha, ka hoʻoikaika kino, nā pae kō koko haʻahaʻa (hypoglycemia) , a me nā waikawa amino .

He aha nā hana nui o ka hormone HGH?

ʻElua mau hana nui a HGH:

1. Hoʻoulu i ka ulu ʻana (ʻoi aku hoʻi i nā keiki)

2. Ka hoʻopilikia ʻana i ka metabolism (ke ʻano o kā mākou hoʻololi ʻana i ka meaʻai a mākou e ʻai ai i ikehu)

HGH a me ka ulu ʻana

Kōkua ʻo HGH i kēlā me kēia ʻiʻo a me nā ʻōkana i loko o ko kākou kino e ulu. Akā, ʻoi aku ka kaulana o ia no ke kōkua ʻana i ka ulu ʻana o ke cartilage a me ka iwi . He mea nui loa kēia i ka wā ʻōpio. Loaʻa i nā pūnaewele i kapa ʻia ʻo chondrocytes i loko o ke cartilage a me nā osteoblasts i loko o nā iwi nā hōʻailona mai HGH e māhele a ulu nui.

Eia naʻe, e like me kaʻu i ʻōlelo ai ma mua, ʻaʻole e hoʻonui ka HGH i ke kiʻekiʻe ma hope o ka pani ʻana o nā papa ulu (epiphyses) i loko o nā iwi o ke keiki. Akā, kōkua ka HGH i ka mālama ʻana i ke ʻano kino maʻamau i ke ola holoʻokoʻa.

HGH a me ka metabolism

ʻO ka metabolism ke kaʻina hana kemika e hoʻololi i ka meaʻai a mākou e ʻai ai i ikehu. Pono kēlā me kēia cell i loko o ko mākou kino i ka ikehu e hana pono ai.

Hoʻopilikia nui ka HGH i ka metabolism ma ka hoʻonui ʻana i ka hana ʻana o IGF-1, kahi e hoʻololi ai i ke ʻano o kona hoʻopilikia ʻana i nā cell o ko mākou kino. ʻO IGF-1 kahi hormone nona ke ʻano like me ka insulin . ʻO ka insulin kahi hormone koʻikoʻi i hana ʻia e kā mākou pancreas e hoʻohaʻahaʻa i nā pae kō koko (glucose) . Loaʻa iā IGF-1 ka hiki ke hoʻohaʻahaʻa i ke kō koko.

ʻO ka maʻamau, hoʻomalu pono ko mākou kino i ka pae o ka glucose i loko o ko mākou koko. ʻO ka glucose koko, a i ʻole ke kō, ke ʻano nui o ke kō i loko o ko mākou koko. Loaʻa iā mākou mai nā meaʻai carbohydrate a mākou e ʻai ai. ʻO kēia kō ka mea e hāʻawi ai i ka ikehu no ko mākou mau ʻōpū, nā ʻiʻo, a me ka ʻōnaehana nerve.

ʻO ka insulin ka hormone nui e hoʻohaʻahaʻa i ke kō koko ke kiʻekiʻe. A hoʻonui ka hormone glucagon i ke kō koko ke haʻahaʻa. Eia nō naʻe, hoʻonui pinepine ka HGH i ke kō koko ke haʻahaʻa. Eia naʻe,Inā piʻi nui ka nui o ka HGH i loko o kou kino, hiki iā ia ke hoʻopilikia i ka hana o ka insulin a hoʻonui i ke kiʻekiʻe o ke kō koko.

Ke hoʻonui maoli nei anei ʻo HGH iā ʻoe?

ʻAe, hiki i ka HGH ke hoʻonui i ke kiʻekiʻe o nā keiki. Akā, ʻo ia wale nō ma mua o ka hui ʻana o nā papa ulu i loko o ko lākou mau iwi. ʻAʻole hiki i ka HGH ke hoʻonui iā ʻoe ma hope o ka hui ʻana o nā papa ulu. Akā, ma hope o kou hiki ʻana i kou kiʻekiʻe loa, kōkua ka HGH i ka mālama ʻana i ke ʻano a me ka metabolism o kou kino.

He aha nā pae maʻamau o ka HGH?

E like me kaʻu i ʻōlelo ai ma mua, hoʻokuʻu ka pituitary gland i ka HGH i nā pahū i ka lā. ʻOkoʻa kēia mau pae ma muli o ka manawa o ka lā, ka makahiki, a me ke kāne. No laila, ʻaʻole pono loa kahi hoʻāʻo koko hoʻokahi e ana i ka HGH no ka ʻike ʻana i kahi maʻi. Akā, nānā nā kauka i nā pae HGH ma o nā hoʻāʻo kūikawā (nā hoʻāʻo hoʻoulu a kāohi paha).

ʻO nā pae HGH maʻamau penei:

• Nā kāne makua: 0.4 a 10 nanograms no ka mililita (ng/mL)
• Nā wāhine makua: 1 a 14 nanograms no ka milliliter (ng/mL)
• Nā keiki: 10 a 50 nanograms no ka milliliter (ng/mL)

Akā e hoʻomanaʻo, hiki ke ʻokoʻa iki kēia mau waiwai mai ka hale hana a i ka hale hana. No laila e hoʻohālikelike iā lākou i ka pae maʻamau ma kāu hōʻike hale hana. Inā he mau hopohopo kāu, e kamaʻilio me kāu kauka.

He aha ka mea e hana ai inā emi nā pae HGH? (Growth Hormone Deficiency)

Ke haʻahaʻa nā pae HGH ma mua o ka maʻamau, kapa mākou ia he Growth Hormone Deficiency . Hoʻokumu pinepine ʻia kēia e kekahi pilikia a i ʻole ka hōʻino ʻana i ka pituitary gland. Hiki i kēia ke alakaʻi i kahi kūlana i kapa ʻia ʻo hypopituitarism . ʻO ke ʻano kēia ua hoʻemi ʻia kekahi a ʻoi aku paha nā hormones i hana ʻia e ka pituitary gland. ʻO HGH kekahi hormone hiki ke hoʻopilikia ʻia ma kēia ʻano.

Hoʻopilikia kēia hemahema HGH i nā pākeke a me nā keiki ma nā ʻano like ʻole.

Inā emi nā pae HGH i nā pākeke:

Inā emi nā pae HGH o kahi pākeke, hiki ke kū mai nā pilikia penei:

• Ua emi ka hauʻoli a me ka ʻoluʻolu i ke ola.
• Hoʻonui ʻia ka momona o ke kino.
• Hoʻonui ʻia ka pilikia o ka maʻi puʻuwai.
• Ka hoʻonāwaliwali ʻana o ka puʻuwai, nā ʻiʻo a me nā iwi.

I nā pākeke, hiki ke hana ʻia kēia kūlana e kahi adenoma pituitary (ʻaʻole kēia he maʻi ʻaʻai, akā he puʻupuʻu) a i ʻole ka hōʻino ʻana i ka pituitary gland/hypothalamus.

Inā haʻahaʻa ka HGH o nā keiki:

Inā emi nā pae HGH o ke keiki, e hoʻopaneʻe ʻia ka ulu ʻana. ʻO ka hōʻailona nui ka lohi o ka piʻi ʻana o ke kiʻekiʻe ma hope o ke kolu o ka lā hānau o ke keiki. ʻO ia hoʻi, ʻaʻole i emi ma mua o 1.4 ʻīniha i kēlā me kēia makahiki. No ka laʻana, inā ʻoi aku ka pōkole o kāu keiki ma mua o nā keiki ʻē aʻe o ka papa, pono ʻoe e hopohopo.

Eia kekahi, hiki i kahi keiki me ka hemahema HGH ke loaʻa nā hōʻailona e like me:

• He helehelena i ʻoi aku ka ʻōpiopio ma mua o kona mau makahiki.
• Ka ulu ʻana o ka lauoho i hoʻopilikia ʻia.
• Ka lohi o ka wā ʻōpiopio.

Hiki i nā keiki ke hānau ʻia me kēia maʻi. I kekahi manawa ʻaʻole ʻike ʻia ke kumu (idiopathic), hiki ke hoʻoilina ʻia, a i ʻole hiki ke hana ʻia e ka hōʻino ʻana i ka pituitary gland i ka wā hāpai a i ʻole i ka wā hānau. I kekahi manawa hiki ke hana ʻia e ka hōʻino ʻana i ka pituitary gland a i ʻole hypothalamus ma hope o ke ola.

He aha ka mea e hana ai inā piʻi aʻe ka pae HGH?

ʻO ke kūlana nui e pili ana me nā pae kiʻekiʻe o ka HGH ma mua o ka maʻamau, ʻo ia ka acromegaly . Hoʻopilikia pū kēia i nā pākeke a me nā keiki i nā ʻano like ʻole. He kūlana kakaikahi loa ia.

ʻAcromegaly i nā pākeke

ʻO ka maʻamau, ʻike nā pākeke me ka acromegaly i nā lima a me nā wāwae i hoʻonui ʻia a pehu paha a me nā loli i nā hiʻohiʻona o ka helehelena .

Loaʻa paha iā lākou nā iwi mānoanoa a me nā ʻōpū kūloko nui aʻe. ʻOi aku ka nui o ko lākou hiki ke loaʻa i nā maʻi e like me ke koko kiʻekiʻe , ka maʻi diabetes type 2, a me nā maʻi puʻuwai. ʻOi aku ma mua o 99% o nā hihia acromegaly i hana ʻia e nā puʻupuʻu ʻaʻole cancerous i loko o ka pituitary gland i kapa ʻia ʻo pituitary adenomas . Hiki i kēia mau puʻupuʻu ke hana i ka nui o ka HGH. ʻO ka Acromegaly ka mea maʻamau ma hope o ka makahiki waena, ma hope o ka pau ʻana o ka ulu ʻana. No laila, ʻaʻole e ulu lōʻihi nā pākeke me ka acromegaly. Akā, mānoanoa paha ko lākou mau iwi.

ʻO ka Acromegaly (Gigantism) i nā keiki

He mea kākaʻikahi loa, hiki i nā keiki ke loaʻa nā pae HGH kiʻekiʻe ma mua o ko lākou hiki ʻana i ko lākou kiʻekiʻe piha. Hiki i kēia ke kumu o ka ulu nui ʻana o nā iwi lōʻihi, e alakaʻi ana i nā keiki kiʻekiʻe ʻole. Ua kapa ʻia kēia maʻi he acromegaly juvenile . I kekahi manawa ua kapa ʻia ʻo gigantism . Inā ʻaʻole mālama ʻia, hiki i kēia mau keiki ke ulu a hiki i ʻehiku kapuaʻi ke kiʻekiʻe a ʻoi aku paha. Hiki iā lākou ke ʻike i nā hōʻailona e like me ka lethargy, ka lohi o ka wā ʻōpiopio, a me nā poʻo ʻeha.

Hoʻokumu pinepine ʻia kēia e ka pituitary adenoma.

Pehea e ana ʻia ai nā pae HGH?

Inā loaʻa iā ʻoe a i kāu keiki paha nā hōʻailona e hōʻike ana he pilikia ko lākou e pili ana i ka HGH, hiki i kāu kauka ke kauoha i kekahi mau hoʻāʻo koko e nānā i kāu mau pae HGH.

E like me kaʻu i ʻōlelo ai ma mua, hoʻokuʻu ka pituitary gland i ka HGH i loko o ke koko i ke ao a me kekahi manawa i ka pō. No laila, he paʻakikī ke hoʻomaopopo pololei i ke kūlana ma ka lawe ʻana i ke koko a me ka nānā ʻana i ka HGH i hoʻokahi manawa wale nō.

No laila, hoʻohana pinepine nā kauka i nā ʻano i kapa ʻia ʻo ka hoʻoulu ʻana o ka hormone ulu a me nā hoʻāʻo hoʻopau ʻana e ʻike i nā kūlana i hoʻokumu ʻia e ka hemahema a i ʻole ka nui o ka HGH.

Eia kekahi, hiki ke hana i kahi hoʻāʻo koko e nānā i nā pae IGF-1 (insulin-like growth factor 1) .

Pehea e hoʻohana ʻia ai ka HGH ma ke ʻano he lāʻau lapaʻau?

Ua ʻāpono ka ʻOihana Meaʻai a me nā Lāʻau Lapaʻau o ʻAmelika Hui Pū ʻIa (FDA) i ka HGH synthetic e mālama i kekahi mau maʻi. Hiki ke loaʻa kēia HGH synthetic me ke kauoha a ke kauka wale nō, a hāʻawi ʻia ia ma ke ʻano he inikini.

Ua kuhikuhi ʻia ka HGH i nā keiki no nā kūlana aʻe:

• Ka nele o ka hormone ulu.
• ʻO nā kūlana e hoʻoulu ai i ke kino pōkole, e like me ka maʻi puʻupaʻa mau loa , ka maʻi Turner , a me ka maʻi Prader-Willi .

Ua kuhikuhi ʻia ʻo HGH no nā pākeke no nā kūlana aʻe:

• Ka nele o ka hormone ulu.
• Ka nalowale ʻana o ka nui o nā ʻiʻo ma muli o ka maʻi HIV .
• ʻO ka maʻi ʻōpū pōkole .

He mea nui loa: Mai hoʻohana i ka HGH synthetic ke ʻole i kuhikuhi ʻia e kāu kauka.

He aha nā hopena ʻaoʻao o ka HGH synthetic?

Hiki ke loaʻa kekahi mau hopena ʻaoʻao i ka wā e hoʻohana ai i ka HGH synthetic ma ke ʻano he lāʻau lapaʻau. Eia kēia mau mea:

• ʻO ka maʻi tunnel carpal (kahi aʻalolo i ʻoki ʻia ma ka pulima).
• Hoʻonui ʻia ke kū'ē ʻana o ka insulin a/a i ʻole ka maʻi diabetes type 2.
• Ka pehu ʻana o nā lima a me nā wāwae (edema) .
• ʻEha hui a me nā ʻiʻo.
• Ka hoʻonui ʻia ʻana o nā ʻiʻo umauma i nā kāne (gynecomastia) .
• Ka hoʻonui ʻia o ka pilikia o kekahi ʻano maʻi kanesa.

ʻAʻole lawa ka ʻike o nā kānaka noiʻi e pili ana i nā hopena lōʻihi o ka mālama ʻana i ka HGH synthetic.

Āhea wau e ʻike ai i ke kauka e pili ana i nā pae HGH?

Inā loaʻa iā ʻoe a i ʻole kāu keiki nā hōʻailona e pili ana i ka hemahema a i ʻole ka nui o ka HGH (e.g., ka ulu lohi, nā lālā i hoʻonui ʻia), e ʻike pono i kāu kauka.

Inā ke mālama ʻia nei ʻoe no kahi ʻano ʻē i nā pae HGH, he mea nui loa e ʻike pinepine i kāu kauka e hōʻoia i ka hana pono ʻana o kāu lāʻau lapaʻau.

He hormone ikaika ka HGH e pono ai no nā kaʻina hana koʻikoʻi he nui i loko o ko kākou kino. I kekahi manawa hiki i ko kākou pituitary gland ke hana nui a liʻiliʻi paha. Inā loaʻa iā ʻoe a i ʻole kāu keiki kekahi o kēia mau hōʻailona, ​​​​ʻoi aku ka maikaʻi o ke kamaʻilio ʻana me ke kauka. Aia lākou ma laila e kōkua iā ʻoe.

Leka Hoʻihoʻi Hope Loa

ʻAe, ua kamaʻilio nui kākou e pili ana iā HGH i kēia lā, ʻeā? E hōʻuluʻulu pōkole kākou:

• He hormone koʻikoʻi ka HGH no ko kākou ulu ʻana, ʻoiai i ka wā kamaliʻi, a no ka metabolism o ke kino.
• Hana ʻia kēia e ka pituitary gland i loko o ko mākou lolo.
• Inā emi ka nui o ka HGH, hiki i nā keiki ke ulu iki, a hiki i nā pākeke ke loaʻa i nā pilikia olakino like ʻole.
• Inā piʻi ka pae HGH, hiki ke loaʻa nā kūlana e like me ka acromegaly.I nā keiki, hiki i kēia ke hōʻike ʻia me ka gigantism, ʻo ia hoʻi ke ulu nei i ke kiʻekiʻe loa.
• Inā manaʻo ʻoe he pilikia paha kāu a i ʻole kāu keiki me HGH, mai kānalua e ʻimi i ke aʻo lapaʻau.
• Mai hoʻohana i ka HGH synthetic me ke kauoha ʻole a ke kauka.

E hoʻomanaʻo, ʻo kēia mau mea a pau ka mea e hoʻonaʻauao iā ʻoe. Inā he mau hopohopo olakino kou, ʻo kāu kauka wale nō ke hāʻawi i ka hopena maikaʻi loa. E noho olakino!

ʻO ka Hormone Ulu Kanaka, HGH, Pituitary Gland, Ulu ʻana o ke Keiki, Piʻi ʻana o ke Kiʻekiʻe, Metabolism, Kaulike ʻole o ka Hormone