"E ke kauka, ua lōʻihi ka manawa mai koʻu hoʻomaka ʻana e lawe i ka lāʻau lapaʻau no kēia cholesterol. Hoʻomalu maikaʻi nō hoʻi au i kaʻu ʻai. Akā, ʻaʻole i iho mai koʻu pae cholesterol..." Ke manaʻo nei ʻoe i kekahi mea e like me kēia? A i ʻole he pilikia kēia i loaʻa i kekahi o kou ʻohana? ʻO ka ʻoiaʻiʻo, he pilikia nui ka kaohi ʻana i ka cholesterol no kekahi poʻe. ʻOiai he nui ka poʻe e loaʻa ana nā hopena maikaʻi mai nā lāʻau lapaʻau ʻano 'statin', ʻaʻole kekahi. No laila, ua hoʻolauna ʻia kahi lāʻau hou i kapa ʻia ʻo Leqvio e kōkua i kēlā poʻe. E kamaʻilio kākou e pili ana i kēia me nā kikoʻī a me ka maʻalahi i kēia lā.
He aha kēia cholesterol kiʻekiʻe (Hyperlipidemia)?
I ka ʻōlelo maʻalahi, ʻo Hyperlipidemia ka wā he nui loa nā ʻano momona (kapa mākou iā lākou he lipids) i loko o kou koko. Pono mākou a pau i kahi momona i loko o ko mākou kino. Hana lākou i nā hana koʻikoʻi he nui. Akā i ka wā e kiʻekiʻe loa ai lākou e hoʻomaka ai nā pilikia. Inā kiʻekiʻe kēia mau pae momona i ka hala ʻana o ka manawa, piʻi nui ka pilikia o ka loaʻa ʻana o nā maʻi koʻikoʻi e like me ka maʻi puʻuwai, ka hahau ʻana, a me ka hōʻeha puʻuwai.
Kamaʻilio pinepine mākou e pili ana i ʻelua o nā ʻano momona nui.
| ʻAno momona | I ka ʻōlelo maʻalahi... |
|---|---|
| ʻO ka cholesterol LDL (Low-Density Lipoprotein) | ʻO kēia ka mea a mākou e kapa nei he "cholesterol maikaʻi ʻole" no ka mea ua waiho ʻia ma nā paia o nā kīʻaha koko, e pani mālie ana iā lākou a hoʻoulu ai i ka maʻi puʻuwai. |
| ʻO ka cholesterol HDL (High-Density Lipoprotein) | Ua kapa ʻia kēia ʻo "cholesterol maikaʻi" no ka mea kōkua ia i ka lawe ʻana i ka cholesterol maikaʻi ʻole (LDL) i ke akepaʻa a hoʻoneʻe aku mai ke kino. |
Eia kekahi, aia kekahi ʻano momona i kapa ʻia ʻo triglycerides. ʻAʻole maikaʻi ka loaʻa ʻana o ka nui o lākou.
He aha nā kumu o ke cholesterol kiʻekiʻe?
ʻO ka hapa nui o ka manawa, ʻo kēia ke kumu o ka hui pū ʻana o ko mākou nohona, ka ʻai, a me kekahi mau maʻi.
- ʻAi a me ka Mea Inu: ʻO ka ʻiʻo ʻulaʻula, nā sausage, ka puaʻa, a me nā mea ʻaila (laiki palai, kebabs, parathas) he kiʻekiʻe i ka momona momona. ʻO ka ʻai pinepine ʻana i kēia mau mea e hoʻonui ai i ka cholesterol.
- Ka nohona:ʻO nā hana e like me ka puhipaka, ka inu ʻona nui, ke kaumaha, a me ka nele i ka hoʻoikaika kino he hopena nui ia i ka hoʻonui ʻana i ka cholesterol.
- Nā kūlana olakino ʻē aʻe: ʻO nā kūlana e like me ka maʻi diabetes, nā pilikia o ke akepaʻa a me nā puʻupaʻa, hypothyroidism, a me ka apnea hiamoe hiki ke hana i ka cholesterol kiʻekiʻe.
ʻO ka pahuhopu nui o ka mālama ʻana, ʻo ia ka hoʻemi ʻana i ka pae o kēia mau momona "maikaʻi ʻole" i loko o ke koko. Hiki i kēia ke hoʻemi i ka pilikia o nā hanana koʻikoʻi e like me nā hōʻeha puʻuwai a me nā hahau.
Pehea e hana ai ka lāʻau lapaʻau ʻo Leqvio?
ʻO Statins ka lāʻau lapaʻau nui no ka cholesterol. Eia nō naʻe, ʻaʻole i loaʻa i kekahi poʻe ko lākou pae cholesterol haʻahaʻa e like me kā lākou makemake me ka lawe ʻana i kēia mau lāʻau lapaʻau a me ka hahai ʻana i kahi ʻai olakino. ʻO ka poʻe me kahi maʻi genetic i kapa ʻia ʻo "primary hyperlipidemia" pono paha i nā lāʻau lapaʻau he nui.
He lāʻau lapaʻau hou ʻo Leqvio i hele mai e kōkua i kēia poʻe. ʻO Inclisiran ka mea hana nui i loko. No kahi papa lāʻau lapaʻau i kapa ʻia ʻo 'small interfering RNA (siRNA)'.
I ka ʻōlelo maʻalahi, hoʻonui kēia lāʻau i ka hiki o ke akepaʻa ke omo i ka "cholesterol maikaʻi ʻole" (LDL) mai ke koko. ʻOi aku ka pololei, kōkua ia i ke akepaʻa e ʻike i nā ʻāpana LDL. Ma hope o ke omo ʻana o ke akepaʻa i kēia mau ʻāpana LDL, hoʻohana ia iā lākou a wehe paha iā lākou mai ke kino. Hoʻemi nui kēia i ka pae o ka LDL i loko o ke koko.
He ʻano ʻokoʻa loa kēia mai ka hana ʻana o nā lāʻau statin.
Hiki i kekahi me ka cholesterol ke hoʻohana iā Leqvio?
ʻAʻole. ʻAʻole kēia he lāʻau lapaʻau no nā kānaka a pau. Ua ʻae ʻia ʻo Leqvio no ka poʻe e ʻai mua ana i ka ʻai a e lawe ana i ka nui o ka statin, akā he kiʻekiʻe nō naʻe ko lākou mau pae cholesterol .
Hiki ke ʻōlelo ʻia kēia lāʻau lapaʻau, ʻoi aku hoʻi no ka poʻe me kahi maʻi genetic i kapa ʻia ʻo 'Heterozygous Familial Hypercholesterolemia (HeFH).' Inā he kiʻekiʻe kou cholesterol a ʻaʻole e iho ana kou mau pae me ka lawe ʻana i nā statins a me ka hahai ʻana i kahi meaʻai olakino, hiki i kāu kauka ke kamaʻilio me ʻoe e pili ana iā Leqvio. ʻO kāu kauka wale nō ke hoʻoholo inā kūpono kēia iā ʻoe.
Pehea e loaʻa ai iaʻu kēia lāʻau pale?
ʻAʻole ʻo Leqvio he pila, he pana ia . He inikini ma lalo o ka ʻili o ke kino. ʻAʻole hiki iā ʻoe ke hāʻawi ma ka home. Hāʻawi ʻia ia e kekahi loea mālama ola (kauka a kahu maʻi paha) ma kahi haukapila a i ʻole ke keʻena lapaʻau.
ʻO ka papa hana hoʻopili penei:
1. Ka lāʻau pale mua: E hāʻawi mua ʻia ʻoe i hoʻokahi lāʻau pale.
2. Ka lua o ka lāʻau pale ʻana:Hāʻawi ʻia ka lua o ka lāʻau pale i 3 mau mahina ma hope o ka mua.
3. Ma hope o kēlā: Ma hope o kēlā, pono ʻoe e loaʻa i hoʻokahi inikini i kēlā me kēia 6 mahina .
Hiki ke hoʻokomo ʻia kēia lāʻau pale i loko o ka ʻūhā, ka ʻōpū, a i ʻole ke kua o ka lima luna. He mea nui loa ia e loaʻa kāu lāʻau pale i ka manawa kūpono a ʻaʻole e haʻalele i nā manawa i hoʻonohonoho ʻia.
He aha kāu e ʻike ai e pili ana i ka holomua o Leqvio?
Ua hana ʻia ʻekolu mau haʻawina nui e ʻike i ka pono a me ka palekana o Leqvio. Ua mālama ʻia kēia mau haʻawina ma luna o 18 mau mahina.
- ʻElua mau haʻawina: Ua komo pū nā mea komo i ka poʻe me ka maʻi puʻuwai i hiki ʻole ke hoʻohaʻahaʻa i ko lākou pae cholesterol me ka hoʻohana ʻana i nā statins.
- Ma kekahi haʻawina ʻē aʻe, ʻo ka poʻe i komo he poʻe me kahi maʻi cholesterol genetic i kapa ʻia ʻo 'HeFH'.
Ma kēia mau haʻawina, ua hāʻawi ʻia kekahi hui i ka lāʻau pale Leqvio a ua hāʻawi ʻia kekahi hui i kahi lāʻau pale placebo ʻaʻohe hopena. Ua maopopo loa nā hopena.
| Hui | Ka loli ʻana o nā pae cholesterol "maikaʻi ʻole" (LDL) ma hope o 18 mau mahina |
|---|---|
| ʻO ka poʻe i loaʻa iā Leqvio | Ma ka awelika, ua emi iho ia ma ka 40% - 51% . |
| ʻO ka poʻe i loaʻa ka placebo (lāʻau lapaʻau hoʻopunipuni) | ʻO ka piʻi ʻana maʻamau he 1% - 8% . |
Hōʻike kēia mau hopena he lāʻau lapaʻau ʻo Leqvio e hiki ke hōʻemi nui i nā pae cholesterol LDL i kāohi ʻole ʻia e nā statins. Hoʻomaka ka emi ʻana o nā pae cholesterol i loko o nā mahina 3 mua.
Ke hōʻemi nei kēia lāʻau lapaʻau i ka pilikia o ka hōʻeha puʻuwai a me ka hahau?
He nīnau koʻikoʻi loa kēia. Ua hōʻike ʻia nā lāʻau Statin e hōʻemi i ka cholesterol LDL a hōʻemi i ka pilikia o ka hōʻeha puʻuwai a me ka hahau. Akā, he lāʻau ʻokoʻa ka hana a Leqvio.
Ua hōʻike ʻia nā haʻawina o kēia manawa hiki iā Leqvio ke hōʻemi nui i ka cholesterol LDL. Eia nō naʻe, ua hana ʻia kēia mau haʻawina no kahi manawa pōkole, ma kahi o 18 mau mahina. No laila, ʻaʻole lawa kēlā manawa e ʻike ai inā hōʻemi maoli ka lāʻau i ka pilikia o ka hōʻeha puʻuwai a me ka hahau.
Eia nō naʻe, ʻo ka emi nui ʻana o ka cholesterol LDL e hōʻike ana e hiki ke hoʻemi ʻia kēia pilikia i ka wā e hiki mai ana. Ke hana ʻia nei nā haʻawina lōʻihi hou aku e hōʻoia i kēia.
Nā hopena ʻaoʻao a pehea e mālama ai iā lākou?
E like me nā lāʻau lapaʻau āpau, hiki iā Leqvio ke hana i nā hopena ʻaoʻao liʻiliʻi. ʻO ka mea maʻamau ka hopena ma kahi i hoʻokomo ʻia ai .
- ʻUlaʻula ma kahi i hoʻokomo ʻia
- ʻĀnai
- ʻEha
No kēia kumu, ʻaʻole e hāʻawi ka loea mālama ola kino nāna e hāʻawi i ka lāʻau pale i kahi wahi i puhi ʻia i ka lā, he ʻulaʻula, a i ʻole i loaʻa i ka maʻi. Inā ua loaʻa iā ʻoe kahi inikini ma mua a ua ʻoi aku ka ʻeha, e haʻi i ke kauka a i ʻole ke kahu maʻi. A laila hiki iā lākou ke koho i kahi wahi ʻē aʻe.
Ma waho aʻe o kēia mau mea, hiki ke loaʻa nā hopena ʻaoʻao ʻē aʻe. Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē, e kamaʻilio koke me kāu kauka.
ʻAʻohe pilina i hōʻike ʻia ma waena o Leqvio a me nā lāʻau lapaʻau ʻē aʻe i kēia manawa. Eia nō naʻe, he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau, nā huaora, a me nā huahana lāʻau lapaʻau āu e lawe nei.
Leka Lawe-Home
- He lāʻau pale hou ʻo Leqvio no ka kaohi ʻana i ka cholesterol.
- Paipai ʻia kēia no nā poʻe me nā pae cholesterol kiʻekiʻe i hiki ʻole ke kāohi ʻia me nā lāʻau statin a me ka ʻai.
- He lāʻau pale kēia i hāʻawi ʻia e kekahi loea mālama ola i kēlā me kēia 6 mahina (ma hope o nā lāʻau mua ʻelua).
- Ua hōʻike ʻia nā noiʻi he mea maikaʻi loa kēia i ka hōʻemi ʻana i nā pae cholesterol LDL "maikaʻi ʻole".
- ʻO kāu kauka wale nō ke hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe, no laila e kamaʻilio me kāu kauka e pili ana i kēia.
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