ʻO ka mea e pono ai ʻoe e ʻike e pili ana i ka lāʻau pale mRNA

Ua lohe pinepine kākou a pau i ka huaʻōlelo "mRNA" me ka maʻi ahulau COVID-19, ʻeā? Akā i ka manawa like, he nui ka poʻe e nīnau ana e pili ana i kēia, a me ka makaʻu iki. "He mea hou anei kēia?", "He aha ka hopena o kēia i ko kākou kino?" Ua noʻonoʻo paha ʻoe. No laila, i kēia lā, e kamaʻilio maʻalahi a me ke akahai e pili ana i ke ʻano o kēia lāʻau pale mRNA a pehea e hana maoli ai i loko o ko kākou kino.

E nānā mua kākou, he aha kēia mRNA?

ʻO ka inoa piha o ka mRNA ʻo messenger Ribonucleic Acid. ʻOiai he paʻakikī iki ka inoa, he maʻalahi loa ka hana. E noʻonoʻo i ka DNA i loko o ko kākou kino e like me kahi puke kuke nui. Aia i loko o kēia puke nā kuhikuhi no ka hana ʻana i nā protein āpau e pono ai ko kākou kino. Akā, ʻaʻole hiki iā ʻoe ke lawe i kēia puke nui holoʻokoʻa i ka lumi kuke (ʻo ia hoʻi, i nā ribosomes i loko o ko kākou mau cell e hana ana i nā protein).

ʻO kēia kahi e komo mai ai ka 'ʻelele' i kapa ʻia ʻo mRNA. ʻO kāna hana, kākau ia ma kahi ʻāpana pepa i ke ʻano hana no ka protein e pono ai e hana mai kēlā puke DNA nui, a lawe i kēlā leka i ka lumi kuke. I ka ʻōlelo maʻalahi, ua like ka mRNA me kahi leka pōkole e kope ana i nā kuhikuhi ma ka DNA a hoʻouna iā lākou i kahi i hana ʻia ai ka protein. He hana kēia e hana maoli ʻia i loko o ko mākou kino i nā manawa a pau.

No laila he aha ka mea e hana me kahi lāʻau pale mRNA?

E like me nā lāʻau pale āpau, hoʻomaʻamaʻa kahi lāʻau pale mRNA i ka ʻōnaehana pale o ko mākou kino e hakakā i kahi maʻi. Akā ʻokoʻa iki ke ʻano o kāna hana ʻana.

E lawe i ka lāʻau pale mRNA no COVID-19 ma ke ʻano he laʻana. ʻO ka hana a kēia lāʻau pale, ʻo ia ka hāʻawi ʻana i ko kākou mau cell i nā kuhikuhi wale nō (ka leka mRNA) e pono ai e hana i ka 'Spike Protein', ʻo ia kekahi ʻāpana o ka maʻi SARS-CoV-2 e hoʻoulu ai i ka COVID-19.

Ke loaʻa i ko kākou mau pūnaewele kēia kuhikuhi, hana lākou i kekahi o kēia 'protein kakalaioa.' Ke ʻike ko kākou ʻōnaehana pale i kēia protein i hoʻokumu hou ʻia, ʻōlelo ia, "ʻAuē... he mea hoʻouka kaua kēia ʻaʻole pono i loko o ko kākou kino." A laila, hoʻomākaukau ia e hana i nā mea kaua, e like me nā antibodies, e hakakā me ia.

No ka mea, ua hoʻomaʻamaʻa mua ʻia mākou ma kēia ʻano, inā komo ka maʻi COVID-19 maoli i ke kino ma hope aku, e ʻike koke ko mākou ʻōnaehana pale iā ia ke ʻike ʻia, e hoʻouka koke a me ka pono, a pale iā mākou mai ka maʻi nui ʻana.

Hoʻopau, hoʻopau, a nalowale ka leka mRNA mai ka lāʻau pale i loko o kekahi mau lā i loko o ke kino. E like me ka puke kuhikuhi a mākou e lawe ai i ka lumi kuke a luku iā ia ke pau mākou. ʻAʻole loa ia e hoʻohui me kā mākou DNA a hoʻololi paha i kā mākou mau genes.

He aha ka ʻokoʻa ma waena o nā lāʻau pale mRNA a me nā lāʻau pale kuʻuna?

ʻO ka ʻokoʻa nui ma ke ʻano o ka hōʻike ʻana o ka maʻi i ka ʻōnaehana pale. E nānā i ka papa ma lalo no ka ʻike hou aku.

He aha ka mea e hana ʻia ke loaʻa iā ʻoe ka lāʻau pale?

E hoʻomaʻemaʻe ke kauka a kahu maʻi paha i ka piko o kou lima me ka waiʻona a hāʻawi iā ʻoe i ka inikini. A laila, e noi ʻia ʻoe e kali ma kahi o 15 mau minuke. ʻO kēia ke nānā i kahi hopena maʻi koke i ka inikini. Manaʻo kekahi poʻe ua nāwaliwali i ka wā o ka inikini, no laila ʻoi aku ka maikaʻi o ka noho ʻana i lalo.

He aha nā pōmaikaʻi a me nā pilikia o nā lāʻau pale mRNA?

Nā Pōmaikaʻi

ʻO kekahi o nā pono nui o ka ʻenehana mRNA ka wikiwiki . Pono nā lāʻau pale kuʻuna e ulu i ka maʻi i loko o kahi keʻena hoʻokolohua. Hiki i kēlā ke hala i nā mahina, a i ʻole nā ​​​​makahiki. Akā, ʻaʻole koi nā lāʻau pale mRNA i kēlā, no laila hiki ke hana koke ʻia, ʻoiai inā loaʻa kahi maʻi ahulau hou.

E kamaʻilio ana e pili ana i nā lāʻau pale COVID-19, ke loaʻa ʻana o ka lāʻau pale,

• Hoʻemi i ka pilikia o ka maʻi COVID-19.
• ʻOiai inā ua loaʻa ka maʻi, ua hoʻemi nui ʻia ka pilikia o ka maʻi nui, ka hoʻokipa ʻana i ka haukapila, a me ka make.
• Hoʻemi i ka pilikia o nā hopena lōʻihi (COVID Lōʻihi) ma hope o ka loaʻa ʻana o ka COVID-19.

Nā Pōʻino a me nā Hopena ʻAoʻao

E like me nā lāʻau pale āpau, hiki i nā lāʻau pale mRNA ke loaʻa nā hopena ʻaoʻao liʻiliʻi. He hōʻailona maoli kēia e hoʻomaka ana kāu ʻōnaehana pale e hana.

Nā hopena ʻaoʻao maʻamau:

• ʻEha a pehu paha ma kahi i inikini ʻia
• Luhi
• ʻEha poʻo
• ʻEha ʻiʻo
• kuni iki

ʻO ka maʻamau, nalo loa kēia mau hōʻailona i loko o hoʻokahi a ʻelua paha lā.

Nā hopena alerika kakaikahi akā koʻikoʻi:

He mea kākaʻikahi loa, loaʻa paha i kekahi kahi hopena maʻi i kekahi mea i loko o ka lāʻau pale. Eia nā hōʻailona:

• ʻŌhūhū ʻili a i ʻole ka maneʻo
• ʻĀnai
• Ka pehu ʻana o ka maka, nā lehelehe, ke alelo, a i ʻole ka puʻu (Anaphylaxis)

He mea hou maoli anei kēia ʻenehana?

ʻAʻole. Ke hoʻomau nei ka noiʻi ʻana i ka ʻenehana mRNA mai ka makahiki 1970. ʻAʻole a hiki i ka makahiki 1990 i hoʻomaka ai ka noiʻi ʻana i ka hoʻohana ʻana i kēia ʻenehana e hana i nā lāʻau pale. Ua hala ma mua o 20 mau makahiki o nā kānaka ʻepekema e noʻonoʻo pehea e hoʻokomo ai i kēia mRNA i loko o nā cell me ka ʻole o ka luku ʻana o kā mākou ʻōnaehana pale.

Ua hoʻohana pono ʻia kēia ʻenehana no kahi lāʻau lapaʻau (Patisiran) e mālama ai i kahi maʻi neurological laha ʻole ma mua o ka maʻi ahulau COVID-19. I ka wā i pā mai ai ka maʻi ahulau COVID-19, ua hiki i nā kānaka ʻepekema ke hoʻohana i ka ʻike i loaʻa mai nā makahiki he ʻumi o ka noiʻi ʻana e hoʻomohala i nā lāʻau pale palekana a maikaʻi hoʻi me ka wikiwiki ma mua o ka wā ma mua.

He mea maʻamau ka makaʻu iki a me ke kānalua i nā mea hou. Akā, he lele nui i mua ka mRNA i ka ʻepekema lapaʻau, i noiʻi ʻia a hoʻomohala ʻia i nā makahiki he ʻumi. Hiki i kēia molekole ʻelele liʻiliʻi ke kōkua iā mākou e mālama i nā maʻi ʻē aʻe he nui, e like me ke kanesa, i ka wā e hiki mai ana.