E aʻo kākou e pili ana i ka lāʻau pale Natalizumab. Ua kuhikuhi ʻia anei kēia lāʻau lapaʻau iā ʻoe?

Ke ʻōlelo aku ke kauka i kahi lāʻau pale i kapa ʻia ʻo Natalizumab iā ʻoe a i ʻole kekahi āu i ʻike ai, he mea maʻamau ka loaʻa ʻana o nā nīnau he nui e pili ana i ia mea. "He aha ka maʻi i hāʻawi ʻia ai kēia?", "E ho'ōla maoli anei ia?", "Aia kekahi mau hopena ʻaoʻao?" Ke noʻonoʻo nei paha ʻoe i ka mea like. No laila, i kēia lā, e kamaʻilio kākou e pili ana i kēia lāʻau i kapa ʻia ʻo Natalizumab ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

He aha ke ʻano lāʻau lapaʻau ʻo Natalizumab?

I ka ʻōlelo maʻalahi, he lāʻau lapaʻau ʻo Natalizumab. ʻO ia hoʻi, ʻaʻole ia e ho'ōla loa i ka maʻi, akā kōkua ia i ka hoʻomalu ʻana i nā hōʻailona a hoʻemi i ke alapine o ka hoʻāla ʻana o ka maʻi. Hoʻohana nui ʻia kēia lāʻau no ʻelua mau kūlana.

1. No ke kūlana o ka Relapsing Multiple Sclerosis:

E noʻonoʻo i kēia ʻano: ua like ko kākou ʻōnaehana nerve me kahi uea e lawe ana i nā hōʻailona uila. I loko o kahi maʻi i kapa ʻia ʻo multiple sclerosis, ua hōʻino ʻia ka uhi pale (myelin) a puni kēia mau olonā nerve. A laila ʻaʻole hele pono kēlā mau hōʻailona uila. Hiki i kēia ke hana i nā hōʻailona e like me ka paʻakikī i ka hele wāwae, nā pilikia ʻike, ka paʻakikī i ka ʻōlelo ʻana, a me ka nalowale o ka ʻike. Hana ʻo Natalizumab ma ka kaohi ʻana i kēia pōʻino a me ka hoʻēmi ʻana i ke alapine o ka hoʻonui ʻia ʻana o ka maʻi.

2. No ka maʻi o Crohn:

ʻO ka maʻi Crohn kahi maʻi mumū mau loa o ka ʻōnaehana hoʻoheheʻe, ʻoiai nā ʻōpū. Hiki iā ia ke hana i nā hōʻailona e like me ka ʻeha o ka ʻōpū, ka pehu ʻana, a me ka pohō kaumaha. Hiki i nā kauka ke ʻōlelo aku i ka lāʻau lapaʻau ʻo Natalizumab ke holo pono ʻole nā ​​​​lāʻau ʻē aʻe.

ʻO ka mea nui loa, ʻo ia ka hoʻoholo ʻana o kāu kauka inā kūpono kēia lāʻau lapaʻau iā ʻoe a me ka lōʻihi o kou lawe ʻana. No laila, he mea nui loa e hahai i kāna mau kuhikuhi.

Hiki i nā kauka ke hoʻohana i kēia lāʻau lapaʻau no nā kūlana ʻē aʻe. Inā he mau nīnau kāu e pili ana i ia mea, e nīnau i kāu kauka a kauka lāʻau paha. ʻO Tysabri ka inoa inoa o kēia lāʻau lapaʻau.

He aha kaʻu e haʻi aku ai i ke kauka ma mua o ka lawe ʻana i kēia lāʻau lapaʻau?

Ma mua o kou hoʻomaka ʻana e lawe iā Natalizumab, he mea nui e haʻi i kāu hui mālama ola (ʻo ia hoʻi, nā kauka a me nā kahu maʻi) i kekahi ʻike, no ka mea, e kōkua kēlā ʻike iā lākou e hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe a i ʻole inā pono ʻoe e lawe i kekahi mau hana palekana kūikawā.

Inā loaʻa iā ʻoe kēia mau mea, e ʻōlelo pono ia:

• Nā pilikia o ka ʻōnaehana pale: Inā he nāwaliwali a pilikia paha kou me ka ʻōnaehana pale maʻi o kou kino (ʻōnaehana pale), e haʻi mai iā mākou e pili ana i ia mea. ʻO kēia no ka mea e hoʻopilikia pū kēia lāʻau i ka ʻōnaehana pale, no laila he mea nui e makaʻala iā ia.
• ʻO kahi kūlana i kapa ʻia ʻo Progressive Multifocal Leukoencephalopathy (PML):He maʻi lolo laha ʻole kēia akā he mea weliweli loa. Inā ua loaʻa iā ʻoe kēia maʻi, pono ʻoe e haʻi mai iā mākou.
• Inā loaʻa iā ʻoe kahi maʻi ʻaleka iā Natalizumab a i ʻole nā ​​​​lāʻau lapaʻau ʻē aʻe, nā meaʻai, nā kala, a i ʻole nā ​​​​mea mālama: Hiki i kekahi poʻe ke maʻi i kekahi mau lāʻau lapaʻau. No laila, inā ua loaʻa iā ʻoe kekahi mau maʻi ʻaleka ma mua i kēia lāʻau lapaʻau a i ʻole kekahi lāʻau lapaʻau ʻē aʻe, e haʻi i kāu kauka.
• Inā hāpai ʻoe a i ʻole e hoʻāʻo ana e hāpai: Hiki i kekahi mau lāʻau lapaʻau ke hōʻeha i ka pēpē i ka wā hāpai, no laila he mea nui e kamaʻilio me kāu kauka e pili ana i kēia.
• Inā he makuahine hānai waiū ʻoe: Hiki i kekahi mau lāʻau lapaʻau ke hele i kāu pēpē ma o ka waiū umauma. No laila e haʻi pū i kāu kauka e pili ana i kēia.

Ma waho aʻe o kēia mau mea, he mea nui loa hoʻi e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei (nā lāʻau lapaʻau i kauoha ʻia, nā lāʻau lapaʻau ma luna o ke kauka kūʻai, nā lāʻau lapaʻau kuʻuna, nā huaora, nā huahana lāʻau lapaʻau).

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Pehea ʻoe e hoʻohana ai i kēia lāʻau lapaʻau?

Hāʻawi ʻia ʻo Natalizumab ma ke ʻano he infusion i loko o kahi aa. Ua like ia me ka hāʻawi ʻana i kahi hopena saline. ʻAʻole hiki iā ʻoe ke hana i kēia ma ka home. Hāʻawi ʻia iā ʻoe e kahi loea mālama ola, e like me ke kauka a kahu maʻi paha, ma kahi haukapila a i ʻole ke keʻena lapaʻau.

ʻO ka maʻamau, hāʻawi ʻia kēia lāʻau lapaʻau i hoʻokahi manawa i ka mahina, akā hiki ke loli kēia ma muli o kou kūlana.

Ke kuhikuhi ʻia kēia lāʻau lapaʻau iā ʻoe, e hāʻawi ka hale kūʻai lāʻau lapaʻau iā ʻoe i kahi alakaʻi kūikawā (MedGuide) . E loaʻa iā ʻoe kēia me kēlā me kēia kauoha, i kēlā me kēia manawa āu e loaʻa ai ka lāʻau lapaʻau. He mea nui loa ia e heluhelu pono i kēia. Aia i loko ka ʻike e pili ana i ka lāʻau lapaʻau, nā hopena ʻaoʻao, a me nā mea e makaʻala ai. Inā he mea āu i maopopo ʻole ai, mai makaʻu e nīnau i kāu kauka a kauka lāʻau paha.

Hiki ke hāʻawi ʻia kēia lāʻau lapaʻau i nā keiki?

ʻAʻole ʻae ʻia kēia lāʻau lapaʻau no ka hoʻohana ʻana i nā keiki. Inā ʻoe e noʻonoʻo ana i kēia lāʻau lapaʻau no kāu keiki, pono ʻoe e kamaʻilio me kāu kauka pediatric e pili ana i ia mea.

He aha kāu e hana ai inā lawe ʻoe i ka nui o ka lāʻau lapaʻau? (Overdosage)

ʻOiai ua hāʻawi ʻia kēia ma ka haukapila, haʻahaʻa ka manawa e hiki ai kēia. Eia nō naʻe, inā manaʻo ʻoe ua lawe nui ʻoe i ka lāʻau lapaʻau, e kāhea koke i kahi kikowaena kaohi lāʻau make a i ʻole ke keʻena pilikia.

Nou wale nō kēia lāʻau lapaʻau! He mea kēia a ke kauka i kuhikuhi ai no kou kūlana a me kou kino. No laila, mai kaʻana like i kēia lāʻau lapaʻau me kekahi.

He aha kāu e hana ai inā e poina iā ʻoe kahi mahele o ka lāʻau lapaʻau?

He mea nui loa ka lawe ʻana i kēia lāʻau lapaʻau i ka manawa kūpono. Inā ʻaʻole ʻoe e haʻalele i kahi manawa i hoʻonohonoho ʻia, e kāhea koke i kāu kauka a i ʻole ke kauka olakino. E haʻi lākou iā ʻoe i ka mea e hana ai ma hope. Mai hoʻoholo i kāu iho.

He aha nā lāʻau lapaʻau ʻē aʻe e launa pū (hakakā) me kēia lāʻau lapaʻau?

He mea nui loa kēia. Aia kekahi mau lāʻau lapaʻau e hiki ke hoʻopilikia i ka wā e lawe ʻia ai me Natalizumab. No laila, he mea nui e ʻike kāu kauka i nā lāʻau lapaʻau āpau āu e lawe nei.

Mai lawe pū me nā lāʻau lapaʻau aʻe ʻo Natalizumab:

• ʻO nā lāʻau lapaʻau biologic, e like me adalimumab, certolizumab, etanercept, golimumab, a me infliximab, hoʻopilikia pū kekahi i ka ʻōnaehana pale, no laila hiki iā lākou ke hoʻonui i ka pilikia o nā maʻi koʻikoʻi.

Hiki i kēia mau lāʻau lapaʻau ke launa pū me Natalizumab:

• ʻAzathioprine
• ʻO Cyclosporine
• Nā Interferon
• 6-mercaptopurine
• ʻO Methotrexate
• Nā lāʻau lapaʻau ʻē aʻe e hoʻohaʻahaʻa i kou manawa e hakakā ai i kahi maʻi
• Nā lāʻau lapaʻau steroid - nā laʻana: prednisone a i ʻole cortisone
• Nā lāʻau pale - E makaʻala i ka wā e loaʻa ai nā lāʻau pale ola, ʻoi aku hoʻi. E kamaʻilio me kāu kauka e pili ana i kēia.

ʻAʻole paha e komo nā lāʻau lapaʻau āpau i kēia papa inoa. No laila, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe ai (me nā mea kanu, nā lāʻau lapaʻau ʻaʻole i kuhikuhi ʻia, a me nā mea hoʻohui meaʻai), a inā ʻoe e puhipaka, inu waiʻona, a hoʻohana paha i nā lāʻau lapaʻau kū ʻole i ke kānāwai. Hiki i kekahi mau mea ke launa pū me kāu mau lāʻau lapaʻau.

He aha nā mea e makaʻala ai i ka wā e lawe ai i kēia lāʻau?

ʻOiai ʻoe e lawe ana i kēia lāʻau lapaʻau, e nānā mau kāu kauka iā ʻoe. E hōʻoia e ʻike i kāu kauka i nā lā i hoʻonohonoho ʻia. E haʻi i kāu kauka inā ʻaʻole hoʻomaikaʻi kāu mau hōʻailona, ​​​​inā e ʻoi aku ka ʻino, a inā hoʻomau lākou.

E noho mamao aku mai ka poʻe maʻi. Hiki i kēia lāʻau ke hoʻopilikia iki i kou ʻōnaehana pale, e hoʻonui ai i kou loaʻa ʻana i nā maʻi. Inā loaʻa iā ʻoe nā hōʻailona e like me ke kuni, ke anu, ka ʻāʻī ʻeha, a i ʻole ka ihu wai, e kāhea koke i kāu kauka no ka ʻōlelo aʻo. Mai hele wale i waho e kiʻi i ka lāʻau lapaʻau.

ʻŌlelo aʻo koʻikoʻi loa: ka pilikia o ka maʻi lolo (PML)

He mea weliweli iki paha kēia, akā he mea nui e makaʻala. I kekahi mau maʻi, ʻoiai he mea kakaikahi loa, hiki i ka lāʻau lapaʻau ʻo Natalizumab ke hoʻoulu i kahi maʻi lolo koʻikoʻi i kapa ʻia ʻo Progressive Multifocal Leukoencephalopathy (PML) . Hiki i kēia ke make.

No laila, inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​​​pono ʻoe e haʻi koke i kāu kauka:

• Nā loli o ka ʻike (e laʻa, ka ʻike pōwehiwehi koke, ka ʻike pālua)
• Nā pilikia noʻonoʻo (e like me ka hoʻonāukiuki, ka nalowale o ka hoʻomanaʻo, ka paʻakikī i ka hoʻoholo ʻana)
• Nā pilikia ma ka ʻōlelo (e laʻa me ka ʻōlelo ʻole ʻana, ka hiki ʻole ke ʻōlelo maopopo)
• Ka paʻakikī o ka hele wāwae (e.g., ka nalowale o ke kaulike, hiki ʻole ke hele pololei)
• Paʻakikī ke kū ʻana

Inā ʻaʻole hiki iā ʻoe ke hoʻokaʻaʻike aku i kāu kauka, e hele koke i ka lumi pilikia. Mai hoʻowahāwahā i kēia. Hiki i kēia mau hōʻailona ke lilo i mau hōʻailona o ka PML a ʻaʻole paha. Akā ʻoi aku ka maikaʻi o ka hoʻāʻo ʻia.

He aha nā hopena ʻaoʻao e hiki ke loaʻa mai kēia lāʻau lapaʻau?

E like me nā lāʻau lapaʻau āpau, hiki iā Natalizumab ke hana i kekahi mau hopena ʻaoʻao. ʻAʻole loaʻa i nā kānaka a pau, akā he mea maikaʻi ke makaʻala iā lākou.

Nā hopena ʻaoʻao e pono e hōʻike koke ʻia i kāu kauka a i ʻole ke kauka olakino:

• Nā hopena maʻi ʻaleka: Nā hōʻailona e like me ka ʻulaʻula o ka ʻili, ka maneʻo, ka hives, ka pehu ʻana o ka maka, nā lehelehe, a me ke alelo.
• Paʻakikī ka hanu ʻana.
• Nā loli i ka ʻike.
• ʻEha ka umauma.
• Huikau, hopohopo.
• ʻAno kaumaha, manaʻo e like me ke nalowale nei kou hauʻoli.
• Pōʻaiʻī.
• Manaʻo nāwaliwali; poʻo māmā; hāʻule.
• Ka maʻi laulā a i ʻole nā ​​​​hōʻailona e like me ka maʻi palū.
• Ka nalowale o ka hoʻomanaʻo.
• ʻO nā wahine i hala ʻole ko lākou mau lā menstrual i ko lākou mau lā palena (Missed menstrual periods).
• Ka nāwaliwali o nā ʻiʻo.
• Nā pilikia me ke kaulike, ke kamaʻilio ʻana, a i ʻole ka hele wāwae ʻana. (Hiki i kēia ke lilo i mau hōʻailona o ka PML, no laila e makaʻala loa!)
• Nā hōʻailona a me nā ʻōuli o ka hōʻeha ʻana o ke akepaʻa: Mimi melemele ʻeleʻele a ʻeleʻele paha; maʻi ʻino, kuni; ʻōpala keʻokeʻo; nalowale o ka makemake e ʻai; nausea; ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū; luhi a nāwaliwali paha; melemele o nā maka a i ʻole ka ʻili.
• Nā manaʻo pepehi kanaka, nā loli o ka naʻau.
• ʻO ka palapū a i ʻole ke kahe koko ma ke ʻano ʻē.
• Nāwaliwali a luhi paha i ka maʻamau.

Nā hopena ʻaoʻao ʻaʻole pono ka ʻōlelo aʻoaʻo lapaʻau (akā pono e hōʻike i ke kauka inā hoʻomau a hoʻopilikia paha):

• ʻEha poʻo
• ʻEha hui
• ʻEhaʻeha o nā ʻiʻo
• ʻEha ʻiʻo
• Ka luaʻi, ka luaʻi
• ʻEha, ʻulaʻula, a huhū paha ma kahi i hoʻokomo ʻia ai
• Luhi

ʻAʻole paha e komo pū kēia papa inoa me nā hopena ʻaoʻao āpau. Inā ʻike ʻoe i kekahi mea ʻē aʻe ma waho aʻe o kēia mau mea, e nīnau i kāu kauka.

Ma hea ʻoe e mālama ai i kēia lāʻau lapaʻau?

ʻAʻole ʻoe e ʻae ʻia e lawe i kēia lāʻau lapaʻau i ka home. Loaʻa a hāʻawi ʻia iā ʻoe ma kahi haukapila a i ʻole ke keʻena lapaʻau. No laila, ʻaʻole pono ʻoe e hopohopo e pili ana i ke ʻano o ka mālama ʻana.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻAe, ua kamaʻilio nui mākou e pili ana iā Natalizumab. Inā he mau nīnau hou kāu e pili ana i kēia lāʻau lapaʻau, mai makaʻu e nīnau i kāu kauka, kahu maʻi, a kauka lāʻau paha. E kōkua lākou iā ʻoe.

ʻO ka mea nui loa, ʻo ia ka lawe ʻana i ka lāʻau lapaʻau e like me ka ʻōlelo a kāu kauka iā ʻoe, i ka manawa kūpono, a ma ke ʻano kūpono. E makaʻala i nā hopena ʻaoʻao, ʻoiai nā hōʻailona o kahi maʻi i kapa ʻia ʻo PML. Inā ʻike ʻoe i kekahi mea ʻē, e haʻi koke i kāu kauka.

Hiki i kēia lāʻau lapaʻau ke kōkua iā ʻoe e kāohi i kou kūlana. No laila, e noho ikaika a hui pū me ke kauka ma kēia huakaʻi. Ke makemake nei iā ʻoe e ho'ōla koke!

ʻO Natalizumab, Multiple Sclerosis, ka maʻi Crohn, PML, nā hopena ʻaoʻao o ka lāʻau lapaʻau, Immunotherapy, Tysabri