Ua haʻi aku kāu kauka iā ʻoe ua kiʻekiʻe kou pae cholesterol? Inā pēlā, ua hoʻomaka paha ʻoe i ka statin. ʻO ia ka laina mua o ka lāʻau lapaʻau. Akā i kekahi manawa ʻaʻole lawa kēlā lāʻau lapaʻau wale nō. A i ʻole ʻaʻole hiki i kekahi poʻe ke ʻae i nā hopena ʻaoʻao o ka lāʻau lapaʻau. ʻO ia ke kumu e kamaʻilio nei nā kauka e pili ana i kahi papa hou o nā lāʻau lapaʻau he 'mea hoʻololi pāʻani'. Ua kapa ʻia kēia mau mea he PCSK9 Inhibitors. E kamaʻilio kākou e pili ana iā lākou ma nā ʻōlelo maʻalahi i kēia lā.
I ka ʻōlelo maʻalahi, he aha kēia mau mea pale PCSK9?
He papa lāʻau lapaʻau hou kēia e hiki ke hoʻemi pono i ka cholesterol 'maikaʻi ʻole', a i ʻole ka cholesterol LDL , i loko o ko kākou koko. Aia ʻelua ʻano lāʻau lapaʻau nui i ʻāpono ʻia ma ka honua i kēia manawa. ʻO lākou ʻo `alirocumab (Praluent)` a me `evolocumab (Repatha)`.
Ua hōʻike ʻia e ka noiʻi he mea kupanaha ka hopena o kēia mau lāʻau lapaʻau, i kapa ʻia ʻo PCSK9 inhibitors. I kekahi mau hihia, hiki iā lākou ke pale aku i nā hōʻeha puʻuwai a me nā hahau . Hiki ke lawe wale ʻia kēia mau lāʻau lapaʻau, a i ʻole me ka hui pū ʻana me kahi lāʻau statin āu e lawe nei. Akā hoʻokahi mea e hoʻomanaʻo ai, ʻoi aku ke kumukūʻai ma mua o nā lāʻau cholesterol ʻē aʻe.
ʻAe, e nānā kākou pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino.
I mea e hoʻomaopopo ai i kēia, e noʻonoʻo kākou i kahi moʻolelo liʻiliʻi. ʻO ke akepaʻa ka ʻāpana nui e kaohi ana i ka cholesterol i loko o ko kākou kino.
E noʻonoʻo he mau "mea ʻimi" liʻiliʻi (nā mea loaʻa) ko kākou mau hunaola akepaʻa e hopu a wehe i ka cholesterol i makemake ʻole ʻia mai ke koko. ʻO kēia ka poʻe e mālama i ko kākou mau kīʻaha koko i maʻemaʻe.
Akā, aia kekahi protein ʻē aʻe i kapa ʻia ʻo PCSK9 a ko kākou kino e hana ai. ʻO kāna hana ka ʻimi a luku i kēlā mau "mea hoʻomaʻemaʻe" maikaʻi. A laila, no ka mea ʻaʻohe mea nāna e wehe i ka cholesterol, hōʻiliʻili ia i loko o ke koko a waiho ʻia i loko o nā paia o nā aʻa.
ʻO kēia kahi e hele mai ai kā mākou mea haʻiʻōlelo, ʻo ia ka lāʻau hoʻopaʻa PCSK9, e hoʻopakele. ʻO ka hana a kēia lāʻau, ʻo ia ke hopu i kēlā protein PCSK9 maikaʻi ʻole a hoʻōki iā ia mai ka hana ʻana. Ua like ia me ka hopu ʻana i kahi keiki kolohe a hoʻokomo iā ia i loko o kahi noho. A laila hiki i kā mākou "mea hoʻomaʻemaʻe" ke hana i kā lākou hana me ke keakea ʻole. ʻO ka hopena? E emi koke ana ka pae o ka cholesterol LDL i loko o ke koko.
He aha ka ʻokoʻa o kēia mau mea mai nā 'statins'?
ʻO Statins a me nā mea hoʻopaʻa PCSK9 ʻelua ʻano lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol, akā hana lākou ma nā ʻano ʻelua. E kōkua kēia papa iā ʻoe e hoʻomaopopo i kēia.
| ʻOkoʻa | ʻO Statin | Nā mea pale PCSK9 |
|---|---|---|
| Hana | Kāohi i ka hana ʻana o ka cholesterol i loko o ke ake. | Kāohi i ka luku ʻia ʻana o nā mea loaʻa e wehe i ka cholesterol mai ke ake. |
| Pehea e lawe ai | He pila i lawe ʻia i kēlā me kēia lā. | He inikini i hāʻawi ʻia i kēlā me kēia 2 a 4 paha pule. |
| Hoʻohana | I ka hoʻohana pinepine ʻia ʻana, ʻo ia ke koho mua no ka kaohi ʻana i ka cholesterol. | Hiki ke hoʻohana ʻia hoʻokahi a i ʻole me ka hui pū ʻana me nā statins. ʻOi aku ka ikaika o nā hopena. |
No laila, ʻo wai ka mea makemake e lawe i kēia lāʻau lapaʻau?
He nīnau koʻikoʻi kēia no ka mea ʻaʻole pono kēia lāʻau lapaʻau i nā kānaka a pau me ka cholesterol kiʻekiʻe. E hoʻāʻo mua kāu kauka e kāohi i kāu cholesterol me nā statins. Akā e noʻonoʻo paha kāu kauka i kahi mea hoʻopaʻa PCSK9 i nā hihia aʻe:
- Nā kūlana cholesterol kiʻekiʻe genetic: Loaʻa i kekahi poʻe kahi kūlana genetic i kapa ʻia ʻo "Familial Hypercholesterolemia." He kīnā ko kēia poʻe i ke ʻano o ko lākou kino e kāohi ai i ka cholesterol. ʻOiai me ka nui o nā statins, he mea paʻakikī loa ia no kēia poʻe ke hoʻohaʻahaʻa i ka LDL cholesterol i kahi pae olakino.
- No nā poʻe i loaʻa i ka pilikia nui o ka hōʻeha puʻuwai a i ʻole ka hahau: Inā loaʻa iā ʻoe ka maʻi puʻuwai, a ʻaʻole i kāohi pono ʻia kāu mau pae cholesterol me nā lāʻau lapaʻau e like me nā statins, e noʻonoʻo paha kāu kauka i kēia lāʻau lapaʻau.
- No ka poʻe hiki ʻole ke ʻae i nā 'statins': Ma kahi o 10%-20% o ka poʻe e lawe ana i nā statins e ʻike i nā hopena ʻaoʻao e like me ka ʻeha ʻiʻo hiki ʻole ke hoʻomanawanui, nāwaliwali, a me nā ʻeha kino . No kēlā poʻe, he koho maikaʻi paha kēia.
Āhea ka manawa e hāʻawi ai ke kauka i kēia lāʻau lapaʻau?
ʻAʻole loa e hāʻawi ke kauka i kēia lāʻau i ka manawa hoʻokahi. Aia kekahi kaʻina hana no ia mea.
1. ʻO ka mea mua, e hoʻololi i kou nohona: ʻŌlelo mua ke kauka e hoʻoikaika kino maikaʻi a ʻai i nā meaʻai olakino haʻahaʻa i ka ʻaila, ke kō, a me ka palaoa .
2. A laila, he 'Statin': Inā ʻaʻole lawa nā loli o ke ʻano o ka nohona, hoʻomaka ʻia kahi statin. Inā ʻaʻole i emi ka cholesterol, e hoʻonui mālie ʻia ka nui.
3. Ma ke ʻano he koho hope loa: Inā ʻaʻole i kāohi ʻia kāu cholesterol me ka nui o nā statins, a inā he koʻikoʻi nā hopena ʻaoʻao, a laila e noʻonoʻo paha kāu kauka i kahi mea hoʻopaʻa PCSK9. Hiki ke hana ʻia kēia hoʻoholo ma ka hana ʻana i kahi hoʻokolohua, e like me ka helu calcium coronary, e loiloi i kou pilikia o ka maʻi puʻuwai.
Pehea e hoʻohana ʻia ai kēia lāʻau lapaʻau a he aha nā hopena ʻaoʻao?
Hele mai ia ma ke ʻano he inikini subcutaneous āu e hāʻawi ai ma lalo o ka ʻili i kēlā me kēia ʻelua a ʻehā paha pule . Hiki iā ʻoe ke loaʻa iā ia ma ka ʻili o kou ʻōpū, ka ʻūhā luna, a i ʻole ka lima luna. E hōʻike kāu kauka a i ʻole kahi kahu maʻi i aʻo ʻia iā ʻoe pehea e hāʻawi pono ai. ʻAʻohe ʻeha a maʻalahi hoʻi.
I ka wā e pili ana i nā hopena ʻaoʻao, ʻo nā mea maʻamau he mea liʻiliʻi.
- ʻEha kua
- Nā hōʻailona e like me ke anu (ʻāʻī ʻeha, hana mucus)
- ʻUlaʻula, palapū, a ʻeha iki paha ma kahi i hoʻokomo ʻia
He mea nui loa: I kekahi manawa, hiki ke loaʻa nā hopena alerika koʻikoʻi. Inā loaʻa koke iā ʻoe nā hives koʻikoʻi, ka pehu ʻana o ka maka a i ʻole nā lehelehe, a i ʻole ka paʻakikī o ka hanu ʻana , he pilikia kēia. Inā hana ʻia kēia, pono ʻoe e hele koke i ka keʻena pilikia o ka haukapila kokoke loa (ETU) .
ʻO ka mea hope loa, i ka wā e pili ana i ke kumukūʻai o kēia mau lāʻau lapaʻau, ʻaʻole like lākou me nā lāʻau lapaʻau maʻamau, a he pipiʻi loa . No laila, ʻaʻole paha e hiki ke kūʻai ʻia kēia lāʻau lapaʻau no nā mea āpau. ʻOi aku ka maikaʻi o ke kamaʻilio ākea me kāu kauka e pili ana i kēia a kūkākūkā inā pono ʻoe, inā kūpono ia iā ʻoe, a he aha kāu mau koho kumukūʻai.
Leka Lawe-Home
- He papa lāʻau ikaika loa nā mea hoʻopaʻa PCSK9, he papa lāʻau hou e hoʻohaʻahaʻa ana i nā pae cholesterol LDL kiʻekiʻe ("maikaʻi ʻole").
- ʻAʻole hele mai kēia mau mea ma ke ʻano he mau pila e lawe i kēlā me kēia lā, akā, ma ke ʻano he inikini i hāʻawi ʻia i kēlā me kēia 2 a 4 paha pule.
- ʻO ka maʻamau, ua ʻōlelo ʻia kēia no nā poʻe me nā maʻi cholesterol genetic, nā poʻe i loaʻa i ka maʻi puʻuwai kiʻekiʻe loa, a i ʻole ka poʻe hiki ʻole ke ʻae i nā lāʻau statin.
- He pipiʻi loa kēia lāʻau lapaʻau, no laila pono ʻoe e hoʻoholo inā kūpono kēia iā ʻoe ma hope o ke kūkākūkā pono ʻana me kāu kauka.
- Mai hoʻoholo i nā lāʻau lapaʻau ma muli o ka lohe a i ʻole nā mea āu e ʻike ai ma ka pūnaewele. E hahai mau i ka ʻōlelo aʻo a kāu kauka.
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