Ua paʻakikī anei iā ʻoe ke kāohi i kāu cholesterol, ʻoiai ua hoʻāʻo ʻoe i nā lāʻau lapaʻau like ʻole, ka ʻai, a me ka hoʻoikaika kino? I kekahi manawa hana ia. He paʻakikī loa kēia ke loaʻa iā ʻoe kahi mōʻaukala ʻohana o ka cholesterol kiʻekiʻe. I kēia lā, ke kamaʻilio nei mākou e pili ana i kahi papa lāʻau hou e hiki ke kōkua. Ua kapa ʻia kēia he mau mea hoʻopaʻa PCSK9.
He aha kēia mau mea pale PCSK9?
I ka ʻōlelo maʻalahi, he mau lāʻau hoʻohaʻahaʻa cholesterol ikaika kēia i hāʻawi ʻia ma ke ʻano he inikini. Hoʻopaʻa nui lākou i ka LDL cholesterol (Low-Density Lipoprotein Cholesterol) , ka "cholesterol maikaʻi ʻole" a mākou e ʻike nei he mea ʻino no ko mākou kino. Hoʻomaopopo pinepine nā kauka i kēia mau lāʻau i ka poʻe i loaʻa ʻole nā hopena i makemake ʻia mai nā lāʻau cholesterol ʻē aʻe, e like me nā statins, a i ʻole i ka poʻe i loaʻa ka mōʻaukala ʻohana o ka cholesterol kiʻekiʻe.
Pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino?
I mea e hoʻomaopopo ai i kēia, e lawe kākou i kahi laʻana liʻiliʻi. E noʻonoʻo i ka cholesterol maikaʻi ʻole (LDL) i loko o kou koko he ʻano ʻōpala. No ka wehe ʻana i kēia ʻōpala a hoʻomaʻemaʻe i ke koko, aia i ko kākou akepaʻa kahi "ʻōpala" kūikawā ma luna o kona ʻili. ʻO kēia ka mea a mākou e kapa nei ma ke ʻano lapaʻau he mau mea loaʻa LDL . ʻO ka hana a kēia mau mea loaʻa, ʻo ia ka hopu ʻana i ka cholesterol LDL i loko o ke koko a lawe iā ia i loko o ke akepaʻa e luku ʻia.
Eia kekahi. He protein i kapa ʻia ʻo PCSK9 . Hana ʻia kēia e ko kākou akepaʻa. Akā, ʻo ka hana a kēia protein PCSK9, ʻo ia ka luku ʻana i nā mea loaʻa LDL (ko kākou mau ʻōpala) e wehe ana i ka cholesterol. Ke piʻi ka pae o PCSK9 i loko o ke kino, ua luku ʻia ka nui o nā mea loaʻa LDL. A laila, emi ka wehe ʻana o ka cholesterol mai ke koko, a piʻi ka pae cholesterol i loko o ke koko.
No laila, ʻo ka hana a ka lāʻau pale PCSK9, ʻo ia ke ālai i kēlā protein PCSK9 luku a hoʻōki iā ia mai ka hana ʻana. A laila, ʻaʻole e luku ʻia kā mākou mau mea loaʻa LDL, a hiki iā lākou ke hana me ke kūʻokoʻa. ʻO ka hopena, ua hoʻoneʻe ʻia ka nui o ka cholesterol LDL mai ke koko, a ua emi nui nā pae cholesterol. He maʻalahi loa, ʻeā?
No wai kēia lāʻau lapaʻau i ʻōlelo ʻia?
ʻAʻole kēia he lāʻau lapaʻau hoʻokahi no nā mea āpau. Na kāu kauka e hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe ma muli o kekahi mau kumu.
| Kūlana | Wehewehena |
|---|---|
| ʻO ka cholesterol kiʻekiʻe i kāohi ʻole ʻia e nā lāʻau lapaʻau ʻē aʻe | Inā kiʻekiʻe mau kāu mau pae LDL ʻoiai ke lawe nei i ka nui o ka statin a me nā lāʻau cholesterol ʻē aʻe. |
| Nā kūlana cholesterol kiʻekiʻe hoʻoilina | ʻO nā kānaka i loaʻa i nā pae cholesterol kiʻekiʻe loa mai ko lākou wā kamaliʻi ma muli o nā kūlana genetic e like me Familial Hypercholesterolemia. |
| No ka poʻe i loaʻa i ka pilikia nui o ka maʻi puʻuwai | Inā ua loaʻa iā ʻoe kahi myocardial infarction a i ʻole ka hahau ʻana, a kiʻekiʻe loa ka pilikia o ia ʻano maʻi i ka wā e hiki mai ana. |
Pehea e loaʻa ai iaʻu kēia lāʻau lapaʻau?
Hāʻawi ʻia kēia mau mea ma ke ʻano he inikini, ʻaʻole he pila. Ma muli o ka ʻōlelo a kāu kauka, e loaʻa pinepine iā ʻoe kēia inikini ma kahi haukapila a i ʻole ke keʻena lapaʻau i kēlā me kēia mau pule a i ʻole nā mahina. ʻO nā ʻano nui ʻelua e hoʻohana ʻia nei ma Sri Lanka ʻo Alirocumab (Praluent®) a me Evolocumab (Repatha®) .
Ma hope o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, e hana kāu kauka i nā hoʻokolohua koko maʻamau a nānā i kāu mau pae cholesterol e ʻike i kona pono.
He aha nā pōmaikaʻi a me nā hopena ʻaoʻao?
ʻO ka pōmaikaʻi nui o kēia lāʻau lapaʻau, ʻo ia ka maikaʻi loa o ka hoʻemi ʻana i nā pae kolesterol LDL. Wahi a kekahi mau noiʻi, hiki iā lākou ke hoʻemi i nā pae LDL ma waena o 50% a me 70% . Hoʻemi nui kēia i ka pilikia o ka hōʻeha puʻuwai, ka hahau ʻana, a me nā maʻi puʻuwai ʻē aʻe.
ʻOiai ʻaʻole ʻike ka hapa nui o ka poʻe i nā hopena ʻaoʻao koʻikoʻi, hiki i kekahi ke ʻike i nā mea liʻiliʻi.
- Ka pehu ʻana, ka ʻulaʻula, a i ʻole ka ʻeha ma kahi i hoʻokomo ʻia
- Manaʻo luhi (Fatigue)
- ʻEha ʻiʻo
- Nā hōʻailona e like me ke anu
He mea kākaʻikahi loa, hiki i kekahi poʻe ke ʻike i kekahi mau hopena ma ko lākou akepaʻa a i ʻole ka hana puʻupaʻa. ʻO ia ke kumu he mea nui loa ka ʻike pinepine ʻana i kāu kauka no nā nānā ʻana . Inā ʻike ʻoe i kekahi mau hōʻailona ʻē, e hoʻomaopopo koke i kāu kauka.
ʻAʻole anei lawa ka hoʻohana wale ʻana i kēia lāʻau lapaʻau?
He nīnau koʻikoʻi loa kēia. ʻO ka pane, "ʻAʻole, ʻaʻole lawa." ʻAʻole he mea kilokilo nā mea hoʻopaʻa PCSK9. He ʻāpana wale nō lākou o kahi hoʻolālā lapaʻau holoʻokoʻa.
E hoʻomanaʻo, ʻo ka kaohi ʻana i ka cholesterol ʻaʻole wale ia e pili ana i ka lawe ʻana i kahi pila. E pili ana ia i ka hoʻololi ʻana i kou nohona holoʻokoʻa.
I ka wā e lawe ai i kēia lāʻau lapaʻau, pono ʻoe e mālama pono i kēia mau mea:
- ʻAi olakino: E ʻai i ka ʻaila, ke kō, a me ka paʻakai e emi iho, a e ʻai i nā huaʻai, nā mea kanu, a me nā meaʻai i kiʻekiʻe i ka fiber.
- Hoʻoikaika kino mau: E hana i nā hoʻoikaika kino e like me ka hele wāwae a i ʻole ka holo ʻana no 30 mau minuke i ka lā, ma ka liʻiliʻi he 5 mau lā o ka pule.
- Hoʻokele koʻikoʻi: Hoʻomaha i ka noʻonoʻo ma o nā mea e like me ka yoga a me ka noʻonoʻo ʻana.
- Hiamoe kūpono: E loaʻa iā ʻoe he 7-8 mau hola o ka hiamoe maikaʻi i kēlā me kēia lā.
- Ka hoʻōki ʻana i ka puhipaka: Ka hoʻōki loa ʻana i ka puhipaka a me nā huahana paka.
E loaʻa iā ʻoe nā hopena maikaʻi loa mai ka lāʻau lapaʻau PCSK9 inhibitor ke hoʻohui ʻoe i kēia mau hoʻololi nohona. Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau a hoʻololi paha i ka nui me ka ʻole o ke aʻo ʻana a kāu kauka.
Leka Lawe-Home
- He ʻano inikini ikaika nā mea hoʻopale PCSK9 i hoʻohana ʻia e hoʻohaʻahaʻa i nā pae cholesterol LDL kiʻekiʻe i kāohi ʻole ʻia e nā lāʻau ʻē aʻe.
- Mālama kēia i nā mea loaʻa LDL o ke akepaʻa a hoʻomaikaʻi i ke kaʻina hana o ka wehe ʻana i ka cholesterol mai ke koko.
- He lāʻau lapaʻau kēia a ke kauka e ʻōlelo wale nei no nā hihia kikoʻī (e.g., ka cholesterol kiʻekiʻe hoʻoilina, ka pilikia nui o ka maʻi puʻuwai).
- He mea nui loa ka mālama ʻana i kahi nohona olakino i ka wā e loaʻa ai kēia lāʻau lapaʻau.
- E hoʻomau i kēia lāʻau lapaʻau ma ke ʻōlelo aʻo a kāu kauka wale nō, e mālama mau i ka launa pū ʻana me ia.
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