Ua lohe paha ʻoe i nā lāʻau lapaʻau e like me Viagra. Ua ʻike ka hapa nui o ka poʻe he mau lāʻau lapaʻau kēia i hāʻawi ʻia no ka hana pono ʻole o ka moekolohe. Akā, ua ʻike anei ʻoe he mau lāʻau lapaʻau ma kahi papa ʻokoʻa, i kapa ʻia ʻo Phosphodiesterase Inhibitors, i hoʻohana ʻia e mālama i nā ʻano maʻi like ʻole, mai ka maʻi puʻuwai a i ka maʻi māmā, ka maʻi ʻili, a me nā maʻi hono? I kēia lā, e kamaʻilio kākou e pili ana i kēia papa lāʻau lapaʻau kupaianaha. E hoʻomaopopo wale kākou i ko lākou ʻano, pehea lākou e hana ai, a he aha nā pōmaikaʻi a me nā pōʻino.
I ka ʻōlelo maʻalahi, he aha nā Phosphodiesterase Inhibitors (PDE inhibitors)?
He ʻano lāʻau lapaʻau kēia e hoʻonui ai i nā kīʻaha koko i loko o ko kākou kino, e hōʻemi ana i ko lākou ʻoʻoleʻa, a e maʻalahi ai ke kahe ʻana o ke koko. E noʻonoʻo i ka wā e paʻa ai kahi paipu wai, inā ʻoe e hoʻonui iki aʻe, e kahe maʻalahi ka wai. Hoʻemi kēia i ke koko a hoʻomaikaʻi i ke kahe ʻana o ke koko i nā ʻāpana like ʻole o ke kino. Ma muli o kēia hiki, hoʻohana ʻia kēia ʻano lāʻau lapaʻau ma ke ʻano he lāʻau lapaʻau no nā ʻano maʻi like ʻole.
Pehea e hana ai kēia lāʻau lapaʻau?
I mea e hoʻomaopopo ai i kēia, pono mua kākou e ʻike e pili ana i kahi ʻelele kemika liʻiliʻi i loko o ko kākou kino. ʻO Phosphodiesterases kona inoa, a i ʻole PDE no ka pōkole. He ʻano enzyme kēia PDE. Ua like nā enzymes me nā mea kōkua liʻiliʻi e hoʻolalelale a hoʻomaʻamaʻa i nā kaʻina kemika ʻē aʻe i loko o ko kākou kino.
Aia kekahi mau ʻano o kēia mau enzyme PDE i loko o ko kākou kino. Ua hoʻohana nā kānaka ʻepekema i nā helu e hoʻokaʻawale iā lākou. ʻO ka mea kūikawā, ʻo kēlā me kēia ʻano PDE ka mea hana nui loa ma nā wahi kikoʻī o ke kino.
- PDE-3: Loaʻa kēia ʻano ma kou puʻuwai a me ka ʻōnaehana hoʻopuni koko . Pili pū ia i ke kaʻina hana hoʻopaʻa koko.
- PDE-4: Loaʻa kēia ma ka hapa nui o nā māmā . Hana ia ma ka hoʻopaʻa ʻana i nā ʻiʻo ma nā ala ea.
- PDE-5: Loaʻa kēia ʻano i loko o nā māmā a me nā ʻōpū kāne .
No laila, hana nā lāʻau i kapa ʻia ʻo Phosphodiesterase Inhibitors (PDE inhibitors) ma ke ālai ʻana i ka hana o nā enzymes PDE i ʻōlelo ʻia ma luna. Ua like ia me ka pani ʻana i ka puka. Hana kekahi mau lāʻau inhibitor PDE me ke koho pono ʻole. ʻO ia hoʻi, kuhikuhi wale lākou i kahi ʻano kikoʻī, e like me PDE-5. Aia kekahi mau lāʻau ʻē aʻe e hana me ke koho ʻole . ʻO ia hoʻi, hiki iā lākou ke hoʻopilikia i nā ʻano PDE āpau i kekahi ʻano.
He aha nā kūlana i mālama ʻia me kēia lāʻau lapaʻau?
Ua ʻāpono ʻia ka papa o nā lāʻau i kapa ʻia ʻo PDE inhibitors e nā keʻena e like me ka U.S. Food and Drug Administration (FDA) e mālama i nā maʻi olakino he ʻumikūmālua. Eia kekahi o lākou.
| Māhele maʻi | Ke kūlana olakino a me ka wehewehe maʻalahi |
|---|---|
| Ka puʻuwai a me ke kahe koko |
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| Nā maʻi mumū |
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| Nā maʻi o ka ʻōnaehana hānau kāne |
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| Nā maʻi o ka ʻōnaehana hanu |
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He aha nā pōmaikaʻi o nā mea hoʻopaʻa PDE?
He mea pono loa kēia ʻano lāʻau lapaʻau i ka mālama ʻana i kekahi mau kūlana olakino. Nui nā kumu no kēia.
- Maʻalahi e hoʻohana: Loaʻa kēia mau lāʻau lapaʻau i nā ʻano he nui. Loaʻa lākou ma ke ʻano he mau pila waha, nā kirīmi topical, a me nā inikini IV. Pono kekahi mau lāʻau lapaʻau e lawe ʻia i kēlā me kēia lā, aʻo kekahi e hiki ke lawe ʻia i ka wā e pono ai.
- Lapaʻau i kuhikuhi ʻia: E like me kaʻu i ʻōlelo ai ma mua, kuhikuhi wale kekahi mau lāʻau lapaʻau i kahi ʻano PDE kikoʻī, no laila ʻaʻole lākou e hoʻoulu i nā hopena makemake ʻole ʻia (nā hopena ʻaoʻao) ma nā ʻāpana ʻē aʻe o ke kino. Me he mea lā e hana pololei ana ka lāʻau lapaʻau ma kahi o ka maʻi.
- Nui nā pono o hoʻokahi lāʻau lapaʻau: I kekahi manawa hiki ke loaʻa ʻelua mau kūlana pili i ke kanaka hoʻokahi. No ka laʻana, hiki ke hana pū ʻia ka benign prostatic hyperplasia (BPH) a me ka erectile dysfunction (ED). Ua ʻae ʻia ka PDE-5 inhibitor tadalafil e mālama i nā kūlana ʻelua. Pēlā nō, aia nā lāʻau lapaʻau e hiki ke mālama i ka gout a me ka arthritis pili.
He aha nā hopena ʻaoʻao a me nā pilikia o kēia lāʻau lapaʻau?
ʻO ka mea nui loa, ʻo ia ka lawe ʻia ʻana o kēia mau lāʻau lapaʻau a pau ma lalo o ke aʻo a ke kauka. Hiki ke ʻokoʻa ka hiki ke loaʻa nā hopena ʻaoʻao mai kēlā lāʻau lapaʻau a i kēia lāʻau a mai kēlā kanaka a i kēia kanaka.
ʻO nā hopena ʻaoʻao nui e pili ana i ke ʻano o ka mea hoʻopaʻa PDE e pili ana ka lāʻau.
| ʻAno Mea Hoʻōki PDE | Nā hopena ʻaoʻao liʻiliʻi a me ke kaulike | Nā hopena ʻaoʻao koʻikoʻi paha (e haʻi koke aku i kāu kauka) |
|---|---|---|
| Nā mea pale PDE-3 (hoʻopilikia i ka puʻuwai a me nā kīʻaha koko) | ʻEha poʻo, nāwaliwali, pehu, nausea, luaʻi, ʻeha ʻōpū, poniuniu, ʻulaʻula o ka ʻili. | ʻO nā ʻano ʻole o ka puʻuwai (arrhythmia), ʻeha umauma, haʻahaʻa ke koko, kahe koko ʻokoʻa a i ʻole ka palapū, hōʻino ʻia ke akepaʻa. |
| Nā mea pale PDE-4 (hoʻopilikia i nā māmā a me ka mumū) | ʻO ka pohō kaumaha, ka nausea, ka luaʻi ʻana, ka maʻi kahe, nā maʻi ʻōpū hanu luna, ka ʻeha poʻo, ka hiamoe ʻole, ka mumū ma kahi i inikini ʻia. | ʻO ka hoʻonui ʻia ʻana o ke kaumaha e kū nei, nā manaʻo pepehi kanaka, nā hopena hypersensitivity (ʻili, pehu, ʻūlū). |
| Nā mea pale PDE-5 (hoʻopilikia i ka impotence moe kolohe a me ke koko kiʻekiʻe pulmonary) | ʻEha poʻo, ʻulaʻula, ihu paʻa, ʻeha kua, ʻeha ʻiʻo, nausea, poniuniu, a me ka ʻike ʻana paha i ke kukui polū (manawa pōkole). | Priapism: He kūkulu ʻeha e mau ana ma mua o 4 mau hola me ka ʻole o ka hoʻoulu ʻana i ka moekolohe. He pilikia olakino kēia. Nā loli/nalowale koke o ka ʻike a i ʻole ka lohe ʻana, hōʻino ʻia ke akepaʻa. |
| Nā mea pale ʻole koho (e.g. caffeine, theophylline) | Hoʻomaha ʻole, hiamoe ʻole, haʻalulu, nausea, luaʻi, kahe koko, poniuniu, ʻeha poʻo. | Puʻuwai wikiwiki, puʻuwai kūpono ʻole, ʻeha umauma, nā maʻi ʻūlū. |
ʻŌlelo aʻo kūikawā: Inā ʻoe e lawe ana i kahi lāʻau lapaʻau e like me ka nitroglycerin ma lalo o ke alelo no ka ʻeha o ka umauma, a loaʻa iā ʻoe ka ʻeha o ka umauma i loko o 24 mau hola o ka lawe ʻana i kahi mea hoʻopaʻa PDE-5 (e.g. Sildenafil, Tadalafil), e hele koke i ka ʻoihana pilikia o ka haukapila (ETU). ʻO ka hui pū ʻana o kēia mau lāʻau lapaʻau ʻelua hiki ke hoʻoulu i kahi koko haʻahaʻa weliweli.
ʻO wai ka mea pono ʻole e lawe i kēia lāʻau lapaʻau?
No kekahi poʻe, ʻaʻole kūpono kēia ʻano lāʻau i kapa ʻia ʻo PDE inhibitors ma muli o ko lākou mau kūlana olakino ʻē aʻe a i ʻole nā lāʻau lapaʻau ʻē aʻe a lākou e lawe nei. Kāhea mākou i kēia mau contraindications . ʻElua ʻano o kēia:
1. Nā contraindications piha loa:
- I kekahi mea hoʻopale PDE: Inā ua loaʻa iā ʻoe kahi hopena alerika koʻikoʻi (hypersensitivity) i kēia lāʻau lapaʻau a i ʻole kekahi mea like.
- No Cilostazol: Inā loaʻa iā ʻoe kekahi ʻano hāʻule puʻuwai.
- No nā mea hoʻopaʻa PDE-5 (e like me Sildenafil, Tadalafil): maʻi puʻuwai koʻikoʻi, ʻeha umauma paʻa ʻole (angina paʻa ʻole), hōʻeha puʻuwai a i ʻole ka hahau ʻana.
2. Nā contraindications pili:
- No nā mea hoʻopaʻa PDE-5: Inā ʻoe e lawe ana i nā nitrates a i ʻole alpha-blockers, pono ʻoe e kamaʻilio me kāu kauka no ka mea hiki iā lākou ke hoʻohaʻahaʻa i kou koko koko i ka weliweli.
- No Cilostazol: Inā he mau maʻi kahe koko kou.
- No Pentoxifylline: Inā ua loaʻa iā ʻoe ke kahe koko ma ka lolo a i ʻole ka maka i hala koke nei.
Inā hāpai ʻoe, e hoʻāʻo ana e hāpai, a i ʻole e hānai waiū ana, e kamaʻilio mau me kāu kauka ma mua o ka lawe ʻana i kekahi lāʻau lapaʻau. Aia nā hōʻike e hiki i kekahi mau mea hoʻopaʻa PDE ke hoʻopilikia i ka ʻōpū i loko o nā haʻawina holoholona.
Āhea ʻoe e ʻike ai i ke kauka?
Inā loli kāu mau hōʻailona a hoʻopilikia paha i kāu mau hana o kēlā me kēia lā, ʻoi aku ka maikaʻi o ka haʻi ʻana i kāu kauka. Eia nō naʻe, inā loaʻa iā ʻoe kekahi o kēia mau mea , e hele koke i ka haukapila a i ʻole ka lumi pilikia (ETU).
- Nā hōʻailona o ka hāʻule puʻuwai: ʻeha o ka umauma, ka hanu pōkole, ka hou ʻana, ka dizziness, ka nausea.
- Priapism: He kūkulu ʻeha e mau ana ma mua o 4 mau hola me ka ʻole o ka hoʻoulu ʻana i ka moekolohe. Hiki i kēia ke hōʻeha mau loa inā ʻaʻole mālama koke ʻia.
- Ka nalowale koke ʻana o ka ʻike a i ʻole ka lohe ʻana: Inā loaʻa iā ʻoe ka nalowale koke ʻana o ka ʻike, ka nalowale ʻana o ka ʻike, a i ʻole ka nalowale ʻana o ka lohe, e ʻimi koke i ke kōkua lapaʻau. Hiki i ka lohi ke hōʻeha mau loa.
Leka Lawe-Home
- He papa lāʻau lapaʻau pono loa nā mea hoʻopaʻa phosphodiesterase (PDE inhibitors) i hoʻohana ʻia ʻaʻole wale no ka hana moekolohe, akā no kekahi mau maʻi puʻuwai, māmā, ʻili, a me nā maʻi pili i nā hono.
- Pono e lawe ʻia kēia mau lāʻau lapaʻau a pau ma ke ʻōlelo a ke kauka wale nō.E haʻi i kāu kauka e pili ana i nā maʻi ʻē aʻe āu e loaʻa nei a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei.
- Hiki ke loaʻa nā hopena ʻaoʻao, no laila e makaʻala iā lākou ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.
- Inā loaʻa iā ʻoe nā hōʻailona koʻikoʻi e like me ka ʻeha o ka umauma, ka pōkole o ka hanu e mau ana ma mua o 4 mau hola, a i ʻole ka nalowale koke ʻana o ka ʻike/lohe, e hele koke i kahi Keʻena Pilikia (ETU).
- ʻO ka hoʻohana ʻana i kēia lāʻau lapaʻau me ke kauoha ʻole a ke kauka, ma ke noi ʻana i nā poʻe ʻē aʻe a i ʻole ke noi ʻana ma nā hale kūʻai lāʻau lapaʻau, hiki ke loaʻa nā hopena koʻikoʻi, a hiki i ka hoʻoweliweli i ke ola.
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