Ke lohe kākou i ka huaʻōlelo 'cholesterol', hopohopo iki ka hapa nui o kākou, ʻeā? ʻOi loa aku i ka wā e ʻōlelo ai ke kauka, "Ua kiʻekiʻe iki kou cholesterol maikaʻi ʻole, ʻo ia hoʻi ka pae LDL," makaʻu iki kākou. ʻO ka mea a kākou e ʻai ai a inu ai, inā paha e hoʻoikaika kino kākou a ʻaʻole paha, a i kekahi manawa hoʻi, pili pū kekahi nā kumu hoʻoilina i kēia. No laila, ua lohe kokoke kākou a pau i nā pila ʻano 'statin' i hāʻawi ʻia e kāohi i ka cholesterol. Akā no kekahi poʻe, ʻaʻole lawa kēia mau lāʻau lapaʻau wale nō, a i ʻole ʻaʻole hiki ke hoʻohana ʻia. I kēia lā, ke kamaʻilio nei kākou e pili ana i kahi ʻano lāʻau lapaʻau hou a holomua iki i hoʻohana ʻia i ia mau hihia. ʻO ia ʻo Repatha.
He aha ʻo Repatha? Pehea e hoʻohaʻahaʻa ai i ka cholesterol?
I ka ʻōlelo maʻalahi, ʻo Repatha kahi lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol "maikaʻi ʻole", a i ʻole nā pae kolesterol LDL (Low-Density Lipoprotein) i loko o ko mākou kino. ʻAʻole kēia he pila a mākou e lawe mau ai, akā he inikini i hoʻokomo ʻia ma lalo o ka ʻili.
I kēia manawa, e nānā i ke ʻano o kēia hana, he mea kupaianaha ia. E noʻonoʻo ʻo ko kākou akepaʻa ke kānana e wehe i ka cholesterol maikaʻi ʻole mai ke koko. Akā, aia pū kekahi protein i ko kākou kino i kapa ʻia ʻo PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) . Ua like kēia me kekahi e hōʻemi ana i ka pono o kēlā kānana, e hoʻopilikia iā ia. Ke piʻi aʻe ka protein PCSK9, e emi ana ka hiki o ke akepaʻa ke wehe i ka LDL mai ke koko.
ʻO ka hana a Repatha , ʻo ia ke kāohi ʻana i ka hana o kēlā protein PCSK9 'hoʻopilikia' . Ke hoʻōki ʻia, hiki i ke kānana o ke akepaʻa ke hana hou me ka pono kiʻekiʻe loa me ka ʻole o ke keakea ʻana, e hopu ana a wehe ikaika i ka cholesterol maikaʻi ʻole (LDL) i loko o ke koko. Maopopo iā ʻoe? ʻO ke ʻano kēia, kōkua kēia lāʻau lapaʻau i ke kaʻina hana kūlohelohe o ko mākou kino e kaohi ana i ka cholesterol.
No wai kēia lāʻau lapaʻau ʻo Repatha i ʻōlelo ʻia?
ʻAʻole kēia he lāʻau lapaʻau no nā kānaka a pau. E ʻōlelo wale aku ke kauka iā ia i kekahi mau hihia kikoʻī.
- No nā pākeke me ka maʻi puʻuwai: Hoʻohana ʻia kēia lāʻau lapaʻau e hōʻemi i ka pilikia o ka hōʻeha puʻuwai, ka hahau ʻana, a i ʻole nā maʻi puʻuwai ʻē aʻe. Hāʻawi pinepine ʻia me nā lāʻau cholesterol ʻē aʻe, e like me nā statins.
- No nā poʻe me ka cholesterol kiʻekiʻe i hoʻoilina ʻia mai ke ʻano genetic: Loaʻa i kekahi poʻe nā pae cholesterol kiʻekiʻe loa ma muli o nā kūlana genetic i hoʻoili ʻia mai kēlā hanauna a i kēia hanauna. Ua kapa ʻia kēia mau kūlana ʻo Heterozygous Familial Hypercholesterolemia (HeFH) a me Homozygous Familial Hypercholesterolemia (HoFH) . Manaʻo ʻia ʻo Repatha no nā pākeke a me nā keiki ma luna o 10 mau makahiki me kēia mau kūlana e kāohi i nā pae LDL.
ʻO ka mea nui loa, he mea nui e hahai i kahi papaʻai olakino a me ka hoʻoikaika kino i ka wā e hoʻohana ai i kēia lāʻau.ʻAʻole he hana kilokilo ʻo Repatha, he ʻāpana wale nō ia o ka hoʻolālā lapaʻau.
He aha nā pono a me nā hopena o kēia lāʻau lapaʻau?
Ua hōʻike nā haʻawina lapaʻau o Repatha i nā hopena maikaʻi. Ua hoʻohālikelike kēia mau haʻawina iā Repatha me kahi placebo (kahi lāʻau lapaʻau dummy) a me nā lāʻau cholesterol ʻē aʻe, e like me nā statins.
E wehewehe hou aku kākou i kēia me ka papa ma lalo nei.
| No wai kēia lāʻau lapaʻau i ʻōlelo ʻia? | Nā pono koʻikoʻi i hōʻoia ʻia e nā hoʻokolohua |
|---|---|
| ʻO nā pākeke i loaʻa i ka maʻi puʻuwai (me nā lāʻau lapaʻau ʻē aʻe e like me nā statins) | Hoʻemi nui i ka pilikia o ka hōʻeha puʻuwai, ka hahau ʻana, a me ka make mai nā maʻi puʻuwai. |
| Nā pākeke a me nā keiki ma luna o 10 mau makahiki me ka cholesterol kiʻekiʻe ma muli o nā kumu genetic | Hoʻemi maikaʻi loa a wikiwiki hoʻi i ka pae o ka cholesterol "maikaʻi ʻole" (LDL) i loko o ke koko. |
Pehea ʻoe e ʻike ai inā e hana ana ka lāʻau lapaʻau?
E kauoha kāu kauka i nā hoʻokolohua koko (nā hoʻokolohua lipid profile) i nā manawa maʻamau. Ma hope o ka hoʻomaka ʻana iā Repatha, e ʻike paha ʻoe i ka emi nui ʻana o kāu mau pae cholesterol LDL i loko o 12 mau pule wale nō .
E makaʻala hoʻi kākou i ka hoʻohana ʻana a me nā hopena ʻaoʻao o Repatha.
Pehea e hoʻohana ai i kēia?
Hele mai ʻo Repatha ma ke ʻano he syringe i hoʻopiha mua ʻia a i ʻole he peni inikini. Hoʻokomo ʻia ia ma lalo o ka ʻili i kēlā me kēia ʻelua pule a i ʻole hoʻokahi manawa i ka mahina, ma muli o ka nui i kuhikuhi ʻia nou.
ʻO ka mea nui loa: He mea nui loa ia e aʻo pono pehea e hoʻohana ai i kēia mai kāu kauka mua. Ma mua o ka hoʻohana ʻana no ka manawa mua, e noi i kahi hōʻike maopopo pehea e hana ai.
He aha nā hopena ʻaoʻao?
E like me nā lāʻau lapaʻau āpau, hiki iā Repatha ke hana i nā hopena ʻaoʻao liʻiliʻi, ʻoiai ʻaʻole i loaʻa i nā kānaka a pau.
| Nā hopena ʻaoʻao maʻamau | Nā ʻōlelo aʻoaʻo no ka pale ʻana a i ʻole ka mālama ʻana |
|---|---|
| ʻUlaʻula, ʻeha, a me ka palapū ma kahi i inikini ʻia. | - E hoʻohuli mau i kahi i inikini ʻia (e.g., kekahi ʻaoʻao o ka ʻōpū, i kekahi manawa ma kekahi ʻaoʻao). - E lawe i ka lāʻau pale mai loko mai o ka pahu hau, e waiho no 30-45 mau minuke , a laila e hoʻokomo ma hope o ka hiki ʻana i ka mahana o ka lumi. |
| Nā hōʻailona e like me ke anu (kuni, ʻeha kino). | He manawa pōkole wale nō kēia. Inā loaʻa iā ʻoe kekahi ʻeha, e kamaʻilio me kāu kauka. |
| ʻEha kua, kiʻekiʻe ke kō koko. | E haʻi i kāu kauka inā hoʻopilikia kekahi mau hopena ʻaoʻao iā ʻoe a hoʻomau paha. |
Nā mea e pono ai ke nānā pono ʻia:
- ʻAleʻaleʻa Latex: Loaʻa paha i kekahi mau nila inikini ka latex i loko o ko lākou mau ʻūpā. Inā loaʻa iā ʻoe kahi maʻi latex, e hōʻoia e haʻi i kāu kauka e pili ana i kēia.
- Hāpai a me ka hānai waiū: Inā hāpai ʻoe, e hoʻāʻo ana e hāpai, a hānai waiū paha, he mea nui e haʻi i kāu kauka ma mua o ka hoʻohana ʻana i kēia lāʻau lapaʻau, no ka mea, ʻaʻohe ʻikepili lawa e pili ana i kona palekana i kēia mau kūlana.
Pehea e loaʻa ai iaʻu kēia lāʻau lapaʻau?
ʻAʻole kēia he lāʻau lapaʻau hiki iā ʻoe ke kūʻai ma kahi hale kūʻai lāʻau. Pono ke kauoha a ke kauka.
ʻO ka maʻamau, e hoʻoholo kāu mea mālama mua a kauka puʻuwai paha inā pono ʻoe i kēia lāʻau lapaʻau a paipai iā ia. Ma muli o ka ʻōlelo aʻo a kāu kauka, hiki paha iā ʻoe ke loaʻa mai nā hale kūʻai lāʻau lapaʻau kūikawā a i ʻole ma o kāu hale kūʻai lāʻau lapaʻau kūloko.
Mai hoʻomaka, hoʻōki, a hoʻololi paha i ka nui o kekahi lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a ke kauka. E kūkākūkā mau me kāu kauka ma mua o ka hoʻoholo ʻana.
Leka Lawe-Home
- He ʻiniki subcutaneous ʻo Repatha e hoʻohaʻahaʻa ana i nā pae cholesterol LDL ("maikaʻi ʻole").
- Paipai nui ʻia kēia no ka poʻe i loaʻa i ka maʻi puʻuwai a me ka poʻe me nā pilikia cholesterol genetic.
- Hoʻopili ia i kahi protein i kapa ʻia ʻo PCSK9, e kōkua ana i ke akepaʻa e wehe i ka cholesterol LDL mai ke koko.
- Hiki ke loaʻa kēia me ke kauoha a ke kauka wale nō. He mea nui loa e hahai i nā kuhikuhi a kāu kauka.
- Hiki ke loaʻa nā hopena ʻaoʻao e like me ka ʻulaʻula a me nā hōʻailona anu ma kahi i inikini ʻia, a pono ʻoe e hoʻomaopopo i kāu kauka e pili ana iā lākou.
- Hiki ke hoʻokō ʻia nā hopena maikaʻi loa ma ka hoʻohana ʻana iā Repatha me kahi nohona olakino.
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