Ke lohe ʻoe i ka huaʻōlelo "cancer," ʻo ka huaʻōlelo aʻe e hiki mai ana i ka noʻonoʻo ʻo ia paha "chemotherapy." Ua ʻike mākou a pau i ka paʻakikī a me ka ʻeha o ka mālama ʻana. Manaʻo pinepine mākou he nalowale ka lauoho a me ke kino make. Akā ua ʻike anei ʻoe ua holomua nui ka ʻepekema lapaʻau a ua hoʻomohala i nā lāʻau lapaʻau hou e kuhikuhi wale ana i nā cell cancer a hoʻemi i ka hōʻino ʻana i nā cell olakino? ʻO ia kekahi o nā lāʻau lapaʻau kikoʻī a holomua a mākou e kamaʻilio ai i kēia lā. Ua kapa ʻia ʻo Targeted Therapy .
I ka ʻōlelo maʻalahi, he aha ka Targeted Therapy?
E noʻonoʻo e hoʻokuʻu ana i nā pōkā ma luna o nā ʻenemi i ka wā kaua. Ke hoʻokuʻu ʻoe i kahi pōkā maʻamau, ʻaʻole wale nā ʻenemi akā ʻo ka poʻe kaua ʻole a me nā hale a puni lākou e luku ʻia. Ua like iki ka chemotherapy me ia. Pepehi ia i nā hunaola maʻi kanesa, akā hiki iā ia ke hōʻino i nā hunaola olakino i loko o ko mākou kino e māhele wikiwiki ana (no ka laʻana, nā hunaola lauoho, nā hunaola waha).
Akā, e noʻonoʻo he sniper, nānā pono ʻo ia i ka pahuhopu a pana wale i ka ʻenemi. ʻAʻohe mea a puni e hōʻeha ʻia. ʻO ia ka hana a Targeted Therapy .
ʻO ka Targeted Therapy kahi ʻano lapaʻau holomua loa e ʻike ana i nā ʻano kikoʻī o nā hunaola kanesa, kuhikuhi iā lākou, a luku i ka kanesa me ka hoʻēmi ʻana i ka hōʻino ʻana i nā hunaola olakino. Ua kapa ʻia hoʻi kēia he Precision Medicine.
Ma kēia lāʻau lapaʻau, ʻimi mua kāu kauka maʻi kanesa i ka hoʻololi ʻana o ka genetic i hoʻololi i kahi cell maʻamau i loko o kou kino i cell cancer. A laila, ʻike lākou i nā pahuhopu kikoʻī ma ka ʻili a i ʻole i loko o ke cell cancer i hoʻokumu ʻia e kēlā hoʻololi genetic, a koho i nā lāʻau lapaʻau e hoʻouka wale i kēlā mau pahuhopu.
Pehea maoli ka hana ʻana o kēia lāʻau lapaʻau?
No ka hoʻomaopopo ʻana i kēia, e hoʻomaopopo mua kākou pehea e ulu ai ke kanesa.
Loaʻa i kēlā me kēia cell i loko o ko kākou kino kahi hoʻonohonoho o nā kuhikuhi. Kāhea mākou iā ia he DNA. Ua like ia me kahi puke kuhikuhi no ka kuke ʻana. Ke haʻi aku nei nā kuhikuhi i loko o kēia puke i kahi cell e māhele, ulu, a make i kahi manawa kikoʻī.
Ke ulu ka maʻi kanesa, no kekahi kumu ua hewa nā kuhikuhi ma kēia puke kuhikuhi. ʻO ia hoʻi, aia kahi loli (mutation) i loko o nā genes. A laila hoʻomaka nā cell e māhelehele me ka ʻole o ke kāohi ʻia. ʻO ia ka mea e lilo ai i maʻi kanesa.
Ma ka Targeted Therapy, hana nā kauka ma ka hoʻomaopopo ʻana i kēia kaʻina hana i kēlā me kēia ʻanuʻu:
1. Ke loaʻa ʻana o nā kuhikuhi hewa: ʻO ka mea mua, ʻike pono nā hoʻokolohua i nā kuhikuhi genetic hewa, ʻo ia hoʻi, ka hoʻololi genetic , i loko o kāu mau cell cancer.
2.Koho ʻana i ka pahuhopu: A laila, ʻike mākou i nā protein kikoʻī a i ʻole nā molekala ʻē aʻe i hoʻokumu ʻia ma luna a i loko paha o ke kelepona kanesa ma muli o kēia kuhikuhi kuhihewa. ʻO ia kā mākou "pahuhopu."
3. Ke hoʻolālā ʻana i ka lāʻau kūpono: ʻO ka mea aʻe, ua hoʻolālā ʻia kahi lāʻau e hoʻopaʻa i ka pahuhopu i ʻike ʻia. Hiki i kēia lāʻau ke pepehi i ke kelepona kanesa a i ʻole e ālai i nā ala hōʻailona e kōkua ai i ka māhele ʻana o ke kelepona.
Ma muli o ke kuhikuhi pololei ʻia ʻana o ka lāʻau lapaʻau ma kēia ʻano, ua emi loa ka hopena ma nā ʻāpana olakino.
He aha nā ʻano nui o ka lāʻau lapaʻau i hoʻolālā ʻia?
Aia nā ʻano like ʻole o kēia ʻano lapaʻau. Ua hoʻokaʻawale ʻia lākou e like me ke ʻano o kā lākou hana. Eia kekahi o nā ʻano nui:
- Nā lāʻau lapaʻau molekole liʻiliʻi: He mau lāʻau lapaʻau liʻiliʻi loa kēia, no laila hiki iā lākou ke komo i loko o nā hunaola kanesa, hoʻouka i nā pahuhopu i loko o ke kelepona, a hoʻōki i ka ulu ʻana o ke kelepona.
- Nā Immunotherapy: He ʻano ʻokoʻa iki kēia. ʻO ka mea a mākou e hana ai ma ʻaneʻi, ʻo ia ka hoʻoulu ʻana i kā mākou ʻōnaehana pale ponoʻī e luku i nā hunaola maʻi kanesa. Nui nā lāʻau lapaʻau ʻē aʻe ma lalo o kēia malu.
- Nā antibodies monoclonal: He mau protein kūikawā kēia i hana ʻia i loko o kahi lab, e like me nā antibodies a ko mākou kino e hana ai. Hiki iā lākou ke hoʻopili i nā pahuhopu ma luna o ka ʻili o nā cell cancer a hōʻailona i ka ʻōnaehana pale e luku i ke kanesa.
- Nā hui pū ʻana o ka antibody-drug: He ʻano akamai loa kēia. Maanei, ua hoʻopili ʻia kahi lāʻau chemo ikaika i ka antibody monoclonal. Ke loaʻa i ka antibody ke keena kanesa kūpono a pili iā ia, ua hoʻokuʻu pololei ʻia ka lāʻau i loko o ke keena kanesa. Ua like ia me kahi pūʻolo, i hāʻawi ʻia i kahi kūpono.
He aha nā ʻano maʻi kanesa i mālama pono ʻia me kēia lāʻau?
ʻAʻole hiki ke hoʻohana ʻia ka Targeted Therapy no nā maʻi kanesa āpau. Eia nō naʻe, i kēia lā ua hoʻohana pono ʻia kēia ʻano lapaʻau no nā ʻano maʻi kanesa he nui. ʻO kekahi o lākou:
- Ka maʻi ʻaʻai umauma
- Ka maʻi ʻaʻai māmā
- Ka maʻi ʻaʻai prostate
- Ka maʻi ʻaʻai koko (e.g. Multiple myeloma, Acute leukemia)
- Ka maʻi ʻili (e.g. Melanoma)
- Ka maʻi ʻaʻai colorectal
- Ka maʻi ʻaʻai puʻupaʻa
- Ka maʻi ʻaʻai thyroid
- Nā maʻi ʻaʻai poʻo a me ka ʻāʻī
- Ka maʻi ʻaʻai o ka ʻōpū
Ke ulu nei kēia papa inoa i kēlā me kēia lā, ʻoiai ke ʻike mau nei ka noiʻi i nā ʻano loli hou a me nā lāʻau lapaʻau e pili ana iā lākou.
Pehea e hāʻawi ʻia ai ka lāʻau lapaʻau a he aha kāu e manaʻo ai?
Aia ma mua o 100 mau ʻano lāʻau lapaʻau i kuhikuhi ʻia. Hiki ke ʻokoʻa ke ʻano o kāu loaʻa ʻana i kēia lāʻau lapaʻau ma muli o kou ʻano maʻi kanesa, ke ʻano o ka lāʻau, a me nā hoʻoholo a kāu kauka.
- Ma ke ʻano he pila: Loaʻa kekahi mau lāʻau lapaʻau ma ke ʻano o nā pila hiki iā ʻoe ke lawe ma ka home.
- Ma ke ʻano he inikini: Hāʻawi ʻia kekahi i loko o ke kino ma ke ʻano he inikini.
- Intravenous (IV): ʻO ka hapa pinepine, hāʻawi ʻia kēia lāʻau i loko o ke kino ma o kahi aʻa, e like me ka saline.
ʻOkoʻa nō hoʻi nā papa hana lapaʻau. Pono paha ʻoe e lawe i nā lapaʻau i kēlā me kēia lā, i kēlā me kēia pule, a i ʻole kēlā me kēia mahina. Pono kekahi mau lapaʻau i kahi manawa lōʻihi, aʻo kekahi e hoʻopau ʻia i loko o kahi manawa i hoʻonohonoho ʻia.
I ka wā o kāu mālama ʻana, e nānā mau kāu kauka iā ʻoe. Hiki iā ia ke hana i nā hoʻokolohua koko a me nā scan CT e nānā i ka maikaʻi o ka hana ʻana o ka lāʻau a me kou manaʻo. E loaʻa nō hoʻi iā ʻoe ka manawa kūpono e kamaʻilio me kāu kauka e pili ana i kekahi ʻeha āu e ʻike nei i ka wā o kāu mālama ʻana.
Nā ʻokoʻa koʻikoʻi ma waena o ka Chemotherapy a me ka Targeted Therapy
ʻO kahi nīnau a ka poʻe he nui, ʻo wai o kēia mau ʻano hana ʻelua ka mea ʻoi aku ka maikaʻi. I mea e maopopo ai kēlā, e nānā kākou i nā ʻokoʻa ma waena o kēia mau ʻano hana ʻelua.
| ʻAno | Hoʻōla i kuhikuhi ʻia | Kemoterapia |
|---|---|---|
| Pehea e hana ai | Hoʻouka wale i nā pahuhopu kikoʻī i loko o nā hunaola kanesa (e like me ka hoʻouka kaua sniper) | Hoʻopau i nā ʻāpana e māhele wikiwiki ana (maʻi ʻaʻai a olakino). (E like me ka hoʻouka kaua ʻana o ka pōkā) |
| Hopena ma nā pūnaewele olakino | ʻEmi paha. | Hiki i ka nui ke hōʻino i ka lauoho, ka ʻili, a me nā hunaola o ke ala ʻai. |
| Nā hopena ʻaoʻao | ʻOkoʻa ia ma muli o ke ʻano o ka lāʻau lapaʻau (e like me ka ʻulaʻula o ka ʻili, ka maʻi kahe, ke koko kiʻekiʻe). | ʻO nā hopena ʻaoʻao maʻamau e komo pū me ka luaʻi ʻana, ka nausea, ka hāʻule ʻana o ka lauoho, a me ka luhi. |
| Hoʻoponopono | Aia nō ia i nā ʻano hoʻoilina o ke kanesa. ʻAʻole kūpono ia i nā kānaka a pau. | Hiki ke hoʻohana ʻia no nā ʻano maʻi kanesa he nui. |
ʻO ka mea nui, ʻaʻohe lāʻau "maikaʻi loa". Na kāu kauka e hoʻoholo i ka lāʻau kūpono a maikaʻi loa nāu. I kekahi mau hihia, hiki ke hoʻohana pū ʻia kēia mau lāʻau ʻelua.
E makaʻala hoʻi kākou i nā hopena ʻaoʻao.
ʻOiai ke hōʻemi nei ka lāʻau lapaʻau i kuhikuhi ʻia i ka hōʻino ʻana i nā ʻāpana olakino, ʻaʻole ia me ka ʻole o nā hopena ʻaoʻao. ʻOkoʻa nā hopena ʻaoʻao mai ka lāʻau a i ka lāʻau a mai ke kanaka a i ke kanaka. ʻO kekahi mau hopena ʻaoʻao maʻamau:
- Ka maʻi kahe: Nā ʻōpala palahalaha.
- Nā pilikia ʻili: ʻili maloʻo, ʻūlū, maneʻo.
- Nā enzymes akepaʻa kiʻekiʻe: Hiki ke ʻike ʻia kēia ma o nā hoʻāʻo koko.
- Hypertension: Hoʻonui ʻia ke koko .
- Nā ʻūpā koko: Ka pilikia o ke kūkulu ʻia ʻana o nā ʻūpā koko i loko o nā kīʻaha koko.
- Maʻi puʻuwai: Hiki i kekahi mau lāʻau lapaʻau ke hoʻopilikia i ka hana puʻuwai.
- Ka lohi o ka ho'ōla ʻana o ka ʻeha.
- Ke kahe koko ʻana o ka ʻōpū: Koko i loko o ka ʻōpala a i ʻole ka ʻōpala ʻeleʻele.
- Hoʻololi i ke kala o ka lauoho.
Mai makaʻu i ka lohe ʻana i kēia mau mea. E hōʻike aku kāu kauka iā ʻoe e pili ana i kēia mau mea a pau. Eia kekahi, e hāʻawi ʻo ia iā ʻoe i nā lāʻau lapaʻau a me nā ʻōlelo aʻoaʻo e pono ai e kāohi i kēia mau hopena ʻaoʻao a hōʻemi i ko lākou hopena. Inā manaʻo ʻoe i kekahi ʻano ʻoluʻolu ʻole, mai hoʻokaʻulua i ka haʻi ʻana aku i kāu kauka.
Leka Lawe-Home
- ʻO ka Targeted Therapy kahi ʻano lapaʻau holomua loa e pili ana i nā hunaola kanesa wale nō a hoʻēmi i ka hōʻino ʻana i nā hunaola olakino.
- ʻAʻole kūpono kēia lāʻau lapaʻau no kēlā me kēia maʻi kanesa a i ʻole kēlā me kēia maʻi. Aia ia i nā ʻano genetic kikoʻī o kou maʻi kanesa.
- ʻOkoʻa paha nā hopena ʻaoʻao mai ka chemotherapy. Hiki ke loaʻa kekahi mau hopena ʻaoʻao, akā e kōkua kāu hui lapaʻau iā ʻoe e hoʻokele iā lākou.
- E kamaʻilio ākea me kāu kauka maʻi kanesa e pili ana i ka lāʻau lapaʻau maikaʻi loa no kou maʻi kanesa. E nīnau i kāu mau nīnau a pau a wehewehe i nā kānalua āu e loaʻa ai.
- Ke holomua nei ka ʻepekema lapaʻau i kēlā me kēia lā. No laila, e hoʻomau i kou manaʻolana no ka mālama ʻana i ka maʻi kanesa.
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