Ua ʻike mākou i ka paʻakikī o ke kaua ʻana i ka maʻi kanesa. He mea maʻamau ke kaumaha i ka wā e ʻōlelo ai nā kauka i nā huaʻōlelo hou a paʻakikī e like me "gene therapy." Akā, mai hopohopo. I kēia lā, e kamaʻilio mākou e pili ana i hoʻokahi ʻano lapaʻau kūikawā. E noʻonoʻo e hoʻohana ana i nā pūnaewele o kou kino ponoʻī, e hoʻomaʻamaʻa iā lākou, a e hoʻouna iā lākou e luku i nā pūnaewele kanesa. ʻO ia ka hana a kēia lāʻau i kapa ʻia ʻo Tisagenlecleucel. E kamaʻilio kākou e pili ana i ia mea me ka maʻalahi a me ka maopopo.
He aha ka Tisagenlecleucel (KYMRIAH)?
I ka ʻōlelo maʻalahi, ʻaʻole kēia he pila āu e lawe ai a i ʻole he lāʻau lapaʻau maʻamau āu e hoʻokomo ai i loko o kahi aa. He lāʻau lapaʻau gene ʻo Tisagenlecleucel. Pili ia i ka lawe ʻana i kahi ʻano cell mai kāu ʻōnaehana pale ponoʻī, hoʻololi iā ia i loko o kahi lab, a hoʻomaʻamaʻa iā ia e ʻike a hoʻouka i nā cell cancer.
I mea e pololei ai, loaʻa i ko kākou kino kahi ʻano cell hakakā i kapa ʻia ʻo T-cells. ʻO kēia mau cell nā mea e hakakā nei i ka maʻi. Ma kēia lāʻau lapaʻau, lawe nā kauka i kekahi o kēia mau T-cell mai kou kino. A laila, ma kahi lab, hoʻohana lākou i ka ʻenehana genetic e kau i ʻelua "aniani kūikawā" ma luna o kēia mau T-cell. ʻO ia hoʻi, hoʻololi lākou i kēia mau cell i hiki iā lākou ke ʻike i nā māka kikoʻī ma ka ʻili o nā cell maʻi kanesa. A laila, ua ulu ʻia nā miliona o kēia mau T-cell "superpowered" a hoʻihoʻi ʻia i loko o kou kino ma o kahi vein. I kēia manawa, hele pololei kēia mau cell i aʻo ʻia i nā cell maʻi kanesa a luku iā lākou.
Hoʻohana nui ʻia kēia lāʻau lapaʻau e mālama i kekahi mau ʻano maʻi kanesa, me ka leukemia lymphoblastic acute (ALL) , kahi ʻano leukemia, a me ka lymphoma non-Hodgkin .
Nā mea e pono ai ʻoe e haʻi i kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau
ʻOiai he lāʻau lapaʻau kēia e hoʻohana ana i kou mau pūnaewele ponoʻī, he mea nui e kamaʻilio ākea me kāu hui mālama ma mua o kou hoʻomaka ʻana. Pono lākou e hoʻomaopopo i kēia mau mea:
- Nā maʻi o kēia manawa: E haʻi mai iā mākou inā loaʻa iā ʻoe kekahi mau maʻi, e like me ke kuni, ka ʻū, ke anu, a i ʻole ka maʻi ʻōpū mimi.
- Nā kūlana mumū: E haʻi i kāu kauka e pili ana i kekahi mau maʻi mumū ma nā wahi āpau o ke kino.
- Nā Allergies: E hōʻoia e haʻi i kekahi mau allergies āu e loaʻa ai, ʻaʻole wale i kēia lāʻau lapaʻau, akā i kekahi lāʻau lapaʻau ʻē aʻe, meaʻai, a mea hoʻoluʻu paha.
- Hāpai: Inā hāpai ʻoe, e hoʻāʻo ana e hāpai, a i ʻole he kānalua paha ʻoe ua hāpai ʻoe, e haʻi koke aku i kāu kauka. He mea nui loa kēia.
- Ka hānai waiū: Inā ʻoe e hānai waiū ana, e hoʻomaopopo pū i ke kauka.
Pehea ʻoe e hāʻawi ai i kēia lāʻau lapaʻau?
Aia kēia lapaʻau i kekahi mau ʻanuʻu a hana ʻia ma lalo o ka mākaʻikaʻi pono ʻana a kahi hui lapaʻau ma kahi haukapila a i ʻole keʻena lapaʻau kūikawā.
1. Hōʻiliʻili ʻana i nā kelepona: Ma kahi o 3-4 mau pule ma mua o ka lāʻau lapaʻau, hōʻiliʻili ʻia nā pūnaewele T mai kou kino. Hana ʻia kēia ma o ke kaʻina hana i kapa ʻia ʻo leukapheresis . Ua like ia me ka hāʻawi ʻana i ke koko. Lawe ʻia ke koko mai kahi aʻa koko, hoʻouna ʻia ma o kahi mīkini kūikawā, kahi e hoʻokaʻawale ai i nā pūnaewele koko keʻokeʻo, me nā pūnaewele T, a laila hoʻihoʻi ʻia ke koko i koe i loko o kou kino.
2. Hoʻomaʻamaʻa kelepona: A laila hoʻouna ʻia kēia mau kelepona i hōʻiliʻili ʻia i ka lab a hoʻomaʻamaʻa ʻia e hakakā i ka maʻi kanesa.
3. Hoʻokomo ʻia: Ke hoʻomaʻamaʻa ʻia a ulu ʻia nā ʻāpana, e hoʻokomo ʻia lākou i loko o kou kino ma o kahi aa koko, e like me ka wai saline. Hana ʻia kēia kaʻina holoʻokoʻa ma ka haukapila.
ʻO ka mea nui loa, no ka mea, ua hana ʻia kēia lāʻau lapaʻau mai kou mau pūnaewele ponoʻī, he lāʻau lapaʻau pilikino ia nou . No laila, ʻaʻole hiki ke kaʻana like ʻia kēia lāʻau lapaʻau me kekahi.
Nā mea e noʻonoʻo ai i ka wā e mālama ʻia ai
E nānā pono ʻia kou kūlana e kāu mau kauka i ka wā o kēia mālama ʻana. Pono ʻoe e makaʻala i kēia mau mea.
- Ka hiamoe a me ka hoʻokele ʻana: Hiki iā ʻoe ke hiamoe a poniuniu . No laila , mai hana i kekahi mea e pono ai ka makaʻala noʻonoʻo, e like me ka hoʻokele ʻana a i ʻole ka hoʻohana ʻana i nā mīkini kaumaha, a hiki i kou ʻike pono ʻana i ka hopena o kēia lāʻau lapaʻau iā ʻoe.
- Ka pilikia o ka maʻi: Hiki i kēia lāʻau lapaʻau ke hōʻemi i ka hiki o kou kino ke pale aku i nā maʻi no kekahi manawa. No laila e ho'āʻo e noho mamao aku mai ka poʻe maʻi. Inā loaʻa iā ʻoe nā hōʻailona e like me ke kuni, ka ʻeha kino, a i ʻole ka ʻāʻī ʻeha , e kāhea koke i kāu kauka ma kahi o ka lāʻau ponoʻī.
- Hāʻawi koko a ʻōkana paha: E pale i ka hāʻawi ʻana i ke koko, nā ʻōkana, nā ʻiʻo, ka sperm, a i ʻole nā hua manu (oocytes) i ka wā e lawe ana i kēia lāʻau a no kekahi manawa ma hope.
- Hāpai (He mea nui loa): Mai hāpai no kekahi kumu i ka wā e lawe ana i kēia lāʻau lapaʻau. Eia kekahi, inā ʻoe e hoʻolālā ana e loaʻa kahi pēpē a manaʻo paha ua hāpai ʻoe, pono ʻoe e haʻi koke i kāu kauka. Hiki i kēia lāʻau lapaʻau ke hōʻeha nui i kahi pēpē i hānau ʻole ʻia.
- Nā lāʻau lapaʻau ʻē aʻe: E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei (me nā huaora a me nā lāʻau lapaʻau lāʻau). ʻAʻole loaʻa nā lāʻau pale ola i kēia manawa.
- Pilikia:Hāʻawi ʻia kēia ma kahi haukapila, no laila ʻaʻole ʻoe e lawe nui i ka lāʻau lapaʻau. Eia nō naʻe, inā loaʻa kahi pilikia, e hoʻomaopopo koke i ka hui lapaʻau. Inā pono, e kuhikuhi lākou iā ʻoe i ka Emergency Treatment Unit (ETU) . Inā kānalua ʻoe i kekahi lāʻau make, hiki iā ʻoe ke kelepona i ke Kikowaena ʻIke Poisons National ma ka Halemai Lahui ʻo Colombo .
Nā hopena ʻaoʻao hiki ke loaʻa o kēia lāʻau lapaʻau
E like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao. Pono e hōʻike koke ʻia kekahi o kēia mau mea, aʻo kekahi he emi iki ka koʻikoʻi. E nānā i ka papa ma lalo.
| Ka hoʻokaʻawale ʻana o nā hopena ʻaoʻao | |
|---|---|
| Nā mea e hōʻike koke aku ai i kāu kauka a i ʻole ka hui lapaʻau | |
| Nā maʻi ʻaleka | ʻŌhūhū ʻili, maneʻo, pehu o ka maka, nā lehelehe a i ʻole ke alelo. |
| Nā pilikia hanu | Paʻakikī ka hanu ʻana. |
| Nā loli noʻonoʻo | Ka huikau, ka paʻakikī i ka ʻōlelo ʻana a i ʻole ka hoʻomaopopo ʻana. |
| Nā hōʻailona o ka helu haʻahaʻa o nā cell koko | Nā hōʻailona o ka maʻi: kuni, anuanu, ʻeha ka puʻu. Nā hōʻailona o ke kahe ʻana o ke koko: ka palapū, nā kiko ʻulaʻula ma ka ʻili, nā ʻeke ʻeleʻele, ke koko i loko o ka mimi. He haʻahaʻa ka helu o nā hunaola koko ʻulaʻula: luhi nui, nāwaliwali, keʻokeʻo. |
| Nā hōʻailona koʻikoʻi ʻē aʻe | Ka maʻi kahe, ka nalowale o ke kaulike, ka ʻeha o nā ʻiʻo a i ʻole nā hono, ka nausea, ka luaʻi ʻana, nā hopu ʻana, nā hōʻailona o ke koko haʻahaʻa (dizziness, fragility). |
| Inā hoʻomau a hoʻopilikia paha, e haʻi i kāu kauka. | |
| Nā hopena ʻaoʻao maʻamau | Paʻa ka ʻōpū, nalowale ka makemake i ka ʻai, ʻeha poʻo, ʻeha ka ʻōpū, pehu o nā wāwae a me nā wāwae. |
ʻAʻole i loko o kēia papa inoa nā hopena ʻaoʻao āpau. Inā loaʻa iā ʻoe kekahi mea ʻē, e kamaʻilio me kāu kauka e pili ana i ia mea.
Leka Lawe-Home
- He lāʻau lapaʻau gene pilikino ʻo Tisagenlecleucel e hoʻohana ana i kāu mau hunaola ponoʻī e mālama i ka maʻi kanesa.
- He lāʻau lapaʻau kūikawā kēia i hāʻawi ʻia ma ka haukapila, hoʻohana ʻia no nā maʻi leukemia koʻikoʻi a me nā maʻi lymphoma.
- He mea nui e haʻi aku i kāu kauka i kāu ʻike olakino āpau (nā maʻi, nā maʻi allergies, ka hāpai ʻana) ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.
- I ka wā e mālama ʻia ai, e makaʻala pono i nā hōʻailona o ka maʻi (kuni, ʻū). Inā loaʻa kēlā mau hōʻailona, e ʻimi koke i ke kōkua lapaʻau.
- I kou hiamoe ʻana paha, e pale i ka hoʻokele kaʻa ʻana a me ka hana ʻana i nā hana e pono ai ka nānā ʻana a hiki i kou hoʻōla piha ʻana.
- E pale loa i ka hāpai ʻana i ka wā o ka mālama ʻana. He mea nui loa kēia.
- Mai makaʻu e kamaʻilio me kāu hui lapaʻau e pili ana i nā hopohopo a kānalua paha āu e loaʻa ai. Aia lākou ma laila e kōkua iā ʻoe.
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