Loaʻa iā ʻoe kahi maʻi i kapa ʻia ʻo Myasthenia Gravis (gMG)? Ke paʻakikī nei ʻoe e hana i nā hana o kēlā me kēia lā, manaʻo ʻoe e like me ka mae ʻana o kou mau lālā, a kaumaha paha kou mau maka? ʻIke wau he ʻike luhi loa kēia. Akā, mai hopohopo, aia nā lāʻau lapaʻau hou a holomua e kōkua i ka mālama ʻana i kēia maʻi. I kēia lā, e kamaʻilio mākou e pili ana i ʻelua o kēia mau lāʻau lapaʻau hou. ʻO Vyvgart lāua ʻo Vyvgart Hytrulo. E nānā kākou i ko lākou ʻano, pehea lākou e hana ai, a inā kūpono lākou iā ʻoe.
I ka ʻōlelo maʻalahi, he aha ka Myasthenia Gravis?
I mea e hoʻomaopopo ai i kēia, e nānā kākou i kahi moʻolelo liʻiliʻi e pili ana i ko kākou kino. E noʻonoʻo ʻoe ʻo kou lolo ke 'luna'. Hāʻawi ia i ke kauoha, "E hāpai i kou lima." Hele kēia kauoha ma o nā aʻalolo e like me kahi leka uila ma kahi 'uea.' Ke hiki kēia leka i ka ʻiʻo, hana ka ʻiʻo i kāna hana, ʻo ia hoʻi ke hāpai nei ka lima.
Akā no ka pololei ʻana o kēia hui ʻana ma waena o ke aʻalolo a me ka ʻiʻo, pono kahi protein kūikawā i kapa ʻia he acetylcholine receptor (AChR) . Ua like kēia me kahi plug.
ʻO ka Myasthenia Gravis (gMG) kahi maʻi autoimmune . I ka ʻōlelo maʻalahi, hoʻomaka nā 'koa' o ko mākou kino ( ka ʻōnaehana pale ) me ka ʻike ʻole e hoʻouka i nā 'plugs' maikaʻi, ʻo ia hoʻi nā AChR. Hoʻohana lākou i nā mea kaua i kapa ʻia he antibodies e hoʻouka iā lākou. ʻO ka hopena, ʻaʻole hiki i nā leka aʻalolo ke hōʻea pono i nā ʻiʻo. ʻO ka hopena? Lilo nā ʻiʻo i nāwaliwali a luhi maʻalahi. Ke alakaʻi nei kēia i nā hōʻailona e like me ke kūlou ʻana o nā maka, ka paʻakikī i ka ʻōlelo ʻana a me ka moni ʻana, a me ka mae ʻana o nā lālā.
No laila pehea e kōkua ai kēia mau lāʻau lapaʻau ʻo Vyvgart lāua ʻo Vyvgart Hytrulo?
ʻO Vyvgart (efgartigimod alfa-fcab) kahi protein i hana kūikawā ʻia i loko o kahi keʻena hoʻokolohua. Ua kapa ʻia kēia he monoclonal antibody .
Hana maikaʻi loa kēia lāʻau lapaʻau. Aia nā antibodies maikaʻi ʻole e hoʻouka i kā mākou AChRs maikaʻi, a hele kēia lāʻau lapaʻau a hoʻopili i kēlā mau antibodies. I ka pololei, hoʻopili ia i kahi ʻāpana o kēlā mau antibodies i kapa ʻia ʻo neonatal Fc receptors (FcRn) . Ke hana ʻia kēia, hiki i ke kino ke wehe maʻalahi i kēlā mau antibodies maikaʻi ʻole.
ʻO ia hoʻi, hoʻopau ka lāʻau Vyvgart i kēlā mau 'koa maikaʻi ʻole' ( nā antibodies ) mai ke koko e hoʻopilikia i kā mākou pilina aʻalolo. A laila hoʻomaka nā leka aʻalolo e hele pololei i nā ʻiʻo, a emi iho kou nāwaliwali.
ʻO Vyvgart Hytrulo ka lāʻau like me Vyvgart, ʻo ia hoʻi ʻo efgartigimod alfa. No laila, hana like ia. Akā, ma waho aʻe o kēlā,Loaʻa iā ia kahi mea i kapa ʻia ʻo hyaluronidase. Kōkua kēia i ke kino e omo maikaʻi i ka lāʻau lapaʻau ke hoʻokomo ʻia ma lalo o ka ʻili.
Aia kahi ʻokoʻa iki i ke ʻano o ka hāʻawi ʻana i ka lāʻau lapaʻau:
- Vyvgart: Hāʻawi ʻia ia ma ke ʻano he hopena saline intravenous ( IV infusion ) ma kahi o 60 mau minuke.
- ʻO Vyvgart Hytrulo: Hāʻawi ʻia ia ma ke ʻano he inikini liʻiliʻi ma lalo o ka ʻili (injection subcutaneous). Hoʻopau ʻia kēia i loko o 20-90 kekona.
Hoʻolako pinepine ʻia kēia mau lāʻau ʻelua i hoʻokahi manawa i ka pule i loko o nā pōʻaiapuni ʻehā pule.
Pehea ʻoe e ʻike ai inā kūpono kēia lāʻau lapaʻau iā ʻoe?
He kūpono paha ʻo Vyvgart a i ʻole Vyvgart Hytrulo iā ʻoe.
- Inā he kanaka makua ʻoe me gMG.
- Inā ua hōʻoia nā hoʻokolohua ua loaʻa iā ʻoe nā antibodies AChR a mākou i kamaʻilio ai i loko o kou koko.
Na kāu kauka , ʻoiai he neurologist , e hoʻoholo inā kūpono kēia lāʻau lapaʻau iā ʻoe ma muli o kāu mau hopena hoʻāʻo koko a me ka mōʻaukala olakino.
He aha ka ʻōlelo a nā haʻawina e pili ana i kēia lāʻau lapaʻau?
Ua mālama ʻia kahi hoʻokolohua lapaʻau kūikawā i kapa ʻia ʻo ka hoʻokolohua ADAPT e noiʻi i ka pono o Vyvgart. ʻO ke kumu nui o kēia hoʻokolohua, ʻo ia ka ʻike ʻana i ka pono o ka lāʻau lapaʻau i ka hōʻemi ʻana i nā hōʻailona i nā poʻe maʻi gMG me nā antibodies AChR.
No ke ana ʻana i kēia, ua hoʻohana nā mea noiʻi i kahi mea hana kūikawā i kapa ʻia ʻo ka Myasthenia Gravis-Specific Activities of Daily Living scale (MG-ADL) . Ana kēia i ka paʻakikī o nā mea maʻi e hana i nā hana o kēlā me kēia lā (e like me ke kamaʻilio ʻana, ka moni ʻana, a me ke ala ʻana mai luna mai o ka noho).
I ka noiʻi, ua māhele ʻia nā maʻi i ʻelua mau pūʻulu.
1. Ua hāʻawi ʻia i kekahi hui ka lāʻau lapaʻau ʻo Vyvgart .
2. Ua hāʻawi ʻia ka hui ʻē aʻe i kahi placebo . ʻO ia hoʻi, kahi mea e like me ka lāʻau lapaʻau, akā ʻaʻohe lāʻau lapaʻau ikaika i loko.
ʻO ka mea kūikawā e pili ana i kēia, ʻaʻole i ʻike nā mea maʻi i lawe i ka lāʻau lapaʻau a me nā kauka i hāʻawi i ka lāʻau lapaʻau i ka mea i loaʻa ka lāʻau lapaʻau maoli a me ka mea i loaʻa ka placebo.
| ʻIke e pili ana i nā mea komo i ka noiʻi | |
|---|---|
| Kūpono e komo |
|
| Nā hōʻole no ke komo ʻana | |
He aha nā hopena o ka noiʻi?
He mea hoʻoikaika maoli nā hopena.
Ma kahi o 68% o ka poʻe i lawe iā Vyvgart i hoʻomaikaʻi nui i ko lākou hiki ke hana i nā hana o kēlā me kēia lā, ke hoʻohālikelike ʻia me 30% wale nō o ka poʻe i lawe i ka placebo.
Hōʻike maopopo kēia i ka pono o Vyvgart i ka hōʻoluʻolu ʻana i nā hōʻailona o gMG. ʻOiai aia ka lāʻau like i loko o Vyvgart Hytrulo, kūpono nā hopena no ia mea.
Pono anei mākou e makaʻala i nā hopena ʻaoʻao?
E like me nā lāʻau lapaʻau āpau, hiki i kēia mau lāʻau lapaʻau ke loaʻa kekahi mau hopena ʻaoʻao. He mea nui e makaʻala i kēia mau mea.
| ʻAno o ka hopena ʻaoʻao | Ka wehewehe a me nā mea e hana ai |
|---|---|
| Nā kūlana koʻikoʻi e pono ai ke kōkua koke ʻana o ke kauka | |
| Nā hopena alerika | Nā hōʻailona e like me ka ʻulaʻula o ka ʻili, ka pehu ʻana ma lalo o ka ʻili, a me ka paʻakikī o ka hanu ʻana. Hiki ke hana ʻia kēia mau mea i loko o hoʻokahi hola a i ʻole ʻekolu pule ma hope o ka lawe ʻana i ka lāʻau. Inā paʻakikī kou hanu ʻana a i ʻole ka manaʻo palupalu, e haʻi koke aku i kāu kauka a i ʻole e hele i ka keʻena pilikia o ka haukapila kokoke loa (ETU). |
| Nā Hana Hoʻokomo/Injection | Ke koko kiʻekiʻe, ke anu, ka haʻalulu, ka umauma, ka ʻōpū, a i ʻole ka ʻeha hope i ka wā a ma hope paha o ka lāʻau lapaʻau. E hoʻomaopopo pū i kāu kauka e pili ana i kēia mau mea. |
| Nā hopena ʻaoʻao maʻamau | |
| Nā maʻi ʻōnaehana hanu | Kuni, anu, ʻū, ihu wai, a pēlā aku. E inu i ka wai he nui, e hoʻomaha, a e pale i nā wahi i piha ai ka poʻe. |
| ʻEha poʻo | Hiki paha iā ʻoe ke loaʻa i kahi ʻeha poʻo maʻamau a i ʻole migraine. E kamaʻilio me kāu kauka e pili ana i kēia. |
| ʻO ka maʻi ʻaʻai mimi (UTI) | Hiki ke pale ʻia nā hōʻailona e like me ka mimi pinepine ʻana, ka wela ʻana o ka ʻōpū mimi, a me ke koko i loko o ka mimi ma ka inu ʻana i ka wai he nui. Inā ʻike ʻoe i kēia mau hōʻailona, e haʻi i kāu kauka. |
| ʻĒ aʻe | Hiki ke loaʻa ka ʻeha o nā ʻiʻo a me ka mae ʻana o ka ʻiʻo. Maʻamau, e emi ana kēia mau mea i loko o kekahi mau lā. Inā hoʻomau lākou, e hoʻomaopopo i kāu kauka. |
ʻO ka mea nui loa: Inā ʻike ʻoe i kekahi mau hōʻailona ʻē e like me kēia, mai hoʻowahāwahā iā lākou, me ka manaʻo he mea liʻiliʻi ia, a e kamaʻilio pono me kāu kauka.
Pono anei iaʻu e hopohopo e pili ana i nā lāʻau lapaʻau a me nā lāʻau pale ʻē aʻe?
ʻAe, ʻoiaʻiʻo nō. ʻO Vyvgart lāua ʻo Vyvgart Hytrulo nā lāʻau lapaʻau e hoʻopilikia i kāu ʻōnaehana pale. No laila,
- Ma mua o kou hoʻomaka ʻana i kēia lāʻau lapaʻau, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei (me nā huaora a me nā lāʻau lapaʻau kuʻuna) .
- Nā lāʻau pale: Inā pono ʻoe e loaʻa i kekahi mau lāʻau pale i ka wā o kēia kaʻina hana lapaʻau, e hoʻomaopopo i kāu kauka ma mua.
- Nā lāʻau pale ola ʻole: No ka laʻana, nā lāʻau pale no ka mumps, ka pneumonia, a me ka maʻi palū. ʻAʻole maopopo inā hiki i kēia mau mea ke emi ka maikaʻi.
- Nā lāʻau pale ola:ʻAʻole ia e ʻōlelo ʻia e loaʻa nā lāʻau pale e like me ka measles, mumps, a me ka rubella i ka wā o kēia mālama ʻana.
Mai hoʻololi i kāu hoʻolālā lapaʻau, hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau, a hoʻololi paha i ka nui a hiki i ka wā e ʻōlelo aku ai kāu kauka.
I ka hopena, hiki ke paʻakikī ke noho me Myasthenia Gravis. Akā me nā lāʻau lapaʻau hou e like me Vyvgart, aia kahi manawa kūpono e hoʻomaikaʻi nui ʻia kou ʻano ola. ʻO ka mea nui loa, ʻo ia ka launa mau ʻana me kāu kauka a hahai i kāna mau kuhikuhi.
Leka Lawe-Home
- ʻO Vyvgart lāua ʻo Vyvgart Hytrulo ʻelua mau lāʻau lapaʻau hou no ka mālama ʻana i ka Myasthenia Gravis (gMG) i nā maʻi me nā antibodies AChR.
- Hana kēia mau hana ma ka wehe ʻana i nā antibodies maikaʻi ʻole e hoʻoulu ai i ka maʻi mai ke kino a me ka hōʻemi ʻana i ka nāwaliwali o nā ʻiʻo.
- E hoʻoholo kekahi neurologist inā kūpono kēia lāʻau lapaʻau iā ʻoe.
- Hiki ke loaʻa nā hopena ʻaoʻao maʻamau e like me nā maʻi hanu a me nā poʻo ʻeha, a pono ʻoe e makaʻala i nā kūlana koʻikoʻi e like me nā maʻi allergies. E haʻi i kāu kauka inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē.
- He mea nui loa e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe a me nā lāʻau pale āu e lawe nei.
- ʻAʻole pono e hoʻōki a hoʻololi paha i ka lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a ke kauka.
💬 Comments (0)
ʻAʻohe manaʻo i kau ʻia. Hoʻohui i kāu manaʻo ma ʻaneʻi no ka manawa mua.
Hoʻohui i kāu manaʻo