Koj puas tau hnov ​​txog cov protein txawv txawv no hauv koj cov ntshav? (Cryoglobulinemia) Cia peb tham txog nws!

Muaj tej lub sij hawm muaj tej yam tshwm sim hauv peb lub cev uas peb tsis xav tias yuav muaj, puas yog? Hnub no peb yuav tham txog ib qho mob uas txawv me ntsis, tab sis nws tsim nyog paub txog. Qhov no hu ua cryoglobulinemia. Lub npe yuav zoo li nyuaj me ntsis, tab sis tsis txhob txhawj, cia peb piav qhia yooj yim.

cryoglobulinemia yog dab tsi? Hais yooj yim xwb...

Hais yooj yim xwb, cryoglobulinemia yog ib yam mob uas qee cov protein tsis zoo hauv koj cov ntshav, hu ua cryoglobulins, khov, sib sau ua ke, thiab tsim cov ntshav txhaws thaum raug rau qhov kub txias. Xav txog nws zoo li roj txiv maj phaub khov thaum koj muab tso rau hauv dej txias. Tab sis qhov no tshwm sim hauv peb cov ntshav. Qhov mob no yog ib hom vasculitis. Nws yog kev o, zoo li o, ntawm koj cov hlab ntsha, cov hlab ntsha me me uas nqa cov ntshav thoob plaws koj lub cev. Thaum cov hlab ntsha no o, cov ntshav ntws tuaj yeem raug cuam tshuam. Tom qab ntawd yuav ua li cas? Koj daim tawv nqaij, cov hlab ntsha, cov pob qij txha, cov leeg, thiab qhov tseem ceeb tshaj plaws, cov kab mob sab hauv xws li koj lub raum, tuaj yeem raug puas tsuaj. Qhov no qee zaum hu ua cryoglobulinemic vasculitis.

Puas muaj hom cryoglobulinemia?

Yog lawm, cov protein no hu ua cryoglobulins kuj yog ib hom antibody. Nyob ntawm seb hom antibody uas peb lub cev tsim tawm li cas, cryoglobulinemia muaj peb hom tseem ceeb:

• Hom I Cryoglobulinemia: Qhov no feem ntau yog tshwm sim los ntawm cov qog nqaij hlav ntsig txog koj cov ntshav lossis cov qog nqaij hlav ntsig txog koj lub cev tiv thaiv kab mob.
• Hom II Cryoglobulinemia thiab Hom III Cryoglobulinemia: Ob hom no feem ntau pom nrog cov mob o ntev (uas yog, ntev mus ntev). Piv txwv li, lawv tuaj yeem pom hauv cov neeg uas muaj cov kab mob autoimmune . Tshwj xeeb, Hom II Cryoglobulinemia yog qhov tshwm sim ntau heev rau cov neeg uas muaj tus kab mob Hepatitis C (HCV). Ob hom no tau sib xyaw ua ke thiab hu ua Mixed Cryoglobulinemia.

Qhov teeb meem no feem ntau tshwm sim li cas?

Cryoglobulinemia yog ib qho mob tsis tshua muaj.Tiamsis cov kws tshawb nrhiav tseem tsis tau hais meej tias muaj pes tsawg tus neeg muaj tus mob no. Vim tias qee tus neeg yuav muaj cov cryoglobulins no qis hauv lawv cov ntshav tab sis tsis qhia cov tsos mob, cov kws tshawb nrhiav kwv yees tias tus mob no cuam tshuam txog li ib ntawm ib lab tus tib neeg thoob ntiaj teb.

Cov tsos mob yog dab tsi? Puas yog txhua tus neeg muaj cov tsos mob?

Tsis yog, tsis yog txhua tus neeg uas muaj cryoglobulinemia yuav muaj cov tsos mob. Tej zaum ib txhia neeg yuav tsis pom dab tsi li. Tab sis thaum cov tsos mob tshwm sim, cov tsos mob feem ntau yog pob khaus tawv nqaij hu ua purpura. Qhov no zoo li cov pob liab lossis cov ntshav ntawm cov ceg qis. Koj kuj tseem yuav xav tias nkees thiab mob pob qij txha. Lwm cov tsos mob kuj tseem yuav tshwm sim. Cov no suav nrog:

• Thaum raug cua txias, cov hlab ntsha hauv tes thiab/lossis ko taw yuav nqaim, ua rau lawv tig xiav. Qhov no hu ua Raynaud's phenomenon .
• Kev poob phaus .
• Ntshav siab (Hypertension).
• O, tshwj xeeb tshaj yog nyob rau hauv pob luj taws thiab ceg (Edema).
• Cov kab mob ntawm daim tawv nqaij thiab qee zaum cov nqaij tuag (gangrene).
• Lub siab loj (Hepatomegaly) lossis lub po loj (Splenomegaly).
• Mob loog , tingling, lossis tsis muaj zog hauv ob txhais ceg.
• Kev puas tsuaj rau lub raum.

Xav txog nws, qhov no tsis yog tsuas yog rooj plaub ntawm koj ob txhais ceg tig xiav vim qhov txias xwb. Qhov no yuav yog ib qho cim ntawm teeb meem loj dua hauv koj lub cev. Yog vim li cas nws thiaj li tseem ceeb kom paub txog tej yam zoo li no.

Dab tsi yog cov ua rau muaj cryoglobulinemia?

Cov kws tshawb nrhiav tseem tsis tau paub meej tias yog dab tsi ua rau muaj cryoglobulinemia. Tab sis raws li peb tau tham ua ntej, nws yog ib hom kab mob autoimmune hu ua vasculitis, uas yog o ntawm cov hlab ntsha. Kab mob autoimmune tsuas yog thaum koj lub cev lub cev tiv thaiv kab mob, lub cev tiv thaiv kab mob uas tiv thaiv koj ntawm kab mob, ua yuam kev tawm tsam koj cov nqaij noj qab haus huv. Muaj ntau yam uas tuaj yeem ua rau muaj qhov kev tsis haum no:

• Cov noob caj noob ces: Yog tias ib tug neeg hauv tsev neeg muaj nws, nws tuaj yeem raug cuam tshuam.
• Qee hom tshuaj: Tsis yog txhua yam tshuaj, tab sis qee yam.
• Cov kab mob thiab cov kab mob: Tshwj xeeb tshaj yog cov kab mob viral.
• Tej yam ib puag ncig: Qee yam nyob rau hauv ib puag ncig peb.

Qee zaum Cryoglobulinemia tuaj yeem tshwm sim nws tus kheej yam tsis muaj laj thawj pom tseeb (qhov no hu ua idiopathic), tab sis feem ntau nws tshwm sim nrog rau lwm yam kab mob. Ib txhia ntawm cov kab mob no suav nrog:

• Kev kis kab mob Hepatitis C: Qhov no yog qhov txuas tseem ceeb thiab feem ntau pom.
• Kev txawv txav hauv cov qe ntshav: Piv txwv li, cov mob qog noj ntshav xws li lymphoma thiab multiple myeloma.
• Cov kab mob ntawm cov nqaij sib txuas: Ib qho piv txwv yog lupus.

Leej twg muaj feem yuav raug qhov no tshaj?

Cryoglobulinemia zoo li cuam tshuam rau cov poj niam ntau dua li cov txiv neej, thiab feem ntau yog rau cov neeg hnub nyoog tshaj 50 xyoo.

Yog tsis kho kom zoo, puas muaj teeb meem tshwm sim tau?

Yog, yeej muaj tseeb tiag. Yog tias cryoglobulinemia tsis kho kom zoo, nws tuaj yeem ua rau koj daim tawv nqaij, cov nqaij, thiab cov kabmob sab hauv puas tsuaj mus tas li. Qee qhov teeb meem loj uas tuaj yeem tshwm sim suav nrog:

• Kab mob ntawm daim tawv nqaij lossis cov qhov txhab uas tsis kho.
• Kev tuag ntawm daim tawv nqaij (necrosis).
• Kev ua haujlwm tsis zoo ntawm lub raum.
• Kev ua tsis tau zoo ntawm daim siab.

Cov no yog cov mob hnyav heev, yog vim li cas nws thiaj li tseem ceeb rau kev kuaj mob thiab kho tus kab mob sai sai.

Cov kws kho mob kuaj mob li cas?

Thaum koj mus ntsib kws kho mob, nws yuav nug txog koj keeb kwm kev kho mob ua ntej thiab kuaj lub cev. Tom qab ntawd, lawv yuav xaj kom kuaj ntshav tshwj xeeb los xyuas seb puas muaj cryoglobulins hauv koj cov ntshav. Qhov kev kuaj ntshav no kuj tseem tuaj yeem qhia koj tias koj muaj hom cryoglobulin twg. Qhov no qee zaum tuaj yeem pab txiav txim siab qhov ua rau koj tus mob thiab yuav kho nws li cas. Ntxiv rau qhov kev kuaj ntshav no, koj tus kws kho mob yuav xaj ntau qhov kev kuaj ntxiv kom paub meej tias kuaj mob thiab nkag siab txog qhov xwm txheej:

• Kev kuaj zis (Urinalysis).
• Ib daim duab X-ray hauv siab.
• Ib daim CT scan (Computed tomography (CT) scan).
• Ib daim duab angiogram (saib seb cov hlab ntsha zoo li cas).
• Kev kuaj mob MRA (magnetic resonance angiogram) lossis CT angiogram (CT angiogram).
• Kev ntsuam xyuas kev xa xov ntawm cov hlab ntsha.
• Kev kuaj electromyography (EMG) (saib kev ua haujlwm ntawm cov leeg nqaij).
• Ib qho biopsy (siv ib daim nqaij me me, tej zaum los ntawm daim tawv nqaij lossis lub raum, los kuaj).

Qhov no kho li cas?

Kev kho mob rau cryoglobulinemia nyob ntawm seb cov kabmob twg raug cuam tshuam, qhov kev puas tsuaj loj npaum li cas, thiab seb koj puas muaj lwm yam mob.Nws yog ib qho tseem ceeb uas yuav tsum kho lwm yam mob uas yuav cuam tshuam nrog cryoglobulinemia, xws li kab mob siab C, thiab lwm yam mob uas yuav cuam tshuam nrog nws. Qhov no yog vim tias kev kho lwm yam mob ntawd qee zaum tuaj yeem pab txo cov tsos mob ntawm cryoglobulinemia. Yog tias koj cov tsos mob tsis hnyav, koj tus kws kho mob yuav pom zoo kom yuav cov tshuaj tua kab mob uas yuav tsis tas yuav muaj daim ntawv yuav tshuaj (xws li NSAIDs) thiab qhia koj kom tsis txhob raug rau qhov kub txias . Lawv kuj tseem yuav pom zoo kom koj mus kuaj mob tsis tu ncua kom saib xyuas koj tus mob. Hauv cov mob uas tsis hnyav heev, lossis nruab nrab mus rau hnyav, kev kho mob yuav txawv me ntsis:

• Cov tshuaj tiv thaiv kab mob: Qhov no yog kev kho mob tseem ceeb. Cov tshuaj Corticosteroids, xws li prednisone, qee zaum muab ua ke nrog lwm cov tshuaj. Qhov no nyob ntawm seb lub cev puas raug mob thiab qhov kev puas tsuaj loj npaum li cas.
• Cov Tshuaj Tiv Thaiv Kab Mob: Yog tias koj tus kws kho mob pom tias koj muaj lwm yam mob, xws li kab mob siab C, nws yuav pom zoo kom siv tshuaj tiv thaiv kab mob. Lawv kuj tseem yuav xa koj mus rau tus kws kho mob siab (kws kho mob siab).
• Biologics: Rituximab yog ib txoj kev kho mob uas siv ntau rau cryoglobulinemia. Biologics yog cov protein sib xyaw ua los ntawm cov kab mob uas muaj sia nyob uas tsom mus rau qee qhov ntawm lub cev tiv thaiv kab mob kom tswj tau qhov o.
• Plasmapheresis: Qhov no yog lwm txoj kev kho mob. Nws ua haujlwm los ntawm kev txo cov cryoglobulins hauv koj cov ntshav. Hauv cov txheej txheem no, cov cryoglobulins raug tshem tawm ntawm koj cov plasma (qhov kua ntawm koj cov ntshav). Qhov no pab tiv thaiv cov cryoglobulins kom tsis txhob txhaws koj cov hlab ntsha, thaiv cov ntshav ntws thiab txo cov kab mob puas tsuaj.

Cia peb kuj paub txog cov kev mob tshwm sim thiab cov teeb meem ntawm kev kho mob.

Cov tshuaj uas cov kws kho mob sau ntawv kom kho tus kab mob cryoglobulinemia muaj qee yam kev mob tshwm sim loj heev. Cov tshuaj tseem ceeb yog osteoporosis thiab txo qis lub cev lub peev xwm los tawm tsam cov kab mob. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom kuaj xyuas. Tom qab ntawd, koj tus kws kho mob tuaj yeem sau ntawv rau lwm cov tshuaj kom tswj tau cov kev mob tshwm sim no. Nws tseem ceeb heev uas yuav tsum tiv thaiv koj tus kheej ntawm cov kab mob. Yog li ntawd, tham nrog koj tus kws kho mob txog kev txhaj tshuaj tiv thaiv kab mob uas tuaj yeem txo qhov kev pheej hmoo ntawm kev kis kab mob.

Puas muaj ib txoj kev los tiv thaiv qhov mob no?

Vim tias qhov ua rau muaj cryoglobulinemia tsis paub meej, tsis muaj txoj hauv kev tshwj xeeb los tiv thaiv nws. Txawm li cas los xij, kev zam kev raug cua txias tuaj yeem pab tau .Nws tuaj yeem pab tswj qee cov tsos mob, xws li Raynaud's phenomenon. Nws tseem ceeb heev uas yuav tsum tau mus kuaj mob Hepatitis C thiab nrhiav kev kho mob yog tias koj muaj.

Yuav muaj kev kwv yees li cas rau ib tus neeg uas muaj tus kab mob no?

Koj txoj kev xav, uas yog, tus kab mob yuav zoo li cas, nyob ntawm ntau yam:

• Lwm yam mob uas koj muaj.
• Qhov kev puas tsuaj rau koj cov kab mob.
• Koj teb tau zoo npaum li cas rau kev kho mob.

Tsis tas li ntawd xwb, qhov mob hnyav ntawm tus kab mob no txawv ntawm ib tus neeg mus rau ib tus neeg. Tej zaum ib txhia neeg yuav tsis muaj tsos mob li, lossis lawv tus mob yuav tsis hnyav heev uas lawv tsis tas yuav kho. Rau cov neeg uas muaj mob nruab nrab lossis mob hnyav, kev kuaj mob thaum ntxov thiab kev kho mob tuaj yeem pab txo cov tsos mob thiab tiv thaiv cov teeb meem mus sij hawm ntev. Yog tias koj cov kab mob tsis raug puas tsuaj mus tas li, qhov kev cia siab zoo heev.

Kuv yuav ua li cas thiaj saib xyuas kuv tus kheej? Leej twg yuav pab kuv?

Qhov zoo tshaj plaws uas koj ua tau yog ua haujlwm nrog koj pab neeg kho mob. Nyob ntawm seb koj qhov cryoglobulinemia tau cuam tshuam rau cov kabmob twg, koj yuav tsum ua haujlwm nrog pab neeg kws kho mob ntau yam. Cov no suav nrog:

• Cov kws kho mob uas tshwj xeeb hauv cov kab mob pob qij txha thiab cov nqaij sib txuas (Rheumatologists).
• Cov kws kho mob tawv nqaij.
• Cov kws kho mob ntshav.
• Cov kws kho mob uas tshwj xeeb hauv kev kho mob raum (Nephrologists).
• Cov kws kho mob plawv.
• Cov kws kho mob hlwb.
• Cov kws kho mob siab.

Paub koj pab neeg kho mob zoo. Hais lus rau koj tus kheej. Nug cov lus nug. Yog tias koj muaj kev txhawj xeeb txog koj txoj kev npaj kho mob, tham txog nws. Koj cov kws kho mob nyob ntawd los mloog koj thiab xyuas kom koj nkag siab txhua yam uas cuam tshuam rau koj txoj kev noj qab haus huv thiab kev saib xyuas.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj muaj cov tsos mob ntawm cryoglobulinemia, koj yuav tsum nrhiav kev kho mob tam sim ntawd. Tsis tas li ntawd, yog tias koj muaj kab mob siab C thiab muaj cov tsos mob no tshwm sim, mus ntsib kws kho mob. Txawm tias kho tau zoo los xij, tus kab mob no qee zaum tuaj yeem rov qab los (rov qab los). Yog tias koj muaj cov tsos mob tshiab, yog tias koj cov tsos mob uas twb muaj lawm zuj zus tuaj, lossis yog tias koj cov tsos mob rov qab los, mus ntsib kws kho mob. Kev kuaj mob tsis tu ncua thiab kev saib xyuas tsis tu ncua yog qhov tseem ceeb kom paub txog kev rov qab los thaum ntxov thiab tiv thaiv cov teeb meem.

Kuv yuav tsum nug tus kws kho mob li cas?

Thaum koj mus ntsib koj tus kws kho mob, nws yog ib lub tswv yim zoo los nug cov lus nug zoo li no:

• Ua cas kuv thiaj muaj tus mob no?
• Koj pom zoo kom muaj kev kho mob dab tsi?
• Kuv yuav tsum txhawj xeeb txog cov kev mob tshwm sim dab tsi ntawm kev kho mob?
• Vim muaj tus mob no, yuav muaj teeb meem dab tsi tshwm sim?
• Kuv ua tau dab tsi los tiv thaiv kom tus kab mob tsis txhob rov tshwm sim dua?

Tej yam tseem ceeb tshaj plaws uas peb yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Kev nyob nrog cryoglobulinemia tuaj yeem nyuaj rau qee lub sijhawm. Cov tsos mob thiab cov kev mob tshwm sim ntawm cov tshuaj tuaj yeem muaj kev cuam tshuam loj rau koj lub hlwb kev noj qab haus huv. Nws kuj tseem tuaj yeem cuam tshuam rau ntau yam ntawm koj lub neej.

Tiam sis nco ntsoov, koj tsis yog tib tug xwb. Nug koj tus kws kho mob kom pab, thiab nrhiav cov pab pawg txhawb nqa uas lwm tus neeg uas muaj teeb meem zoo sib xws tuaj yeem sib sau ua ke. Kev sib qhia koj cov kev paub dhau los thiab yam koj paub tuaj yeem pab koj nyob nrog cryoglobulinemia. Kev tiv thaiv koj tus kheej ntawm qhov mob khaub thuas, nrhiav kev pab kho mob, tsis txhob haus luam yeeb, thiab noj zaub mov kom zoo yog qhov tseem ceeb.

Vam tias cov ntaub ntawv no yuav pab tau koj. Nyob zoo!