Koj puas tau hnov txog acetylcholine , lossis (ACh)? Tej zaum koj tus kws kho mob tau qhia koj txog nws, lossis koj tau nyeem txog nws qhov twg. Nws yog ib qho tshuaj me me tab sis tseem ceeb heev hauv peb lub cev. Nws zoo li tus neeg xa ntawv me me uas nqa cov lus hauv peb lub cev. Yog li, hnub no peb yuav tham txog acetylcholine hauv txoj kev yooj yim uas koj tuaj yeem nkag siab.
Acetylcholine yog dab tsi tiag?
Hais yooj yim xwb, acetylcholine yog ib yam neurotransmitter . Xav txog nws, koj lub hlwb yuav tsum xa cov lus hluav taws xob me me los txav koj txhais tes, xav, nco qab ib yam dab tsi, tag nrho cov no. Acetylcholine yog ib yam tshuaj xa xov uas pab nqa cov lus ntawd hla cov hlwb hlab ntsha .
Qhov no kuj hu ua " excitatory " neurotransmitter . Koj puas paub qhov ntawd yog dab tsi? Nws "tsa" lub hlwb, uas yog, ua kom nws ua haujlwm, thiab ua rau nws "xa" cov lus sai dua. Nws zoo li khob lub qhov rooj ntawm tus neeg pw tsaug zog thiab hais tias, "Nov, coj tsab ntawv no mus."
Lub npe acetylcholine los ntawm ob yam uas ua rau nws. Ib qho yog ib pawg acetyl . Qhov no los ntawm ib qho tshuaj hu ua acetyl coenzyme A, uas yog ua los ntawm cov suab thaj glucose. Qhov thib ob yog ib qho khoom noj khoom haus hu ua choline . Choline pom muaj nyob rau hauv cov qe qe, taum pauv, siab, zaub, thiab legumes. Choline kuj tseem ua nyob rau hauv peb lub siab.
Acetylcholine koom nrog ntau yam haujlwm tseem ceeb hauv peb lub cev, tshwj xeeb tshaj yog kev txav mus los ntawm cov leeg nqaij.Qhov no ua lub luag haujlwm tseem ceeb hauv peb tej kev ua ub ua no, xws li kev txav peb ob txhais ceg thiab kev taug kev. Nws ua rau cov hlab ntsha hauv peb cov leeg nqaij ua haujlwm, ua rau lawv qaug zog. Tsis yog li ntawd xwb, tab sis nws tseem ceeb heev rau cov hlab ntsha hauv peb lub hlwb, thiab rau cov txheej txheem xws li kev nco, kev xav, thiab kev kawm.
Acetylcholine (ACh) ua haujlwm li cas?
Acetylcholine khaws cia rau ntawm qhov kawg ntawm cov hlwb paj hlwb, kom txog thaum xav tau xa xov. Thaum "lub teeb liab" tuaj txog los xa xov, cov acetylcholine khaws cia no raug tso tawm. Thaum tso tawm, nws mus rau hauv qhov sib txawv me me ntawm ob lub hlwb paj hlwb. Qhov sib txawv no hu ua synaptic cleft .
Tom qab hla qhov synaptic cleft, muaj ob hom receptors uas acetylcholine tuaj yeem khi rau. Lawv yog:
- Cov neeg txais Nicotinic
- Cov receptors muscarinic
Tom qab khi rau cov receptors no, cov lus tshuaj lom neeg mus rau lub hlwb tom ntej. Tom qab cov lus raug xa mus, acetylcholine uas tseem nyob hauv qhov synaptic cleft tsis tsuas yog pov tseg xwb. Lwm lub enzyme hu ua acetylcholinesterase tuaj thiab rhuav cov acetylcholine no ua nws cov khoom sib xyaw, choline thiab acetate. Tom qab ntawd cov khoom tawg no raug nqus rov qab, rov ua dua tshiab, thiab siv los nqa lwm cov lus tshuaj lom neeg. Ib lub kaw lus ua haujlwm zoo heev!
Ua li cas rau acetylcholine (ACh)?
Acetylcholine muaj ntau yam txiaj ntsig rau peb lub cev. Cia peb saib cov tseem ceeb.
| Hom txais | Cov haujlwm tseem ceeb |
|---|---|
| Cov receptors muscarinic | |
| Cov receptors Nicotinic (Nicotinic) |
|
Ob hom receptors no muaj feem cuam tshuam rau peb lub cim xeeb . Qhov ntawd yog, lawv tseem ceeb rau kev nco qab mus sij hawm ntev, kev nco qab luv luv, kev tsim cov cim xeeb, lawv txoj kev sib sau ua ke, thiab lawv txoj kev rov qab tau. Hauv lub hlwb, acetylcholine muaj feem cuam tshuam rau lwm yam. Nws txhawb kev txhawb zog, kev txaus siab/kev mloog zoo, kev kawm, thiab kev pw tsaug zog REM (theem ntawm kev pw tsaug zog uas peb npau suav).
Cov mob dab tsi tshwm sim thaum cov acetylcholine (ACh) theem txo qis?
Cov acetylcholine tsawg, lossis qhov tsis txaus, tuaj yeem ua rau muaj ntau yam kab mob. Qhov tseem ceeb tshaj plaws ntawm cov no yog:
- Kab mob Alzheimer : Cov neeg uas muaj kab mob Alzheimer tsis muaj acetylcholine txaus hauv lawv lub hlwb. Yog li ntawd, kev nco tsis zoo yog ib qho tsos mob loj.
- Lambert-Eaton myasthenic syndrome : Tus kab mob no yog tshwm sim los ntawm kev txo qis ntawm kev tso tawm acetylcholine los ntawm cov hlwb paj hlwb.
- Myasthenia gravis : Qhov no yog ib yam kab mob autoimmune uas ua rau cov leeg nqaij tsis muaj zog sai tom qab siv ntau zaus.
Tseem Ceeb:Yog koj muaj ib qho ntawm cov tsos mob no, mus ntsib kws kho mob tam sim ntawd. Tsis txhob kuaj mob koj tus kheej.
Cov tshuaj twg uas tsom mus rau acetylcholine (ACh)?
Cov tshuaj Cholinesterase inhibitors yog ib hom tshuaj uas ua haujlwm los ntawm kev ua kom cov enzyme uas rhuav acetylcholine tsis ua haujlwm thiab ua kom cov acetylcholine receptors ua haujlwm ntau dua. Lawv siv los kho tus kab mob Alzheimer thiab myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), thiab Galantamine (Razadyne®) yog qee cov tshuaj no.
Cov khoom noj twg muaj choline, uas pab tsim cov acetylcholine (ACh)?
Choline, ib yam khoom noj uas hloov mus ua acetylcholine, pom muaj nyob rau hauv ntau yam khoom noj. Piv txwv li:
- siab nyuj
- Qe (tshwj xeeb tshaj yog cov qe daj)
- Nqaij nyuj puag ncig sab saud
- Cov taum pauv ci, cov taum pauv hauv cov kaus poom
- Nqaij qaib ci hauv siab
- Ntses Cod `(Cod)`
- Quinoa siav lawm
- Cov nceb shiitake siav lawm, broccoli siav lawm thiab cov zaub paj Brussels
- Mis nyuj (1%) `(Mis nyuj (1%)`, mis nyuj vanilla tsis muaj roj `(mis nyuj vanilla tsis muaj roj)`
Sim ntxiv cov khoom noj no rau hauv koj cov zaub mov noj. Kev noj zaub mov kom sib npaug yog qhov tseem ceeb heev rau lub neej noj qab haus huv.
Cov Lus Qhia Txog Kev Coj Mus Tsev
Yog li, tam sim no koj yuav nkag siab tias acetylcholine (ACh) yog ib qho neurotransmitter uas tseem ceeb heev rau peb lub hlwb ua haujlwm, nco, thiab lub cev ua haujlwm zoo li cov leeg nqaij contraction. Yog tias nws cov theem txo qis, teeb meem nco thiab cov kab mob ntsig txog cov leeg nqaij tuaj yeem tshwm sim. Qhov tseem ceeb tshaj plaws yog, yog tias koj muaj teeb meem kev noj qab haus huv, tham nrog kws kho mob txog nws. Tsis txhob mus kho mob raws li kev xav. Nyob kom noj qab haus huv!
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus