Yog tias ib tug neeg hauv koj tsev neeg, tej zaum yog ib tug niam, txiv, pog lossis phauj uas koj hlub, raug kev txom nyem los ntawm tus kab mob Alzheimer, peb paub tias nws mob npaum li cas. Nws nyuaj rau hais tawm qhov mob uas koj hnov thaum koj saib koj lub cim xeeb maj mam ploj mus thiab koj poob koj lub peev xwm los paub koj tus kheej. Txawm hais tias cov tshuaj tam sim no rau tus kab mob no tuaj yeem tswj cov tsos mob rau qee qhov, tseem tsis muaj kev kho. Txawm li cas los xij, kev kho mob yeej tsis tso tseg. Tam sim no, cov kws tshawb fawb thoob ntiaj teb tab tom tshawb nrhiav tshuaj tiv thaiv kab mob uas tuaj yeem kho, tswj thiab tiv thaiv tus kab mob no. Yog li cia peb tham txog qhov kev cia siab tshiab no hnub no.
Cov tshuaj tiv thaiv kab mob twg tuaj yeem pab tau rau tus kab mob Alzheimer's?
Qhov tseeb, qee qhov kev tshawb fawb tau qhia tias cov neeg laus uas tau txais qee yam tshuaj tiv thaiv kab mob rau cov kab mob xws li mob qaib ntxhw (piv txwv li, tshuaj tiv thaiv kab mob shingles) thiab tshuaj tiv thaiv kab mob xws li qhua pias muaj qhov pheej hmoo qis dua me ntsis ntawm kev mob Alzheimer's. Tab sis cov no tsis yog cov tshuaj tiv thaiv kab mob tshwj xeeb uas tsom mus rau tus kab mob Alzheimer's.
Thaum tsim cov tshuaj tiv thaiv kab mob Alzheimer's, cov kws tshawb fawb feem ntau tsom mus rau peb qhov kev hloov pauv tseem ceeb hauv lub hlwb uas tshwm sim los ntawm tus kab mob. Hais yooj yim xwb, muaj peb tus "neeg ua txhaum" tseem ceeb hauv lub hlwb ntawm tus neeg mob Alzheimer's.
1. Cov protein Tau sib xyaw ua ke: Cov no sib sau ua ke hauv cov hlwb hlwb.
2. Cov Beta-amyloid plaques: Cov no sib sau ua ke ntawm cov hlwb hlab ntsha, uas yog, nyob rau hauv qhov chaw nruab nrab ntawm ob lub hlwb.
3. Kev o hauv lub hlwb: Ob tug neeg ua txhaum no ua rau muaj kev o tas li, lossis kev o, hauv lub hlwb.
Lub hom phiaj ntawm txhua hom tshuaj tiv thaiv kab mob uas tab tom tsim tawm tam sim no yog los tswj ib lossis ntau yam ntawm cov neeg ua phem no. Cia peb saib txhua hom tshuaj tiv thaiv kab mob sib cais.
| Hom tshuaj tiv thaiv kab mob thiab lub hom phiaj | Cov txheej txheem thiab qhov cuam tshuam |
|---|---|
| Cov tshuaj tiv thaiv kab mob uas tsom mus rau Tau proteins | Xav txog tias sab hauv cov hlwb ntawm koj lub hlwb, muaj ib lub qauv zoo li lub tsheb ciav hlau los thauj cov as-ham rov qab los. Cov protein no hu ua 'tau' yog qhov ua rau cov 'kev tsheb ciav hlau' ruaj khov. Hauv tus kab mob Alzheimer's, cov protein tau no dhau los ua tsis zoo, es tsis txhob ua zoo li txoj kev, lawv sib xyaw ua ke thiab dhau los ua 'pob xov'. Tom qab ntawd kev thauj mus los hauv cov hlwb nres, thiab cov hlwb pib tuag. Cov tshuaj tiv thaiv no sim tiv thaiv qhov kev sib xyaw no. Cov tshuaj tiv thaiv tam sim no nyob rau theem sim yog AADvac1 thiab ACI-35.030/JACI-35.054 . |
| Cov tshuaj tiv thaiv kab mob uas tsom mus rau beta-amyloid | Qhov no zoo li 'cov khib nyiab' lossis 'cov khoom seem zoo li kua nplaum' sib sau ua ke ntawm cov hlwb hlwb. Cov protein no hu ua beta-amyloid sib sau ua ke thiab tsim cov khoom hu ua 'plaques'. Qhov no tiv thaiv cov hlwb hlwb kom tsis txhob sib txuas lus zoo, uas txhais tau tias lawv raug tiv thaiv los ntawm kev xa 'cov cim'. Cov tshuaj tiv thaiv no ua yog txhawb lub cev tiv thaiv kab mob kom tshem tawm cov 'khib nyiab' no. Cov tshuaj tiv thaiv xws li ALZ-101, ABvac40, thiab UB-311 yog cov khoom no. |
| Cov tshuaj tiv thaiv kab mob uas tsom mus rau kev o ntawm lub hlwb | Hauv lub hlwb noj qab nyob zoo, muaj cov hlwb tshwj xeeb hu ua microglia. Lawv zoo li lub hlwb 'neeg ua haujlwm ntxuav'. Lawv txoj haujlwm yog tshem tawm cov khib nyiab thiab cov tshuaj lom uas tsis xav tau. Tab sis hauv tus kab mob Alzheimer, cov neeg ua haujlwm no mus ua haujlwm tsis zoo. Es tsis txhob tshem tawm cov khib nyiab, lawv tsim cov tshuaj lom neeg uas ua rau lub hlwb o tas li. Qhov no kuj ua rau cov hlwb noj qab nyob zoo puas tsuaj. Cov tshuaj tiv thaiv no sim kho qhov 'kev ntxuav tsis huv' no. GV1001 thiab Protollin yog ob qho ntawm cov tshuaj tiv thaiv sim no. |
Yog li, thaum twg peb thiaj yuav tau txhaj tshuaj tiv thaiv kab mob Alzheimer?
Qhov no yog lo lus nug loj tshaj plaws uas txhua tus neeg xav txog. Yog hais qhov tseeb, qhov no yuav siv sijhawm me ntsis. Tag nrho cov tshuaj tiv thaiv kab mob no uas peb tau tham txog tseem nyob rau theem sim tshuaj. Qhov ntawd txhais tau tias lawv tseem raug sim seb puas muaj kev nyab xeeb rau kev muab rau tib neeg thiab lawv ua haujlwm tau zoo npaum li cas.
Qhov tseem ceeb tshaj plaws yog tias yog tias qhov kev tshawb fawb no ua tiav, tus kab mob Alzheimer yuav tiv thaiv tau lossis kho tau thaum ntxov yav tom ntej.
Raws li cov ntaub ntawv tam sim no, ntawm cov tshuaj tiv thaiv kab mob uas tau hais los saum toj no, GV1001Cov tshuaj tiv thaiv kab mob tau ua tiav me ntsis hauv kev sim tshuaj, tab sis cov no tseem tsis tau yog qhov kawg.
Peb yuav ua li cas txog thaum ntawd?
Zoo siab uas muaj kev cia siab rau cov tshuaj tiv thaiv kab mob tshiab no. Tab sis txog thaum ntawd, yog tias koj lossis ib tug neeg hauv koj tsev neeg raug kev txom nyem los ntawm tus kab mob no, qhov zoo tshaj plaws uas yuav tsum ua yog ua raws li kev kho mob uas koj tus kws kho mob pom zoo tam sim no.
Cov tshuaj kho mob tam sim no, xws li Aducanumab thiab Lecanemab, tau pom tias ua rau tus kab mob qeeb qeeb yog tias kuaj pom ntxov. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum sib cuag nrog koj tus kws kho mob tsis tu ncua thiab ua raws li nws cov lus qhia.
Yog tias koj xav koom nrog kev sim tshuaj zoo li no, koj tuaj yeem tham nrog koj tus kws kho mob txog qhov ntawd. Nws yuav muaj peev xwm muab cov lus qhia tseeb rau koj txog seb puas muaj lub sijhawm tsim nyog rau koj thiab seb koj puas tsim nyog rau nws.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kab mob Alzheimer yog ib yam mob uas tshwm sim los ntawm kev hloov pauv ntau yam hauv lub hlwb (tau protein tangles, beta-amyloid deposits, o).
- Cov kws tshawb fawb tab tom ua haujlwm hnyav los tsim cov tshuaj tiv thaiv kab mob uas tuaj yeem tsom mus rau cov kev hloov pauv no thiab tiv thaiv, kho, lossis tswj tus kab mob.
- Vim tias cov tshuaj tiv thaiv no tseem nyob rau theem kev tshawb fawb, nws yuav siv sijhawm me ntsis rau lawv kom muaj dav.
- Qhov zoo tshaj plaws ua lub sijhawm no yog txuas ntxiv kev kho mob uas koj tus kws kho mob pom zoo thiab ua raws li nws cov lus qhia.
- Thaum twg tshuaj tiv thaiv kab mob tau tsim tiav lawm yav tom ntej, koj pab neeg kho mob yuav qhia rau koj txog nws.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus