Koj puas pib koj hnub nrog kev mob nraub qaum thiab mob thaum koj sawv thaum sawv ntxov? Qhov mob no puas txo qis thaum koj taug kev me ntsis, ua haujlwm me ntsis, thiab nce ntxiv dua thaum koj nyob twj ywm? Cov no tuaj yeem yog cov tsos mob ntawm tus kab mob hu ua Ankylosing Spondylitis (AS). Qhov no yog ib qho mob uas cuam tshuam rau lub neej txhua hnub. Ua kev kho mob rau qhov no, cov kws kho mob yuav tsum sau cov tshuaj tua kab mob (NSAIDs) ua ntej. Yog tias cov no tsis tswj tau tus kab mob, lawv yuav xa koj mus rau cov tshuaj txhaj hu ua biologics. Txawm li cas los xij, qee tus neeg tsis tau txais kev pab los ntawm cov kev kho mob no, lossis lawv cov kev phiv tsis yooj yim rau kev zam. Koj puas tab tom ntsib tib yam? Yog tias yog, tsis txhob txhawj. Nrog kev nce qib ntawm kev tshawb fawb kho mob, lwm txoj kev kho mob tshiab thiab ua tiav tau los rau hauv lub teeb. Ntawd yog Janus Kinase (JAK) inhibitors . Cia peb tham txog qhov no hnub no.
Cov tshuaj JAK inhibitors yog dab tsi?
Cov tshuaj JAK inhibitors yog ib pawg tshuaj tshiab rau kev kho mob ankylosing spondylitis. Ib yam li cov tshuaj biologics, lawv koom nrog ib pawg tshuaj hu ua disease-modifying antirheumatic drugs (DMARDs). "Disease-modifying" txhais tau hais tias cov tshuaj no tsis yog tsuas yog txo qhov mob xwb. Lawv kuj tswj kev puas tsuaj rau tus txha nraub qaum thiab lwm cov pob qij txha, ua rau qeeb qeeb ntawm tus kab mob.
Tab sis cov no tsis yog siv rau Ankylosing Spondylitis xwb. Hom tshuaj no kuj tau pom zoo rau ntau lwm yam kab mob autoimmune. Ntawd yog, cov kab mob uas lub cev tiv thaiv kab mob tawm tsam nws cov hlwb.
- Mob pob qij txha caj qaum
- Mob pob qij txha caj qaum tsis paub meej (JIA) rau cov menyuam yaus uas muaj ntau yam mob sib kis
- Mob pob qij txha psoriasis
- Mob plab hnyuv
Qhov tshwj xeeb yog koj tuaj yeem noj cov no ua cov tshuaj ntsiav es tsis tas yuav txhaj tshuaj zoo li cov tshuaj biologics. Yog li qhov no yog qhov kev pab loj rau cov neeg uas ntshai txhaj tshuaj.
Cov hom twg siv rau Ankylosing Spondylitis?
Tam sim no, ob hom tshuaj JAK inhibitors tau pom zoo rau kev kho mob Ankylosing Spondylitis.
- Tofacitinib (Hom npe: Xeljanz, Xeljanz-XR)
- Upadacitinib (lub npe lag luam: Rinvoq)
Feem ntau cov tshuaj no yog muab rau cov neeg mob uas cov tsos mob tsis tau tswj hwm los ntawm ib lossis ntau yam tshuaj biologic hu ua TNF inhibitors, lossis cov neeg uas tsis tuaj yeem zam cov kev phiv los ntawm cov tshuaj no. Yog li ntawd, koj tus kws kho mob yuav ua tib zoo saib xyuas koj cov keeb kwm kev kho mob ua ntej muab cov tshuaj no.
Cov tshuaj no ua haujlwm li cas?
Yuav kom nkag siab qhov no, cia peb muab ib qho piv txwv me me. Xav txog tias peb lub cev tiv thaiv kab mob yog ib pab tub rog loj. Hauv ib qho kab mob zoo li Ankylosing Spondylitis, pab tub rog no tau txais cov lus tsis raug thiab pib tawm tsam nws lub teb chaws (peb lub cev) cov pob qij txha. Qhov kev tawm tsam no yog qhov ua rau mob thiab o (o).
Muaj qee cov "neeg xa xov" uas xa cov lus tsis raug no. Lawv hu ua JAK enzymes . Cov enzymes no yog cov uas qhia cov hlwb tiv thaiv kab mob kom "mus thiab tawm tsam," cov tshuaj hu ua cytokines.
Cov tshuaj hu ua JAK inhibitors ua yog thaiv cov messenger (JAK enzymes). Qhov no txwv tsis pub cov lus tsis raug xa mus thiab txo qhov kev tiv thaiv kab mob tsis muaj peev xwm tawm tsam cov pob qij txha.
Cov tshuaj biologic ua haujlwm txawv me ntsis. Cov tshuaj biologic tsom thiab thaiv ib qho cytokine tshwj xeeb, xws li TNF lossis IL-17. JAK inhibitors thaiv kev tsim ntau yam cytokines ib zaug. Hais yooj yim xwb, lawv thaiv qhov teeb meem thaum xub thawj.
Puas muaj tej yam tshwm sim tsis zoo?
Ib yam li lwm yam tshuaj, muaj feem yuav muaj kev phiv. Tab sis rau feem ntau ntawm cov neeg, lawv muaj kev nyab xeeb. Koj tus kws kho mob yuav saib xyuas koj ze ua ntej koj pib noj cov tshuaj no thiab thaum koj noj nws.
| Hom kev phiv tshuaj | Kev piav qhia |
|---|---|
| Cov kev mob tshwm sim feem ntau (feem ntau tsis loj heev) |
|
| Cov kev mob tshwm sim loj heev tsawg tsawg (Ceeb Toom Boxed) |
Me ntsis ntxiv txog cov kev mob tshwm sim loj heev
Vim tias cov tshuaj no ua rau lub cev tiv thaiv kab mob tsis muaj zog, lub cev lub peev xwm los tawm tsam cov kab mob xws li cov kab mob bacteria thiab cov kab mob viruses raug txo qis me ntsis. Qhov no ua rau muaj kev pheej hmoo ntawm kev kis kab mob ntau ntxiv.
Kev kuaj mob ntsws (TB): Ua ntej pib noj tshuaj no, koj tus kws kho mob yuav kuaj koj seb puas muaj mob ntsws. Tej zaum yuav muaj cov kab mob ntsws uas tseem tsis tau loj hlob hauv lawv lub cev. Thaum koj siv tshuaj JAK inhibitor, cov kab mob uas tsis tau loj hlob no yuav ua haujlwm tau. Yog li ntawd, koj tus kws kho mob yuav saib xyuas koj rau qhov no thaum lub sijhawm kho mob.
Tseem Ceeb: Thaum noj cov tshuaj no, koj yuav tsum tsis txhob txhaj tshuaj tiv thaiv kab mob uas muaj sia nyob. Piv txwv li, qhua pias, mob qog, mob rubella (MMR), thiab mob rotavirus. Cov tshuaj tiv thaiv kab mob no tuaj yeem ua rau koj mob vim tias koj lub cev tiv thaiv kab mob tsis muaj zog thaum ntawd. Nco ntsoov nrog koj tus kws kho mob tham ua ntej txhaj tshuaj tiv thaiv kab mob.
Kuv yuav tsum tau tos dab tsi thaum pib noj tshuaj?
Muaj ib txhia neeg pib hnov tias lawv cov tsos mob zoo li qub hauv ob lub lis piam tom qab pib noj cov tshuaj no. Txawm li cas los xij, nws yuav siv sijhawm txog 6 lub hlis rau qee tus neeg kom hnov tias lawv zoo tag nrho. Qhov no txawv ntawm ib tus neeg mus rau ib tus neeg.
Yog tias koj tsis xis nyob tom qab noj tshuaj tau ob peb lub hlis, tsis txhob ntshai thiab nrog koj tus kws kho mob tham txog qhov ntawd thiab tau txais cov lus qhia txog yuav ua li cas tom ntej.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj JAK inhibitors yog ib hom tshuaj tshiab uas muaj nyob rau hauv daim ntawv tshuaj rau cov neeg mob ankylosing spondylitis. Feem ntau lawv muab rau cov neeg uas tsis tau ua tiav lwm yam kev kho mob.
- Cov tshuaj no tsis yog tsuas yog txo qhov mob xwb, tab sis kuj tswj kev puas tsuaj rau cov pob qij txha.
- Cov no yooj yim heev rau siv vim lawv tsis tas yuav txhaj tshuaj zoo li biologics.
- Ib yam li txhua yam tshuaj, cov tshuaj no muaj tej yam tshwm sim tsis zoo. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau kuaj ntshav tas li nyob rau hauv kev saib xyuas ntawm tus kws kho mob.
- Tsis txhob pib, tsum, lossis hloov qhov ntau npaum li cas ntawm cov tshuaj no yam tsis tau koj tus kws kho mob qhia.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus