Koj puas muaj mob tam sim ntawd thiab? Kab mob dab tsi uas tshwm sim yam tsis muaj laj thawj? (Mast Cell Activation Syndrome)

Puas muaj tej lub sij hawm koj xav tias koj mob heev tam sim ntawd? Zoo li koj muaj kev tsis haum tshuaj hnyav heev. Tej zaum koj lub cev tag nrho yuav liab, khaus, o, mob plab, ntuav, lossis ua pa tsis tau zoo. Tab sis tej yam no tsis tshwm sim vim koj noj ib yam dab tsi lossis kov ib yam dab tsi. Yog tias tej yam no tshwm sim yam tsis muaj laj thawj pom tseeb, nws yuav yog ib qho mob hu ua 'Mast Cell Activation Syndrome (MCAS).' Cia peb tham txog qhov no kom ntxaws ntxiv hnub no.

"Mast Cell Activation Syndrome (MCAS)" yog dab tsi?

Hais yooj yim xwb, MCAS yog ib qho mob uas ib hom cell hauv peb lub cev hu ua "mast cells" ua haujlwm ntau dhau yam tsis muaj laj thawj pom tseeb, ua rau muaj cov tsos mob hnyav. Tam sim no koj yuav xav tias, "Qhov ntawd yog qhov ua xua." Yog lawm, kev ua xua kuj cuam tshuam nrog kev ua haujlwm ntawm "mast cells." Tab sis kev ua xua feem ntau muaj qhov ua rau pom tseeb . Piv txwv li, qee tus neeg ua xua rau cw, txiv laum huab xeeb, lossis cov kab me me. Tab sis hauv MCAS, nws nyuaj rau nrhiav qhov ua rau tshwj xeeb. Cov tsos mob no tshwm sim sai sai.

Muaj tej lub sij hawm, qhov ua kom cov mast cell no ua hauj lwm tau zoo tuaj yeem ua rau muaj kev tsis haum tshuaj loj heev, uas ua rau tuag taus hu ua anaphylaxis. Qhov no tuaj yeem ua rau ua pa nyuaj thiab ntshav siab poob qis. Yog tias koj muaj teeb meem loj heev ntawm anaphylaxis, koj yuav tsum hu rau 911 lossis mus rau chav kho mob ceev ze tshaj plaws tam sim ntawd.

Cov hlwb mast zoo li cov tub rog hauv peb lub cev tiv thaiv kab mob. Lawv pab tiv thaiv kev kis kab mob. Yog li, nws yog ib qho ib txwm muaj kev ntshai thaum koj muaj cov tsos mob tsis tau kuaj pom no. Tab sis nws yog ib qho ib txwm muaj rau cov hlwb mast kom ua haujlwm. Piv txwv li, cov hlwb mast raug ua haujlwm hauv cov mob xws li mob ua xua rau lub qhov ntswg, mob hawb pob, anaphylaxis rau cov tshuaj lossis cov khoom noj, thiab mastocytosis. Qhov no yog qhov ua rau peb muaj cov tsos mob tsis zoo no, qee zaum txaus ntshai.

Txawm li cas los xij, "Mast Cell Activation Syndrome (MCAS)" yog ib qho mob tsis tshua muaj . Cov kws kho mob kuaj mob MCAS yog tias muaj cov yam hauv qab no:

• Yog tias koj muaj cov tsos mob rov tshwm sim uas koj xav tias yuav yog anaphylaxis yam tsis muaj laj thawj pom tseeb.
• Yog tias cov tsos mob no cuam tshuam ntau dua ib qho ntawm koj lub cev tib lub sijhawm (piv txwv li, ob qho tib si ntawm daim tawv nqaij thiab txoj hnyuv).
• Yog tias cov kev kuaj pom tias cov hlwb mast tau qhib.
• Yog tias koj cov tsos mob raug txo los ntawm cov tshuaj uas tsom rau cov hlwb mast.

Mast cells thiab lawv lub luag haujlwm

Cov hlwb mast yog cov hlwb ntawm peb lub cev tiv thaiv kab mob .Ib feem. Lawv txoj haujlwm ib txwm yog tiv thaiv peb lub cev ntawm cov kab mob (piv txwv li cov kab mob parasitic, cov kab mob virus) lossis lwm yam khoom phem uas nkag mus rau hauv peb lub cev. Cov hlwb no zaum hauv peb cov nqaij, thiab thaum lawv pom qee yam uas lawv xav tias ua rau muaj kev phom sij, lawv tso tawm cov tshuaj xws li histamine, uas ua rau lub cev tiv thaiv kab mob ua haujlwm thiab sim tawm tsam tus neeg nkag mus.

Qee zaum, lawv ua xua rau tej yam uas lawv tsis tas yuav ua xua. Thaum ntawd peb thiaj li ua xua . Tab sis feem ntau ua xua ua rau muaj cov tsos mob me me xws li khaus qhov muag thiab ntswg ntws. Qhov uas tshwm sim hauv MCAS yog tias muaj cov tsos mob hnyav dua yam tsis muaj laj thawj pom tseeb.

"Mast Cell Activation Syndrome (MCAS)" loj npaum li cas?

Qhov hnyav ntawm MCAS nyob ntawm cov tsos mob uas koj ntsib. Ib txhia neeg yuav muaj cov tsos mob me me xwb, tsuas yog cov tsos mob ntawm daim tawv nqaij xwb. Lwm tus yuav muaj cov mob hnyav dua, xws li anaphylaxis. Anaphylaxis tuaj yeem ua rau tuag taus yog tias tsis kho kom zoo. Txawm li cas los xij, cov tshuaj tiv thaiv uas ua rau tuag taus rau MCAS yog qhov tsawg heev .

Cov tsos mob ntawm 'Mast Cell Activation Syndrome (MCAS)' yog dab tsi?

MCAS tuaj yeem ua rau muaj cov tsos mob hnyav thiab rov tshwm sim dua hauv ntau qhov ntawm koj lub cev. Cov tsos mob no yuav suav nrog:

• Ntshav siab qis.
• Tawv nqaij pib liab, liab dawb, thiab sov ('Flushing').
• Khaus tawv nqaij.
• Qhov ntswg txhaws.
• O - tshwj xeeb tshaj yog ntawm lub ntsej muag, daim di ncauj, qhov muag, tus nplaig lossis caj pas ('Angioedema').
• Cem quav los yog raws plab (tej zaum yuav hloov pauv ntawm ob qho tib si).
• Mob plab.
• Ua pa nyuaj.
• Tsis muaj zog los yog tsaus muag.
• Tsis nco qab lossis xav tau teeb meem (lub hlwb tsis meej).
• Kev tsis muaj zog.
• Mob pob qij txha.
• Anaphylaxis (kev ua xua hnyav nrog ib lossis ntau yam ntawm cov tsos mob saum toj no).

Yuav kom paub tseeb tias koj muaj MCAS, cov tsos mob no yuav tsum cuam tshuam tsawg kawg yog ob yam ntawm koj lub cev. Ntawd yog:

• Lub paj hlwb (lub hlwb thiab cov hlab ntsha).
• Lub cev ua pa (lub ntsws thiab txoj hlab pa).
• Lub plawv thiab cov hlab ntsha (lub plawv thiab cov hlab ntsha).
• Kev zom zaub mov (plab thiab txoj hnyuv).

Nws xav li cas thaum cov mast cells raug qhib tam sim ntawd?

Yog tias koj tau muaj kev ua xua, tej zaum koj yuav paub tias nws zoo li cas thaum cov hlwb mast raug qhib. Tab sis rau cov neeg uas muaj MCAS, qhov mob hnyav dua li kev ua xua ib txwm muaj, thiab nws cuam tshuam rau ntau qhov ntawm lub cev. Koj daim tawv nqaij yuav o, tig liab, pib khaus, lossis txawm tias los ntshav. Koj yuav raws plab thiab ntuav. Hauv cov xwm txheej hnyav, koj lub ntsej muag thiab caj pas yuav o, thiab koj cov ntshav siab yuav poob qis. Nco ntsoov, yog tias koj muaj cov tsos mob hnyav no, koj yuav tsum hu rau 911 lossis mus rau tsev kho mob ze tshaj plaws tam sim ntawd.

Dab tsi yog cov ua rau muaj 'Mast Cell Activation Syndrome (MCAS)'?

MCAS yog tshwm sim los ntawm koj cov hlwb mast ua haujlwm thaum lawv tsis tsim nyog. Cov hlwb mast xav tias muaj qee yam tsis zoo tau nkag mus rau hauv lub cev thiab xav tau kev tiv thaiv. Thaum ntawd lawv tso cov protein uas ua rau muaj cov tsos mob. Hauv kev ua xua, peb tuaj yeem xam seb dab tsi ua rau lub cev ua haujlwm ntau dhau. Tab sis hauv MCAS, nws nyuaj rau nrhiav qhov laj thawj meej rau cov hlwb mast tso cov protein no.

Qhov tseeb, tseem tsis tau muaj leej twg paub meej tias vim li cas cov hlwb mast thiaj li rhiab heev rau cov khoom tsis xav tau.

Dab tsi yog cov ua rau muaj kev ua haujlwm ntawm mast cell?

Txawm hais tias muaj ntau yam, xws li cov khoom noj thiab paj ntoos, tuaj yeem ua rau cov hlwb mast ua haujlwm thiab tso cov histamine, nws tsis tuaj yeem hais tias cov tsos mob hnyav ntawm MCAS yog tshwm sim los ntawm ib qho allergen tshwj xeeb. Txawm li cas los xij, koj yuav pom tias cov tsos mob no hnyav dua thaum muaj kev hloov pauv hauv koj lub neej lossis ib puag ncig, piv txwv li, thaum lub sijhawm muaj kev ntxhov siab ntau lossis thaum huab cua hloov pauv. Yog tias koj cov tsos mob tsuas yog tshwm sim tom qab raug rau ib yam khoom tshwj xeeb, qhia rau koj tus kws kho mob. Hauv qhov xwm txheej ntawd, koj yuav tsis muaj MCAS, tab sis yog kev ua xua.

Yuav kuaj mob Mast Cell Activation Syndrome (MCAS) li cas?

Tus kws kho mob yuav xav tias koj muaj MCAS tom qab kuaj koj, tham txog koj cov tsos mob, thiab keeb kwm kev kho mob. Cov kws kho mob yuav kuaj koj tus mob MCAS yog tias muaj cov mob hauv qab no:

• Yog tias koj muaj cov tsos mob ntawm kev ua haujlwm ntawm mast cell.
• Yog tias koj teb tau zoo rau kev kho mob rau kev ua haujlwm ntawm mast cell.
• Yog tias cov kev kuaj pom cov cim qhia tias mast cell ua haujlwm.
• Yog tias koj muaj cov mast cells ib txwm muaj hauv koj lub cev (muaj ntau cov mast cells dhau txhais tau tias koj yuav muaj lwm yam teeb meem mast cell, xws li mastocytosis).

Kev xeem MCAS

Yuav kom kuaj tau MCAS, koj tus kws kho mob yuav kuaj ntshav seb puas muaj tshuaj hu ua "tryptase" hauv koj cov ntshav. "tryptase" yog ib yam uas nce ntxiv thaum "mast cells" raug qhib. Qhov kev kuaj no yuav tsum tau ua ntau zaus - thaum koj noj qab nyob zoo thiab thaum koj muaj cov tsos mob hnyav. Tab sis nco ntsoov tias, "tryptase" kuj tseem tuaj yeem nce ntxiv rau lwm yam mob. Yog li ntawd, "tryptase" ib leeg tsis tuaj yeem qhia tau tias koj muaj MCAS. Qee tus neeg yuav muaj "tryptase" ntau dua li qhov xav tau txawm tias tsis muaj tsos mob los xij.

Koj tus kws kho mob kuj tseem yuav ua qhov kev kuaj mob ua xua rau daim tawv nqaij lossis kev kuaj ntshav ua xua kom paub seb puas muaj lwm yam ua rau.

Tseem Ceeb: Txawm tias qhov kev kuaj ntshav histamine qhia tau tias muaj cov histamine ntau, cov kws kho mob tsis xaus lus tias koj muaj MCAS.

Yuav kho tus mob Mast Cell Activation Syndrome (MCAS) li cas?

Cov kws kho mob siv cov kev kho mob los kuaj mob MCAS thiab txo koj cov tsos mob. Yog tias koj tsis zoo dua nrog cov tshuaj uas tsom rau cov hlwb mast, tej zaum koj tsis muaj MCAS.

Nyob ntawm koj cov tsos mob, koj tus kws kho mob yuav sau ntawv rau cov tshuaj xws li cov no:

• Cov tshuaj thaiv kab mob Histamine hom 1 (Antihistamines) : Cov no yog cov tshuaj siv los kho cov tsos mob ntawm kev ua xua. Piv txwv li: Loratadine, Cetirizine, Fexofenadine.
• Cov tshuaj histamine type 2 receptor blockers (cov tshuaj antihistamines uas txo cov kua qaub hauv plab) : Cov no yog muab rau kev xeev siab thiab mob plab. Piv txwv li: Ranitidine lossis Famotidine.
• Tshuaj Aspirin : Koj tuaj yeem muab tshuaj Aspirin rau koj kom txo qhov mob ntawm daim tawv nqaij.
• Cov tshuaj hloov kho Leukotriene : Cov no pab ua kom ua pa yooj yim dua. Piv txwv li: Montelukast, Zafirlukast.
• Omalizumab (XOLAIR®) : Qhov no tuaj yeem txo qhov kev pheej hmoo ntawm anaphylaxis.
• Epinephrine : Cov kws kho mob siv epinephrine los tiv thaiv anaphylaxis. Koj tuaj yeem khaws lub koob txhaj tshuaj epinephrine (EpiPen®, Auvi-Q®) kom yooj yim yog tias koj muaj anaphylaxis.
• Cov tshuaj stabilizers rau mast cell : Cov tshuaj xws li cromolyn sodium tiv thaiv kev tso tawm cov tshuaj lom neeg los ntawm mast cell (degranulation).
• Cov tshuaj Corticosteroids : Cov no txo ​​qhov o, qhib txoj hlab pa, thiab txo cov kua dej hauv cov nqaij. Txawm li cas los xij, vim muaj kev pheej hmoo ntawm cov kev mob tshwm sim, cov kws kho mob feem ntau tsis sau ntawv kom siv cov tshuaj steroids rau MCAS.

Puas yuav kho tau Mast Cell Activation Syndrome (MCAS) kom zoo tag nrho?

Tsis yog, tsis muaj kev kho rau MCAS. Yog tias koj muaj MCAS, koj yuav tsum tau siv tshuaj los kho nws.

Lub neej ntev npaum li cas ntawm ib tus neeg uas muaj MCAS?

Cov kws kho mob xav tias feem ntau cov neeg uas muaj MCAS yuav nyob ntev npaum li ib tus neeg uas tsis muaj nws. Tab sis vim qhov no yog ib qho mob tshiab uas tau kuaj pom, peb tsis tuaj yeem hais meej tias nws yuav cuam tshuam li cas rau lub neej.

Kuv yuav saib xyuas kuv tus kheej li cas?

Nov yog qee txoj hauv kev uas koj tuaj yeem saib xyuas koj tus kheej nrog MCAS:

• Sau koj cov tsos mob rau hauv ib phau ntawv sau txog koj tus kheej. Sau seb koj cov tsos mob yog dab tsi, koj noj dab tsi thiab haus dab tsi thaum lub sijhawm ntawd, thiab tej yam uas koj tau raug kab mob. Xav txog seb muaj dab tsi txawv thaum lub sijhawm no piv rau thaum koj tsis muaj tsos mob. Yog tias koj pom muaj tej yam tshwm sim, qhia rau koj tus kws kho mob.
• Qhia rau koj cov phooj ywg ze tshaj plaws, cov txheeb ze, lossis cov neeg uas koj feem ntau nrog ua ke seb koj yuav ua li cas rau qhov xwm txheej no, thiab koj lub tshuaj txhaj epinephrine lossis lwm yam tshuaj kho mob thaum muaj xwm txheej ceev nyob qhov twg.

Kuv yuav tsum mus rau Chav Kho Mob Thaum Muaj Xwm Ceev (ETU) thaum twg?

Txawm hais tias cov kev tsis haum tshuaj loj heev rau MCAS tsis tshua muaj, yog tias koj muaj cov tsos mob ntawm kev tsis haum tshuaj loj heev lossis anaphylaxis, siv cov tshuaj txhaj epinephrine yog tias koj muaj ib qho. Tom qab ntawd hu rau 911 lossis mus rau chav kho mob ceev ze tshaj plaws tam sim ntawd. Cov tsos mob ntawm anaphylaxis suav nrog:

• O ntawm lub ntsej muag, daim di ncauj, tus nplaig, lossis caj pas.
• Ua pa nyuaj los yog nqos nyuaj.
• Lub plawv dhia tsis xwm yeem.
• Ntshav siab qis.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Tej zaum yuav pab tau yog koj nug koj tus kws kho mob cov lus nug zoo li no:

• Kuv yuav tsum ua li cas yog tias qhov mob no zuj zus tuaj/ntxiv zuj zus rau kuv?
• Kuv yuav tsum noj kuv cov tshuaj li cas ?
• Kuv yuav tsum siv kuv lub tshuaj txhaj epinephrine li cas thiab thaum twg?
• Kuv yuav tsum mus rau chav kho mob ceev thaum twg?
• Kuv yuav tsum rov qab los ntsib koj dua thaum twg?

Puas yog "Mast cell activation" yog ib qho kab mob autoimmune?

Tsis yog, MCAS tsis yog kab mob autoimmune.

Xav txog lub tswb ceeb toom. Cov tub rog kev ruaj ntseg tab tom tuaj. Koj cov "mast cells" tau pom muaj kev phom sij thiab tab tom hu kom tau kev pab. Tab sis ... yeej tsis muaj kev phom sij. Zoo li ib tug neeg ua yeeb yam tsis zoo, koj cov "mast cells" tsuas yog ua lub tswb ceeb toom yam tsis muaj kev kub ntxhov. Es tsis txhob tiv thaiv koj ntawm kab mob, lawv yog cov uas ua rau koj mob.

Txawm hais tias peb tsis paub meej tias vim li cas qee tus neeg cov mast cell thiaj li ua haujlwm ntau dhau, muaj ntau txoj hauv kev los tswj MCAS. Paub txog cov cim qhia ntxov ntawm kev ua haujlwm. Yog tias koj xav tias koj cov tsos mob tsis zoo, tham nrog koj tus kws kho mob. Qhov tseem ceeb tshaj plaws yog kom ib txwm nqa lub koob txhaj tshuaj epinephrine thiab paub tias yuav siv nws li cas thiab thaum twg. Tej zaum koj yuav tsis xav tau nws, tab sis kev npaj rau kev ua haujlwm tsis tau xav txog tuaj yeem ua rau koj muaj kev thaj yeeb nyab xeeb.

Tej yam koj yuav tsum paub (Cov Lus Coj Mus Tsev)

• Kab mob Mast cell activation syndrome (MCAS) yog ib yam mob tsis tshua muaj uas ua rau muaj cov tsos mob ua xua hnyav yam tsis muaj laj thawj pom tseeb.
• Qhov no tuaj yeem cuam tshuam rau ntau lub cev tib lub sijhawm.
• Tej yam mob uas ua rau tuag taus xws li 'Anaphylaxis' tuaj yeem tshwm sim, yog li nrhiav kev pab kho mob tam sim ntawd yog tias muaj cov tsos mob hnyav tshwm sim.
• Txawm hais tias MCAS kho tsis tau tag nrho los xij, cov tsos mob tuaj yeem tswj tau nrog kev siv tshuaj.
• Paub txog koj cov tsos mob, khaws ib lub tshuaj txhaj epinephrine kom yooj yim siv thaum muaj xwm txheej ceev, thiab qhia rau koj tsev neeg paub txog qhov ntawd.
• Yog koj muaj lus nug txog MCAS, tsis txhob ntshai nug koj tus kws kho mob.

Cov hlwb mast, MCAS, kev ua xua, anaphylaxis, histamine, tryptase, lub cev tiv thaiv kab mob