Gịnị bụ Acetylcholine (ACh)? Ka anyị chọpụta kpọmkwem ihe ọ na-eme n'ahụ anyị!

Ị nụtụla maka acetylcholine , ma ọ bụ (ACh)? Ma eleghị anya, dọkịta gị agwaala gị maka ya, ma ọ bụ na ị gụọla maka ya ebe ụfọdụ. Ọ bụ obere kemịkalụ dị oke mkpa n'ahụ anyị. Ọ dị ka obere onye na-eziga ozi nke na-ebu ozi n'ime ahụ anyị. Ya mere, taa, anyị ga-ekwu maka acetylcholine n'ụzọ dị mfe nke ị nwere ike ịghọta.

Kedu kpọmkwem ihe bụ Acetylcholine?

N'ikwu ya n'ụzọ dị mfe, acetylcholine bụ ihe na-akpata neurotransmitter . Chee echiche banyere ya, ụbụrụ gị kwesịrị izipu obere ozi eletriki iji megharịa aka gị, chee echiche, cheta ihe, ihe ndị a niile. Acetylcholine bụ ozi kemịkalụ nke na-enyere aka ibuga ozi ndị ahụ site na mkpụrụ ndụ akwara .

A na-akpọkwa nke a " ihe mkpali " neurotransmitter . Ị ma ihe ọ bụ? Ọ "na-eteta" mkpụrụ ndụ akwara, ya bụ, na-akpali ya, ma na-eme ka ọ "zipu" ozi ngwa ngwa. Ọ dị ka ịkụ aka n'ọnụ ụzọ onye na-ehi ụra wee sị, "Lee, were akwụkwọ ozi a."

Aha acetylcholine sitere n'ihe abụọ na-eme ya. Otu bụ otu acetyl . Nke a sitere na ihe mejupụtara a na-akpọ acetyl coenzyme A, nke e ji shuga glucose mee. Nke ọzọ bụ ihe na-edozi ahụ a na-akpọ choline . A na-ahụ choline n'onwe ya na nkochi akwa, soy, imeju, akwụkwọ nri, na agwa. A na-emekwa choline n'ime imeju anyị.

Acetylcholine na-arụ ọrụ dị mkpa n'ahụ anyị, ọkachasị mmegharị ahụ ike afọ ofufo.Nke a na-arụ ọrụ dị mkpa n'ihe anyị na-eme n'uche anyị, dịka ịkwaga akụkụ ahụ anyị na ije ije. Ọ na-akpali mkpụrụ ndụ akwara dị n'ime akwara anyị, na-eme ka ha gbakọta. Ọ bụghị naanị nke ahụ, kamakwa ọ dị oke mkpa maka mkpụrụ ndụ akwara dị n'ụbụrụ anyị, yana maka usoro dịka icheta ihe, iche echiche, na mmụta.

Kedu ka acetylcholine (ACh) si arụ ọrụ?

A na-echekwa Acetylcholine n'ọnụọgụgụ mkpụrụ ndụ akwara, ruo mgbe a ga-eziga ozi. Mgbe "mgbaàmà" rutere izipu ozi, a na-ahapụ acetylcholine a echekwara. Ozugbo a tọhapụrụ ya, ọ na-aga n'ime obere oghere dị n'etiti mkpụrụ ndụ akwara abụọ. A na-akpọ oghere a synaptic cleft .

Mgbe ha gafere oghere synaptic, e nwere ụdị ihe nnabata abụọ acetylcholine nwere ike ijikọ. Ha bụ:

• Ndị na-anabata Nicotinic
• Ndị na-anabata Muscarinic

Mgbe e jikọtara ya na ndị nnata ndị a, ozi kemịkalụ ahụ na-aga n'ime mkpụrụ ndụ akwara ọzọ. Mgbe e zigasịrị ozi ahụ, acetylcholine nke fọdụrụ n'ime oghere synaptic anaghị efufu naanị. Enzyme ọzọ a na-akpọ acetylcholinesterase na-abịa wee gbajie acetylcholine a ka ọ bụrụ akụkụ ya, choline na acetate. Mgbe ahụ, a na-amịkọrọ akụkụ ndị a gbajiri agbaji, na-emegharị ha, ma jiri ha bufee ozi kemịkalụ ọzọ. Sistemụ dị irè nke ukwuu!

Gịnị na-eme acetylcholine (ACh)?

Acetylcholine nwere ọtụtụ uru maka ahụ anyị. Ka anyị leba anya na ndị bụ isi.

Ụdị ihe nnabata abụọ a na-etinye aka na ncheta anyị. Ya bụ, ha dị mkpa maka ncheta ogologo oge, ncheta obere oge, nhazi nke ncheta, njikọta ha, na inwetaghachi ha. N'ime ụbụrụ, acetylcholine na-etinye aka n'ihe ndị ọzọ. Ọ na-akwalite mkpali, mmasị/nlebara anya, mmụta, na ụra REM (oge ụra anyị na-arọ nrọ).

Kedu ọnọdụ ndị na-eme mgbe ọkwa acetylcholine (ACh) belatara?

Obere ọkwa acetylcholine, ma ọ bụ enweghị ya, nwere ike ibute ọtụtụ ọrịa. Ihe kachasị mkpa n'ime ha bụ:

• Ọrịa Alzheimer : Ndị nwere ọrịa Alzheimer enweghị acetylcholine zuru oke n'ụbụrụ ha. N'ihi ya, enweghị ncheta bụ nnukwu ihe mgbaàmà.
• Ọrịa Lambert-Eaton myasthenic : Ọrịa a na-akpata mbelata na mwepụta nke acetylcholine site na mkpụrụ ndụ akwara.
• Myasthenia gravis : Nke a bụ ọrịa autoimmune nke na-eme ka akwara ọkpụkpụ ghara ịdị ike ngwa ngwa mgbe ejiri ya ugboro ugboro.

Kedu ọgwụ ndị na-achọ acetylcholine (ACh)?

Ọgwụ ndị na-egbochi cholinesterase bụ otu ọgwụ ndị na-arụ ọrụ site n'ịkwụsị enzyme nke na-emebi acetylcholine ma na-amụba ọrụ nke ndị na-anabata acetylcholine. A na-eji ha agwọ ọrịa Alzheimer na myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), na Galantamine (Razadyne®) bụ ụfọdụ n'ime ọgwụ ndị a.

Kedu nri nwere choline, nke na-enyere aka imepụta acetylcholine (ACh)?

Choline, ihe na-edozi ahụ nke na-agbanwe ghọọ acetylcholine, dị n'ọtụtụ nri. Dịka ọmụmaatụ:

• Imeju anụ ehi
• Àkwá (karịsịa nkochi ime akwa)
• Agba anụ ehi dị n'elu
• Soybean a ṅara n'ọkụ, agwa akụrụ a kpụkọrọ akpụkọ
• Ara ọkụkọ a ṅara n'ọkụ
• Azụ̀ cod `(Kod)`
• Quinoa esiri esi
• Ero shiitake esiri esi, broccoli esi nri na Brussels pulite
• Mmiri ara ehi (1%) `(Mmiri ara ehi (1%)`, yogọt vanilla na-abụghị abụba `(yogọt vanilla na-abụghị abụba)`

Gbalịa itinye nri ndị a na nri gị. Nri kwesịrị ekwesị dị oke mkpa maka ndụ dị mma.