Yu dɔn yɛri bɔt dis strenj prɔtin we de na yu blɔd? (Cryoglobulinemia) Lɛ wi tɔk bɔt am!

Sɔntɛnde, tin dɛn kin apin na wi bɔdi we wi nɔ de ɛkspɛkt, nɔto so? Tide wi go tɔk bɔt wan kɔndishɔn we strenj smɔl, bɔt i rili fayn fɔ no bɔt. Dɛn kɔl dis krayoglobulinemia. Di nem kin tan lɛk se i kɔmplikt smɔl, bɔt nɔ wɔri, lɛ wi ɛksplen am simpul wan.

Wetin na krayoglobulinemia? Fɔ tɔk am simpul wan...

Fɔ tɔk am simpul wan, krayoglobulinemia na wan sik we sɔm abnɔmal prɔtin dɛn na yu blɔd, we dɛn kɔl krayoglobulin, kin strɔng, kin gɛda togɛda, ɛn mek klot we yu de na kol tɛmpracha. Tink bɔt am lɛk se kokonat ɔyl de friz we yu put am insay kol wata. Bɔt dis kin apin insay wi blɔd. Dis kכndyushכn na rili wan kayn vaskulεt. Na inflamɛns, lɛk swel, na yu blɔd vesel dɛm, di smɔl smɔl tiub dɛm we de kɛr blɔd ɔlsay na yu bɔdi. We dɛn blɔd vesel ya inflam, blɔd kin ambɔg. Wetin kin apin da tɛm de? Yu skin, yu nerv dɛm, yu jɔyn dɛm, yu mɔsul dɛm, ɛn di impɔtant tin, di insay pat dɛm lɛk yu kidni dɛm, kin pwɛl. Sɔntɛnde dɛn kin kɔl dis krayoglobulinemik vaskulaytis.

Yu tink se kayn krayoglobulinemia de?

Yes, dεn protin dεm ya we dεn kכl krayoglobulin dεm na wan kayn antibodi bak. dipכnt pan di kayn antibodi we wi bכdi de mek, dεn kin sheb krayoglobulinemia to tri men tכp dεm:

• Tayp I Cryoglobulinemia: Dis kin kam mɔs pan kansa wae gɛt fɔ du wit yu blɔd ɔ kansa wae gɛt fɔ du wit yu imyun sistɛm.
• Tayp II Cryoglobulinemia ɛn Tayp III Cryoglobulinemia: Dɛn kin si dɛn tu kayn ya mɔ wit krɛse (dat na fɔ lɔng tɛm) inflammatory kɔndishɔn. Fɔ ɛgzampul, dɛn kin si dɛn pan pipul dɛn we gɛt sik dɛn we dɛn kin gɛt we dɛn de fɛt dɛnsɛf . Na mɔtalman, Tayp II Krayoglobulinemia kin rili kɔmɔn pan pipul dɛn we gɛt di Epatitis C vayrɔs (HCV). Dɛn tu kayn ya kin kam togɛda ɛn dɛn kin kɔl dɛn Mixed Cryoglobulinemia.

Aw kɔmɔn tin dis kin apin?

Krayoglobulinemia na rili wan sik we nɔ kin apin so ɔltɛm.Bɔt di wan dɛn we de stɔdi bɔt dis stil nɔ ebul fɔ tɔk klia wan ɔmɔs pipul dɛn gɛt dis sik. Bikɔs sɔm pipul dɛn kin gɛt dɛn krayoglobulin ya smɔl na dɛn blɔd bɔt dɛn nɔ kin sho ɛni sayn, sɔm pipul dɛn we de stɔdi bɔt dis sik kin afɛkt lɛk wan pan ɛvri milyɔn pipul dɛn ɔlsay na di wɔl.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik? Ɔlman kin gɛt sɔm sayn dɛn?

Nɔ, nɔto ɔlman we gɛt krayoglobulinemia go gɛt di sik. Sɔm pipul dɛn nɔ kin notis ɛnitin. Bɔt we di sayn dɛn de sho, di tin we kin apin mɔ na di skin we dɛn kɔl purpura. Dis kin apin lɛk rɛd spat ɔ pepul brus na di ɔda leg dɛn we de dɔŋ. Yu kin fil bak taya ɛn yu kin gɛt pen na yu jɔyn dɛn. Ɔda sayn dɛn kin apin bak. Dɛn tin ya na:

• We dɛn put am na kol tɛmpracha, di blɔd vesel dɛn na di an ɛn/ɔ fut kin kɔnstrikt, we kin mek dɛn tɔn blu. Dɛn kɔl dis tin we Raynaud bin de du .
• We yu de lɔs yu wet .
• Ay blɔd prɛshɔn (Hypertension).
• Swel, mɔ na di anklɛ ɛn leg (Edima).
• Skin ɔlsa ɛn sɔm tɛm dɛn tisu day (gangrene).
• di liva we big (Hepatomegaly) ɔ di splin we big (Splenomegaly).
• Numbness , tingling, ɔ wik na di an ɛn fut dɛn.
• Kidni dɛn we dɔn pwɛl.

Tink bɔt am, dis nɔto jɔs wan kes we yu limb dɛn tɔn blu bikɔs ɔf di kol. Dis kin bi sayn fɔ wan big prɔblɛm insay yu bɔdi. Na dat mek i impɔtant fɔ no bɔt tin dɛn lɛk dis.

Wetin na di tin dɛn we kin mek pɔsin gɛt krayoglobulinemia?

Risach pipul dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek pɔsin gɛt krayoglobulinemia. Bɔt as wi bin dɔn tɔk, na wan kayn ɔtoimyun sik we dɛn kɔl vasculitis, we na inflamɛns na di blɔd vesel dɛm. Autoimyun sik na jɔs we yu bɔdi in yon imyun sistɛm, di bɔdi in difens sistɛm we de protɛkt yu frɔm sik, mistek atak yu yon wɛlbɔdi tisu dɛm. Bɔku tin dɛn de we kin mek pɔsin gɛt dis riakshɔn:

• Jɛnɛtiks: If pɔsin na di famili gɛt am, i kin afɛkt am.
• Sɔm kayn mɛrɛsin: Nɔto ɔl mɛrɛsin, bɔt sɔm.
• Infεkshכn εn vayrus: εspεshali vayral infεkshכn.
• Di tin dɛn we de apin na di envayrɔmɛnt: Sɔm tin dɛn we de na di envayrɔmɛnt we de rawnd wi.

Sɔntɛnde, krayoglobulinemia kin apin in wan we nɔ gɛt ɛni klia kɔz (dɛn kin kɔl dis idiopathic), bɔt bɔku tɛm i kin apin we i gɛt fɔ du wit ɔda sik dɛn. Sɔm pan dɛn sik ya na:

• Epataytis C infεkshכn: Dis na di men εn di link we dεn kin si mכst.
• Di tin dɛn we nɔ de apin na di blɔd sɛl: Fɔ ɛgzampul, kansa lɛk limfoma ɛn mɔltipɛl mayloma.
• Kɔnɛktiv tisu sik dɛm: Wan ɛgzampul na lupus.

Udat de pan denja pas ɔl fɔ dis?

I tan lɛk se krayoglobulinemia kin afɛkt uman dɛn pas man dɛn, ɛn i kin apin mɔ pan pipul dɛn we dɔn pas 50 ia.

Kɔmplikɛshɔn kin apin if dɛn nɔ trit dɛn fayn?

Yɛs, na fɔ tru. If dɛn nɔ trit krayoglobulinemia fayn, i kin mek yu skin, yu tisu dɛn, ɛn di ɔgan dɛn we de insay yu bɔdi pwɛl fɔ ɔltɛm. Sɔm pan di siriɔs prɔblɛm dɛn we kin apin na:

• Infɛkshɔn na di skin ɔ wund dɛn we nɔ de wɛl.
• Skin day (nɛkrɔsis).
• Kidni we nɔ de wok fayn.
• Liva nɔ de wok fayn.

Dis na rili siriɔs kɔndishɔn, na dat mek i impɔtant fɔ no ɛn trit di sik kwik kwik wan.

Aw dɔktɔ dɛn kin no bɔt dis sik?

We yu go to dɔktɔ, i go aks yu fɔs bɔt yu mɛdikal istri ɛn du yu bɔdi ɛgzam. Dɔn, dɛn go ɔda fɔ mek dɛn du spɛshal blɔd tɛst fɔ chɛk if krayoglobulin dɛn de na yu blɔd. Dis blɔd tɛst kin tɛl yu bak us kayn krayoglobulin yu gɛt. Sɔmtɛm dis kin ɛp fɔ no wetin mek yu gɛt dis sik ɛn aw fɔ trit am. Apat frɔm dis blɔd tɛst, yu dɔktɔ kin ɔda fɔ du sɔm ɔda tɛst fɔ no if yu gɛt di sik ɛn fɔ ɔndastand di tin we de apin:

• Wan tɛst fɔ urine (Urinalysis).
• Wan ɛkstrem rayt na di chɛst.
• Wan CT skan (Kɔmpyuta tomografi (CT) skan).
• wan angiogram (de luk di kondishכn fכ di bכdi vεsul dεm).
• MRA (magnεtik rεsכnans angiogram) כ CT angiogram (CT angiogram) tεst dεm.
• Wan tɛst fɔ kɔndɔkt di nerv.
• wan εlektromayografi (EMG) tεst (luk di mכsul fכnshכn).
• bayɔpsi (we dɛn tek wan smɔl pat pan di tisu, sɔntɛm frɔm di skin ɔ di kidni, fɔ mek dɛn chɛk am).

Aw dɛn kin trit dis?

Di tritmɛnt fɔ krayoglobulinemia dipen pan us ɔgan dɛn de afɛkt, di kayn we aw di bɔdi dɔn pwɛl, ɛn if yu gɛt ɔda mɛrɛsin.I impɔtant fɔ trit ɔda sik dɛn we kin gɛt fɔ du wit krayoglobulinemia, lɛk epataytis C, ɛn ɔda tin dɛn we kin gɛt fɔ du wit am. Dis na bikɔs fɔ trit dɛn ɔda sik dɛn de, sɔntɛnde kin ɛp fɔ ridyus di sayn dɛm fɔ krayoglobulinemia. If yu sik nɔr bad, yu dɔktɔ kin tɛl yu fɔ yuz mɛrɛsin fɔ mɛn yu pen (lɛk NSAID) ɛn advays yu fɔ avɔyd fɔ de na kol tɛmpracha . Dɛn kin tɛl yu bak se yu fɔ de chɛk yu ɔltɛm fɔ wach aw yu sik. Na di kayn kes dɛm wae nɔr kin pasmak, ɔr wae nɔr kin pasmak, di tritmɛnt kin difrɛn smɔl:

• Immunosuppressive drugs: Dis na di men tritmɛnt. Sɔntɛnde dɛn kin gi kɔtikosterɔyd, lɛk prɛdnisɔn, togɛda wit ɔda mɛrɛsin dɛn. Dis kin dipen pan di ɔgan we di sik afɛkt ɛn aw di damej go rich.
• Antivayrɔs mɛrɛsin: If yu dɔktɔ si se yu gɛt ɔda sik, lɛk epataytis C, i kin tɛl yu fɔ gi yu tritmɛnt fɔ antivayrɔs. Dɛn kin rifer yu bak to dɔktɔ we de mɛn yu liva (hepatologist).
• Bayolojikal: Rituximab na kɔmɔn tritmɛnt fɔ krayoglobulinemia. bayolojikal na komplex protin dεm we dεn mek frכm layf כganism dεm we de tכk to spεsifi k pat dεm na di imyun sistεm fכ kכntrכl inflameshn.
• Plasmapheresis: Dis na ɔda tritmɛnt. I de wok bay we i de ridyus di krayoglobulin dɛn we de na yu blɔd. insay dis prכsεs, dεn de pul di krayoglobulin dεm na yu plasma (di likwid pat pan yu blכd). Dis kin ɛp fɔ mek di krayoglobulin dɛn nɔ klɔg yu at, i kin mek di blɔd nɔ flɔ ɛn i kin mek di ɔgan dɛn nɔ pwɛl.

Lɛ wi no bak bɔt di sayd ɛfɛkt ɛn kɔmplikeshɔn dɛm wae de kam wit tritmɛnt.

Di mɛrɛsin dɛm wae dɔktɔ dɛn kin gi fɔ trit krayoglobulinemia kin gɛt sɔm siriɔs sayd ɛfɛkt dɛm. Di men wan dɛm na ɔstioporosis ɛn di bɔdi in ebul fɔ fɛt infɛkshɔn we de go dɔŋ. So, i rili impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ mek dɛn chɛk yu. Dɔn, yu dɔktɔ kin gi yu ɔda mɛrɛsin fɔ kɔntrol dɛn bad bad tin ya. I impɔtant bak fɔ protɛkt yusɛf frɔm infɛkshɔn. So, tɔk to yu dɔktɔ bɔt di vaysin dɛn we go mek yu nɔ gɛt di sik.

Wan we de fɔ mek dɛn nɔ gɛt dis sik?

Bikɔs dɛn nɔ no di rayt tin we kin mek pɔsin gɛt krayoglobulinemia, no patikyula we nɔ de fɔ mek i nɔ apin. Bɔt fɔ avɔyd fɔ de na kol, dat kin ɛp .I kin ɛp fɔ kɔntrol sɔm sayn dɛm, lɛk di tin wae de apin to Raynaud. I rili impɔtant bak fɔ mek dɛn du tɛst fɔ di Epatitis C infɛkshɔn ɛn gɛt tritmɛnt if yu gɛt am.

Wetin na de prognosis fɔ pɔrsin wae gɛt dis sik?

Aw yu de si tin, dat na aw de sik go tan lɛk, de pan sɔm tin dɛm:

• Ɔda ɔndalayn mɛdikal kɔndishɔn dɛn we yu gɛt.
• Di kayn we aw yu ɔgan dɛn dɔn pwɛl.
• Aw yu de ansa fayn to tritmɛnt.

Dɔn bak, aw di sik kin tranga kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm pipul dɛn nɔ kin gɛt ɛni sayn atɔl, ɔr dɛn sik kin so smɔl dat dɛn nɔr nid tritmɛnt. Fɔ pipul dɛm wae gɛt mɔdaret ɔr siriɔs kes, fɔ no bɔt di sik kwik kwik wan ɛn trit dɛn kin ɛp fɔ pul di sik ɛn fɔ mek dɛn nɔ gɛt prɔblɛm dɛn we go de fɔ lɔng tɛm. If yu ɔgan dɛn nɔ pwɛl fɔ ɔltɛm, di we aw yu de si tin kin rili fayn.

Aw a kin kia fɔ misɛf? Udat de fɔ ɛp mi?

Di bɛst tin we yu go du na fɔ wok togɛda wit yu mɛdikal tim. Dipen pan us ɔgan yu krayoglobulinemia dɔn afɛkt, yu kin nid fɔ wok wit wan tim we gɛt bɔku bɔku dɔktɔ dɛn. Dɛn tin ya kin bi:

• Dɔktɔ dɛn we spɛshal pan jɔyn ɛn kɔnɛktiv tisu sik dɛn (Rheumatologists).
• Di wan dɛn we de mɛn di bɔdi.
• Di wan dɛn we de stɔdi bɔt blɔd.
• Dɔktɔ dɛn we spɛshal pan kidni sik dɛn (Nephrologists).
• Di wan dɛn we de mɛn di at.
• Di wan dɛn we de stɔdi bɔt nyurolɔji.
• Di wan dɛn we de mɛn pipul dɛn we gɛt ɛpatɔlɔji.

No yu mɛdikal tim gud gud wan. Tɔk fɔ yusɛf. Aks kwɛstyɔn dɛn. If yu gɛt ɛnitin fɔ wɔri bɔt yu tritmɛnt plan, tɔk bɔt am. Yu dɔktɔ dɛn de fɔ lisin to yu ɛn mek shɔ se yu ɔndastand ɔltin we de afɛkt yu wɛlbɔdi ɛn kia.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt ɛni sayn fɔ krayoglobulinemia, yu fɔ go to dɔktɔ wantɛm wantɛm. Dɔn bak, if yu gɛt epataytis C ɛn ɛni wan pan dɛn sayn ya de sho, go to dɔktɔ. Ivin if yu trit am fayn, sɔmtɛm de sik kin kam bak (i ​​kin kam bak). If yu gɛt nyu sik, if yu sik dɛn we yu bin dɔn gɛt, de wɔs, ɔ if yu sik kam bak, go to dɔktɔ. Di mɛdikal chɛk-ap ɔltɛm ɛn fɔ fala am ɔltɛm impɔtant fɔ no if i kam bak kwik kwik wan ɛn fɔ mek yu nɔ gɛt prɔblɛm dɛn.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

We yu go to yu dɔktɔ, i go fayn fɔ aks kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin mek a gɛt dis sik?
• Us tritmɛnt dɛn yu kin advays?
• Us sayd ɛfɛkt dɛn we di tritmɛnt kin gɛt we a fɔ wɔri bɔt?
• Us kɔmplikɛshɔn kin apin bikɔs ɔf dis kɔndishɔn?
• Wetin a kin du fɔ mek di sik nɔ kam bak?

Di impɔtant tin dɛn we wi nid fɔ mɛmba (Take-Home Message) .

Fɔ liv wit krayoglobulinemia kin tranga sɔm tɛm. De sayn dɛm ɛn sayd ɛfɛkt dɛm wae mɛrɛsin kin gɛt kin gɛt big impak pan yu maynd wɛl bɔdi. I kin afɛkt bak bɔku ɔda tin dɛn na yu layf.

Bɔt mɛmba se nɔto yu wangren de. Aks yu dɔktɔ fɔ ɛp, ɛn fɛn sɔpɔt grup usay ɔda pipul dɛn we de go tru di sem kayn tin kin kam togɛda. If yu tɛl yu bɔt yu ɛkspiriɛns ɛn wetin yu no, dat kin ɛp yu fɔ liv wit krayoglobulinemia. Fɔ protɛkt yusɛf frɔm kol, fɔ go to dɔktɔ, nɔ fɔ smok, ɛn fɔ it tin dɛn we go mek yu it fayn, ɔl na impɔtant tin.

A op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!