Yu no bɔt dis smɔl mɛsenja we de na yu bɔdi? (Adrenokortikotropik Ɔmɔn - ACTH) .

Yu dɔn ɛva tink bɔt wetin kin apin insay yu bɔdi we yu strɛs ɔ fil bɔku prɛshɔn? Wi bɔdi gɛt smɔl padi we wi nɔ kin si we kin ɛp wi pan tɛm lɛk dis. Dɛn kɔl am ACTH. Tide, wi go tɔk bɔt dis ACTH.

Wetin na ACTH?

Fɔ tɔk am simpul wan, ACTH na ɔmon we yu pituitary gland de mek. I de ple big pat pan aw yu bɔdi de ansa we yu strɛs . We ACTH kɔmɔt, i de gi yu adrenal gland dɛn sayn fɔ mek dɛn mek kɔtisol, we wi ɔl no as di “stress hormone,” ɛn wan grup we gɛt sɛks ɔmon dɛn we dɛn kɔl androgens.

Naw yu go mɔs de wɔnda wetin na dɛn ɔmon dɛn ya, nɔto so? Ɔmon na kemikal dɛn we de kɔdinɛt difrɛn wok dɛn na yu bɔdi. Dɛn tan lɛk mɛsenja dɛn. Dɛn mɛsej ya kin pas tru yu blɔd to yu ɔgan dɛn, yu skin, yu mɔsul dɛn, ɛn ɔda tisu dɛn. Dɛn sayn ya de tɛl yu bɔdi wetin fɔ du ɛn ustɛm fɔ du am.

yu pituitary gland na sכmכl gland we saiz fכ pis we de na di bכs pat na yu bren, jכs dכn di haypothalamus. Na pat pan yu ɛndokrin sistɛm. di pituitary gland gεt tu pat dεm: di antεriכr lכb εn di posita lכb. yu antεriכr pituitary gland na in de mek εn rilis ACTH.

Wetin kin rili apin wit ACTH?

di men wok we ACTH de du na fכ mek yu adrenal gland dεm fכ rilis di כmon kכtisol. Tink bɔt am lɛk se ACTH tan lɛk di kɔmand ɔfisa we de tɛl yu adrenal gland fɔ mek kɔtisol.

Kɔtisol na wan rili impɔtant ɔmon we wi bɔdi nid. I kin afɛkt ɔlmost ɔl ɔgan ɛn tisu na di bɔdi. Dɛn kɔl kɔtisol di “stress hormone,” bɔt fɔ tru, i gɛt bɔku ɔda impɔtant wok dɛn na wi bɔdi.

Na sɔm impɔtant tin dɛn bɔt kɔtisol:

• Yu kin kɔntrol aw yu bɔdi kin biev we yu strɛs .
• I de ɛp fɔ kɔntrol di we aw yu bɔdi de yuz fat, prɔtin, ɛn kabɔhaydrɛt, dat na, yu mɛtabolism .
• Inflameshɔn , we min se di difrɛn pat dɛn na di bɔdi kin swel ɛn rɛd, kin ridyus.
• I de mek di blɔd prɛshɔn rigul .
• I de rigul di blɔd shuga lɛvɛl .
• I kin ɛp bak fɔ mek yu slip ɛn wek .

Nɔto dis nɔmɔ, ACTH de du ɔda tin. dat min se i de mek di adrenal gland dεm fכ rilis sεks כmon dεm we dεn kכl andrכjen. pan tap dat, ACTH de εp fכ mek kεmikכl dεm we de mek dεn prodyuz mכr כmon dεm lεk adrenaline εn noradrenaline.

Aw dɛn kin kɔntrol di ACTH lɛvɛl?

di ACTH lεvεl dεm na yu bכdi de kכntro bay wan sistεm we rili intrestin. Dɛn kɔl am fidbak sistɛm. I kin gɛt fɔ du wit yu haypothalamus, pituitary gland, adrenal gland, ɛn sɔm ɔmon dɛn. wi kכl dis כl sistεm di Hypothalamic-Pituitary-Adrenal (HPA) aks . I tan lɛk se i kɔmplikt smɔl, nɔto so? Bɔt i simpul.

Imajin se yu pituitary gland de kɔnɛkt to yu haypothalamus bay wan smɔl smɔl blɔd vesel ɛn nerv dɛn. Dɛn kɔl dis di pituitary stalk. na tru dis stכl di haypothalamus de tכk to di pituitary gland εn tεl am fכ rilis sכm כmon dεm. Yu haypothalamus na pat pan yu bren we de kɔntrol tin dɛn lɛk blɔd prɛshɔn, at rit, bɔdi tɛmpracha, ɛn aw yu de digest.

di adrenal gland dεm na tu sכm sכm triangul gland dεm we de oba yu kidni dεm.

Naw lɛ wi si aw dis fidbak sistɛm we de kɔntrol di ACTH lɛvɛl dɛn de wok:

• We di kɔtisol lɛvɛl na yu bɔdi go dɔŋ, yu haypothalamus de pul wan ɔmon we dɛn kɔl Kɔtikotrofin-Rilizin Ɔmon (CRH) .
• dis CRH de mek yu antεriכr pituitary lobe fכ rilis ACTH.
• afta dat ACTH de mek yu adrenal gland dεm, spεshal wan di adrenal kכtεks, fכ rilis kכtisol εn andrכjen dεm.
• we di kכtisol lεvεl dεm de inkrεs lεk dis, i de sεnd signal bak to di haypothalamus fכ lכs di CRH lεvεl dεm. Ɛn na so di saykl kin dɔn. I tan lɛk ‘on-off switch’ .

nכto dis nכmכ, we yu strεs , dat min se yu strεs na yu maynd, di ACTH prodakshכn de stimulate εn di kכtisol lεvεl de inkrεs.

Bɔt if prɔblɛm de wit yu haypothalamus, pituitary gland, ɔ adrenal gland, di balans pan di ɔmon dɛn we de insay dis prɔses, we na ACTH, kin ambɔg.

Aw fɔ chɛk di ACTH lɛvɛl dɛn?

Dɛn kin du blɔd tɛst fɔ chɛk yu ACTH lɛvɛl. Dis min se yu fɔ tek smɔl blɔd frɔm wan vein we de na yu an.

Bɔku tɛm, dɔktɔ dɛn kin ɔda fɔ mek dɛn du kɔtisol tɛst wit ACTH tɛst fɔ no if prɔblɛm de wit di pituitary gland ɔ di adrenal gland dɛn.

Dɔn bak, sɔntɛnde dɔktɔ dɛn kin du sɔntin we dɛn kɔl ACTH stimulation test . Dis de tεst aw yu adrenal gland dεm de rεspכnd fayn to ACTH. dis kin εp bak fכ no di prכblεm dεm wit di pituitary εn/כ adrenal gland dεm.

Wetin na nɔmal ACTH lɛvɛl?

Lεk kכtisol, di lεvεl fכ ACTH na yu bכdi kin hכy pasmak na di ali mכnin. I de dכn sכmtεm as di de de go, i de rich in lכs lεvεl arawnd midnayt. Bɔt if yu de wok na nɛt shift ɛn slip difrɛn tɛm dɛn na di de, dis we aw yu de du tin kin chenj.

So, ACTH tɛst kin nid fɔ pul blɔd na mɔnin. in jεnarכl, di nכmal rεnj fכ ACTH lεvεl bitwin 7:00 a.m. εn 10:00 a.m. na 7.2 to 63.3 pikogram pan wan mililita (7.2 to 63.3 pg/mL) .

Bɔt mɛmba wan tin. Dɛn nɔmal rɛnj ya kin difrɛn frɔm wan lab to ɔda lab, frɔm wan tɛm to ɔda tɛm, ɛn frɔm wan pɔsin to ɔda pɔsin. If yu gɛt ACTH tɛst, na yu dɔktɔ go rid yu rizɔlt ɛn tɛl yu if yu nid fɔ du ɔda tɛst ɔ nɔ nid fɔ du am.

Wetin kin apin if di ACTH lɛvɛl go ɔp?

If yu ACTH lεvεl dεm hכy, i go bi se yu kכtisol lεvεl dεm bak hכy. Bikɔs kɔtisol kin afɛkt di bɔdi bɔku we dɛn, yu kin gɛt di sayd ifɛkt dɛn we kɔtisol gɛt bɔku pas di sayn dɛn we de sho se yu gɛt bɔku ACTH. Sɔntɛnde, we yu adrenal gland dɛn nɔ de mek inof kɔtisol, di ACTH lɛvɛl kin go ɔp. Na dɛn kayn tin ya, yu kin gɛt di sayn dɛm fɔ lɛ kɔtisol nɔ bɔku, nɔto fɔ gɛt bɔku ACTH.

Bɔku rizin dɛn de we kin mek di ACTH lɛvɛl go ɔp:

• Cushing’s disease: Dis na di mכst kכmכn tin wae kin mek di ACTH lεvεl go כp. dis kin kכz fכ wan tכmכro we nכ de kεnsar (adenoma) na di pituitary gland we de mek tu mכch ACTH. dis kin mek di kכtisol lεvεl dεm go כp. I impɔtant fɔ ɔndastand di difrɛns bitwin di sik we dɛn kɔl Cushing ɛn di sik we dɛn kɔl Cushing . Di sik we Cushing gɛt na jɔs wan pan di bɔku tin dɛn we kin mek pɔsin gɛt di sik we dɛn kɔl Cushing.
• εktopik adrenocorticotropic hormone tumor: Na sכm tεm, tכmכro we de divεlכp ausayd yu pituitary gland kin rilis tu mכch ACTH. di tכmכro dεm we kin prodyuz ACTH dis we (pan כl we i nכ kin bכku) inklud di tכmכro dεm we nכ de fכ kansa na di lכng, di aylet sεl t כmכro dεm na di pankrias, mεdula kansa na di tayroyd, sכm sכm sεl tכmכro dεm na di lכng, εn tכmכro dεm na di taymus gland .
• Praymari adrenal insufficiency: Dis kכndyushכn kin apin we sכmtin dεn dכn pwεl yu adrenal gland dεm εn dεn nכ ebul fכ prodyuz kכtisol fayn fayn wan. Di sik we Addison bin gɛtDis na di mכst kכmכn kכz fכ praymar adrenal insufisεns. dis kin mek yu pituitary gland de rilis mכr ACTH biכs i want fכ mek di adrenal gland dεm wok.

Wetin kin apin if di ACTH lɛvɛl go dɔŋ?

if di ACTH lεvεl dεm lכw biכs fכ prכblεm wit di pituitary gland, di kכtisol lεvεl dεm go כlwayz dכn lכw bak. כltu, if di kכtisol lεvεl dεm hכy bikoz fכ prכblεm wit di adrenal gland, di ACTH lεvεl kin lכw.

Bɔku rizin dɛn de we mek di ACTH lɛvɛl kin smɔl:

• Cushing’s syndrome: Cushing’s syndrome, we kin kam bikɔs ɔf wan adrenal gland tumor ɔ bay we dɛn yuz kɔtikosterɔyd mɛrɛsin fɔ lɔng tɛm fɔ ɔda kɔndishɔn, kin mek di ACTH lɛvɛl smɔl. dis na biכs yu pituitary gland nכ de ebul fכ rilis ACTH nכmal wan biכs fכ di kכtisol we pasmak.
• Hypopituitarism: Dis na wan sik we nɔ kin apin so ɔltɛm. Dis na we yu pituitary gland de mek tumɔs smɔl pan wan, sɔm, ɔ ɔl di ɔmon dɛn. ACTH na wan pan di ɔmon dɛm we kin afɛkt. Ɛnitin we pwɛl yu pituitary gland, lɛk tumbu, ɔpreshɔn, ɔ redyushɔn tɛrapi, kin mek yu gɛt hypopituitarism.

Bay naw yu go dɔn ɔndastand se ACTH impɔtant fɔ rigul yu kɔtisol lɛvɛl. If yu de gɛt sɔm sayn dɛn we de sho se yu gɛt bɔku ɔ smɔl kɔtisol, lɛk we yu de gɛt bɔku bɔku bɔdi ɔ yu de lɔs, yu blɔd prɛshɔn ay ɔ smɔl, mek shɔ se yu go to yu dɔktɔ. I kin du kɔtisol ɛn ACTH blɔd tɛst fɔ no if na yu adrenal gland ɔ pituitary gland na in de mek yu gɛt di sik.

So wetin na di tin dɛn we wi nid fɔ mɛmba?

ACTH na wan rili impɔtant ɔmon we di pituitary gland de mek we de ɛp fɔ kɔntrol strɛs na wi bɔdi.

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- dis na wetin de mek di adrenal gland dεm fכ prodyuz di "strεs כmon" kכtisol .

- Kɔtisol de kɔntrol bɔku tin dɛm, lɛk wi mɛtabolism, blɔd prɛshɔn, ɛn blɔd shuga lɛvɛl.

- di ACTH lεvεl dεm de kכntro bay wan kכmpleks sistεm we involv di haypothalamus, pituitary gland, εn adrenal gland dεm .

- If di ACTH lεvεl dεn go כp כ dכn, i kin mek yu gεt Cushing in sik, Addison in sik.Difrɛn wɛlbɔdi prɔblɛm dɛn kin apin.

- If yu gɛt ɛni sayn pan dis, i bɛtɛ fɔ go to dɔktɔ we yu nɔ de fred ɛn go to advays.

` ACTH, Adrenokortikotropik Hכmon, Kכtisol, Pituitary gland, Adrenal gland dεm, Hכmon dεm, Strεs