Yu de gɛt smɔl smɔl wayt blɔd sɛl? Lɛ wi lan bɔt Autoimmune Neutropenia (AIN)!

Yu dɔn ɛva wɔnda wetin mek wi yon imyun sistɛm, instead fɔ protɛkt wi, kin bigin fɔ atak wi yon sɛl dɛn sɔntɛnde? Dat na sɔm kayn tin we kɔmplikt, bɔt we pɔsin kin ɔndastand we dɛn kɔl Autoimmune Neutropenia (AIN) . Wetin kin apin na wi yon imyun sistεm de atak wan rili imכtant kayn wayt bכdi sεl na wi bכdi, we dεn kכl `nyutrofil.` So lε wi tכk bכt dis jכs, insay wan we we yu go כndastand.

So, wetin na Autoimyun Nyutropenia (AIN)?

Fɔ tɔk am simpul wan, `Autoimmune Neutropenia` (AIN) na wan sik we gɛt fɔ du wit blɔd. wetin de apin ya na we wi imyun sistεm we dεn se de protεkt wi, de mistek atak wi כwn wayt bכdi sεl dεm we dεn kכl `nyutrofil`. Imajin dis, lɛk di ami we de protɛkt wi kɔntri we mistek atak wi yon pipul dɛn.

Wetin na `Nyutrofil`?

Nyutrofil na rili impɔtant pat pan wi imyun sistɛm. Dɛn tan lɛk smɔl sojaman dɛn na wi bɔdi. Dɛn men wok na fɔ fɛn ɛn pwɛl bad bad tin dɛn we kin kam insay di bɔdi, lɛk baktri ɛn fɛns we kin mek pɔsin gɛt sik. so, insay di kes fכ `Autoimmune Neutropenia`, wi כwn imyun sistεm de pwεl dεn valyu `nyutrofil` sεl dεm ya, so di nכmba fכ `nyutrofil` na di bכdi de dכn dכn dכn nכmal lεvεl dεm.

Tu men kayn AIN de:

1. Primary Autoimmune Neutropenia (AIN): Dɛn kin si dis mɔ pan bebi ɛn yɔŋ pikin dɛn . wetin de apin ya na di nכmba fכ `nyutrofil` dεm de dכn witout nכ כda rizin. Bɔt di gud nyus na dat, dis sik kin sɔlv insɛf insay sɔm ia.

2. Sɛkɔndari Ɔtoimyun Nyutropenia (AIN): Dis kin apin mɔ pan pikin dɛn we dɔn ol ɛn big pipul dɛn . na ya, di lכw nyutrofil kכnt na כda mεdikal kכndyushכn de kכz am. Fɔ ɛgzampul, i kin kam bikɔs ɔf infekshɔn, ɔda blɔd prɔblɛm, ɔ ɔda ɔtoimyun sik (wan sik we di imyun sistɛm kin atak in yon bɔdi). Dis sɛkɔndari AIN kɔndishɔn kin bi we nɔ de mɛn .

Aw smɔl di nɔmba fɔ di nyutrofil dɛn we dɛn kɔl nyutropenia?

Awtoimyun Nyutropenia na jɔs wan kayn sik we brayt wan we dɛn kɔl Nyutropenia. di nyutropenia dεn kin kכl am sכm kayn, mכdarεt, כ siriכs, dipכnt pan di nכmba fכ nyutrofil dεm pan wan maykrolit (maykroL) bכdi.

• Mild Nyutropenia: 1,000 – 1,500 nyutrofil pan wan maykroL.
• mכdarεt Nyutropenia: 500 – 1,000 nyutrofil dεm pan wan maykroL.
• Sivεr Nyutropenia: Nyutrofil dεm we less dan 500 pan wan maykroL.

Di tin we impɔtant pas ɔl na dat, dɔktɔ fɔ kɔnfirm dɛn valyu ya. If yu gɛt ɛni dawt bɔt dis, i rili impɔtant fɔ go to dɔktɔ.

Aw AIN de afɛkt mi bɔdi?

Di we aw AIN de afɛkt yu kin difrɛn frɔm wan pɔsin to ɔda pɔsin. I dipen pan bɔku tin dɛn, so i bɛtɛ fɔ tɔk to yu dɔktɔ bɔt dis. If yu nyutrofil kɔnt go dɔŋ tumɔs, yu go gɛt infɛkshɔn . Sɔmtɛm dɛn infɛkshɔn ya kin mek yu layf de pan denja, mɔ if yu nɔr go to dɔktɔ kwik kwik wan.

Bɔt sɔm tɛm dɛn, ɔtoimyun nyutropenia kin jɔs mek pɔsin gɛt smɔl smɔl infɛkshɔn. Ɔ i kin bi se i nɔ gɛt ɛni sayn. Na dat mek i impɔtant fɔ wok wit dɔktɔ fɔ no wetin de mek yu gɛt nyutropenia. Dipen pan de kɔz, yu dɔktɔ kin wach yu sik ɛn ɛp yu fɔ kɔntrol di infekshɔn.

Udat kin gɛt Ɔtoimyun Nyutropenia (AIN)?

• Praymari AIN: Dis kin mɔs afɛkt bebi ɛn yɔŋ pikin dɛn . Dɛn kin no am arawnd 8 mɔnt.
• Sεkɔndari AIN: Dis kin apin bɔku tɛm wit ɔda ɔtoimyun sik, lɛk lupus ɔr rεumatoid at. Pikin dεm we gεt sεkכnd AIN kin gεt am arawnd 10 ia.Dεn kin no big pipul dεm we gεt AIN bitwin 40 εn 60 ia.

Aw kɔmɔn tin na ɔtoimyun nyutropenia?

Praymari AIN na wan sik we nɔ kin apin so ɔltɛm . Na lɛk wan pan ɛvri 100,000 pikin dɛn we nɔ rich 10 ia nɔmɔ i kin afɛkt. So yu kin si aw i nɔ kin apin so ɔltɛm.

Wetin na di sayn dɛm fɔ Autoimmune Neutropenia?

Autoimyun Nyutropenia nɔ kin ɔltɛm mek yu gɛt big big sik. Bɔt sɔntɛnde, yu kin si sayn dɛn fɔ se yu gɛt di sik. Fɔ ɛgzampul:

• Infεkshכn na yu yes: Dis na wan pan di sayn dεm we de sho se yu de fil. Imajin se yu smɔl pikin de kɔntinyu fɔ gɛt in yes pen, ɛn we yu go to dɔktɔ, dɛn tɛl yu se na ɔda infɛkshɔn na in yes.
• Infεkshכn dεm we yu de blo: I kin kol, kכf, εn fiva bכku tεm.
• Infεkshכn na yu mכt: Tin dεm lεk mכt כlsa εn gingivitis.
• Infεkshכn dεm na di skin.
• Nyumonia.
• Meningitis we gɛt di sik.
• Infεkshכn dεm na di urinary tract (UTIs).
• Sepsis: Dis na wan sik we rili siriɔs, we kin mek pɔsin in layf de pan denja.

Infεkshכn dεm we de asai wit praymar AIN kin sכmtεm sכmtεm, bכt siriכs infεksh כn lεk nyumonia, mεningaytis, εn sεpsis kin kכmכn mכr pan sεkכnd AIN.

Wetin kin mek di ɔtoimyun nyutropenia?

AIN dεn kכl am praymari כ sεkכnd dipכnt pan di kכz fכ di lכw nyutrofil lεvεl dεm.

Praymari Ɔtoimyun Nyutropenia (Praymari AIN) .

insay praymari AIN, di antibodi dεm de tכk εn dεstroy nyutrofil dεm. Antibodi dεm na wan kayn protin we de insay wi imyun sistεm. Dɛn nɔmal wok na fɔ pwɛl di bad tin dɛn lɛk vayrɔs ɛn baktri dɛm we de kam insay di bɔdi. Bɔt na dis tɛm, di wan dɛn we de stɔdi bɔt dis stil nɔ no bɛtɛ bɛtɛ wan wetin mek wi yon antibodi dɛn de atak dɛn nyutrofil ya.

Sεkɔndari Ɔtoimyun Nyutropenia (Sεkɔndari AIN) .

insay sεkכnd AIN, di nכmba fכ nyutrofil dεm de rεdכks bikoz fכ כda kכz כ kכndishכn. dis kin mek di imyun sistεm de pwεl di nyutrofil dεm.

Sɔm tin dɛn we kin mek dis apin na:

• Ɔda sik dɛn we pɔsin kin gɛt we i de fɛt insɛf: Sɔm ɛgzampul dɛn na rεumatoid at, lupus, ɛn autoimmune hemolytic anemia.
• kansa: fכ egzampl, `big granul limfosayt lukimiya`.
• Infεkshכn: Infεkshכn dεm lεk `HIV`, `Parvovirus`, `hepatitis B`.
• Tumɔs: Lɛk `Wilms tumor`, `Hɔdgkin in sik`.
• Nyurolɔjik sik dɛm: Fɔ ɛgzampul, multiple sclerosis.
• Kidni ɔ bon mɛro transplant.
• Sɔm mɛrɛsin dɛn: Ɛspɛshali sɔm kemotɛrapi mɛrɛsin dɛn we dɛn kin gi fɔ kansa.

Aw dɛn kin no bɔt Autoimmune Neutropenia? (Diagnosis) .

We yu gɛt fiva ɔ yu gɛt infekshɔn, yu dɔktɔ kin si se yu nyutrofil nɔ bɔku we yu de wok fɔ blɔd fɔ no wetin mek yu gɛt am. Fɔ no bɔt AIN kin tranga smɔl, bikɔs bɔku tin dɛn de we kin mek yu gɛt am. Yu dɔktɔ kin no se yu gɛt AIN afta i dɔn pul ɔda tin dɛn we kin mek yu nyutrofil dɛn nɔ bɔku.

Fɔ no ɔ fɔ wach `Autoimmune Neutropenia`, yu dɔktɔ kin du dɛn tɛst ya:

• Kɔmplit blɔd kɔnt (CBC): CBC kin chɛk di nɔmba fɔ di nyutrofil dɛn we de na yu blɔd. Bikɔs dɛn lɛvɛl ya kin difrɛn, bɔku tɛm yu dɔktɔ go du mɔ pas wan CBC fɔ kɔnfɔm nyutropenia ɛn fɔ wach yu nyutrofil lɛvɛl. CBC dɛn we yu kin du ɔltɛm kin ɛp bak fɔ no if yu AIN nɔ de mɛn.
• Peripheral blood smear: Dɛn kin chɛk wan blɔd sɛmpul ɔnda maykroskɔp fɔ chɛk di shep ɛn di kayn we aw di nyutrofil dɛn tan. Dis kin ɛp bak fɔ no di sik.
• Vitamin B12, folate, ɛn kɔpa tɛst: Dɛn tɛst ya kin chɛk fɔ si if dɛn tin ya nɔ de. Di bɔdi nid dɛn tin ya fɔ mek nyutrofil dɛn.
• Tεst dεm fכ di liva fכnshכn: Dis kin chεk bak fכ di liva fכnshכn εn if vayral epataytis de.
• HIV ɛn ɔda vayral stɔdi dɛm: Vayral infɛkshɔn lɛk HIV kin mek bak di wayt blɔd sɛl dɛm go dɔŋ.
• Flow cytometry: Dis na labכtכri tεst we de luk di sεl dεm fכ sayn dεm fכ sik. Dɛn kin yuz am fɔ no if nyutropenia na ɔtoimyun kɔndishɔn.
• Imej: If dɛn tink se na kansa lɛk limfoma de mek AIN, dɛn kin du MRI ɔ CT skan.
• Bone marrow aspiration and biopsy: Na ya, di dɔktɔ kin tek smɔl smɔl bon mɛrɔ ɛn chɛk am fɔ si if i gɛt sayn dɛn fɔ sik. Dis kin ɛp fɔ no if nyutropenia na blɔd kansa lɛk lukimiya.

Yu dɔktɔ kin tɛl yu bak fɔ mek dɛn du blɔd tɛst fɔ chɛk fɔ si if antibodi dɛn de na yu blɔd we de atak nyutrofil dɛn. di tεst dεm we kכmכn pas כl na di I-GIFT (Indaykt granulocyte immunofluorescence test) εn di GAT (Granulocyte agglutination test).

כnכfכs, dεn tεst ya nכto כltεm we dεn kin abop pan fכ no AIN. Dipen pan wetin mek yu nyutropenia ɛn di tɛm we dɛn de tɛst yu, dɛn tɛst ya nɔ kin no antibodi ɔ dɛn kin gi lay lay rizɔlt. Falz-positiv rizulyt na we di tεst sho se antibodi dεm de we dεn nכ de.

If di dɔktɔ tink se na wan patikyula sik de mek nyutropenia, i kin ɔda fɔ mek dɛn du ɔda tɛst dɛn.

Aw dɛn kin trit Ɔtoimyun Nyutropenia?

Di tritmɛnt dipen pan aw yu sik tranga. fכ egzampl, pikin we gεt asymptomatic nyutropenia kin כnli nid fכ gεt CBC rεgulεr εn nyutrofil kכnt, bכt i nכ nid fכ trit am kwik kwik wan. If yu pikin gɛt infɛkshɔn bɔku tɛm, yu dɔktɔ kin gi yu antibayɔtiks we de protɛkt am fɔ mek i nɔ gɛt di sik. Dɛn kin gi antibayɔtik fɔ trit infɛkshɔn, bɔt dɛn kin gi dɛn prɔfylaktik antibayɔtik ya fɔ mek infɛkshɔn nɔ apin.

Fɔ pɔsin we gɛt sɛkɔndari AIN, di dɔktɔ go trit di ɔndalayn kɔndishɔn we de mek di nyutrofil lɛvɛl smɔl. Dɛn kin gi am bak:

• Granulocyte colony-stimulating factor (G-CSF): Dis na di men tritmɛnt fɔ siriɔs kes dɛm we gɛt nyutropenia. I de ɛp di bɔdi fɔ mek mɔ nyutrofil dɛn. G-CSF kin bak fɔ mek dɛn nɔ gɛt infɛkshɔn ɔltɛm we gɛt fɔ du wit praymari AIN.
• Kɔtikosterɔyd: Kɔtikosterɔyd, lɛk prɛdnison, de stɔp yu bɔdi in imyun sistɛm, we de ridyus di nɔmba fɔ di antibodi dɛm we de atak nyutrofil dɛm.
• Ɔda tritmɛnt dɛm: Dɛn dɔn yuz ɔda mɛrɛsin dɛm lɛk IVIG, rituximab, ɛn alemtuzumab bak pan pipul dɛm we sik bad bad wan wit siriɔs ɔtoimyun nyutropenia.

Yu tink se dɛn kin mek dɛn nɔ gɛt Autoimmune Neutropenia?

Nɔbɔdi nɔ go ebul fɔ stɔp Praymari AIN ɔ Sɛkɔndari AIN . Bɔt yu kin mek yu nɔ gɛt di kɔmplikeshɔn dɛn we gɛt fɔ du wit `Autoimmune Neutropenia`, dat na di divɛlɔpmɛnt fɔ infɛkshɔn. Fɔ du dis, yu nid fɔ du di tin dɛn we yu nid fɔ protɛkt yusɛf frɔm infɛkshɔn. Fɔ ɛgzampul, fɔ avɔyd ples dɛn we pipul dɛn kin bɔku, fɔ was yu an ɔltɛm, ɛn fɔ de fa frɔm pipul dɛn we sik.

Us kayn fiuja pɔsin we gɛt Autoimmune Neutropenia kin ɛkspɛkt?

Praymari AIN kin sɔlv fɔ insɛf . כlmost 95% pan di pikin dεm we gεt AIN kin gεt dεn nyutrofil lεvεl dεm we de kam bak to nכmal we dεn ol tu to tri ia. Klose to ɔl pikin dɛn we gɛt praymari AIN kin wɛl ful wan we dɛn ol 11. Dis kin rili mek dɛn fil fayn, nɔto so?

כda kes dεm, we dεn kכl sεkכnd AIN, yu rεkכvεshכn de dipכnt pan sεvεra tin dεm, spεshal wan di כndalayn kכndyushכn we mek yu nyutropenia. Fɔ trit da sik de ɛn fɔ mek yu nɔ gɛt infɛkshɔn kin ɛp fɔ mek yu nyutrofil kɔnt bak to nɔmal.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt siriɔs ɔtoimyun nyutropenia ɛn yu gɛt fiva, go to dɔktɔ wantɛm wantɛm . Sɔntɛnde, yu dɔktɔ kin dɔn gi yu antibayɔtik bifo tɛm fɔ tek if yu gɛt fiva. Bɔrku tɛm, yu go nid fɔ gɛt tritmɛnt na ɔspitul.

If yu gɛt siriɔs, lɔng tɛm ɔtoimyun nyutropenia, yu dɔktɔ go ɛksplen to yu us sayn dɛm yu fɔ no bɔt ɛn wetin yu kin du fɔ mek yu nɔ gɛt prɔblɛm.

Mɛmba: If dɛn no se yu ɔ yu pikin gɛt AIN, tɔk to yu dɔktɔ bɔt aw i kin afɛkt yu. Pan ɔl we di simptom ɛn kɔz kin difrɛn, di gud nyus na dat tritmɛnt lɛk G-CSF kin rili wok fɔ mek di nyutrofil lɛvɛl go ɔp.

If yu pikin gɛt AIN, de du blɔd tɛst ɔltɛm lɛk aw yu dɔktɔ tɛl yu. Yu fɔ de wach fɔ sayn dɛn we de sho se yu gɛt di sik, ɛn go to tritmɛnt kwik kwik wan if yu notis ɛni wan, fɔ mek yu nɔ gɛt prɔblɛm dɛn we kin apin.

Sɔma (Mɛsej we dɛn kin tek go na os) .

Okay, so a op se yu naw gɛt bɛtɛ ɔndastandin bɔt di `Autoimmune Neutropenia` (AIN) we wi bin tɔk bɔt.

• AIN na wan kכndyushכn we wi כwn imyun sistεm de pwεl wi wayt bכdi sεl dεm we dεn kכl `nyutrofil`.
• Dis kin apin pan yɔŋ pikin dɛm (Primary AIN) ɔ pan big pipul dɛm (Sɛkɔndari AIN). Praymari AIN na yɔŋ pikin dɛn kin sɔlv fɔ insɛf.
• Di men risk na fɔ gɛt infɛkshɔn ɔltɛm.
• Blɔd tɛst ɛn ɔda tɛst dɛn de fɔ no if pɔsin gɛt am.
• Di tritmɛnt inklud fɔ wach, fɔ tek mɛrɛsin fɔ mek pɔsin nɔ gɛt di sik, G-CSF, ɛn fɔ tek kɔtikosterɔyd.
• Di tin we impɔtant pas ɔl na fɔ nɔ panik ɔ panik ɛn go to dɔktɔ if yu ɔ yu pikin gɛt dɛn sik ya. If dɛn no di sik kwik kwik wan ɛn dɛn mɛn yu fayn fayn wan, yu kin liv wɛl bɔdi layf ivin wit AIN.

If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, mek shɔ se yu tɔk to yu dɔktɔ. Na dɛn go ebul fɔ gi yu di bɛst advays.

` Nyutropenia, Awtoimyun Nyutropenia, Wait Blɔd Sɛl, Imyun Sistɛm, Infɛkshɔn, Blɔd Sik, Pikin Sik