Lɛ wi lan bɔt di strenj prɔtin dɛn we de na di at? (Kɔdiak Amyloidosis) .

Sɔntɛnde yu kin fil taya ɔ yu kin gɛt smɔl prɔblɛm fɔ blo? Sɔntɛm yu nɔ go pe atɛnshɔn tumɔs to dɛn tin ya. Bɔt sɔntɛnde, dɛn tin ya kin bi sayn fɔ se yu gɛt at prɔblɛm. Tide wi go tɔk bɔt wan sik we de afɛkt di at, we yu nɔr dɔn yɛri bɔt , bɔt i fayn fɔ no bɔt. Nɔ wɔri, wi go tɔk bɔt dis simpul wan ɛn di we we yu go ɔndastand.

Wetin na dis (Cardiac Amyloidosis)?

Fɔ tɔk am simpul wan, `(Cardiac Amyloidosis)` na sik we de kam bikɔs ɔf di protin dɛn we nɔ shep fayn na wi bɔdi, we de put insay ɛn rawnd di at. Tink bɔt am lɛk we wata paip blok. Dis we aw di prɔtin dɛn we de bɔku kin mek yu at nɔ ebul fɔ pɔmp blɔd. Dɔn di at gɛt fɔ wok tranga wan. tεm, dis εkstra εfכt kin wik εn damej di at, we kin mek i gεt `(Hat Failure)`.

Bɔku rizin dɛn kin de fɔ dis. Sɔm pipul dɛn kin gɛt am frɔm dɛn mama ɛn papa, we min se na in jɛnɛtiks . Ɔda pipul dɛn kin gɛt dis sik we nɔ gɛt ɛni jɛnɛtik link. I kin kam bak wit ɔda sik dɛn lɛk kansa. pan ɔl we dis kכndyushכn we dεn kכl ``Amyloidosis``, dεn nכ kin kכl am kכmplit, gud tritmεnt de fכ sכm kayn dεm.

Wetin na di kayn sik we dɛn kɔl Cardiac Amyloidosis?

di protin dεm we de insay wi bכdi na lכng chen dεm fכ mכlikul dεm. dis protin dεm de εp wi fכ du bכku tin dεm, lεk fכ gi εnεji, fכ du kεmikכl riakshכn dεm na wi bכdi, εn fכ tכk mεsej bitwin difrεn sistεm dεm. Bɔt prɔblɛm de. wi sεl dεm kin כnli yuz dεn protin chen dεm ya if dεn de insay di rayt shep. di sik dεm we de mek di protin dεm we de fכl fayn, lεk amyloidosis, kin mek dεn protin dεm ya twist, misfold, εn dεn nכ kin ebul fכ wok fayn.

we di protin dεm tu dכn כganayz, dεn kin tכng tכgeda εn di bכdi nכ kin yuz dεm. We dɛn nɔ gɛt say fɔ go, dɛn prɔtin dɛn ya we tandul kin gɛda togɛda, stik togɛda, ɛn stɔp na difrɛn pat dɛn na di bɔdi.

Amyloidosis kin afɛkt bɔku sistɛm dɛn na di bɔdi, mɔ di at. tri men kayn amyloidosis de we de afɛkt di at (ɔda kayn kin afɛkt di at bak, bɔt dɛn nɔ kin bɔku).

AL (Layt Chen) Amyloidosis we de mek pɔsin gɛt sik

wi bכdi de yuz tin dεm we dεn kכl ``layt chen`` as pat pan in imyun sistεm. Dɛn tin ya de protɛkt wi frɔm jem lɛk vayrɔs ɛn baktri dɛm. ``AL Amyloidosis`` kin apin we di sεl dεm na wi bon mכro nכ de wok fayn εn prodyuz tu mכch pan dεn ``layt chen dεm.`` Dis kin apin insεf, כ i kin kכz fכ sכm kayn bכdi kεnsar כ kεnsar dεm na di imyun sistεm. Dɛn kin no dis kayn sik afta dɛn dɔn ol 50 ia.

ATTR amiloidosis we dɛn kɔl

Transthyretin (TTR) na wan protin we de ɛp fɔ muv sɔm kemikal dɛn rawnd na wi bɔdi. I gɛt in nem bikɔs i de transpɔt tayroyd ɔmon ɛn vaytamɛn A (rɛtinol). Fɔs, dɛn bin de kɔl am Thyroxine-binding prealbumin (TBPA), bɔt dɛn nɔ de yuz da nem de igen.

Di simptom dɛm fɔ `ATTR Amyloidosis` kin rili chenj. I kin tan lɛk se i yɔŋ lɛk 20 ia ɔ i kin tan lɛk 70 ia. Tu men sɔbtayp dɛn de:

• Hereditary ATTR: Dis na jεnεtik kכndishכn. Dis min se yu gɛt am frɔm yu mama, papa, ɔ ɔl tu.
• Wail-tayp ATTR: dis kin apin we di TTR protin jכs bigin fכ wok fayn, we nכ gεt nכ jεnεtik mכtεshכn. Dis kin apin afta i ol 60. Fɔs, dɛn bin de kɔl am Senile Systemic Amyloidosis ɔ Senile Cardiac Amyloidosis, bɔt dɛn nɔ de yuz dɛn nem ya igen.

Amyloidosis we gɛt fɔ du wit dayalaysis

Pipul wae dɔn de pan dayalaysis fɔ lɔng tɛm bikɔs ɔf kidni sik kin gɛt mɔ risk fɔ gɛt amyloidosis. dis na biכs wan protin we dεn kכl beta-2 maykroglobulin (beta-2 maykroglobulin) nכ kin filta aut we dεn de du di dayalaysis. dis protin we dεn kכl beta-2Ms de kכmכt na di at εn כda pat dεm na di bכdi.

Di kayn dɛn we nɔ kin bɔku (Cardiac Amyloidosis).

apat frכm dis, sεvεra כda sכbtayp dεm de fכ ``Cardiac Amyloidosis'', bכt dεn kin rili rare.

Udat dɛn kin gɛt dis sik mɔ?

Bɔku men tin dɛn de we kin afɛkt udat gɛt dis sik:

• Ej: Pan ɔl we sɔm pipul dɛn kin gɛt amyloidosis we dɛn ol 20 ia, i nɔ kin bɔku pan pipul dɛn we nɔ rich 40 ia.
• Jɛnda: Man dɛn kin gɛt kadyak amyloidosis pas uman dɛn. εspεshali wit wayl-tayp ATTR amyloidosis, 25 to 50 mכr man dεm de afekt fכ εvri uman.
• Di kɔntri we dɛn bɔn am: Wan jɛnɛtik muteshon we de mek famili ATTR amyloidosis kin rili kɔmɔn na sɔm kɔntri dɛn. Fɔ ɛgzampul, kɔntri dɛn lɛk Pɔtyugal, Jepan, Swidan, Finland, ɛn sɔm ɔda kɔntri dɛn na Yurop.
• Ras/etnik: כda jεnεtik mכtεshכn we de mek famili ATTR amyloidosis de fכn insay lεk 4% pan blak pipul dεm we kכmכt na Wεst Afrika. Dis inklud Afrikan Amɛrikin dɛn ɛn bak blak pipul dɛn we kɔmɔt na Latin Amɛrika ɛn di Karibian.
• Kɔntinyu fɔ dayalaysis fɔ lɔng tɛm: Di mɔ yu de du dayalaysis, na di mɔ yu go gɛt dɛn sik ya.

Aw dis sik kin bɔku?

In jɛnɛral, `(Amyloidosis)` na sik we nɔ kin bɔku. כltu, sכm kayn `(Amyloidosis)` kin kכmכn pas כda wan dεm.

• AL Amyloidosis: Na Amɛrika nɔmɔ, dɛn kin ripɔt lɛk 4,000 nyu kes dɛm fɔ AL Amyloidosis ɛvri ia. Dat na lɛk wan pan ɛvri 64,500 big pipul dɛn.
• Hereditary `ATTR Amyloidosis`: yu kin si dis kכndyushכn pan 4% pan blak pipul dεm we kכmכt na Wεst Afrika. Insay pipul dɛn we kɔmɔt na Yurop, dɛn kin si am pan lɛk wan pan ɔl wan ɔndrɛd tawzin pipul dɛn. Bɔt na di kɔntri dɛn we wi dɔn tɔk bɔt, dis nɔmba pas am fa fawe. Fɔ ɛgzampul, na Pɔtyugal, na lɛk wan pan ɛvri 538 pipul dɛn gɛt dis sik.
• Wild-type ATTR Amyloidosis: Di masta sabi pipul dεm biliv se dis na wan kכndyushכn we dεn nכ no, wit εstimat dεm se i kin afekt te to 20% pan man dεm we pas 80 ia.
• amyloidosis we gɛt fɔ du wit dayalaysis: Dis kin apin to lɛk 20% pan di pipul dɛn we de du dayalaysis fɔ tu to 4 ia. I kin apin to ɔlmost ɔlman wae de du dayalaysis fɔ 13 ia ɔr mɔr.

Aw dis sik kin afɛkt di bɔdi?

Cardiac Amyloidosis na sik wae de chenj di strכkchכ na yu at εn i de ambɔg in ebul fכ pכmp. I kin apin insay dɛn we ya:

• di at wכl dεm de tik: we di `(Amyloid)` protin dεm de dכn na di at mכsul, di at wכl dεm de tik εn di at de big. We dis kin apin, di at kin gɛt fɔ wok tranga wan fɔ pɔmp blɔd ɔlsay na di bɔdi. dis ekstra efכt kin εva lid to `(Hat Failure)` .
• di kadyak amyloidosis kin mek di at ritm dεm we nכ de rεgεl (arrhythmias), כ di ilektrikal signal dεm na di at wik. Atrial fibrillation na wan kɔmɔn kayn aritmia we gɛt fɔ du wit amyloidosis.
• di amyloid diposit dεm: di amyloid protin dεm na wax, stika protin dεm we de kכlכp togeda izi wan εn fכm big kכlכm. If dɛn klɔmp ya stɔp na wan at valv, di valv kin blok sɔm pat pan am, ɛn dis kin mek di blɔd nɔ go flɔ.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

Nɔto ɔlman wae gɛt jɛnɛtik muteshon wae kin mek yu gɛt amyloidosis go gɛt dis sik. Sɔm pipul dɛn nɔ kin ɛva gɛt am. Ɔda pipul dɛn kin du dat, bɔt i nɔ kin rili bad.

di kadyak Amyloidosis simptom dεm kin involv di at, bכt i kin involv כda imכtant כgan dεm lεk di liva εn kidni dεm. Insay di las stej dɛm fɔ di Kadiak Amyloidosis, di sayn dɛm fɔ siriɔs at pwɛl (we dɛn rayt dɔŋ ya) kin apin.

Di sayn dɛm we kin apin kin bi:

• Fɔ blo shɔt: Dis kin apin we yu de du tin ɔ we yu de ledɔm.
• Swel bikɔs ɔf wata we de gɛda: Dɛn kin si dis na di leg, anklɛ, groin, ɛn bɛlɛ.
• Taya:Fɔ fil taya pasmak fɔ sɔm dez ɔ mɔ.
• At Palpitations: Na tin we nɔ fayn we yu kin fil lɛk se yu at de bit we yu nɔ tray fɔ du ɛnitin.
• Varicose veins in di nek: Dis kin apin we di at de fεl, biכs i kin at fכ pכmp fayn fayn wan. dis prεshכn we de go כp de put prεshכn bak pan di vein dεm na di nεk, we de mek dεn big.
• Epatomegaly: Dis na kכmכn kכmplikεshכn bak fכ at fεl, εn na di sem rizin we mek di vein dεm na di nεk de distend. Di prɛshɔn we de go ɔp frɔm di at kin put prɛshɔn bak pan di blɔd vesel dɛn na di liva, we kin mek di ɔgan swel.
• Kidni prɔblɛm: Tin dɛn lɛk inflamɛns na di kidni ɔ chenj na di kidni wok.

Ɔda tin dɛm wae kin bi sayn dɛm fɔ ``Cardiac Amyloidosis'' wae nɔr gɛt ɛnitin fɔ du wit di at, liva, ɔ kidni:

• Brus we nɔ kɔmɔn .
• Tɔng we dɔn swel.
• Carpal Tunnel Syndrome (Pulmonary Nerve Compression - Dis kin bi sayn fɔ wɔn pɔsin kwik kwik wan, bɔku tɛm ia bifo di sik kam).
• Lumbar Spinal Stenosis (we de sכmtεm di spεs we de rawnd di spεnal kכd na di lכw bכk).
• Prɔblɛm dɛn we pɔsin kin gɛt we i de si.
• Prɔblɛm fɔ yɛri ɛn dɛf.
• Di an ɔ fut kin swɛla ɔ swɛt.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt Cardiac Amyloidosis?

Bɔku difrɛn tin dɛn de we kin mek wi gɛt difrɛn kayn amyloidosis, bɔt bɔku pan dɛn gɛt fɔ du wit wi DNA .

Tink bɔt am lɛk famili buk fɔ kuk. I gɛt instrɔkshɔn dɛn bɔt aw wi sɛl dɛn fɔ wok, aw fɔ mek sɔm prɔtin dɛn. Fɔ pas DNA frɔm mama ɛn papa to pikin dɛn tan lɛk we yu mama ɛn papa de rayt da rɛsipɛkt buk de to yu wit dɛn an.

Jɛnɛtik muteshɔn tan lɛk tayp mistek dɛn na yu DNA rɛsipɛkt buk. Kapital lɛta kin mek wan risɛp nɔ fayn. Na di sem tin wit sik dɛm lɛk amyloidosis. Yu sɛl dɛn de wok tranga wan as dɛn ebul, bɔt dɛn jɔs no aw fɔ fala di risɛp. Dɛn typos ya kin apin to yu tu we dɛn.

Na inhɛrit

Bɔku tɛm, di sik we dɛn kɔl Cardiac Amyloidosis na wan sik we dɛn kin gɛt na di famili. Dis min se yu gɛt am. Dis kin apin we wan ɔ ɔl tu pan yu mama ɛn papa gɛt muteshon na dɛn DNA, ɛn di mistek we dɛn mek na da "rɛsipɛkt buk" de kɔpi insay yu yon.

Dɔn gɛt

Sik wae yu kin gɛt na sik wae yu nɔr kin gɛt, bɔt kin kam sɔm tɛm na yu layf. Wail-tayp ATTR amyloidosis εn dialysis-related amyloidosis na dεn tu εgzampl fכ dεn sik dεm ya we dεn kin gεt. Bɔt nɔto ɔl dɛn tin ya gɛt fɔ du wit di chenj dɛn we de apin na yu DNA.

• Wail-tayp ATTR amyloidosis de apin biכs yu bכdi de mek protin dεm kכrekt, bכt as tεm de go dεn protin dεm de nכ stebul (dat na di rizin we mek dis sik de so rilet to di ej). Afta sɔm tɛm, di prɔtin kin jɔs fold di rɔŋ we.
• di amyloidosis we gɛt fɔ du wit dayalaysis kin apin we wan nɔmal protin we dɛn nɔ kin ebul fɔ filta bay dayalaysis, lɛk yu kidni, kin gɛda na yu bɔdi. As tɛm de go, da prɔtin de kin bɔku te i kin mek prɔblɛm.

Yu tink se dis kin pas?

Nɔ, `(Amyloidosis)` nɔto sik we pɔsin kin gɛt pan ɛni we.

Aw dɔktɔ kin no bɔt dis? (Diagnosis) .

Dɔktɔ go fɔs sɔspɛkt `(Cardiac Amyloidosis)` bay yu simptom dɛm, wan fyzikal ɛgzam (di dɔktɔ de luk, fil, ɛn lisin to yu bɔdi fɔ sayn dɛm fɔ sik), ɛn yu famili mɛdikal histri. Dɔn dɛn go du diagnostik tɛst, imej tɛst, ɛn lab tɛst fɔ kɔnfɔm if yu gɛt `(Cardiac Amyloidosis)` ɔ nɔ gɛt.

If pɔsin na yu famili gɛt wan kayn sik we dɛn kɔl amyloidosis na yu famili, yu nɔ go nid fɔ du sɔm tɛst ɔ yu go nid fɔ du ɔda tɛst. Dɛn kin du jɛnɛtik tɛst bak fɔ si if yu gɛt jɛnɛtik muteshon we kin mek yu gɛt kadyak amyloidosis.

Us tɛst dɛn kin du fɔ no dis sik?

If yu dɔktɔ sɔspɛkt se yu gɛt ``Cardiac Amyloidosis'', dɛn kin ɔda wan ɔ mɔ pan di tɛst dɛm we de dɔŋ ya.

Lab testing

Dɛn tɛst ya kin tek sɔm pan di tisu, blɔd, ɔ ɔda wata we de na di bɔdi. Dɛn kin yuz wan spɛshal day we dɛn kɔl Kongo rɛd fɔ bɔku pan dɛn tɛst ya. dis day de mek di say dεm we di amyloid de dכn gכ grεn כnda sכm layt kכndishכn dεm.

• Tisu biopsy: Insay dis, dɔktɔ dɛn kin tek smɔl tisu frɔm wan eria, lɛk di at mɔsul, ɛn tɛst am na lab. yu kin tek tisu sεmpl dεm bak frכm כda εria dεm, bכt if sεmpl frכm εria we nכ de na di at gi positifu risכlt, i nid fכ kכnfכm am wit imej tεst.
• bכdi tεst: Insay sכm kayn kadyak amyloidosis, amyloid protin dεm de sכkכt insay di bכdi. Lab test kin no dis protin dεm.
• urine testing: Sɔntɛnde, amyloid protin dɛn kin de na di urine. we yu tεst if dεn protin dεm ya de na di urine i kin εp bak fכ no di sik.

Test dɛn fɔ tek imej

Bikɔs di kadyak amyloidosis kin mek yu at big ɛn chenj in shep, tɛst fɔ tek pikchɔ kin ɛp fɔ no di sik. Di tɛst dɛn we dɛn kin du na:

• Ikokadiogram: .Dis tɛst tan lɛk bat we de yuz sawnd fɔ fɛn in we. I de yuz sawnd wev dɛn we gɛt ay frikshɔn. wan divays we de mek sawnd dεn de put am na di skin na di chεst, εn dכkta dεm kin "si" di at bay we dεn de luk aw di sawnd wev dεm de bכns כf difrεn strכkchכ dεm insay di bכdi. Dis kin rili yusful fɔ si if sɔm pat dɛn na di at tik pasmak.
• Scintigraphy: Fɔ dis tɛst, dɔktɔ dɛn kin put wan tin we dɛn kɔl tracer, we na wan tin we gɛt smɔl redioaktiv (bɔt we nɔ bad) insay yu blɔd. di traysa de kכlekt na di εria dεm we di amyloid protin dεn dכn akumulet. Dɔn i izi fɔ si dɛn say dɛn ya wit wan imej tɛst we dɛn kɔl SPECT scan (Single-Photon Emission Computed Tomography) .
• Magnetic Resonance Imaging (MRI): Dis tɛst de yuz wan rili pawaful magnet ɛn kɔmpyuta teknɔlɔji fɔ mek wan pikchɔ bɔt di at. MRI kin rili ditayli, so dɔktɔ dɛn kin si we di at de tik ɔ ɔda tin dɛn we de chenj.

Ilɛktrokardiogram (ECG ɔ EKG) .

Insay ECG, sɔm sɛns dɛn (bɔku tɛm na 12) kin atak di skin na yu chɛst. Di sɛns dɛn kin no di ilɛktrik kɔrɛnt we de flɔ na yu at ɛn dɛn kin sho di trɛnk we da ilɛktrik signal de gɛt lɛk wev na pepa ɔ skrin. Spɛshal pipul dɛn we dɛn dɔn tren, lɛk dɔktɔ dɛn, kin chɛk di wef fɔ si if ɛni chenj de we nɔ kɔmɔn na di we aw sɔm pat dɛn na yu at kin kɔndɔkt ilɛktrishɔn.

Tɛst dɛn we dɛn kin du fɔ tɛst dɛn jɛnɛtiks

Dipen pan di rizɔlt fɔ ɔda tɛst dɛn, yu dɔktɔ kin se yu fɔ tɛst yu jɛnɛtiks. dis tεst dεm kin no di mכtεshכn dεm na yu DNA we kin de mek yu amyloidosis.

Yu tink se tritmɛnt de fɔ Amyloidosis?

Bɔrku kayn `(Cardiac Amyloidosis)` kin trit, bɔt di sik nɔr kin wɛl ɔltɛm . di tritmεnt de difrεnt bak dipכnt pan di kayn `(Amyloidosis). Jɛnɛral wan, fɔ no di sik kwik kwik wan rili impɔtant . if dεn kech `(Amyloidosis)` kwik, di damej we go de fכ di at fכ lכng tεm kin sכm. If dɛn nɔ no am ɛn trit am kwik, i kin pwɛl fɔ ɔltɛm. di onli we fכ ripεr di at we dεn dכn pwεl fכ כltεm na `(Hat Transplant)`.

AL amyloidosis we dɛn kɔl

Di tritmɛnt fɔ AL Amyloidosis na di sem we lɛk di we aw dɛn kin trit kansa. Dɛn na:

• Kimotɛrapi: Jɔs lɛk kansa, kemotɛrapi kin pwɛl di plasma sɛl dɛn we nɔ de wok fayn.
• Stem sel transplant: Dɛn kin du dis tritmɛnt wit kemotɛrapi, ɛn i kin tek nyu sɛl dɛn fɔ tek di ples fɔ di plasma sɛl dɛn we nɔ de wok fayn. dεn stεm sεl dεm ya dεn kin tek frכm yu (autologous). Bikɔs na yu yon, yu bɔdi de no dɛn ɛn nɔ de rijek ɔ du bad to dɛn.
• Imyunotɛrapi: .Nɔmal wan yu imyun sistɛm kin no ɛn pwɛl di sɛl dɛn we nɔ de wok fayn. pan sik dεm lεk kεnsar כ AL Amyloidosis, yu imyun sistεm nכ de no dεn sεl dεm de fכ fכlt. Immunotherapy de tich yu imyun sistɛm fɔ no ɛn pwɛl di sɛl dɛn we nɔ fayn.

ATTR amiloidosis we dɛn kɔl

dis kayn ``(Amyloidosis)`` de apin we yu liva de mek protin dεm we de brok dכn izi wan. Dis prɔblɛm nid fɔ stɔp ɔl di tritmɛnt dɛn. Di list we de dɔŋ ya gɛt ɔl tu di tritmɛnt dɛn we gɔvmɛnt dɔn gri fɔ ɛn di wan dɛn we stil de na di risach pat.

• Liva transplant: Trade, liva transplant na bin di wangren we fɔ stɔp yu liva fɔ mek di rɔng prɔtin dɛn. Pan ɔl we nɔto dis nɔmɔ yu kin du igen, i stil fayn ɛn i kin wok fayn.
• Jεnεtik saylεns dεm: ATTR Amyloidosis de kכz bay wan jεnεtik mכtεshכn na yu DNA, lεk wan typo na rεsipi buk. Jɛnɛtik saylɛns na drɔgs we de wok lɛk tɛmporari rɛsipɛkt kad. Instead of your cells following the wrong recipe, they give them new instructions so they can make the protein correctly.
• Stabiliza: Dɛn drɔgs ya de stɔp di TTR mɔlyul dɛn fɔ misfold ɔ brok.
• di fibril inhibito dεm: we di amyloid protin dεm bigin fכ kכlכp togeda, dεn de fכm strכkchכ dεm we lεk fayv we dεn kכl fibril. Dɛn drɔgs ya kin stɔp di fɔmɛshɔn fɔ di fibril dɛn.

Amyloidosis we gɛt fɔ du wit dayalaysis

dis kayn `(Amyloidosis)` de divεlכp pan pipul dεm we nid `(dialysis)` biכs di `(beta-2M)` protin de kכmכt. nכmal wan, yu kidni dεm de filta εn pul da protin de, bכt rεgul `(dialysis)` nכ kin du dat. Dis na wae mek e kin tek ia fɔ mek pipul dɛm wae de pan `(dialysis)` gɛt dis sik. Naw, tu we dɛn de fɔ trit am:

• Kidni transplant: Kidni we gɛt wɛlbɔdi min se yu nɔ nid dayalaysis igen, ɛn we yu transplant kidni kin filta di beta-2M protin we pasmak. If dɛn transplant di kidni, dat kin mek di amyloidosis we gɛt fɔ du wit dayalaysis nɔ wɔs, bɔt di wan dɛn we de stɔdi bɔt dis nɔ shɔ if i go pul di amyloid protin we dɔn bil bak na di bɔdi.
• spεshal filta dεm: pan כl we rεgulεr dayalysis filta dεm nכ kin pul di beta-2M protin dεm, spεshal filta dεm de we kin atכs pat pan dεm. כnכfכs, dεn filta dεm ya nכ de filta כl di protin, εn dεn nכ de filta כl am. dis min se ivin afta di ia dεm we dεn dכn dכn dayalaysis, di amyloidosis we de fכ di dayalaysis kin εva divεlכp.

Tritmɛnt dɛn we nɔto spɛshal tritmɛnt

Difrɛn ɔda tritmɛnt ɛn mɛrɛsin dɛn de we kin ɛp pipul dɛn we gɛt Cardiac Amyloidosis. Dɛn tin ya kin trit di sayn dɛm fɔ di sik ɛn kin inklud:

• Hat transplant: Pipul wae gɛt siriɔs hat damej bikɔs ɔf kadyak amyloidosis sɔmtɛm kin nid at transplant. Bɔku tɛm dɛn kin du dis ɔpreshɔn afta dɛn dɔn sɔlv ɔ trit di tin we mek di amyloidosis.
• Mεdikeshכn dεm wae de mek yu nɔr de fil fayn: Dɛn mεdikeshɔn ya de ɛp fɔ mek yu nɔr de bit ɔltɛm, sɔm pan dεm kin denja.
• Divays dɛn we dɛn kin put insay pɔsin in bɔdi: Dɛn tin ya we dɛn kin yuz fɔ mek pɔsin in bɔdi gɛt peshɛnt ɛn mashin dɛn we dɛn kin put insay pɔsin in bɔdi (ICD) . Dɛn kin manej yu at rit bay we dɛn kin gi yu ilɛktrik shɔk ɛn mek yu nɔ gɛt di denja aritmia.
• Diuretic medications: Dɛn mɛrɛsin ya kin ɛp spɛshal fɔ mek yu nɔ gɛt wata (na kɔmɔn sayn fɔ mek yu at nɔ wok fayn) bay we dɛn kin mek yu kidni wok fayn. Bɔt yu nɔ fɔ tek dɛn mɛrɛsin ya if yu gɛt wan sik lɛk siriɔs kidni sik.
• Doxycycline : di layt chen dεm we de insay AL amyloidosis de tכxik bak to yu hat sεl dεm. Fɔ rizin dɛn we masta sabi pipul dɛn stil nɔ ɔndastand gud gud wan, di antibayɔtik dɔksisayklin kin kɔba dɛn pɔyzin ifɛkt dɛn de.

Ɛni bad tin de we di tritmɛnt kin du?

Di kɔmplikeshɔn ɛn sayd ɛfɛkt dɛm we pɔsin kin gɛt we i de trit dis sik kin difrɛn bad bad wan. Dis dɔŋ ya na sɔm kɔmɔn tin dɛn we pɔsin kin ebul fɔ du. Bɔt yu dɔktɔ kin ɛksplen to yu di prɔblɛm dɛn we kin apin, di bad tin dɛn we kin apin to yu, ɛn ɔda tin dɛn we kin apin to yu. Dis na bikɔs dɛn no yu sik fɔ dɛnsɛf, so dɛn kin mek dɛn infɔmeshɔn ɛn ɛksplen to yu patikyula tin.

Aw kwik a go fil fayn afta dɛn dɔn trit mi?

Di tritmɛnt fɔ Kadyak Amyloidosis kin jɔs bi fɔ kɔntrol yu simptom dɛm. Sɔm tritmɛnt dɛn kin mek pɔsin fil sɔm kayn we, bɔt di tin dɛn we kin apin to pɔsin nɔ kin te. Sɔntɛnde, tritmɛnt kin mek yu fil bad fɔ sɔm tɛm, bɔt yu dɔktɔ kin gi yu mɛrɛsin ɛn gayd fɔ ɛp fɔ ridyus di bad bad tin dɛn we kin apin to yu.

Yu tink se dɛn go ebul fɔ stɔp dis? Ɔ yu tink se dɛn kin ridyus di prɔblɛm?

כnכfכs, dεn nכ kin ebul fכ sכpכt amyloidosis (wit wan εksepshכn, si dכn). Bikɔs dɛn nɔ no wetin kin mek pɔsin gɛt amyloidosis we pɔsin nɔ kin gɛt frɔm in mama ɛn papa, no we nɔ de fɔ mek i nɔ apin. Dɛn nɔ kin ebul fɔ stɔp di amyloidosis we yu kin gɛt frɔm yu mama ɛn papa bak, bikɔs i de insay di DNA we yu gɛt frɔm yu mama ɛn papa.

Di wangren tin we nɔ de insay di at na di kadyak amyloidosis, we gɛt fɔ du wit dayalaysis. dis kכndyushכn kin bi if yu nכ de du dayalaysis fכ lכng tεm, כ if yu yuz spεshal filta fכ stכp di bכlכp fכ beta-2M protin dεm. Bɔt dɛn filta ya nɔ kin stɔp di bɔku bɔku wan, we min se bɔku tɛm dɛn kin jɔs bi we fɔ delay fɔ mek di sik bigin.

Wetin na di lukin-grɔn fɔ dis sik?

Cardiac Amyloidosis na wan sik we de go bifo, wit di sayn dɛm fɔ at pwɛl we de wɔs smɔl smɔl. As tɛm de go, di sik kin mek yu at wik te i nɔ ebul fɔ wok igen. If dɛn nɔ trit am, di we aw pipul dɛn kin si tin nɔ kin fayn mɔ.

If dɛn nɔ gɛt tritmɛnt, di avɛrej tɛm fɔ liv fɔ pipul dɛn we gɛt AL Amyloidosis nɔ rich et mɔnt. Fɔ di wan dɛn we gɛt di sik we rili bad, i kin tek tri to siks mɔnt. Fɔ di wan dɛn we gɛt ATTR Amyloidosis, di avɛrej tɛm fɔ liv na tu to fayv ia. Fɔ di wan dɛn we gɛt famili we nɔ gɛt tritmɛnt wit ATTR Amyloidosis, di tin kin ivin wɔs, wit avrej tɛm fɔ liv fɔ tu to tri ia.

Aw a go tek kia ɔf misɛf ɛn kɔntrol mi sik dɛn?

Na ɔnfɔni, nɔr bɔrku tin de wae yu kin du fɔ ɛp yusɛf kwik kwik wan afta yu gɛt amyloidosis. If pɔsin na yu famili gɛt dis sik, yu fɔ tɔk to yu dɔktɔ bɔt aw fɔ tɛst yu jɛnɛtiks. Pan ɔl we nɔto ɔlman we gɛt muteshon we gɛt fɔ du wit kadyak amyloidosis go gɛt dis sik, i impɔtant fɔ no if yu kin gɛt am. Da we de, yu kin de wach bɔt de sik ɛn bigin fɔ trit yu kwik kwik wan.

If yu gɛt `(Cardiac Amyloidosis)`, i rili impɔtant fɔ fala yu dɔktɔ in instrɔkshɔn bɔt mɛrɛsin ɛn tritmɛnt. Bɔku pan dɛn mɛrɛsin ya kin wok pan patikyula we dɛn, ɛn fɔ mek dɛn wok fayn, i impɔtant fɔ tek dɛn jɔs lɛk aw yu dɔktɔ tɛl yu.

Ustɛm a fɔ go to dɔktɔ ɔ fɔ go to dɔktɔ kwik kwik wan?

Afta dɛn dɔn no se yu gɛt Cardiac Amyloidosis, yu dɔktɔ go sɛtul fɔ go fɛn yu ɔltɛm. Dipen pan aw yu sik tranga, yu kin nid fɔ go to yu dɔktɔ bɔku tɛm.

Yu dɔktɔ go tɛl yu bak us sayn dɛn fɔ mek yu go to dɔktɔ kwik kwik wan. Bɔt, in jɔnal, kɔl yu dɔktɔ if yu gɛt ɛni wan pan dɛn sik ya:

• Fɔ fil diziz ɔ fɔdɔm we yu sidɔm ɔ tinap: Dɛn kɔl dis ``Orthostatic Hypotension.'' Dis kin apin bikɔs di blɔd prɛshɔn we de dɔŋ de ridyus di blɔd we de go na di bren we yu tinap.
• di limb dεm כ di bεlε de swεla: Dis kin bi fכ di wata we de kכmכt.
• Wantɛm we yu de lɔs yu wet wantɛm wantɛm: Dis na impɔtant sayn, mɔ we yu nɔ de tray fɔ lɛf fɔ it bɔku bɔku it.

Ustɛm a fɔ go na di ER (Imejɛnsi Rum)?

Bikɔs di sik we dɛn kɔl kadyak amyloidosis kin rili ambɔg yu at fɔ wok, sɔm sayn dɛn kin sho se yu nid fɔ go to dɔktɔ wantɛm wantɛm.I nid fɔ du dat. Sɔm pan dɛn na:

• Fɔ fil se yu at de bit.
• Wan at bit we nɔ kɔmɔn fast, sloslo, ɔ we nɔ de bit ɔltɛm.
• I nɔ izi fɔ yu fɔ blo fɔ ɛni rizin.

Fɔ dɔn, sɔm impɔtant pɔynt dɛn (Take-Home Message) .

Cardiac Amyloidosis na rili wan sik wae kin kɔmplikt smɔl, bɔt i rili impɔtant fɔ no bɔt am.

Mɛmba se pan ɔl we dis sik kin go bifo smɔl smɔl, if yu no dis sik kwik kwik wan ɛn trit yu fayn, dat kin ɛp fɔ mek yu liv lɔng ɛn mek yu liv bɛtɛ layf.

Sɔntɛnde, fɔ transplant ɔgan dɛn kin mɛn di sik. Tɛnki fɔ nyu mɛrɛsin ɛn tritmɛnt, bɔrku pipul dɛm wae gɛt dis sik kin kɔntrol dɛn sik ɛn liv fɔ lɔng lɔng tɛm afta di sik dɔn bigin.

If yu gɛt ɛni dawt ɔ kwɛstyɔn bɔt dis, fɔ tru, tɔk to yu dɔktɔ . Dɛn kin gi yu di rayt advays. Nɔ fred, gɛt infɔmeshɔn, aks kwɛstyɔn. Nɔto yu wan de.

` Kadyak Amyloidosis, Kadyak Amyloidosis, Protein Deposit, At sik, At sik Simptom, Amyloidosis Tritmɛnt, AL Amyloidosis, ATTR Amyloidosis, At sik