Sɔntɛnde yu kin wek na mɔnin wit yu spayna we stif ɛn pen we kin mek yu nɔ ebul fɔ stret yu spayna? Dis kayn pen, mɔ na di ɔda pat na di bɔdi ɛn di hip, kin bi di biginin fɔ sɔntin we rili dip pas jɔs simpul bak pen, mɔ we yu yɔŋ. Dis nɔto jɔs wan simpul bak-ak. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya, we na ankylosing spondylitis (AS), we na wan kayn at at sik we nɔ kin bɔku. Lɛ wi tɔk bɔt wetin kin kam wit am ɛn udat de pan denja fɔ am pas ɔl.
Fɔ tɔk am simpul wan, wetin na Ankylosing Spondylitis (AS)?
Ankylosing Spondylitis, ɔ AS fɔ shɔt, na wan kayn at at sik. I kin afɛkt di spayna mɔ. I kin mek yu gɛt inflamɛns, we min se i kin mek di jɔyn dɛn na di spayna ɛn sɔm tɛm dɛn ɔda jɔyn dɛn lɛk di hip dɛn kin swel ɛn stif. Dis kin mek yu stif ɛn pen na mɔnin.
If dis inflamɛns de fɔ lɔng tɛm, as wi bɔdi de tray fɔ wɛl, nyu bon pat dɛn kin bigin fɔ mek. as sayd ifekt fכ dis, di vεrbra dεm kin kכmprεs εn di spayna kin lכs in fleksibiliti. Dis kin mek i nɔ izi fɔ mek di spayna stret ɛn bɛn.
Yu tink se dɔktɔ dɛn no di rayt rizin fɔ dis?
Fɔ bi ɔnɛs, dɔktɔ dɛn stil nɔ ebul fɔ tɔk wit 100% shɔ wetin ɛksaktɔli kɔz AS. Bɔt naw, pipul dɛn biliv se na tu tin dɛn we dɛn jɔyn togɛda kin mek i apin: wi jin ɛn di tin dɛn we de arawnd wi.
Tink bɔt am dis we: wi jin dɛn tan lɛk gɔnpawda pila. Bɔt fɔ mek i layt, i nid spak we de na do. Na di sem tin kin apin na ya. ivin if jεnεtik prεdispכzishכn de fכ divεlכp AS, sכm kayn ‘trigεr’ כ ‘spark’ frכm di envayroment nid fכ di sik fכ apin.
Jɛnɛtik inflɔɛns ɛn HLA-B27
We wi de tɔk bɔt AS, wan tin we wi rili nid fɔ tɔk bɔt na di jin we dɛn kɔl HLA-B27 . dis na jin we de mek wan spεshal protin, כ ‘jεnεtik mak’, insay wi bכdi. Di men wok we dis jin de du na fɔ ɛp wi imyun sistɛm . Dat na fɔ ɛp fɔ no ɛn fɛt bad bad tin lɛk baktri ɛn vayrɔs we de kam insay di bɔdi.
di mכtalman we gεt AS gεt dis HLA-B27 jin na dεn bכdi. Bɔt di tin we impɔtant pas ɔl na ya na:
nכto כlman de divεlכp AS jכs biכs dεn gεt di HLA-B27 jin.Infakt, bɔku pipul dɛm we gɛt dis jin nɔ go ɛva gɛt AS insay dɛn layf. Dɔn bak, i pɔsibul fɔ mek pɔsin we nɔ gɛt dis jin gɛt AS.
Dat min se HLA-B27 na jɔs pat pan di stori. Sayɛnsman dɛn dɔn no bɔku ɔda jin dɛn we gɛt fɔ du wit AS. Klose to ɔl dɛn jin ya de involv sɔm we dɛn fɔ mek wi imyun sistɛm wok.
Di tin we de mek pɔsin want fɔ du sɔntin
Okay, so lɛ wi se yu gɛt jɛnɛtik prɛdispɔzishɔn, ɔ ‘shotgun’, fɔ divɛlɔp AS. Naw yu nid ‘spark’ fɔ ignite am. Sayɛnsman dɛn stil de du risach bɔt wetin na dis spak.
Wan men tin we dɛn kin tɔk na dat, na baktriyal infɛkshɔn kin mek dis flawa . Spɛshal wan, dɛn kin tink se dis kin bi bikɔs di natura difens dɛn we de na wi dijestiv sistɛm, we na di intestinal dɛn , brok . We dis kin apin, sɔm kayn bɔdi we de kɔmɔt na di bɔdi kin go insay di blɔd.
We baktri dɛn go insay di blɔd dis we, di imyun sistɛm fɔ pɔsin we gɛt jɛnɛtiks kin riak pasmak, ɛn i kin kray. dis kin mek di imyun sistεm bigin fכ atak di hεlty pat dεm na di bכdi, spεshal wan di jכint dεm na di spayna. Dis na aw AS de bigin.
Udat de pan denja pas ɔl fɔ dis?
Pan ɔl we ɛnibɔdi kin gɛt AS, sɔm pipul dɛn kin gɛt di risk smɔl. Lɛ wi tek wan luk pan udat dɛn bi.
| Risk Factor | Tɔk bɔt |
|---|---|
| Famili istri | If pɔsin na yu famili, mɔ mama, papa, ɔ brɔda ɛn sista gɛt AS, yu de pan ay risk fɔ gɛt am pas di avɛrej pɔsin. Dis de sho di inflɛns we di jin dɛn gɛt. |
| Ej | AS kin bigin bɔku tɛm pan yɔŋ pipul dɛm wae ol bitwin 17 ɛn 45. Bɔrku tɛm i kin bigin kwik pas ɔda kayn at at sik wae kin kam wit dɛn ej. |
| Bɔy ɔ gal | Man dɛn kin gɛt AS tu tɛm pas uman dɛn. |
| Infεkshכn dεm na di intestinal bכku tεm | Dis risk kin go ɔp smɔl fɔ pɔrsin wae kin gɛt bɛlɛ at ɛn infekshɔn na in dijestiv trakt bɔrku tɛm. Dat na bikos of di ‘faya spark’ we wi bin tok abaut bifo. |
| Ɔda sik dɛn we pɔsin kin gɛt we i de fɛt insɛf | If yu dɔn gɛt ɔda sik we yu kin gɛt we yu de fɛt, lɛk psoriasis , Crohn’s disease , ɔ ulcerative colitis , yu kin gɛt AS. Wetin ɔl dɛn sik ya gɛt fɔ du wit dɛnsɛf na di imyun sistɛm we nɔ de wok fayn. |
If yu gɛt bak pen ɔ yu stiff lɛk dis, mɔ if i wɔs na mɔnin ɛn i kin te pas af awa, nɔ jɔs ignore am. Nɔ jɔs tink se, ‘Na dis kin apin we yu dɔn ol.’ Si yu dɔktɔ wantɛm wantɛm ɛn tɔk bɔt am. Di kwik we yu no se yu gɛt di sik, na di mɔ yu go gɛt chans fɔ kɔntrol am, fɔ mek yu jɔyn dɛn nɔ pwɛl bɛtɛ, ɛn fɔ liv fayn layf.
Mɛsej we dɛn kin kɛr go na os
- Ankylosing Spondylitis (AS) na wan kayn at at sik we de afɛkt di spayna, nɔto jɔs ɔdinari bak pen.
- pan ɔl we no patikyula kɔz nɔ de fɔ dis, dɛn tink se na wan kɔmbayn jin dɛm lɛk HLA-B27 ɛn tin dɛm we de mek di envayrɔmɛnt trig dɛm lɛk baktriyal infɛkshɔn de mek am.
- If yu gɛt di HLA-B27 jin ɔ yu gɛt ɔda tin dɛn we kin mek yu gɛt prɔblɛm, dat nɔ min se yu go rili gɛt AS.
- Bɔrku tɛm dis sik kin bigin pan yɔŋ ej, bitwin 17-45 ia.
- If yu gɛt bak pen ɛn stiffness we de kam bak, mɔ na mɔnin, nɔ west tɛm ɛn go to dɔktɔ.
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