I nɔmal fɔ fil frayd we yu dɔktɔ tɛl yu ɔ yu pikin se yu gɛt kidni prɔblɛm, ɛn di sem tɛm, i tɛl yu wan lɔng, kɔmplikɛt nem lɛk `Complement 3 Glomerulopathy`. Dɛn kɔl dis `C3G` fɔ shɔt. Dis na sik we nɔ kin bɔku na di kidni. Pan ɔl we dis sik kin afɛkt pikin ɛn yɔŋ pipul dɛn mɔ, i kin rili gɛt ɛni ej. So tide, lɛ wi tɔk bɔt dis sik we dɛn kɔl C3G, lɛk se wi de tɔk to wi padi, insay wan rili simpul we.
Wetin na dis C3G?
Fɔ tɔk am simpul wan, C3G na kidni sik we di "kɔmplimɛnt sistɛm" kin mek, we na pat pan wi bɔdi in imyun sistɛm, we nɔ de wok fayn. Dis kɔmplimɛnt sistɛm tan lɛk polis fɔs we de fɛt di jem ɛn baktri dɛm we de kam insay wi bɔdi. Bɔt pan pɔsin we gɛt C3G, dis sistɛm in wok kin ambɔg, ɛn i kin bigin fɔ pwɛl dɛn yon kidni.
Tu men kayn C3G sik de:
1. Dens Dipɔsit Sik (DDD) .
2. C3 Glomerulonephritis (C3 Glomerulonephritis - C3GN) we de mek pɔsin gɛt sik.
Dɛn tu kayn ya kin bi bikɔs ɔf jɛnɛtik kɔz (sɔntɛm na frɔm in mama ɛn papa) ɔ ɔda wɛl bɔdi prɔblɛm dɛn we kin apin we pɔsin de liv.
Wetin kin mek dis apin? Wetin kin apin to di kidni dɛn?
Tink bɔt wi kidni dɛn lɛk ti filta. Dɛn kɔl dɛn filta ya glomeruli . Na dɛn tin ya kin filta wi blɔd, klin am, ɛn pul dɔti tin dɛn we wi nɔ want tru urine.
insay C3G sik, di malfunction we wi bin dכn tכk bכt na di kompliment sistεm de damej dεn dilik filta dεm ya we dεn kכl glomeruli. we dis damej de apin, di pores dεm na di filta de big, εn di protin dεm, εn di rεd εn wayt blכd sεl dεm, we fכ de na di bכdi, bigin fכ lik insay di urine. As tɛm de go, dis damej kin bɔku ɛn ivin mek di kidni nɔ wok fayn. Sɔm stɔdi dɛn sho se DDD kin afɛkt yɔŋ pipul dɛn pas C3GN.
Wetin na di sayn dɛm fɔ C3G sik?
Nɔto ɔlman wae gɛt C3G go gɛt di sem kayn sik. Bɔt, i impɔtant fɔ no bɔt dis. Lɛ wi luk di men sayn dɛm.
| Di sayn we de sho se di sik de | Wan simpul ɛksplen |
|---|---|
| Protein we de na di urine (Proteinuria) . | di protin we pasmak na di urine. Di urine kin gɛt fom, klawd, ɔ dak. We dis sik tranga (nephrotic syndrome), ɔda sayn dɛm lɛk fɔ swel kin apin bak. |
| Blɔd we de na di urine (Hematuria) . | di damej pan di kidni filta dεm de mek di rεd bכdi sεl dεm de kכmכt na di urine. Di urine kin tɔn rɛd, pink, ɔ brawn. |
| Ɛdima | Bikɔs di kidni dɛn nɔ de wok fayn, wata kin gɛda na di bɔdi, ɛn dis kin mek di leg, an, anklɛ, ɛn rawnd di yay swel. |
| Ay Blɔd Prɛshɔn | di prεshכn we de go כp na di bכdi bכdi bikoz fכ di wata we dεn nכ de pul fayn fayn wan na di kidni dεm. |
| Taya ɛn slip | Bikɔs di kidni dɛn nɔ de filta di dɔti tin dɛn fayn fayn wan, dɛn kin gɛda na di blɔd. Dis kin afɛkt di bren ɛn mek i taya, i kin slip, ɛn i nɔ kin izi fɔ pe atɛnshɔn pan sɔntin. Kidni sik kin mek bak yu nɔ gɛt bɛtɛ blɔd, ɛn dis kin mek yu taya bak. |
| Infɛkshɔn dɛn we kin apin ɔltɛm | di kompliment sistεm we wik de ridyus di bכdi in ebul fכ fכt di jεm dεm, we kin mek i gεt infεkshכn bכku tεm. |
| Prɔblɛm dɛn we de na di Ay | di we aw yu de si kin apin bikoz fכ di protin εn fεt dεposit (drusen) na di rεtina. |
| di fεt we de na di skin we nכ de dכn rεgulεr (Acquired partial lipodystrophy) . | di dεstrukshכn fכ di fεt sεl dεm bay di kompliment sistεm kin mek sכm εria dεm na di bכdi tכn, we כda εria dεm kin big εn gεt mכr fεt we de dכn. |
Apat frɔm dat, sɔm sayn dɛn lɛk fɔ nɔs, fɔ vɔmit, fɔ nɔ want fɔ it, fɔ nɔ ebul fɔ slip, fɔ mek yu skin dray ɛn it, fɔ te yu mɔt lɛk mɛtal, ɛn fɔ mek yu mɔsul dɛn de shek shek na nɛt we yu kidni nɔ de wok fayn .
Aw yu go fɛn dis, Dɔktɔ?
di onli we fכ no if yu gεt C3G sik na fכ gεt kidni bayopsi . Dis min se yu fɔ tek wan smɔl pat pan di kidni tisu ɔnda layt anestetik ɛn chɛk am ɔnda maykroskɔp. Dis na di wangren we fɔ no aw di kidni dɛn dɔn pwɛl.
Apat frɔm dat, yu dɔktɔ kin tɛl yu fɔ du blɔd ɛn urine tɛst ɛn sɔntɛm fɔ tɛst yu jɛnɛtiks.
Wetin a fɔ aks di dɔktɔ?
Na dis kayn tɛm, yu kin gɛt bɔku kwɛstyɔn dɛn na yu maynd. Tɔk bɔt dɛn tin ya klia wan wit yu dɔktɔ. Fɔ ɛgzampul:
- Aw a bin gɛt C3G?
- Us kayn C3G a gɛt? (DDD ɔ C3GN?)
- Wetin na de bɛst we fɔ mɛn mi wɛl bɔdi wit dis sik?
- Us tritmɛnt opshɔn dɛn a gɛt?
- Wetin a kin ɛkspɛkt tumara bambay wit dis sik?
Wetin na di tritmɛnt dɛm fɔ dis?
Fɔ tɔk tru, nɔr wan tritmɛnt nɔr de we go ebul fɔ mɛn C3G sik ɔltogɛda yet. Bɔt sɔm tritmɛnt dɛn de we kin kɔntrol di sik, ridyus di sayn dɛm, ɛn ridyus di damej pan di kidni dɛm.
- Kɔntrol di blɔd prɛshɔn ɛn di prɔtin we de kɔmɔt na di bɔdi: Blɔd prɛshɔn mɛrɛsin (Angiotensin-converting enzyme (ACE) inhibitors ɛn Angiotensin II type-1 receptor blockers (ARB)) kin ridyus di protin we de kɔmɔt na di urine ɛn slo di sik fɔ go bifo.
- Kɔlɔstrel kɔntrol: If yu gɛt ay kɔlɔstrel (hyperlipidemia), risach dɔn sho se mɛrɛsin dɛn we de mek yu nɔ gɛt bɔku kɔlɔstrel kin ɛp fɔ kɔntrol aw C3G sik de wɔs.
- Immunosuppressive drugs: Na wan kɔmbayn drɔgs we de stɔp di imyun sistɛm, lɛk glucocorticoids ɛn mycophenolate mofetil (MMF), kin mek sɔm sik pipul dɛn nɔ gɛt di sik bak.
- di mכdan tritmεnt dεm: Anti-kכmpliment drog dεm lεk `eculizumab` kin kכntro di aktiviti fכ di kompliment sistεm εn slo dכn di prכgreshכn fכ di sik. Apat frɔm dat, dɛn de stɔdi wan nyu mɛrɛsin we dɛn kɔl `iptacopan` naw. I dɔn sho se i rili fayn fɔ du am, so dɛn dɔn gri fɔ mek dɛn du risach bɔt am kwik kwik wan.
Aw a fɔ kia fɔ misɛf?
Jɔs lɛk mɛrɛsin, aw yu de kia fɔ yusɛf impɔtant bak fɔ kɔntrol dis sik.
- It fayn fayn it: It bɔku frut, vɛjitebul, ligɛm, ɛn ɔl gren. Ridyus di sɛtyuret fat, sɔl, ɛn shuga. Yu dɔktɔ go tɛl yu fɔ ridyus di potashɔm, sɔdiɔm (sɔl), ɔ fɔsfɛt we yu de it. Nɔ ɛva mek ɛni big chenj na yu it we yu nɔ go to yu dɔktɔ fɔs.
- Tek kia ɔf yu wɛlbɔdi: Ilɛksɛf yu fil fayn, tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek. Tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin, vaytamɛn, ɔ sɔpɔtmɛnt we yu de tek.
- Ɛksesaiz: We yu de du bɔdi wok, dat kin ɛp yu fɔ slip fayn, mek yu gɛt mɔ trɛnk, ɛn mek yu nɔ gɛt at sik. Tɔk to yu dɔktɔ bɔt ɛksɛsayz plan we go fayn fɔ yu.
- Nɔ smok: Dis kin rili fayn fɔ yu ɔl yu wɛlbɔdi.
- Limit alcohol: Tɔk to yu dɔktɔ bɔt aw fɔ drink rɔm ɛn aks fɔ advays.
Wetin wi go ɛkspɛkt fɔ tumara bambay?
Wae dɛn dɔn no se yu gɛt C3G sik, yu mɛdikal tim go ɛp yu fɔ fɛn di bɛst tritmɛnt plan.
Sɔntɛnde, di sik kin tranga. Na lɛk 50% pan di pipul dɛm wae gɛt C3G kin gɛt ɛnd-stej rεnal sik (ESRD) insay 10 ia afta dεn no di sik. na dis tεm ya, di kidni dεm fכ pul di dɔti tin dεm de lכs kכmplit. I kin nid fɔ mek dɛn du dayalaysis ɔ fɔ transplant di kidni .
Bɔt i impɔtant fɔ mɛmba se ivin afta dɛn dɔn transplant di kidni, chans de fɔ mek C3G sik kam bak na di nyu kidni. So tɔk to yu dɔktɔ fɔ lɔng tɛm bɔt di bɛst tin fɔ yu.
Yu mɛdikal tim kin gɛt dɔktɔ we de mɛn yu nɛfrolɔg, dɔktɔ we de mɛn yu blɔd, ɛn dɔktɔ we de mɛn sik dɛn. I impɔtant fɔ mek wi kɔntinyu fɔ gɛt gud padi biznɛs wit dɛn.
Mɛsej we dɛn kin kɛr go na os
- C3G na wan sik we nɔ kin apin so ɔltɛm bɔt we siriɔs bɔt di kidni we kin kam bikɔs ɔf wan difrɛns na di kɔmplimɛnt sistɛm, we na pat pan di bɔdi in imyun sistɛm.
- Di men sayn dɛm kin bi prɔtin ɔ blɔd na di urine, swel, ay blɔd prɛshɔn, ɛn taya.
- Dɛn kin no di sik klia wan wit kidni bayɔpsi.
- Pan ɔl we no patikyula mɛrɛsin nɔ de fɔ dis, dɛn kin ebul fɔ kɔntrol di sik ɛn protɛkt di kidni dɛn bay we dɛn de kɔntrol di blɔd prɛshɔn, mɛrɛsin dɛn we de kɔntrol di we aw dɛn de fɛt di sik, ɛn liv fayn layf.
- I rili impɔtant fɔ de kɔntakt yu mɛdikal tim ɔltɛm ɛn fala dɛn instrɔkshɔn dɛn di rayt we.
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