Yu dɔn yɛri bɔt wan strenj sik we kin afɛkt di bren? Lɛ wi lan bɔt Creutzfeldt-Jakob Disease (CJD).

Yu kin dɔn kɔnfyus smɔl we yu yɛri di nem fɔ dis sik, ɛn tink se, "Wetin na dis strenj sik?" Creutzfeldt-Jakob disease, ɔ CJD (Creutzfeldt-Jakob Disease) as wi kin kɔl am fɔ shɔt tɛm, na wan sik we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs we kin pwɛl di we aw wi bren de wok . Fɔ tɔk am simpul wan, wetin kin apin na we wi bren sɛl dɛn kin pwɛl smɔl smɔl. Dis kin mek tin lɛk wae yu nɔr de mɛmba fayn, yu kin kɔnfyus, ɛn yu kin chenj yu bihayvya ɛn i nɔr kin izi fɔ waka.

Wetin na di sayn dɛm fɔ CJD?

De sayn dɛm fɔ dis sik nɔr kin apin wan tɛm. Dɛn kin divɛlɔp smɔl smɔl. Dɛn kin bigin smɔl ɛn dɛn kin tranga pasmak as tɛm de go. Lɛ wi luk di men sayn dɛm, in ɔda frɔm di fɔs wan to di wan dɛm wae kin tranga pas ɔl:

• Fɔgɛt ɛn mɛmba prɔblɛm: I kin bigin wit fɔgɛt smɔl smɔl tin dɛn. Tin dɛn lɛk usay yu ki dɛn de, pɔsin in nem. Bɔt dis na smɔl tin pas fɔ jɔs fɔgɛt we nɔmal.
• Kɔnfyushɔn ɛn disoriɛnteshɔn: I nɔ kin izi fɔ mɛmba tin dɛn lɛk usay yu de ɛn us tɛm i de. I nɔ izi fɔ fɛn yu we ivin na say dɛn we yu sabi.
• Chenj pan di we aw pɔsin de biev ɛn di kayn pɔsin we i bi: Nɔ fɔ bi di sem we aw i bin de bifo, fɔ du tin we nɔ rayt, fɔ vɛks pan strenj we, ɔ fɔ kwayɛt wantɛm wantɛm . Fɔ tray fɔ pul yusɛf kɔmɔt na di sosayti.
• Prɔblɛm fɔ si ɛn i nɔ kin izi fɔ ɔndastand wetin yu de si: Sɔntɛnde yu kin si dɛbul, ɔ yu nɔ kin ebul fɔ no wetin yu de si.
• Hallucinations or delusions: Fɔ si ɔ yɛri tin wae nɔr de, ɔr gɛt lay lay biliv se ɔda pipul dɛn de tray fɔ du yu bad.
• Prɔblɛm fɔ lɛ yu nɔ balans ɛn fɔ wok togɛda (ataxia): Fɔ fil se yu nɔ ebul fɔ kɔntrol yusɛf we yu de waka, stɔp, ɛn fɔdɔm. I nɔ kin izi fɔ kɔntrol di an ɛn fut dɛn.
• di mכsul dεm we dεn nכ de kכntro (myoclonus) εn di mכsul dεm de stiff (dystonia): di mכsul dεm na di bכdi de jכk wan wan, di limb dεm de shek. Sɔntɛnde, di mɔsul dɛn kin stif ɛn twist di we we nɔ kɔmɔn.
• Seizures: I kin kam pan lɛk fit.
• Paralayz: As tɛm de go, sɔm pat dɛn na di bɔdi kin paralayz.
• di mכsul dεm we de atrofi: di mכsul dεm de atrofi εn di bכdi de tכn.

Dɛn sik ya nɔ kin kam di sem we ɔ di sem spid fɔ ɔlman, bɔt if yu ɔ pɔsin we yu sabi de gɛt ɛni wan pan dɛn sik ya, i go fayn fɔ mek yu go to dɔktɔ kwik kwik wan.

Wetin mek CJD kin apin? Wetin kin mek i apin?

Dis kin tan lɛk se i at fɔ ɔndastand smɔl, bɔt lɛ a ɛksplen am simpul wan. Wi bɔdi gɛt wan kayn prɔtin we dɛn kɔl prɔtin . Dɛn tin ya tan lɛk smɔl mashin dɛn we de du dɛn wok wan bay wan. fכ mek dεn protin dεm ya wok fayn fayn wan, dεn nid fכ "fold" insay wan spεsifi k shep. Tink bɔt am lɛk origami lif, if yu fold am kɔrɛkt wan, yu go gɛt fayn fayn shep.

So, sכmtεm dεn protin dεm ya kin fold kכrekt wan. Wan prɔtin we nɔ fold fayn, wi bren sɛl dɛn nɔ kin yuz am. CJD kin kam bikɔs ɔf wan pan dɛn prɔtin dɛn we nɔ fold fayn ɛn we nɔmal. Dɛn kɔl dɛn tin ya "prions."

dis prion protin dεm de bigin fכ kכmכt insay di bren sεl dεm. Bikɔs di sɛl dɛn nɔ kin ebul fɔ pul dɛn, dɛn kin pwɛl di sɛl dɛn smɔl smɔl ɛn leta dɛn kin day. Di tin we denja pas ɔl na dat dɛn priɔn ya kin misfold nɔmal protin dɛn bak, ɛn tɔn dɛn to priɔn. Lɛk sik we pɔsin kin gɛt, dɛn priɔn ya kin bɔku ɛn skata ɔlsay na di bren. Dis na wae mek de sik kin kam tranga kwik kwik wan.

Imajin, dis priɔn de akt lɛk rɔtin apul we de pwɛl ɔl di ɔda gud apul dɛn.

Difrɛn kayn CJD de?

Yes, sɔm men kayn CJD de. Dɛn kin sheb dɛn tin ya akɔdin to aw dɛn de divɛlɔp.

1. Sporadic CJD: Dis na di kayn we we pipul dɛn kin gɛt mɔ. I kin kam wantɛm wantɛm, ɛn i nɔ kin gɛt ɛni patikyula rizin. Wi nɔ stil no di rayt tin we mek i apin.

2. Jεnεtik CJD: Dis kin apin we dεn gεt wan abnכmal jin frכm wan כ di tu mama εn papa. Tu sɔbtayp dɛn de fɔ dis: Gerstmann-Sträussler-Scheinker (GSS) sindrom ɛn Fatal Familial Insomnia . Dɛn tin ya nɔ kin apin so ɔltɛm.

3. Acquired CJD: Dis kin bi bikɔs ɔf ɛksternal kɔz. Fɔ ɛgzampul, i kin bi bikɔs dɛn transplant ɔgan , tisu transplant , ɔ yuz ɔspitul inschrumɛnt dɛn we dɛn nɔ sterilayz fayn. Bɔt dɛn tin ya nɔ kin bɔku dis tɛm ya, bikɔs di mɛdikal tɛknɔlɔji dɔn rili impɔtant.

4. Variant CJD (vCJD): Yu go dɔn yɛri bɔt dis as i gɛt fɔ du wit di sik "Mad Cow Disease" ɔ Bovine Spongiform Encephalopathy (BSE) . Yu kin gɛt vCJD bay we yu it mit frɔm kaw we gɛt BSE. di prion we de mek BSE kin pas to mכtalman bak. Bɔt dis nɔ kin apin naw na di wɔl, bikɔs ɔf di sef tin dɛn we dɛn kin du we dɛn de mɛn animal dɛn.

Udat kin gɛt CJD mɔ? Yu tink se i kin pas?

Infakt, ɛnibɔdi kin gɛt CJD. Sɔmtɛm yu kin gɛt di prion na yu bɔdi fɔ lɔng lɔng tɛm ɛn yu nɔ kin sho ɛni sayn. Bɔt we di sik dɔn sho, di sik kin rili bad kwik kwik wan as di bren kin pwɛl.

Dis sik kin ambɔg pipul dɛm wae ol bitwin 50 ɛn 80. Bɔt sɔmtɛm dɛn kin si di jɛnɛtik fɔm dɛm fɔ CJD pan pipul dɛm wae ol bitwin 30 ɛn 50 ia.

Naw yu go de wɔnda if dis na sik we pɔsin kin pas . Pɔrsin wae gɛt CJD nɔr kin pas frɔm wan pɔrsin to ɔda pɔrsin tru kɔshɔl kɔntakt, sniz, ɔr sheb it. Natin nɔ de fɔ wɔri bɔt. Di wangren we fɔ gɛt CJD na, lɛk aw wi bin dɔn tɔk, fɔ transplant wan ɔgan ɔ tisu frɔm pɔsin we gɛt CJD, ɔ tru injɛkshɔn fɔ sɔm ɔmon dɛn frɔm pɔsin we gɛt CJD.

Dɛn dɔn si se difrɛn kayn CJD (vCJD) kin pas tru blɔd transfyushɔn , bɔt dat bak nɔ kin apin so ɔltɛm. Di kayn vCJD nɔ kin bɔku bak ɔlsay na di wɔl.

Aw dɔktɔ dɛn kin no di kɔrɛkt we aw pɔsin gɛt CJD?

If yu tink se yu gɛt sayn dɛm fɔ CJD, di fɔs tin we dɔktɔ go du na fɔ tek tɛm lisin to yu simptom dɛm ɛn du yu bɔdi ɛn nyurolɔjik ɛgzam. Sɔmtɛm dɛn go aks yu fɔ du smɔl smɔl tin dɛn so dat dɛn go gɛt aydia bɔt aw yu bren de wok.

CJD de pan wan grup fɔ sik dɛn we dɛn kɔl Transmissible Spongiform Encephalopathy . Di nem kɔmɔt frɔm di tru tin we se di bren we priɔn dɔn pwɛl kin tan lɛk spɔnj we gɛt ol we yu si am ɔnda maykroskɔp.

Dɔktɔ dɛn de rɔn sɔm ɔda tɛst fɔ kɔnfɔm CJD.

• MRI (Magnetic Resonance Imaging) scan: Dis kin tek ditayli pikchɔ dɛn bɔt di bren ɛn chɛk fɔ ɛni abnɔmal tin na di bren.
• spεnal tap כ lכmba pankshכn: Dis involv fכ tek sεmpl fכ wata frכm di spεnal kכd εn tεst am fכ prion protin dεm.
• EEG (Electroencephalogram) test: Dis de mכsu di ilektrikal aktiviti na di bren εn de luk fכ abnכmal patεn dεm. Yu kin si wan patikyula patɛn na CJD.

Apat frɔm dat, dɛn kin du ɔda tɛst fɔ no ɔda tin dɛn we gɛt di sem kayn sayn to CJD.

• Blɔd tɛst dɛn
• Jεnεtik tεst: If dεn sכspεkt jεnεtik CJD.
• Urinalysis we dɛn kin du
• Bren bayɔpsi: Dɛn nɔ kin du dis, na if ɔl di ɔda tɛst dɛn nɔ kin kɔnfɔm di sik, bikɔs na smɔl ɔpreshɔn.

Tritmɛnt de fɔ CJD?

Bɔt i sɔri fɔ no se naw, no mɛrɛsin nɔ de fɔ CJD, no tritmɛnt nɔ de fɔ stɔp di sik fɔ skata, ɔ no tritmɛnt nɔ de fɔ slo am . Dis na de pat wae de mek wi at pwɛl pas ɔl pan dis sik.

Bɔt dɛn kin gi di pɔsin kia we de mek i nɔ fil fayn fɔ mek i nɔ fil fayn we di sik kin mek i nɔ fil fayn ɛn fɔ mek i gɛt sɔm rilif to di pɔsin. Fɔ ɛgzampul, dɛn kin gi mɛrɛsin fɔ kɔntrol di sik we pɔsin kin gɛt, fɔ mek i ebul fɔ kɔntrol di chenj we i de biev, ɔ fɔ ridyus di mɔsul dɛn we nɔ de kɔntrol. Bɔt di bɛnifit dɛn we dɛn tritmɛnt ya kin gi nɔ bɔku.

Bikɔs dis sik kin wɔs kwik kwik wan, i impɔtant fɔ mek di pɔsin ɛn in famili gɛt sɔpɔt fɔ kia fɔ am. Na di las stej dɛm fɔ di sik, hospice savis kin ɛp di pɔsin fɔ kɔntinyu fɔ fil fayn ɛn nɔr gɛt pen.

Sɔntɛnde, if yu fit, yu mɛdikal tim kin tɛl yu bak fɔ tek pat pan klinik trial dɛm, we de stɔdi nyu tritmɛnt dɛm.

Wetin yu kin ɛkspɛkt if yu gɛt CJD?

Bikɔs CJD nɔ de mɛn ɛn i nɔ gɛt ɛni mɛrɛsin, na smɔl op de fɔ dis sik. Afta di sayn dɛm bigin, di ebul fɔ wok, waka, ɛn tɔk kin go dɔŋ smɔl smɔl as tɛm de go.

Bikɔs chenj kin apin kwik kwik wan, i impɔtant fɔ wok wit yu wɛlbɔdi tim fɔ tɔk bɔt wetin yu want ɛn wetin yu nid ɛn disayd fɔ du sɔntin. Infakt, i fayn fɔ mek wi ɔl, ilɛksɛf wi gɛt sik, fɔ gɛt wan dɔkyumɛnt lɛk advans dairektv . Dis min se if yu nɔ ebul fɔ tɔk wetin yu de tink, yu dɔn rayt us mɛrɛsin yu want ɛn wetin yu nɔ want. I impɔtant mɔ fɔ du dis kwik kwik wan pan sik we de prɛd kwik kwik wan lɛk CJD.

Bikɔs dis sik rili bad, i kin rili ɛp yu ɛn di wan dɛn we yu lɛk fɔ aks fɔ advays frɔm pɔsin we sabi bɔt mental wɛlbɔdi biznɛs . I kin bi big trɛnk fɔ ajɔst to dɛn chenj ya ɛn mek yu gɛt kɔnfidɛns.

Wetin na di layf we pɔsin we gɛt CJD kin liv?

Bɔku pan di wan dɛn we gɛt CJD kin day insay sɔm mɔnt ɔ wan ia afta dɛn dɔn no se dɛn gɛt di sik. Di wangren tin we nɔ de de na di jenɛtik CJD , we pipul dɛn kin liv frɔm wan to tɛn ia afta dɛn dɔn bigin fɔ gɛt di sik.

Yu dɔktɔ kin gi yu patikyula, ɔp-to-dɛt infɔmeshɔn bɔt yu sik. Mɛmba se, statystik na jenɛralizeshɔn, ɛn ɔlman difrɛn.

Yu tink se dɛn kin ebul fɔ stɔp CJD?

Bɔku kayn CJD nɔ kin ebul fɔ stɔp. Ɛspɛshali CJD we kin apin wan wan tɛm, we kin apin fɔ insɛf, nɔ gɛt ɛni we fɔ mek i nɔ apin.

di onli tכp we dεn kin prεvεnt na vεryכnt CJD (vCJD) . I kin kam we yu it bif we gɛt BSE ("mad kaw sik"), ɛn yu kin ebul fɔ avɔyd am.

Animal test de mek kaw we gɛt BSE nɔ go insay di it chen. Bɔt mit dɛn we dɛn nɔ tɛst ɛn we dɛn nɔ pripia fayn kin bi prɔblɛm. So, i bɛtɛ fɔ avɔyd fɔ it mit dɛn we nɔ gɛt rayt ɛn we dɛn nɔ tɛst, mɔ di wan dɛn we gɛt pat dɛn lɛk bren ɛn bon mɛro .

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

If yu no se yu gɛt CJD, dat kin chenj yu layf. I kin fil lɛk se yu ɛn di wɔl we de rawnd yu dɔn go insay wan blink ɔf wan yay. Dis kayn chenj kin at fɔ yu ɛn di wan dɛn we yu lɛk fɔ bia.

If yu nɔr shɔ wetin fɔ tink bɔt dis ɔr aw fɔ go bifo, yu mɛdikal tim de ya fɔ ɛp. Dɛn kin ɛp yu fɔ plan bifo tɛm ɛn rɛdi fɔ wetin gɛt fɔ apin. Jɔs mɛmba se nɔto yu wangren de.

` Creutzfeldt-Jakob Sik, CJD, Prion, Bren Sik, Nyurolɔjik Sik, Mɛmori Lɔs, Dimɛnshɔn, BSE, Mad Kaw Sik