We yu go si dɔktɔ, sɔntɛnde dɛn kin gi yu mɛrɛsin we yu nɔ ivin no di nem, nɔto so? Ɛspɛshali we wi de tɔk bɔt mɛrɛsin dɛn we gɛt fɔ du wit maynd wɛlbɔdi, wi kin want fɔ no smɔl, ɛn sɔntɛm wi kin ivin fred smɔl. Tide wi go tɔk bɔt wan pan dɛn kayn mɛrɛsin ya we kɔmplikt smɔl, bɔt we rili impɔtant. Dat na di klas fɔ mɛrɛsin dɛn we dɛn kɔl Dopamine Antagonists. Nɔ fred we yu yɛri di nem, lɛ wi ɔndastand dis rili simpul wan.
Wetin na di ɛksaktɔli dopamin antagonist dɛn?
Bifo wi ɔndastand dis, wi nid fɔ no wetin na "Dopamine". Fɔ tɔk am simpul wan, dopamin na kemikal mɛsenja na wi bren. We wi de tɔk bɔt mɛrɛsin, wi kin kɔl dis nyurotransmit. Imajin se infɔmeshɔn de chenj bitwin di sɛl dɛn na wi bren tru dɛn mɛsenja dɛn ya.
di sεl dεm na wi bren gεt pat dεm we dεn kכl "rεsεptor dεm." Dɛn tin ya tan lɛk ki dɛn we fit insay ki ol. di mεsenja we dεn kכl dopamin na di ki we fit dis kihol. we dis ki (dopamin) go kכnekt to di kihol (di rεsεpכta), di sεl we dεn de kכwεshכn "de כn."
Naw luk, wan drɔg we dɛn kɔl dopamine antagonist de du wan tin we rili strenj. Dis drɔg kin go bak to da ki de (rɛsɛptɔ) ɛn sɛt am. Bɔt i nɔ de mek di sɛl wok. I tan lɛk se wan brok ki we dɔn stɔp na di ki. Dat min se dis drɔg de blok di rial ki, dat na, dopamin, fɔ mek i nɔ kam ɛn kɔnɛkt to di ki.
Fɔ tɔk am simpul wan, dɛn mɛrɛsin ya de wok bay we dɛn de kɔntrol di wok we dopamin de du na di bren to di lɛvɛl we dɛn nid. Dis kɔntrol rili impɔtant bikɔs di dopamin lɛvɛl de go ɔp we nɔ nid fɔ apin pan sɔm mental sik dɛm.
Us kɔndishɔn dɛn kin yuz dis mɛrɛsin fɔ?
Dɛn kin sheb di mɛrɛsin dɛn we de agens di dopamin to tu men kategori:
1. Antipsychotic drugs: Na dɛn wan ya dɛn kin yuse mɔ.
2. Antiemetic drugs: Sɔm mɛrɛsin dɛn kin fɔdɔm insay dɛn tu kategori ya.
Fɔ mental sik (Antipsychotics) .
Dɛn mɛrɛsin ya rili impɔtant fɔ mɛn dɛn sik ya:
- Schizophrenia ɛn ɔda mental sik dɛm wae gɛt fɔ du wit am
- Bipola muud disɔda
- Disɔda we de mek pɔsin fil bad
- Mania we de mek pɔsin vɛks
- Big big pwɛl hat sik wit ɔr nɔr gɛt saykotik simptom
- Sivɛri agiteshɔn
- Mental sik wae kin kam wae yu de tek drɔgs
Fɔ vɔmit ɛn nɔs (Antimetics) .
Pan ɔl we fɔ vɔmit ɛn nɔs na smɔl tin fɔ sɔm pipul dɛn, sɔm tɛm dɛn kin denja. Fɔ ɛgzampul, dɛn mɛrɛsin ya kin ɛp fɔ kɔntrol di vɔmit we pasmak we dɛn de tek kimotɛrapi pan di wan dɛn we gɛt kansa. Dɛn kin yuz dɛn bak fɔ stɔp di nɔs ɛn vɔmit we dɛn kin gɛt we dɛn de anestez afta dɛn dɔn du di ɔpreshɔn.
| Kategori fɔ drɔgs | Sɔm ɛgzampul dɛn we pipul dɛn kin yuz |
|---|---|
| Fɔs-jɛnɛreshɔn (Typical) Antisaykotiks | Haloperidol, Klɔrpromazin, Flufenazin |
| Sɛkɔn-jɛnɛreshɔn (Atypical) Antisaykotiks | Olanzapin, Risperidon, Kwitiapin, Aripiprazol, Klɔzapin |
| Drug dɛn we de mek pɔsin nɔ gɛt bɛtɛ blɔd | Metoklopramid, Prochlorperazine, Domperidone (dɛn kin yuz am na Sri Lanka) . |
Impɔtant: Dis na jɔs sɔm ɛgzampul dɛn. Na yu dɔktɔ nɔmɔ go ebul fɔ no di bɛst tritmɛnt fɔ yu.
Wetin na di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi?
Dɛn mɛrɛsin ya kin ɛp bɔrku pipul dɛm wae gɛt maynd sik fɔ liv nɔrmal layf. If dɛn nɔ bin de, sɔm pasɛnt dɛn kin go na ɔspitul fɔ di res ɔf dɛn layf. Dɛn mɛrɛsin ya kin protɛkt di sik pipul dɛn frɔm bad tin ɛn mek dɛn liv fayn na sosayti.
Dɔn bak, if yu vɔmit bad bad wan we yu de trit kansa, dat kin mek yu layf de pan denja. We dɛn kayn tin ya kin apin, dɛn mɛrɛsin ya kin wok lɛk se dɛn de sev layf.
Lɛ wi no bak bɔt di bad tin dɛn we kin apin to wi ɛn di bad tin dɛn we kin apin to wi.
Lɛk ɛni mɛrɛsin, dopamine antagonist kin mek yu gɛt sayd ɛfɛkt. Dɛn tin ya kin difrɛn difrɛn wan bay di kayn mɛrɛsin we yu de tek, di doz, ɛn yu bɔdi. If yu gɛt ɛni sayd ɛfɛkt, nɔ stɔp fɔ tek di mɛrɛsin ɛn tɛl yu dɔktɔ wantɛm wantɛm.
| Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt | Simpul ɛksplen |
|---|---|
| Sedeshɔn fɔ mek pɔsin fil fayn | Na sɔntin we bɔku pipul dɛn kin gɛt. I kin mek pɔsin taya ɛn slip. |
| Prɔblɛm dɛn we gɛt fɔ du wit muvmɛnt | Tin dεm lεk we yu nכ de rεst (akathisia), di mכsul dεm we nכ de twitch כ twit (dystonia), εn we di mכsul dεm de muv fכ lכng tεm na di fes כ bכdi (tardive dyskinesia). |
| Lɔw blɔd prɛshɔn | We yu tinap wantɛm wantɛm, yu yay kin blu ɛn yu kin fil fɔdɔm (Orthostatic hypotension). |
| Di chenj dɛn we de apin na di ɔmon dɛn | we di כmon we dεn kכl prolaktin inkrεs kin mek uman dεn stכp fכ mεnstral εn dεn kin gεt milk we de kכmכt na dεn brεst. |
| Nyurolɛptik Malignant Sindrom | Dis na tin we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs, we kin mek pɔsin in layf de pan denja. If yu gɛt sɔm sayn dɛn lɛk ay fiva, mɔsul dɛn we de stif, ɛn kɔnfyushɔn, yu fɔ go wantɛm wantɛm na ɔspitul in Imejɛnsi Tritmɛnt Yunit (ETU). |
A kin drayv we a de tek dis mɛrɛsin?
Bɔrku dopamin antagonist kin mek yu slip ɛn nɔr de wach. So, i fayn fɔ avɔyd fɔ drayv ɔ yuz mashin dɛn we nid fɔ de wach we yu fɔs bigin dis mɛrɛsin ɔ we yu de chenj di doz. I bɛtɛ fɔ aks yu dɔktɔ bɔt dis ɛn fala in advays.
Mɛsej we dɛn kin kɛr go na os
- Dopamine antagonist na wan rili impɔtant klas fɔ mɛrɛsin we de blok di akshɔn fɔ wan kemikal we dɛn kɔl dopamine na di bren ɛn dɛn kin yuz am fɔ trit maynd sik ɛn vɔmit.
- Dis mɛrɛsin de mek bɔrku pipul dɛn liv nɔrmal, wɛl bɔdi layf.
- Lɛk ɔl di mɛrɛsin dɛn, dɛn tin ya kin gɛt sayd ɛfɛkt, mɔ we yu gɛt prɔblɛm wit yu muvmɛnt ɛn we yu de slip.
- Nɔ ɛva stɔp fɔ tek dis mɛrɛsin ɔ chenj di doz if yu nɔ gɛt dɔktɔ advays. If yu du dat, dat kin mek yu denja.
- If yu gɛt ɛni sayd ɛfɛkt, tɔk to yu dɔktɔ bɔt am opin wan. Bɔku pan di sayd ɛfɛkt dɛn kin bi.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu de tek.
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