We dɛn tɛl yu se yu gɛt ay kɔlɔstrel, yu dɔktɔ go mɔs bigin yu fɔ tek wan mɛrɛsin we dɛn kɔl statin. Dat na di tritmɛnt we kɔmɔn pas ɔl we wi no bɔt. Bɔt mɛrɛsin sayɛns de go bifo ɛvride. Tide a go tɛl una bɔt sɔm pan di layt ɛn advans tritmɛnt dɛm we dɔn kam ɛn we de kam fɔ kɔntrol kɔlɔstrel. Dɛn tin ya tan lɛk di tumara bambay fɔ mɛrɛsin.
Tri tin dɛn we wi nid fɔ no bɔt kɔlɔstrel fɔs
Bifo wi tɔk bɔt nyu mɛrɛsin, i rili impɔtant fɔ mɛmba dɛn tri tin ya bɔt kɔlɔstrel.
1. Kɔlɔstrel na di men tin we kin mek pɔsin gɛt at sik: Wi bɔdi sɛl dɛn nid sɔm kɔlɔstrel. Bɔt if i bɔku, i kin rili denja. Dis kכlestכl we pasmak kin kכlכp na wi bכdi vεsul dεm (plak), we kin kכl dεm. Dis na di men tin we kin mek pɔsin gɛt at atɔk.
2. Wan tritmɛnt de fɔ dis: Ivin if di kɔlɔstrel dɔn de insay yu blɔd vesel, fayn mɛrɛsin dɛn de tide we kin ridyus ɛn kɔntrol am.
3. Dɛn tritmɛnt ya nɔ bad: Dɛn mɛrɛsin ya nɔ bad ɛn dɛn kin rili wok. Sɔntɛnde, smɔl smɔl sayd ɛfɛkt dɛn kin de, bɔt yu kin ebul fɔ kɔntrol dɛn bay we yu tɔk to yu dɔktɔ. So nɔ wɔri.
Nyu drɔgs we de go bifo pas statin
Statin na di men tin we dɛn kin yuz fɔ mɛn di kɔlɔstrel, bɔt naw dɛn gɛt mɔ advans mɛrɛsin dɛn we dɛn kin gɛt. Lɛ wi tek tɛm luk sɔm pan dɛn.
| Tayp fɔ mɛrɛsin | Simpul opareshɔn ɛn impɔtant pɔynt dɛn |
|---|---|
| Ezetimibe (Zetia) we dɛn kɔl . | Dis na drɔg we dɛn kin gi togɛda wit statin. Naw i nɔ dia so igen. I kin fayn mɔ fɔ pipul dɛn we dɔn pas 75. Dis na fayn sɔlv fɔ di wan dɛn we gɛt prɔblɛm fɔ kɔntrol dɛn kɔlɔstrel lɛvɛl wit statin nɔmɔ. |
| PCSK9 Inhibitɔ dɛn | Dis na rial gem-chenja. dis na wan kayn monoklonal antibodi dεm we dεn gi as vaysin. Fɔ tɔk am simpul wan, di ‘bad’ kɔlɔstrel we de na wi bɔdi, dat nadi lכw dεnsiti lipoprotein (LDL) nid fכ go na di liva fכ klin am. Bɔt wan prɔtin we dɛn kɔl PCSK9 de ambɔg di klin we dis LDL de klin. dis dכg de blכk da PCSK9 protin de. Dɔn di liva kin klin ɛn pul di LDL kɔlɔstrel kwik kwik wan. |
| Inclisiran (Lɛkviɔ) ɛn ɔda pipul dɛn. | Dis tan lɛk ‘vaysin’ fɔ kɔlɔstrel. Na shot we dɛn kin gi ɛvri 6 mɔnt. i de afekt wan mכlikul we dεn kכl RNA , we de kכri infכmeshכn insay wi jin dεm, εn i de ridyus di prodakshכn fכ di PCSK9 protin we wi bin dכn tכk bכt. Dat min se na tritmɛnt we dɛn kin rili tɔch. |
| Bempedoik Asid we dɛn kɔl | Dis kin fiba di statin, bɔt i kin afɛkt difrɛn pat pan di kɔlɔstrel prodakshɔn prɔses. I nɔ de mek di mɔsul dɛn pen (myalgia) we kin apin wit statin. Bɔt i kin mek di yurik asid lɛvɛl go ɔp ɛn i kin mek i bɔku pan pipul dɛn we gɛt gaut. Dɛn kin tɔk bak bɔt di risk fɔ mek di tɛndon brok. So, i impɔtant fɔ tɔk to yu dɔktɔ ɔltɛm we yu de yuz dis mɛrɛsin. |
| Vascepa (Fish Ɔyl we dɛn dɔn klin) . | Dis nɔto yu avrej fish ɔyl pil frɔm di famasi. Dis na spɛshal fish ɔyl we dɔktɔ kin gi pɔsin. Na EPA we dɛn dɔn klin nɔmɔ i gɛt . If yu de tek statin bɔt yu triglisɛrɛyd lɛvɛl stil ay, dis kin ɛp fɔ ridyus yu risk fɔ gɛt at atak ɛn strok. |
Kɔlɔstrel frɔm di jin dɛn (Familial Hypercholesterolemia) .
Sɔm pipul dɛn de we, ilɛksɛf dɛn it fayn ɛn ɛksesaiz, dɛn gɛt bɔku bɔku kɔlɔstrel. Di rizin fɔ dis na wan sik we kɔmɔt frɔm dɛn jin, we dɛn kɔl famili haypa kɔlɔstrelemia (FH) . Fɔ dɛn pipul ya, i nɔ kin izi fɔ kɔntrol dɛn kɔlɔstrel wit standad tritmɛnt.
"Wetin mek a fɔ blem mi kɔlɔstrel ɔltɛm?" Dat na sɔntin we mi pasɛnt dɛn we gɛt FH kin aks ɔltɛm. Wi nid fɔ ɔndastand se dis nɔto dɛn fɔlt, na jenɛtik kɔndishɔn.
Imajin aw nyu drɔgs lɛk `PCSK9 Inhibitors` valyu to pipul dɛm lɛk dis. Bikɔs ɔf dɛn mɛrɛsin dɛn de, fɔ di fɔs tɛm insay istri, pipul dɛn we gɛt FH gɛt tritmɛnt we go wok fayn.
Smɔl mɔ bɔt di ‘kɔlestɔl vaysin’.
Pan ɔl we sɔm pipul dɛn kin lɛk di aidia fɔ tek Inclisiran ɛvri 6 mɔnt, ɔda pipul dɛn kin fred. "A go de pan dis mɛrɛsin fɔ 6 mɔnt? Ɛn if a gɛt sayd ɛfɛkt, dɛn go las fɔ 6 mɔnt?" I fayn fɔ aks kwɛstyɔn dɛn lɛk dis. Tɔk bɔt ɛnitin we de mɔna yu ɔr de fred wit yu dɔktɔ bɔt ɛni mɛrɛsin we yu de tek. Na yu rayt.
Medisin nɔmɔ nɔ go du fɔ am! Di we aw pɔsin de liv in layf na di men tin
I nɔ mata aw wi de tɔk bɔt advans mɛrɛsin, wan tin de we yu nɔ fɔ ɛva fɔgɛt. Ɛn dat na layf we gɛt wɛlbɔdi.
- Dayt: I impɔtant fɔ it tin dɛn we de mek wi nɔ gɛt bɔku kɔlɔstrel (ɔt, bali, nɛt, vɛjitebul, frut), ɛn avɔyd tin dɛn we dɛn dɔn prosɛs, lɛk sosish, mitbɔl, ɛn ɔda tin dɛn.Sɔv dɔn sho se 58% pan di it dɛn we wi de it na ɔlta-prosɛs.
- Ɛksesaiz: Ɛksesaiz ɛvride nɔto jɔs fɔ kɔntrol di kɔlɔstrel, bɔt i fayn fɔ di wan ol bɔdi.
- Smok ɛn rɔm: Fɔ avɔyd dɛn tin ya kpatakpata rili impɔtant fɔ mek yu at gɛt wɛlbɔdi.
Jɔs tink bɔt, ilɛksɛf yu tek mɛrɛsin ɛn mek yu kɔlɔstrel nɔ bɔku, if yu kɔntinyu fɔ it tin dɛn we nɔ fayn ɛn nɔ du ɛksɛsayz, di chans we yu gɛt fɔ gɛt at atak nɔ go go dɔŋ so.
Pil nɔ go ɛva ebul fɔ tek ples fɔ wɛlbɔdi layf. Dɛn tu nid fɔ go togɛda.
If yu dɔn ɔlrɛdi gɛt at sik, yu dɔn gɛt at atak, ɔ yu dɔn put stent, yu nɔ gɛt tɛm fɔ wet. Yu nid fɔ bigin tek yu mɛrɛsin wantɛm wantɛm, lɛk aw yu dɔktɔ tɛl yu. Yu nid bak fɔ chenj di we aw yu de liv yu layf.
Mɛsej we dɛn kin kɛr go na os
- Kɔlɔstrel na wan men tin we kin mek pɔsin gɛt at sik. Bɔt nɔ wɔri, tritmɛnt dɛn de we go wok ɛn we nɔ bad fɔ am.
- apat frכm di statin dεm, naw mכr advans, tכgεt tεrapi dεm lεk PCSK9 inhibito dεm εn Inclisiran.
- If yu gɛt jɛnɛtik kɔlɔstrel kɔndishɔn (FH), dis nyu mɛrɛsin kin rili ɛp yu.
- If yu gɛt ɛni kwɛstyɔn bɔt di mɛrɛsin we yu de tek, mek shɔ se yu tɔk bɔt am wit yu dɔktɔ.
- Di tin we impɔtant pas ɔl: I nɔ mata aw di mɛrɛsin gud, yu nɔ go ebul fɔ kɔntrol yu kɔlɔstrel if yu nɔ gɛt wɛlbɔdi layf (gud it, ɛksesaiz). Mɛrɛsin na jɔs sɔpɔt, di fawndeshɔn fɔ bi yu layf stayl.
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