Prɔblɛm de insay yu blɔd vesel? Lɛ wi lan bɔt Endothelial Dysfunction.

Yu dɔn ɛva tink bɔt aw di blɔd vesel dɛn na wi bɔdi impɔtant? Dɛn tan lɛk smɔl rod dɛn we de kɛr mɛsej ɛn tin dɛn we de mek wi gɛt tin fɔ it ɔlsay na wi bɔdi. So wetin kin apin if wikɛd tin de na di dilik layn we de insay dɛn rod ya, we dɛn kɔl di ɛndoteyl? Na dat wi kin kɔl ``Endothelial Dysfunction''. Mek wi tok abaut dis likl mo, okay?

Wetin na di Endothelial Dysfunction?

Fɔ tɔk am simpul wan, Ɛndothelial Dysfunction na we di tin layεr sεl dεm we de insay yu bכ di we dεn kכl εndothelium nכ de wok fayn. dis εndoteyl sεl dεm nכmal fכ εp fכ kip yu bכdi vεsul dεm opin (dilated) we yu nid am. Bɔt we dis disfɔkshɔn apin, di ɔpɔsitet kin apin. Dat min se di blɔd vesel dɛn kin bigin fɔ kɔntrakt ɛn smɔl.

Tink bɔt am lɛk wata paip. If di layn we de insay am nɔ rayt, i nɔ go izi fɔ mek di wata pas, nɔto so? Na so i bi. di men rizin fכ dis kכndyushכn na wan kכndyushכn we dεn kכl ``Vasospasm`` we riliyt to di korona at dεm na di at. Insay dis, pan ɔl we natin nɔ rili blok insay yu korona at, di at dɛn kin jɔs smɔl. כlso, ``Endothelial Dysfunction`` de inkrεs di risk fכ ``Atherosclerosis``, we na di fεt we de dכn pan di wכl dεm na di at dεm εn fכ sכm di at dεm.

So wetin na di wok we dis εndoteyl de du?

εvri bכdi vεsul dεm na wi bכdi (dat na atεri, vein, kapilari) de layn insay wit wan layεr sεl dεm we dεn kכl εndoteyl sεl dεm. Yu no se dis εndoteyl na wan pan di big big כgan sistεm dεm na wi bכdi!

di εndoteyl sεl dεm de kכl difrεn tin dεm. dis sכbstans dεm de kכntro di opin εn klos we di at dεm de opin (dεn kכl dis ``Vascular Tone``). dis ``Vascular Tone`` de sho wi bכdi prεshכn, εn aw di at gεt fכ pכmp bכdi.

nכto dat nכmכ, bכt yu εndoteyl insεf de du bכku כda imכtant wok dεm:

• I de rigul di wata ɛn ilɛktrɔlayt dɛn we de na yu blɔd.
• I de ɛp fɔ mek blɔd klɔt we nid de.
• I de mek pɔyzin nɔ go insay di tisu dɛn.
• I de rigul di inflameshn na di tisu dεm.

Jɔs imajin aw dis smɔl smɔl sɛl dɛn de du bɔku wok na wi bɔdi!

Aw kכmכn dεn kכl dis kכndyushכn εndoteyl disfכnkshכn?

Fɔ lɔng tɛm, di wan dɛn we sabi bɔt mɛrɛsin bin de tink se di ɛndoteyl na jɔs wan tin we de ambɔg di blɔd vesel dɛn. Bɔt leta dɛn kam fɔ no se dis na impɔtant ɔgan sistɛm bak. na da tεm dεn kin no dis kכndyushכn we dεn kכl ``Endothelial Dysfunction`` as sεparat sik.

Dɛn bin dɔn fɛn dɛn tin ya insay di let 1990 dɛm, we min se dɛn nɔ bin no di kɔndishɔn fɔ lɔng tɛm. So masta sabi pipul dɛn stil nɔ ebul fɔ tɔk klia wan aw i bɔku pan pipul dɛn.

Wetin mek dis εndoteyl disfכnkshכn de apin?

Di men rizin fɔ dis sik na bikɔs di gas we dɛn kɔl Naytric Oxide (NO) nɔ de insay di wɔl dɛn na yu blɔd vesel. Di wɔndaful tin na dat, na yu ɛndoteyl insɛf de mek dis naytrik ɔksayd! dis naytrik oksayd na ``(Vasodilator)'', we min se i de opin di bכdi vεsul dεm εn alaw bכdi fכ fכlכ fri wan.

So, wetin kin apin we di naytrik ɔksayd lɛvɛl go dɔŋ?

• Blɔd vesel dɛn kin smɔl: Dis kin mek pɔsin gɛt ay blɔd prɛshɔn.
• inflameshn kin apin na di atεri wכl dεm: Dis kin mek di atεrosklεrosis, כ di atεri dεm at.
• di pletlet we de mek i de go ɔp: Dis kin mek di blɔd klɔt.
• di wכl dεm na di bכdi vεsul dεm kin bi porous: Dis kin mek di tisu dεm kכmכt pan di lipoprotein dεm we de du bad εn כda tכxin dεm.

Wetin na di sayn dɛm fɔ Endothelial Dysfunction?

Di men sayn fɔ korona at sik (endothelial dysfunction) na angina , we na pen na yu chɛst. Dis chɛst pen kin apin bikɔs yu at dɛn de lɔk we dɛn fɔ de opin. Dis chɛst pen kin wɔs bɔku tɛm we yu de du ɛksɛsayz.

Sɔm pipul kin gɛt pen na dɛn chɛst we nɔ de dɔn (`Angina`) ivin we dɛn nɔ de du natin. Dis kin bi sayn fɔ se yu gɛt at atɔk. If dis apin, di sayn dɛm na di chɛst we de pen ɔltɛm, taya pasmak, ɛn we i nɔ de blo fayn. Dis na mɛdikal imejensi we nid fɔ gɛt tritmɛnt kwik kwik wan.

Udat de pan denja pas ɔl fɔ dis? (Di tin dɛn we kin mek pɔsin gɛt prɔblɛm)

Sɔm tin kin mek yu gɛt mɔr risk fɔ gɛt Endothelial Dysfunction. Yu de pan big risk if yu gɛt dɛn kayn tin ya:

• Dayabitis (`Dayabɛt Mɛlitɔs`) .
• Ay blɔd prɛshɔn (Hypertension) .
• Di blɔd shuga lɛvɛl ay (`Hyperglycemia`) .
• Ay Kɔlestɔl
• Mɛtabolik Sindrom we pɔsin kin gɛt
• Fɔ smok
• Fat
• Sɔm sik dɛn we pɔsin kin gɛt we i de fɛt insɛf

Us ɔda kɔndishɔn dɛn kin kam wit di Endothelial Dysfunction?

Dis kכndyushכn (Endothelial Dysfunction) de mek yu gεt di risk fכ kכdivaskyul sik dεm (Cardiovascular Diseases) εn nכmba כf כda sik dεm. Fɔ ɛgzampul:

• Atɛrosklɛrosis ɛn Korona Atɛri Disizin
• Blɔd Klɔt ɛn Strɔk
• At we dɔn big (Hypertrophic Cardiomyopathy) .
• At Atak ɛn At Fayla
• Ay blɔd prɛshɔn (Hypertension) .
• Kidni we nɔ de wok fayn
• Pɛriferal Atɛri Disizin (PAD) .
• Pulmonari Haypatɛnshɔn (PH) .
• Smɔl Vesɛl Sik (Koronary Microvascular Disease) .

Wetin na de prɔblɛm wae kin kam wit dis sik?

Endothelial Dysfunction kin mek yu gɛt wan sik we dɛn kɔl Acute Coronary Syndrome . Dis na tri kayn korona at sik we dɛn jɔyn togɛda. Dis kin mek di risk fɔ mek wan fat we de insay di blɔd vesel brok. Dis kayn tin we de brok brok kin mek di blɔd nɔ go na di at mɔsul ɛn mek pɔsin gɛt at atak.

Aw dɛn kin no dis sik? (Diagnosis) .

Dɔktɔ dɛn kin yuz difrɛn difrɛn tɛst dɛn we dɛn kin yuz fɔ mek pikchɔ dɛn fɔ luk dairekt wan aw blɔd de pas na di blɔd vesel dɛn. Dɛn tɛst ya kin ɛp di dɔktɔ fɔ si if sayn dɛn de fɔ se di ɛndoteyl nɔ de wok fayn. Dɛn tɛst ya na:

• Ilektrokardiogram (`Ilektrokardiogram - EKG`)
• Angiogram, inklud Koronari Kɔmpyuta Tomografi Angiogram (CCTA).

כlso, yu kin yuse sכm ``Stress Imaging'' tεst dεm fכ si if bכdi fכ fכlכ tru yu blכd vesel dεm dכn rεdכks, we kin de mek yu at de wok tranga wan. Ɛgzampul dɛn:

• Ekokardiogram (`Ekokardiogram - ɛko`) .
• MRI (`MRI`) na di .
• Positron Emishin Tomografi (PET skan) .

Aw dɛn kin trit dis? (Tritmɛnt)

If yu gɛt korona ɔ periferik at sik (COPD) bikɔs ɔf di ɛndoteyl disfɔkshɔn, yu dɔktɔ kin gi yu sɔm mɛrɛsin dɛn. Fɔ ɛgzampul:

• Aspirin ɔ tin dɛn we de mek blɔd tan.
• Mɛrɛsin dɛn we de kɔntrol blɔd prɛshɔn, lɛk di wan dɛn we de blok di kalsiɔm chanɛl.
• Dεn dεm we de dכn kכlestכl lεk statin.
• Mɛrɛsin dɛn we de opin blɔd vesel, lɛk naytrɛt.

Dɔn bak, if yu gɛt Endothelial Dysfunction, yu kin ridyus yu sik bay we yu chenj di it ɛn layf . Dɛn tin ya na:

• Fɔ it tin dɛn we go ɛp yu at ɛn fɔ du ɛksɛsayz ɔltɛm.
• Fɔ stɔp fɔ drink rɔm.
• Lɔs yu wet (if nid de) ɛn mek yu gɛt wɛlbɔdi.
• Fɔ fɛn wɛlbɔdi we fɔ kɔntrol strɛs .
• Gɛt ɛp fɔ lɛf fɔ smok ɛn avɔyd fɔ smok we yu de smok.
• Gud kɔntrol pan tin dɛm lɛk ay blɔd prɛshɔn, dayabitis, ɛn ay kɔlɔstrel.

Wetin na de luk fɔ pipul dɛm wae gɛt Endothelial Dysfunction?

Endothelial Dysfunction kin trit wit layf stayl chenj ɛn mɛrɛsin.Na wan sik we dɛn kin rili trit. Bɔt sɔm pipul dɛn we gɛt nonobstructive coronary artery disease (NOCAD) kin kɔntinyu fɔ gɛt pen na dɛn chɛst pan ɔl we dɛn dɔn trit dɛn.

Dis kayn pen wae de kam na yu chɛst we nɔr de dɔn kin ambɔg di tin dɛm wae yu kin du ɛvride. E kin mek bak yu gɛt tin dɛn lɛk fɔ wɔri ɛn pwɛl hat. Saykotɛrapi, mɛrɛsin, ɛn strɛs mɛnejɛmɛnt tɛknik kin ɛp.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt dɛn sik ya, go to dɔktɔ wantɛm wantɛm:

• Chɛst de pen
• I nɔ kin izi fɔ yu fɔ blo
• Di sayn dɛm fɔ at atak (e.g., bad bad chɛst pen, pen we de rayt dɔŋ di lɛft an, pen na di jaw, swet, nɔs)
• Taya pasmak fɔ natin

Wetin a fɔ aks mi dɔktɔ?

Yu kin aks yu dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin mek a bin gɛt dis sik (Endothelial Dysfunction)?
• A nid mɛrɛsin?
• Us chenj dɛn we a fɔ chenj di we aw a de liv mi layf ɛn di tin dɛn we a de it?
• A de pan denja fɔ gɛt at sik? Aw a go ridyus da risk de?
• A fɔ no bɔt di sayn dɛn we de sho se a gɛt prɔblɛm dɛn?

Mɛsej we dɛn kin kɛr go na os

Endothelial Dysfunction na wan kayn korona at sik. We naytric oxide nɔ de na di wɔl dɛn na yu blɔd vesel, di at dɛn kin smɔl. Dis narrowing de ridyus di blɔd flɔ to di at. Dis sik kin mek yu gɛt angina, ɔr yu chɛst pen, ɛn i kin mek yu gɛt at sik mɔ ɛn mɔ.

Di bɛst tin na dat, if yu no am kwik ɛn gɛt di rayt tritmɛnt, ɛn bak fɔ chenj yu layf, yu gɛt bɔku chans fɔ protɛkt yusɛf frɔm siriɔs at sik. So, nɔ ignore ɛni sayn we de sho se yu gɛt dis sik. If yu gɛt dawt, i go fayn fɔ mek yu go to dɔktɔ.

` εndoteyl Disfכnkshכn, At sik, Blכd Vεsεl dεm, Angina, Naytrik כksayd, Blכd Prεshכn, Kכlestכl