Yu blɔd de klɔt fɔ natin? Lɛ wi lan mɔ bɔt Factor V Leiden Thrombophilia!

Nɔto ɔl wi bɔdi na di sem, nɔto so? Sɔntɛnde, wi kin gɛt smɔl smɔl difrɛns dɛn na wi bɔdi we wi nɔ kin ivin no. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya we wi kin gɛt frɔm wi mama ɛn papa, we kin mek wi blɔd klɔt smɔl tumɔs, we min se i kin izi fɔ mek i rɔtin we nɔ nid. Dɛn kɔl dis Factor V Leiden Thrombophilia .

So wetin na Factor V Leiden?

Fɔ tɔk am simpul wan, dis na wan sik we pɔsin kin gɛt frɔm in mama ɛn papa we kin mek i blɔd klɔt . Dat min se dɛn bɔn yu wit chenj na yu jin. Dis chenj de mek yu blɔd kin klɔt pas aw i kin klɔt. Dis kin put yu pan ay risk fɔ gɛt sik lɛk:

• Dip Vein Thrombosis (DVT): Dis na we blɔd kin klɔt na di dip vein dɛn na yu bɔdi, mɔ na yu leg ɔ yu an. Bɔt sɔm tɛm dɛn kin fɔm na di vein dɛn na say dɛn lɛk di liva, di kidni, di bren, ɛn di yay.
• Pulmonary Embolism (PE) : Dis kin denja smɔl. Wetin kin apin ya na dat wan pan di blɔd we wi dɔn tɔk bɔt, ɔ blɔd we dɔn fɔm ɔdasay, brok, travul tru di blɔd, ɛn stɔp na wan pan yu lɔng.

Bɔt na di tin ya, jɔs bikɔs yu gɛt dis kɔndishɔn nɔ min se yu go mɔs gɛt DVT ɔ PE . Infakt, lɛk nayn pan ɛvri tɛn pipul dɛn we gɛt dis sik nɔ go ɛva gɛt blɔd we nɔrmal insay dɛn layf. Bɔt, e fayn fɔ ɔndastand se yu de pan denja smɔl pas ɔda pipul dɛm.

Di insidɛns fɔ dis `Factor V Leiden` kɔndishɔn kin difrɛn bitwin difrɛn etnik grup dɛm. Dɛn kin si am mɔ pan wayt pipul dɛn na Amɛrika ɛn Yurop.

• Na lɛk 5 pan ɔl 100 pipul dɛn we kɔmɔt na Yurop.
• Na lɛk 2 pan ɔl 100 pipul dɛn we kɔmɔt na Hispanik.
• Na lɛk 1 pan ɛvri 100 pipul dɛn we na blak ɔ Indian pipul dɛn na Amɛrika.
• Pan pipul dɛn we kɔmɔt na Eshia, i nɔ rich 1 pan ɛvri 100 pipul dɛn.

כltu, dεn fכnshכn se lεk wan pan fayv pipul dεm we gεt bכdi kכlכt na dεn vein dεm gεt di `Factor V Leiden` jin vεryכnt. Dɛn kɔl dis ``Factor V Leiden.'' Di lɛta V tinap fɔ di Roman nɔmba fɔ fayv.

Wetin na di sayn dɛm fɔ dis sik?

Na sɔntin we yu fɔ mɛmba: Dis jenɛtik mutation nɔmɔ nɔ de mek yu gɛt ɛni sayn . Yu kin gɛt am fɔ di res ɔf yu layf we yu nɔ no. Bɔt lɛk aw wi bin dɔn tɔk, di sayn dɛn nɔmɔ kin apin if blɔd klɔt.

Impɔtant: If yu tink se yu gɛt sayn dɛn fɔ `DVT` ɔ `PE`, kɔl 911 ɔ yu lokal imejensi nɔmba wantɛm wantɛm . If nɔto dat, go na di ɔspitul imejensi dipatmɛnt we de nia yu kwik kwik wan wit pɔsin. Dis nɔto sɔntin we wi fɔ put bifo.

Di sayn dɛm fɔ dip vein thrombosis (DVT) kin bi:

• Yu leg ɔ an kin swel, yu kin fil wam we yu tɔch yu, ɛn yu skin kin chenj (sɔntɛm i kin tɔn rɛd ɔ blu).
• Fɔ fil pen we yu tɔch da leg ɔ an de, pen we yu prɛs .
• di vein dεm we de כnda di skin we big pas nכmal εn we yu kin si pan di sכfa .
• If blɔd klɔt fɔm na di vein dɛn we de insay di bɛlɛ, yu kin gɛt bɛlɛ pen ɔ pen na yu bɛlɛ we de dɔŋ .
• If blɔd klɔt fɔm na di bren, i kin mek yu ed at wantɛm wantɛm, bad bad wan ɛn/ɔ yu kin gɛt sik .

Di sayn dɛm fɔ pulmonary embolism (PE) kin bi:

• I nɔ kin izi fɔ blo wantɛm wantɛm .
• Shap pen na yu chɛst we yu de tek dip briz, kɔf, ɔ sniz.
• Kɔf, sɔntɛnde wit smɔl blɔd we de kɔmɔt wit di mucus .
• Wiz sawnd we yu de blo.
• Wan at bit we rili fast (tachycardia) .
• Fɔ fil se yu de wɔri ɛn nɔ gɛt rɛst .
• Fɔ fil lɛk yu ed de tɔn, fil lɛk yu de kam lɔs kɔnshɛns (nɔ kin ɔltɛm, yu kin ivin lɔs kɔnshɛns) .

Wetin kin mek Factor V Leiden?

Di men rizin fɔ dis na wan jin we difrɛn . wan protin de na wi bכdi we de εp fכ blכd kכlכt, dεn kכl am `Coagulation factor V` . Fɔ tɔk di kɔrɛkt tin, i kin ɛp fɔ stɔp blɔd we pɔsin wund. so, wi bכdi de instrכkt fכ mek dis protin bay wan jin we dεn kכl `F5` .

nכmal wan, wi כl de inhεrit tu nכmal kכpi dεm fכ dis `F5` jin. כltu, if yu inhεrit wan כ mכr abnכmal kכpi fכ dis jin, dεn se yu gεt di `Factor V Leiden` vεryכnt (sכmtεm dεn kכl am `mutation`). di nem `Leiden` kכmכt frכm di siti na Leiden na di Netherlands usay risecharch dεm fכnshכn dis jin vεryכnt.

dis `Factor V Leiden` jin vεryכnt de mek sכm sכm strכkchכral chenj na di `factor V` protin we de prodyuz insay wi bכdi. fכ dis chenj, dis כltεr `faktכ V` protin de rεsist to di akshכn fכ tu כda imכtant protin dεm we de kכntro di bכdi kכlכt , Protein C (`Protein C`) εn Protein S (`Protein S`) . Fɔ tɔk am simpul wan, dɛn prɔtin dɛn we de kɔntrol am nɔ ebul fɔ stɔp am. afta dat, di `factor V` protin de bi mכr aktiv pas aw i fכ du, εn di bכdi de bigin fכ kכlכt we nכ nid, ivin we i nכ nid am.

Dis na sɔntin we kin pas frɔm wan famili to ɔda famili?

Yɛs, na fɔ tru. Yu kin gɛt dis sik frɔm yu mama ɔr yu papa, ɔr ɔl tu. Fכktכ V Leiden de inhεrit insay wan כtosom dכminant inhεritεns patεn.Dat min se, ivin if yu nכ gεt dis abnכmal jin vεryכnt frכm wan pan yu mama εn papa, yu kin stil gεt dis kכndyushכn.

כl di pipul dεm (wit Factor V Leiden) kin gεt wan abnכmal kכpi fכ di jin nכmכ. Dɛn kɔl dis hɛtɛrozaygɔs . Na smɔl tɛm nɔmɔ yu kin gɛt ɔl tu di kɔpi dɛn we nɔmal fɔ di jin frɔm yu mama ɛn papa. Dɛn kɔl dis homozygous .

Us ɔda tin dɛn kin mek di blɔd klɔt?

Pɔsin we gɛt Factor V Leiden kin gɛt blɔd klɔt if:

• if yu dכn inhεrit di tu kכpi dεm fכ di abnכmal `F5` jin lεk aw wi bin dכn mεnshכn (if yu na `homozygous`) .
• If yu fambul dɛm na yu blɔd (lɛk mama, papa, brɔda ɛn sista dɛm) gɛt histri fɔ DVT ɔ PE .
• If yu gɛt ɔda tin dɛn we kin mek yu blɔd klɔt .
• If yu de du ɔpreshɔn (especially afta big ɔpreshɔn, as yu go de na wan ples fɔ lɔng tɛm).
• if yu bεlε (insay dis tεm, di כmon dεm de chenj εn di pikin kin mek prεshכn pan di vein dεm).
• If yu de tek sɔm kayn bɔn kɔntrol pils (we gɛt ɛstrojen) ɔ ɔmon riplesmɛnt tɛrapi (ɔmon riplesmɛnt tɛrapi) .

If yu gɛt ɛni wan pan dɛn tin ya we kin mek yu gɛt prɔblɛm, i rili impɔtant fɔ tɔk to yu dɔktɔ ɛn lan bɔt di prɔblɛm we kin mek yu blɔd klɔt ɛn di tin dɛn we yu kin tek fɔ tek tɛm wit.

Us kɔmplikɛshɔn kin apin bikɔs ɔf dis kɔndishɔn?

If yu gɛt Factor V Leiden Thrombophilia, yu kin gɛt dɛn tin ya:

• Divεlכp wan `DVT` כ `PE` bifo i ol 50 ia .
• Mɔ pas wan tɛm, we min se bɔku bɔku tin dɛn kin apin to `DVT` ɔ `PE`.
• Blɔd klɔt kin kam na di vein dɛn we nɔmal fɔ mek smɔl blɔd klɔt, fɔ ɛgzampul, na di vein dɛn na di liva, bren, ɛn kidni.
• DVT ɔ PE we uman gɛt bɛlɛ ɔ afta we i bɔn pikin .
• DVT ɔ PE kin apin insay shɔt tɛm afta dɛn dɔn bigin fɔ yuz bɔn kɔntrol pils .

Aw dɔktɔ dɛn kin no bɔt dis sik?

Dɔktɔ dɛn kin no if yu gɛt dis sik bay we dɛn de du blɔd tɛst . Dis kin inklud bak fɔ tɛst di jɛnɛtiks . Yu dɔktɔ kin tɛl yu fɔ tɛst fɔ dis sik, mɔ:

• If yu dɔn gɛt DVT ɔ PE bifo , mɔ if i apin we yu yɔŋ pas aw yu bin de tink.
• If wan ɔ mɔ pan yu fambul dɛn we gɛt blɔd dɔn gɛt istri fɔ mek blɔd klɔt .

Aw dɛn kin trit Factor V Leiden?

Factor V Leiden na wan sik we pɔsin kin gɛt fɔ ɔl in layf. Dat min se naw nכ spεshal tritmεnt כ mεrεj de fכ dis jin vεryכnt. Bifo dat, di tritmɛnt dɛn de wok fɔ sɔlv di blɔd we dɔn de ɛn fɔ ridyus di risk fɔ mek di blɔd klɔt tumara bambay . Yu dɔktɔ kin tɛl yu fɔ du tritmɛnt dɛn lɛk:

• Antikoagulant mεdikeshכn dεm (dεn kin kכl dεm bak bכdi tכn) : dεn ya de εp fכ sכlv di blכd kכlכt dεm we bin de εn mek nyu kכlכt nכ fכm.
• Kɔmpreshɔn stɔking : Dis na spɛshal tayt sɔks we dɛn kin wɛr na di leg fɔ mek di blɔd go fayn ɛn fɔ mek di blɔd nɔ klɔt.
• Vena cava filter placement : Dis na smɔl tin we dɛn kin put insay wan big vein fɔ mek di blɔd nɔ go na di lכng. Nɔto ɔlman nid am.
• Ɔpreshɔn fɔ pul di blɔd we dɔn klɔt : Sɔntɛnde, i kin nid fɔ du ɔpreshɔn fɔ pul di big big blɔd we dɔn klɔt.

Aw lɔng yu nid fɔ tek mɛrɛsin we de mek yu blɔd tan, dipen pan di risk we yu gɛt fɔ gɛt ɔda blɔd klɔt. Sɔm pipul dɛn jɔs nid fɔ tek dis mɛrɛsin fɔ sɔm mɔnt. Ɔda pipul dɛn kin nid fɔ tek am fɔ lɔng tɛm, ivin fɔ di res ɔf dɛn layf. Yu dɔktɔ go ɛksplen di tritmɛnt plan we go fayn fɔ yu.

Ustɛm yu fɔ go to dɔktɔ?

If yu no se yu gɛt dis sik, i impɔtant fɔ de tɔk to dɔktɔ ɔltɛm.

• Go fɔ wan jenɛral mɛdikal chɛk-ap at le wan tɛm insay di ia .
• If yu gɛt DVT ɔ PE ɛn yu de gɛt tritmɛnt, yu go nid fɔ go to yu dɔktɔ fɔ ɔltɛm fɔ fala-ap apɔntinmɛnt fɔ si aw di tritmɛnt de go.
• If yu de tek wan blɔd tina lɛk Warfarin , yu fɔ gɛt blɔd tɛst (Prothrombin time test - PT/INR test) ɔltɛm fɔ chɛk if di mɛrɛsin de wok fayn ɛn di doz kɔrɛkt.

Dɔn bak, i impɔtant fɔ tɔk to dɔktɔ we tin dɛn lɛk dis:

• Bifo yu yuz bɔn kɔntrol (espɛshali di wan dɛn we gɛt ɛstrojen).
• Bifo yu bigin fɔ tek ɔmon riplesmɛnt tritmɛnt .
• If yu de plan fɔ gɛt bɛlɛ, bifo dat .

Wetin dis tɔk bɔt di layf we pɔsin kin liv?

Fɔ bɔku pipul dɛn, we dɛn gɛt Factor V Leiden , i nɔ kin afɛkt dɛn nɔmal layf . Ivin if yu gɛt blɔd we de rɔtin, if yu gɛt tritmɛnt kwik kwik wan ɛn di rayt we, yu go mek yu nɔ gɛt siriɔs prɔblɛm dɛn . If yu gɛt ɛnitin fɔ wɔri bɔt aw yu go liv yu layf ɔr prɔblɛm dɛn we go mit yu tumara bambay, tɔk to yu dɔktɔ bɔt dɛn.

Wetin wi fɔ avɔyd if wi gɛt Factor V Leiden?

Yu dɔktɔ go gi yu advays bay aw yu wan wan sityueshɔn, bɔt in jɔnal, i bɛtɛ fɔ avɔyd dɛn tin ya:

• Smok, vap, ɛn yuz ɔda tin dɛn we dɛn kin yuz fɔ smok .
• Fɔ sidɔm na di sem pozishɔn fɔ lɔng tɛm (e.g., fɔ wok na ɔfis, fɔ tek lɔng bɔs ɔ tren rayd, ɔ fɔ flay fɔ lɔng tɛm). If i pɔsibul, grap ɛn waka rawnd wan tɛm insay di awa.
• Nɔ drink bɔku rɔm , mɔ we yu de flay fɔ lɔng tɛm.
• Bɔn kɔntrol pils ɛn ɔmon riplesmɛnt tɛrapi we gɛt ɛstrojen (yu fɔ rili tɔk to yu dɔktɔ bifo yu yuz dɛn tin ya).

Factor V deficiency ɛn Factor V Leiden na di sem tin?

Yɛs, nɔ kɔnfyus di tu. Dis na tu kɔmplit difrɛn jɛnɛtik kɔndishɔn dɛn . כltu, dεn tu kכndishכn dεm ya de sho se dεn de chenj di `F5` jin.

Insay Factor V Leiden Thrombophilia, wan jenɛtik mutation de mek yu blɔd klɔt izi wan.

כltu, insay wan kכndishכn we dεn kכl `Factor V deficiency` , wan jεnεtik mכtεshכn de mek yu bכdi nכ kכlכt fayn fayn wan we nid de. Dis min se yu de pan denja fɔ blɔd. `Factor V deficiency` na wan tin we rili rare (lɛk wan pan wan milyɔn) blɔd disɔda. I kin mek tin dɛn lɛk we pɔsin de blɔd na in nos ɔltɛm, we i de gɛt bɔku blɔd we i de gɛt mɔnt, ɛn we i de blɔd ɔltɛm afta dɛn dɔn du di ɔpreshɔn.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

So, if yu kam fɔ no se yu ɔ pɔsin we yu sabi gɛt Factor V Leiden Thrombophilia, nɔ panik wantɛm wantɛm. Mɛmba se bɔku pan di pipul dɛn we gɛt dis sik kin liv fayn layf ɛn nɔ kin gɛt ɛni blɔd we kin klɔt .

Bɔt if yu gɛt blɔd we de rɔtin, sɔm tritmɛnt dɛn de we go ɛp yu . De tin wae impɔtant pas ɔl na fɔ fala yu dɔktɔ in instrɔkshɔn fayn fayn wan, gɛt di tɛst ɛn tritmɛnt wae yu nid, ɛn liv nɔrmal, gladi layf wit de sik, ɛn mɛn am fayn fayn wan bifo i bi prɔblɛm.

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