Yu kin gɛt fiva bak ɔltɛm fɔ natin? Yu gɛt ɔda prɔblɛm dɛn wit dɛn? Dis kin bi Familial Mɛditarenian Fiva (FMF)!

Yu kin gɛt fiva wantɛm wantɛm we yu nɔ wɔn yu? Yu kin gɛt bɛlɛ bak, yu kin fil se yu chɛst tayt, ɔ yu jɔyn dɛn kin pen? Sɔmtɛm dɛn sik ya kin dɔn afta sɔm dez, bɔt dɛn kin kam bak afta sɔm tɛm? Na nɔmal tin fɔ fil bad bad wan we dis apin. Tide wi go tɔk bɔt wan sik we de mek wi gɛt dɛn kayn sik ya, we na strenj smɔl, bɔt i rili impɔtant fɔ no bɔt.

Wetin na `Familial Mɛditarenian Fiva (FMF)`?

Fɔ tɔk am simpul wan, Famili Mɛditarenian Fiva, ɔ FMF fɔ shɔt, na wan sik we kin apin to wi layf we kin kɔmɔt frɔm wi jin dɛn. Wetin kin apin pan dis na dat, fɔ no rizin, wi kin gɛt fiva wantɛm wantɛm, ɛn di sem tɛm, inflamɛns kin de na difrɛn pat dɛn na di bɔdi. Fɔ tɔk tru, dis na sɔntin we kin apin bikɔs ɔf wan smɔl prɔblɛm we de na wi yon imyun sistɛm. Na dat mek dɛn kin kɔl am bak ɔtoinflammatory disease .

I kin mɔna pipul dɛn we de na di kɔntri dɛn we de na di Mɛditarenian. i de mek di tכn mεmbran dεm we dεn kכl `serous membranes` (dεn ya kכba εria dεm lεk di chεst kεviti εn bכdi), we dεn kכl `serositis`. i kin mek bak inflameshn pan di `synovial membranes` we de kכba wi joyn dεm, we dεn kכl `synovitis`. Bɔrku tɛm, de sik kin de fɔ sɔm dez ɛn afta dat dɛn kin stɔp.

Wetin na di sayn dɛm fɔ FMF?

FMF simptom kin bigin wae yu smɔl, bifo yu ol 20. Dɛn sayn ya kin tranga fɔs, bɔt dɛn kin bɛtɛ smɔl smɔl as yu de ol. Wae yu dɔn gɛt dis sik, yu nɔr kin gɛt ɛni sayn fɔ sɔm wik, mɔnt, ɔr ivin ia. Bɔt fɔ no ɛn trit am kwik kwik wan kin ɛp fɔ ridyus di simptom dɛm ɛn fɔ mek dɛn nɔ gɛt prɔblɛm dɛn we kin de fɔ lɔng tɛm lɛk amyloidosis.

Naw lɛ wi si wetin na dɛn sayn ya:

• Wan ay fiva we kin rich 40.6 digri sɛlshiɔs (105 Fahrenheit), sɔntɛnde i kin kam wit kol ɛn shek shek.
• I kin kam wit ed we de at ɛn stif nɛk.
• Bɛlɛ de pen ɛn blo (blɔt).
• Di bɛlɛ mɔsul dɛn kin tayt ɛn kɔnstipɛshɔn kin apin.
• Chɛst pen , we kin bɔku we yu de blo.
• Jɔyn pen ɛn swel (bɔku tɛm na wan jɔyn).
• Swel ɛn pen na di tɛstikul dɛn na man dɛn.
• Mɔsul dɛn kin at , mɔ na di bɔdi we de dɔŋ.
• Wan rɛd, rayz skin lɛshɔn kin kam na di leg dɛn .

Dɛn sayn ya kin apin wantɛm wantɛm insay sɔm awa. Bɔt nɔto ɔlman go gɛt ɔl dɛn sik ya.. Fiva na di sayn we kin apin pas ɔl. Na pikin, fiva kin bi di wangren sayn. Bɔrku tɛm, de sik kin te fɔ sɔm dez.

Prodromal Simptom dɛm fɔ FMF

Sɔm pipul dɛn kin bigin fɔ fil smɔl smɔl sɔm dez bifo dis fiva bigin. Jɔs lɛk aw sɔm pipul dɛn kin fil am bifo dɛn gɛt ``maygren`` ɔ uman dɛn kin fil am bifo dɛn ``mɛnstrueshɔn``. Wi kin kɔl dɛn tin ya ``prodromal simptom dɛm`` . Wen yu fil dis, yu get hint se ''Ah... now dat trobul de kam''.

Wetin na dɛn sayn dɛn ya we de sho wi?

• Fɔ wɔri, fɔ nɔ gɛt rɛst
• Di we aw pɔsin kin vɛks
• Ed de at
• Vɔmit
• Bɔdi pen
• Malaise ( nɔ gɛt zil, nɔ gɛt layf ) .

Wetin mek dis `FMF` de apin?

dis na bikoz fכ chenj dεm na di `MEFV` jin na wi bכdi. dis `MEFV` jin de εp fכ mek wan rili imכtant protin, dat na wan protin we dεn kכl `pyrin`. wi innate imyun sistεm – dat na di pat pan di imyun sistεm we de wok agens trεt lεk infεkshכn we de kam wan wan – de dip pan dis `pyrin` protin. so, we di `MEFV` jin nכ kin mek `pyrin` fayn, dat protin nכ kin wok fayn insay di imyun sistεm. Na da tɛm de dis prɔblɛm kin apin.

dεn dכn no lεk 30 jεnεtik mכtεshכn dεm (`vεryushכn`) we de mek `FMF`. Fɔ dɛn wan ya, di wan dɛn we kɔmɔn pas ɔl na `V726A`, `M680I`, `E148Q`, `M694V` ɛn `M694I`. Dɛn tin ya kin apin mɔ pan pipul dɛn we kɔmɔt na Mɛditarenian ɛn Midul Ist. Fɔ ɛgzampul:

• Arab pipul dɛn
• Di pipul dɛn na Aminia
• Grik dɛn
• Iranian pipul dɛn
• Itali pipul dɛn
• Ju pipul dɛn
• Kurd pipul dɛn
• Turks pipul dɛn

Trig fɔ FMF

Pan ɔl we bɔku tɛm i kin tan lɛk se FMF kin kam wantɛm wantɛm ɛn we nɔ gɛt ɛni rizin we klia, fɔ sɔm pipul dɛn na sɔm tin dɛn kin mek i apin. Fɔ sɔm pipul dɛm, dis sik kin kam bikɔs ɔf strɛs na dɛn bɔdi ɔr maynd. Pipul se FMF kin trigεr bay tin dεm lεk:

• Fɔ de na kol
• Ɛksesaiz ɔ taya pasmak
• Wan infɛkshɔn we dɛn jɔs dɔn gɛt
• Wan injuri ɔ ɔpreshɔn we dɛn jɔs dɔn du
• Bɔrku strɛs (lɛk big prɔblɛm wit yu layf) .
• Di tɛm we uman dɛn kin gɛt dɛn mɔnt ɔ ovulation

Posisibul komplikashכn dεm fכ FMF

Pan ɔl we di fiva fɔ FMF kin stɔp afta sɔm dez, di kɔntinyu inflamɛns na di bɔdi kin afɛkt wi bɔdi as tɛm de go. Na dat mek dɔktɔ dɛn kin se fɔ kɔntinyu fɔ trit dis. we kכntinyu fכ inflammatory prכsεs lεk dis, wi imyun sistεm de put כnda big prεshכn, εn כda sik dεm kin apin bak.

di mכst siriכs komplikεshכn fכ dis na wan kכndyushכn we dεn kכl `sεkכnd amyloidosis` . Dis kin ivin mek di kidni nɔ wok fayn. Na dat mek i rili impɔtant fɔ tek tɛm wit dis.

Ɔda prɔblɛm dɛn kin bi bak:

• Splenomegaly (splenomegaly) we pɔsin kin gɛt .
• Di we aw pɔsin nɔ ebul fɔ bɔn pikin
• Ɔda ɔtoimyun sik dɛm (`Sɛkɛnd ɔtoimyun sik`)

Aw dɛn kin no FMF?

Aw dɔktɔ kin no if i gɛt FMF? Dɛn kin du tin dɛn lɛk:

• Dɛn go tek tɛm lisin to yu sik dɛn, aw ɔltɛm dɛn kin apin, ɛn aw lɔng dɛn dɔn de .
• Dɛn go aks if ɛnibɔdi na yu famili dɔn gɛt dis sik ɛn aw yu jɛnɛtik ɛritij tan lɛk .
• We yu sik, dɛn go chɛk yu fɔ si if ɛnitin de we de mek yu bɔdi wam ɔ we de mek yu vɛks .
• We pɔsin sik , dɛn kin du blɔd tɛst fɔ si if ɛni sayn de we de sho se pɔsin gɛt inflamɛns .
• i rεkomεnd fכ tεst jεnεtik fכ chεk fכ mכtεshכn dεm na di MEFV jin, we kin kכmכn fכ FMF.
• Dɛn go luk bak aw yu de ansa di tritmɛnt dɛm fɔ FMF.

Tritmɛnt fɔ `FMF`

Di men tritmɛnt fɔ FMF na di anti-inflammatory drɔg we dɛn kɔl kolchicine. Dis kin wok bay we i de ridyus di wok we wan kayn wayt blɔd sɛl we dɛn kɔl nyutrofil, we de insay inflamɛns, de du. Kɔlchisin kin ɛp fɔ mek dɛn nɔ gɛt ɔ ridyus di frɛkuɛns we FMF flawa kin kam, ɛn ridyus di risk fɔ kɔmplikeshɔn. Mɔr pas 90% pan di pipul dɛm wae gɛt FMF kin wɛl . Bɔrku pipul kin gɛt fɔ tek dis mɛrɛsin ɛvride fɔ di res ɔf dɛn layf.

Bɔt na smɔl pipul dɛn nɔ kin gɛt di tin we dɛn want frɔm kolchisin, ɔ dɛn nɔ kin ebul fɔ tek dis mɛrɛsin bikɔs ɔf ɔda wɛlbɔdi rizin. Fɔ dɛn kayn pipul ya, dɔktɔ dɛn kin tɛl dɛn fɔ tek ɔda kayn mɛrɛsin. Sɔm pan dɛn na:

• `Anakinra` (`Anakinra`) .
• `Rilɔnasept`
• `Kanakinumab`

Wetin kin apin if yu gɛt `FMF`?

Pan ɔl we no mɛrɛsin nɔ de fɔ FMF, dɛn kin ebul fɔ mɛn am fayn wit mɛrɛsin . Fɔ bɔku pipul dɛn, di fiva ɛn bɔdi pen kin dɔn ɔlmost we dɛn bigin fɔ tek mɛrɛsin. Fɔ ɔda pipul dɛn, di frɛkuɛns ɛn di frɛkuɛns we di flawa kin gɛt kin ridyus. Bɔt fɔ mek dɛn mɛrɛsin ya wok fayn, dɛn fɔ tek dɛn ɔltɛm, ivin we dɛn nɔ gɛt ɛni sayn.. If yu tek dis mɛrɛsin we yu dɔn ɔlrɛdi sik, dat nɔ go stɔp di sik wantɛm wantɛm. Dis mɛrɛsin de jɔs mek di sik nɔ kam.

Yu tink se dɛn kin ebul fɔ stɔp FMF?

bכku pipul dεn nכ ivin no se dεn gεt di jin vεryכnt we de mek FMF. fכ gεt FMF, yu nid fכ gεt tu kכpi fכ di jin vεryכnt frכm yu mama εn papa. If yu gɛt wan kɔpi nɔmɔ, yu nɔ go gɛt FMF simptom. Bɔt yu kin pas da kayn jin de to yu pikin dɛn. If yu patna gɛt da jin we de bak, yu pikin dɛn kin gɛt FMF. Jεnεtik tεst kin εp yu fכ no if yu na di wan we de kכri di jin vεryכnt.

Ripɔt dɔn de bɔt dis kayn fiva bɔku tɛm frɔm trade trade. Sɔntɛm dis sik we dɛn kɔl `FMF` dɔn ol jɔs lɛk aw i dɔn ol. Sɔm risach pipul dɛm tink se dis sik kin dɔn kam as we fɔ ɛp fɔ fɛt big big infɛkshɔn lɛk `tuberculosis` we bin de ɔlsay da tɛm de. Infakt, sɔm bɛnifit dɛn de we pɔsin kin gɛt we i gɛt inflamɛns na di bɔdi, bɔt na we i tumɔs nɔmɔ i kin gɛt prɔblɛm. Laki, gud drɔgs de naw fɔ kɔntrol dis sik. So ivin if yu gɛt `FMF`, yu kin liv nɔmal layf.

Di tin we impɔtant pas ɔl fɔ mek yu mɛmba! (Mɛsej we dɛn kin tek go na os)

Okay, so naw yu get beta andastan of wetin wi tok abaut tide, `FMF`. Di tin we impɔtant pas ɔl na dat if yu ɔ pɔsin na yu famili gɛt fiva fɔ natin, bɛlɛ at, jɔyn pen, ɛn ɔda tin dɛn, nɔ dismis am as jɔs kol, bɔt go to dɔktɔ fɔ no di rayt tin we de apin. If yu no di sik ɛn bigin fɔ trit am kwik, yu kin avɔyd bɔku prɔblɛm dɛn ɛn liv nɔmal layf. Mɛmba se, i rili impɔtant bak fɔ yuz di mɛrɛsin we yu dɔktɔ gi yu di rayt we, lɛk aw dɛn tɛl yu fɔ du am. Nɔ fɔgɛt fɔ tɔk to yu dɔktɔ bɔt ɛni kwɛstyɔn ɔ tin we de mɔna yu.

` FMF, famili fiva sindrom, fiva ɔltɛm, bɛlɛ de at, jɔyn pen, jɛnɛtik sik, kolchicine, amyloidosis