We yu ɔ pɔsin we yu sabi de du
tritmɛnt fɔ kansa , dat na,
kemotɛrapi , lɛk aw wi ɔl no, bɔku tɛm dɔktɔ dɛn kin se, “Yu nid fɔ tek tɛm, bikɔs di sɛl dɛn we de fɛt sik kin go dɔŋ.” Di rizin fɔ dis na bikɔs we di kansa sɛl dɛn pwɛl, di wɛlbɔdi sɛl dɛn we impɔtant to wi bɔdi kin pwɛl bak te to sɔm mak. So, wan spɛshal kayn mɛrɛsin de we de ɛp di bɔdi in difens dɛn dis tɛm. Na dat wi de tɔk bɔt tide.
Fɔ tɔk am simpul wan, wetin na G-CSF?
G-CSF na wan mɛrɛsin we de ɛp wi bɔdi fɔ mek mɔ
nyutrofil, we na wan kayn wayt blɔd sɛl we de ɛp wi bɔdi fɔ fɛt sik. Dɛn nyutrofil ya tan lɛk di men sojaman dɛn we de fɛt wi bɔdi. We tin dɛn lɛk
jem , vayrɔs, ɛn baktri dɛn kam insay di bɔdi, dɛn sɛl dɛn ya kin fɛt dɛn ɛn sev wi fɔ mek wi nɔ sik. If wi luk di minin fɔ di nem G-CSF, wi go ɔndastand dis mɔ:
- Granulocyte: Dis na di nem we dɛn kin gi wan kayn wayt blɔd sɛl . Nyutrofil dεm na wan kayn granulosayt dεm bak. G-CSF de mεnli stimulat di prodakshכn fכ dεn nyutrofil dεm ya.
- Colony-Stimulating Factor: dis lεk wan protin we de tεl di sεl dεm "wetin fכ du." G-CSF kin tel wan stεm sεl na wi bon mכro se, "Yu go bi nyutrofil naw." i kin tεl bak wan nyutrofil we de naw fכ "divayd εn mכltiply."
Fɔ tɔk am simpul wan, G-CSF na drɔg we de go na wi bon mɛro ɛn sɛn mɛsej se, "Imejɛnsi! Wi nid mɔ difɛns sojaman dɛn (nyutrofil), mek dɛn kwik ɛn rilis dɛn insay di blɔd."
Us kɔndishɔn dɛn dɛn kin yuz G-CSF fɔ?
G-CSF na in dɛn kin yuz mɔ fɔ trit ɛn protɛkt
nyutropenia . Nyutropenia na we di nɔmba fɔ di nyutrofil dɛn we de na di blɔd smɔl pas aw i kin bi. We dis kin apin, di bɔdi in ebul fɔ fɛt infɛkshɔn kin ridyus bad bad wan. Bɔku men rizin dɛn de we mek yu dɔktɔ kin gi yu dis mɛrɛsin.
We dɛn de trit kansa (Kɛmotɛrapi) .
We kemotɛrapi drɔgs kil kansa sɛl dɛn, dɛn kin kil nyutrofil dɛn bak we gɛt wɛlbɔdi. Dis na di rizin we mek nyutropenia kin rili kɔmɔn afta dɛn dɔn tek kimotɛrapi. Sɔntɛnde, dis kin mek pɔsin in layf de pan denja. G-CSF de ridyus dis risk bay we i de mek di bon mכro prodyuz nyu nyutrofil dεm kwik kwik wan.
We dɛn de transplant stem sɛl
Pipul dɛn we gɛt kansa ɔ sɔm blɔd sik dɛn kin nid fɔ transplant stem sɛl. G-CSF de ɛp wit dis prɔses bifo ɛn afta.
- Bifo di transplant: we dεn gi G-CSF, bכku stεm sεl dεm frכm di bon mכro de kכmכt na di bכdi. Dɔn dɔktɔ dɛn kin gɛda dɛn stem sɛl dɛn de we gɛt wɛlbɔdi.
- Afta di transplant: Afta di abnכmal sεl dεm na di sikman in bכdi dεn dכn dכn, di hεlty stεm sεl dεm we dεn bin kכlekt bifo dεn de kam bak na di bכdi. G-CSF de ɛp dɛn sɛl dɛn de fɔ gro fayn ɛn bi nɔmal blɔd sɛl dɛn .
Ɔda nyutropenia kɔndishɔn dɛn
Sɔm pipul dɛn kin bɔn wit siriɔs nyutropenia. Ɔda pipul dɛn kin gɛt dis sik fɔ no rizin. insay dεn kes dεm ya, dεn kin yuz G-CSF bak fכ inkrεs di nyutrofil lεvεl dεm.
Di kayn G-CSF ɛn aw dɛn kin gi dɛn
Di drɔg G-CSF de na di makit ɔnda difrɛn nem dɛn. Dɛn tin ya kin difrɛn smɔl pan aw dɛn kin tek akshɔn ɛn aw dɛn kin mek dɛn.
| Di kayn drɔg we dɛn kin yuz | Diskripshɔn ɛn ɛgzampul dɛn |
|---|
| G-CSF we de wok fɔ shɔt tɛm | Bɔku tɛm, dɛn kin nid fɔ tek dɛn tin ya ɛvride. Di men mɛrɛsin na Filgrastim (brand nem: Neupogen®). Bɔku mɛrɛsin dɛn de we fiba, we sef ɛn we go wok fayn (biosimilars). |
| G-CSF we de wok fɔ lɔng tɛm | Dɛn tin ya kin las fɔ lɔng tɛm na di bɔdi, so yu nɔ nid fɔ gɛt injɛkshɔn ɔltɛm. Di men mɛrɛsin na Pegfilgrastim (brand nem: Neulasta®). I kin du fɔ gɛt jɔs wan injɛkshɔn bitwin tu rawnd dɛn we dɛn tek di kemotɛrapi. |
Di tin we impɔtant pas ɔl na fɔ mek yu dɔktɔ disayd di kayn mɛrɛsin ɛn di doz fɔ yu we go fayn fɔ yu.
Dɛn kin gi G-CSF as injɛkshɔn we de ɔnda di bɔdi. Sɔntɛnde dɛn kin gi am as IV infushɔn. If yu ebul fɔ gi yusɛf di injɛkshɔn na os, yu dɔktɔ ɔ nɔs go ɛksplen aw fɔ du am.
Wetin na di sayd ɛfɛkt dɛm we G-CSF kin gɛt?
Lɛk ɛni mɛrɛsin, G-CSF gɛt bɛnifit ɛn sayd ɛfɛkt. Bɔt mɛmba se dɔktɔ de gi yu dis mɛrɛsin bikɔs di bɛnifit dɛn pas di prɔblɛm dɛn we i go gɛt fa fawe. Bɔku pan di sayd ɛfɛkt dɛn kin go we dɛn stɔp di tritmɛnt.
| Kɔmɔn sayd ɛfɛkt dɛn | Rarely siriɔs kɔndishɔn dɛn |
|---|
| - Sivɛri alɛji riakshɔn (Anaphylaxis) .
- Spleen we kin brok
- Akyu respiratɔri distres sindrom (ARDS) .
- Di bɔdi we de swel
|
Wetin mek G-CSF kin mek yu bon pen?
Dis na wan kɔmɔn sayd ɛfɛkt we bɔku pipul dɛn kin gɛt. Pan ɔl we wi nɔ no di rayt tin we kin mek i apin, sayɛnsman dɛn tink se na bikɔs G-CSF kin mek di bon mɛro bigin fɔ mek nyu sɛl dɛn wantɛm wantɛm kwik kwik wan. De prɛshɔn wae de kam wit dis kwik growth na in wi kin fil lɛk pen. Bɔku tɛm, pɔsin kin ebul fɔ bia wit dis pen. Yu kin tɔk to yu dɔktɔ bɔt am ɛn gɛt wan fayn mɛrɛsin fɔ mɛn yu pen.
Ustɛm yu fɔ go to dɔktɔ?
I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni sayd ɛfɛkt we yu gɛt we yu de tek G-CSF. Mɔtalman, if yu gɛt ɛni wan pan dɛn sik ya, yu fɔ
go to dɔktɔ wantɛm wantɛm . Sɔntɛnde, yu kin nid fɔ go na di ɔspitul in Imejɛnsi Dipatmɛnt (ETU).
- Di sayn dɛm fɔ wan infekshɔn: fiva, kol, trot we de at, kɔf.
- Di sayn dɛn we de sho se pɔsin gɛt alɛji:Skin de rɔsh, swel, i nɔ izi fɔ blo .
- Di briz we kin shɔt wantɛm wantɛm.
- At bit kwik kwik wan.
- Di an ɔ fut kin swel wantɛm wantɛm.
Nɔ fɔgɛt, yu sef de kam fɔs. If yu gɛt ɛni dawt, ilɛksɛf na smɔl tin, nɔ ɛva fred fɔ kɔl yu dɔktɔ ɛn aks am.
Mɛsej we dɛn kin kɛr go na os
- G-CSF na wan mɛrɛsin we dɛn kin gi fɔ mek di wayt blɔd sɛl dɛn we de fɛt di sik we dɛn kɔl nyutrofil, we tin dɛn lɛk kansa tritmɛnt (kimotɛrapi) kin ridyus.
- Dis go ridyus yu risk fɔ gɛt infɛkshɔn ɛn ɛp yu fɔ kɔntinyu fɔ gɛt yu kansa tritmɛnt di tɛm we yu dɔn plan.
- Bɔn ɛn mɔsul pen na wan kɔmɔn sayd ɛfɛkt we dis mɛrɛsin kin gɛt, bɔt bɔku tɛm i kin bia.
- If yu gɛt sɔm sayn dɛn lɛk fɔ mek yu nɔ ebul fɔ blo fayn, yu gɛt siriɔs alɛji, ɔ yu gɛt fiva , tɛl yu dɔktɔ wantɛm wantɛm.
- Na yu dɔktɔ nɔmɔ go disayd if yu nid dis mɛrɛsin ɔ yu nɔ nid am, ɛn us kayn we fayn fɔ yu. So tɔk ɔltin wit am.
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