Yu wayt blɔd sɛl dɛn de dɔŋ we denja? Na agranulocytosis dat? Lɛ wi tɔk bɔt am!

Yu kin sik ɔltɛm? Yu kin fil wik ɛn taya ivin fɔ smɔl tɛm? Sɔntɛnde dis kin bi bikɔs yu bɔdi in difɛns dɛn we de mek yu bɔdi nɔ gɛt bɛtɛ wɛlbɔdi, dat na nyutrofil, we na wan kayn wayt blɔd sɛl, we denja. Tide wi de tɔk bɔt wan siriɔs bɔt we pɔsin kin trit we dɛn kɔl agranulocytosis . Nɔ wɔri, i impɔtant fɔ no bɔt dis.

Wetin rili na agranulocytosis?

Fɔ tɔk am simpul wan, Agranulocytosis na wan sik we kin mek pɔsin in layf de pan denja we di nɔmba fɔ di wayt blɔd sɛl dɛn we dɛn kɔl nyutrofil na wi bɔdi kin go dɔŋ to wan rili smɔl lɛvɛl. Yu no se wayt blɔd sɛl dɛn tan lɛk sojaman dɛn na wi imyun sistɛm? Na dɛn de protɛkt wi frɔm smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. We di nɔmba fɔ dɛn nyutrofil ya de go dɔŋ, wi bɔdi kin gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Ivin di jem dɛm wae nɔrmal nɔr kin kɔz wi bɔrku bad kin mek wi sik. Imajin, if wan spɛshal fɔs yunit na wi kɔntri in ami nɔ de igen wantɛm wantɛm, yu tink se ivin smɔl ɛnimi nɔ go bi big prɔblɛm? Dis na di sem tin. di nem "agranulocytosis" kכmכt frכm di wכd granulocytes . Granulocytes na wan kayn wayt blɔd sɛl bak. Dɛn gɛt ɛnzaym dɛn we de pwɛl di jem dɛn. Tri kayn granulosayt dεm de: Nyutrofil , Eosinofil, εn Basofil . Nyutrofil na di wayt blɔd sɛl dɛn we bɔku pas ɔl na wi bɔdi. Na dat mek dɔktɔ dɛn kin tɛst di nyutrofil lɛvɛl fɔ no if pɔsin gɛt agranulocytosis. Sɔntɛnde dɛn kin kɔl dis granulocytopenia .

Wetin na di difrɛns bitwin Nyutropenia ɛn Agranulocytosis?

כl tu de sho se di nyutrofil dεm de dכn. Bɔt agranulocytosis na di kayn we we kin rili bad fɔ nyutropenia .

• Nyutropenia na wan sik we di nɔmba fɔ di nyutrofil dɛn na di blɔd smɔl pas aw i fɔ bi. Dɛn se pipul dɛn we nɔ rich 1,500 nyutrofil pan wan maykrolita (mL) blɔd kin gɛt nyutropenia.
• Agranulocytosis na di las stej we denja pas ɔl, we di nyutrofil kכnt de dכn dכn 100 pan wan maykrolit bכdi. Dɔn gɛt am? Dis na di kayn we we kin rili bad fɔ nyutropenia.

Yu tink se kayn agranulocytosis de?

Yes, dis kin kam insay tu men we: 1. Inherited agranulocytosis:Dis kin kam bikɔs ɔf wan sik we dɛn kɔl jenɛtik disɔda. Dat min se prɔblɛm de wit di jin dɛn we de ɛp wi bɔdi fɔ mek nyutrofil. Dis sik kin afɛkt bebi ɛn smɔl pikin dɛn mɔ. 2. Acquired agranulocytosis: Dis kin gεt bכku kכz dεm. Bɔt bɔku tɛm (lɛk 70% pan di tɛm!) na wan sayd ɛfɛkt we sɔm mɛrɛsin dɛn we wi de tek kin gɛt. Dis kayn kin kam pan big pipul dɛm.

Aw dis sik kin kɔmɔn?

Dis na rili wan sik we nɔ kin apin so ɔltɛm. Na avrej, na lɛk sɛvin pipul dɛn pan ɛvri ɔndrɛd tawzin pipul dɛn kin gɛt dis sik ɛvri ia. So nɔ fɔ fred we yu nɔ nid fɔ fred, bɔt i impɔtant fɔ no.

Wetin na di sayn dɛm fɔ Agranulocytosis?

Insay dis kes, di men sayn dɛm kin gɛt fɔ du wit infɛkshɔn. Dɛn tin ya kin bigin wantɛm wantɛm, ɔ dɛn kin bɔku smɔl smɔl as tɛm de go. Si if dɛn sayn ya kin tan lɛk se yu sabi:

• Fɔ gɛt fiva, fil kol ɛn shek shek.
• Di at rit ɛn di brith rit we de go ɔp.
• Fɔ fil se yu nɔ gɛt layf ɛn yu taya pasmak.
• Trot we de at (pharyngitis), gingival rεsεshכn, blɔd we de kɔmɔt na di g כm.
• Sɔm na di mɔt ɛn trot, we kin mek i nɔ izi fɔ swɛla it ɛn drink.
• Wantɛm we yu blɔd prɛshɔn go dɔŋ (haypotension), yu ed kin tɔn, yu kin fɔdɔm, ɛn sɔntɛm yu kin ivin nɔ no natin.

If yu gɛt sayn dɛn lɛk dis, mɔ if dɛn kin apin bɔku tɛm, yu fɔ rili go to dɔktɔ.

Wetin mek agranulocytosis kin apin? Wetin na di tin dɛn we kin mek i apin?

Di men rizin fɔ dis na we di wayt blɔd sɛl dɛn we dɛn kɔl nyutrofil na wi bɔdi de go dɔŋ we denja. Tu rizin dɛn de we kin mek wi du dis:

• εither wi bכdi nכ de mek inof nyutrofil dεm fכ wok fayn fayn wan.
• If nɔto dat, di nyutrofil dɛn we de na di bɔdi kin pwɛl, ɔ dɛn kin day bifo tɛm.

Naw lɛ wi si wetin na di patikyula rizin dɛn fɔ dis.

Agranulocytosis we dɛn kin gɛt frɔm dɛn mama ɛn papa

insay dis, prכblεm de wit wan jin we de εp fכ mek nyutrofil dεm. dis na kכndyushכn we de we dεn bכn am (congenital). Fɔ ɛgzampul, if wi tek Kostmann syndrome , ɔ congenital agranulocytosis , we na wan sik we nɔ kin apin so ɔltɛm, bɔku tɛm di pikin dɛn we dɛn jɔs bɔn kin gɛt infɛkshɔn, fiva, inflamɛns, ɛn prɔblɛm wit dɛn bon.

Agranulocytosis we dɛn kin gɛt

Bɔku rizin dɛn kin de fɔ dis. Lɛ wi si wetin dɛn bi:

• Sɔm mɛrɛsin dɛn: Dis na di tin we kin mek pɔsin gɛt dis sik pas ɔl . Sɔm antibayɔtik , antisaykotik mɛrɛsin , ɛn tayroyd mɛrɛsin kin mek dis sik.
• כtoimyun sik dεm : Dis na sik dεm we di imyun sistεm de atak di bכdi in כwn sεl dεm. Sɔm ɛgzampul dɛn na lupus ɛn rεumatoid atraytis .
• Bɔn mɛro sik ɛn bon mɛrɔ we nɔ de wok fayn: Fɔ ɛgzampul , aplastic anemia . Di bon mɛro na di say we dɛn mek wi blɔd sɛl dɛn.
• Kansa: Kansa we kin afɛkt di bon mɛrɔ, mɔ di lukimiya .
• Tritmɛnt fɔ kansa (Kɛmotɛrapi): Dɛn tritmɛnt ya kin pwɛl di sɛl dɛn we gɛt wɛlbɔdi ɛn bak di nyutrofil dɛn.
• Fɔ gɛt pɔyzin ɔ kemikal: Fɔ de pan tin dɛn lɛk lid ɔ mɛkkyuri fɔ lɔng tɛm.
• Infɛkshɔn: Na bad bad infɛkshɔn lɛk malaria , TB , ɛn Rɔki Mawnt spɔt fiva .
• di nyutrishכn dεm we dεn nכ gεt: di dεfisit fכ di imכtant nyutriεnt dεm lεk Vitamin B12 εn Folate.

Udat de pan denja pas ɔl fɔ gɛt dis sik?

Uman dɛn kin gɛt dis sik smɔl pas man dɛn. Dɔn bak, agranulocytosis kin afɛkt ɛnibɔdi we ol ɛni ej. Bɔt dɛn pipul ya kin gɛt patikyula prɔblɛm:

• Pipul dɛn we de du kemotɛrapi fɔ kansa.
• Pipul dɛm wae gɛt ɔtoimyun sik dɛm lɛk lupus ɛn rεumatoid arthritis .
• Pipul dɛm wae de tek sɔm mɛrɛsin dɛm, lɛk Clozapine (Clozaril®) , wan antisaykotik , Trimethoprim/sulfamethoxazole (BactrimTM) , ɛn Methimazole (Tapazole®), wan tayroyd mɛrɛsin.

Wetin na di kɔmplikɛshɔn dɛm we kin apin bikɔs ɔf agranulocytosis?

Dis kכndyushכn kin mek yu gεt infεkshכn plεnti tεm כ fכ lכng tεm (krεse infεkshכn).

if agranulocytosis de fכ mכr dan tri to fכ wik, 100% chans de fכ divεlכp infεkshכn.

If dɛn nɔ trit am, sepsis kin mek i gɛt wan bad bad, layf-threating imyun sistɛm riakshɔn we dɛn kɔl sɛpsis. Sepsis na wan bad bad infεkshכn we de spre כlsay na di bכdi. Pipul wae dɔn pas 65 ia ɔr wae gɛt ɔda wɛl bɔdi prɔblɛm, lɛk hat sik, kidni sik, ɔr lɔng sik, kin gɛt bɔrku risk fɔ gɛt dɛn kayn prɔblɛm ya.

Aw yu kin no bɔt dis?

Aw dɔktɔ kin no se i gɛt agranulocytosis? Bɔku tɛm, dɛn kin fala dɛn tin ya:

• Kɔmplit Blɔd Kɔnt (CBC) ɛn difrɛns: Dis tɛst de luk di difrɛn kayn sɛl dɛn na yu blɔd, mɔ di nɔmba fɔ di nyutrofil dɛn. absכlut nyutrofil kכnt (ANC) we less dan 100 pan wan maykrolit bכdi dεn kin kכnsidr am as agranulocytosis. (Nɔmal valyu fɔ pɔsin we gɛt wɛlbɔdi pas 1,500.)
• Bon mכro bayopsi εn aspirayt: sכmtεm, dεn kin du dis tεst fכ si aw yu bon mכro de prodyuz nyutrofil dεm.
• Di sayn dɛm ɛn di mɛdikal histri: Di ​​dɔktɔ go aks yu bɔt yu sik dɛm, di mɛrɛsin dɛm wae yu de tek, di sik dɛm wae yu dɔn gɛt dis biɛn tɛm, ɛn ɛnitin wae yu gɛt wit kemikal.
• Jεnεtik tεst: If dεn sכspεkt wan jεnεtik kכndyushכn, dεn kin du jεnεtik tεst fכ kכnfכm am. Dis kin min fɔ tek di skin bayɔpsi ɔ fɔ tɛst di blɔd.

Wetin na di tritmɛnt dɛm fɔ dis?

Di gud nyus na dat, tritmɛnt dɛn de fɔ dis sik, we na agranulocytosis. Di tritmɛnt dipen pan di tin we mek i apin.

• Stɔp di mɛrɛsin we de mek yu gɛt di sik: If wan mɛrɛsin de mek yu gɛt di sik, di fɔs tin we yu fɔ du na fɔ stɔp fɔ tek am sef wan lɛk aw yu dɔktɔ tɛl yu fɔ tek am. Nɔ ɛva stɔp fɔ tek mɛrɛsin we yu nɔ go to dɔktɔ.
• Antibayɔtik: If yu gɛt infekshɔn, yu dɔktɔ go gi yu di rayt antibayɔtik ɛn ɔda mɛrɛsin fɔ mek yu nɔ gɛt di sik.
• granulocyte colony-stimulating factor (G-CSF): dεn kin gi dis kayn injεkshכn fכ εp di bכdi fכ mek nyutrofil dεm kwik kwik wan. Sɔm ɛgzampul dɛn na drɔgs lɛk Filgrastim (Neupogen®) , Pegfilgrastim (Neulasta®) , ɛn Lenograstim (Granocyte®) .
• Immunosuppressants: If di sik na wan ɔtoimyun disɔda, dɛn kin gi yu mɛrɛsin dɛn we de stɔp di imyun sistɛm, lɛk Prednisone .
• Bɔn mɛrɔ transplant: If ɔda tritmɛnt dɛn nɔ wok, yu kin nid fɔ gɛt bon mɛrɔ transplant. Insay dis, dɛn go gi yu bon mɛro frɔm pɔsin we gɛt wɛlbɔdi. Dis go ɛp yu bɔdi fɔ mek nyutrofil dɛn we gɛt wɛlbɔdi bak.
• Fɔ mek yu nɔ gɛt di sik: Dis rili impɔtant. Pipul wae gɛt dis sik nid fɔ tek tɛm bad bad wan fɔ avɔyd infɛkshɔn.
• Wash yu an fayn fayn wan wit sop ɔltɛm.
• Avɔyd ples dɛn we pipul dɛn kin bɔku as yu ebul.
• Wear fes kɔva/mask we yu de go na do.
• Tɔk to yu dɔktɔ bɔt wetin ɔda tin yu kin du fɔ mek yu nɔ sik.

Aw kwik a go wɛl afta dɛn dɔn trit mi?

di tεm we yu de rεkכv de dipכnt pan di kכz fכ yu lכw nyutrofil kכnt εn aw di kכndyushכn siriכs. If na sayd ɛfɛkt fɔ wan mɛrɛsin, i kin tek wan wik to tri wik fɔ mek yu nyutrofil kɔnt kam bak to nɔmal afta yu dɔn stɔp fɔ tek di mɛrɛsin.

Yu tink se dɛn go ebul fɔ stɔp dis?

Sɔntɛnde, dɛn nɔ kin ebul fɔ stɔp agranulocytosis ɔltogɛda. Bɔt if yu de tek mɛrɛsin we kin mek yu nyutrofil dɛn dɔŋ (e.g., kemotɛrapi, sɔm saykayatrik mɛrɛsin dɛn), i impɔtant fɔ tɔk to yu dɔktɔ ɛn mek dɛn chɛk yu nyutrofil lɛvɛl ɔltɛm. If yu de tek kemotɛrapi fɔ kansa, yu dɔktɔ kin tɛl yu fɔ gi yu G-CSF injɛkshɔn fɔ ɛp fɔ mek yu gɛt mɔ nyutrofil.

Wetin na de luk fɔ pɔrsin wae gɛt agranulocytosis?

Pan ɔl we dis na sik we pɔsin kin trit, di tin dɛn we kin apin kin difrɛn frɔm wan pɔsin to ɔda pɔsin. If dɛn trit am fayn, ɔ if dɛn stɔp di mɛrɛsin we de ridyus di nyutrofil, bɔku tɛm di sik kin dɔn.

Bɔt if dɛn nɔ trit am, i kin gɛt siriɔs infɛkshɔn ɛn ivin day. di lכng we di nyutrofil kכnt de na wan denja lεvεl, na di mכr risk fכ infεkshכn εn kכmplikεshכn dεm. Dis kin bi mɔ fɔ pipul dɛm wae pas 65 ia ɛn wae gɛt ɔndalayn mɛrɛsin (lɛk kidni, at, ɔr lɔng sik).

Ustɛm yu fɔ go to dɔktɔ?

Agranulocytosis na wan sik we de mek pɔsin in layf de pan denja. So, i impɔtant fɔ gɛt diagnosis ɛn tritmɛnt kwik kwik wan. Go to dɔktɔ wantɛm wantɛm if yu gɛt ɛni wan pan dɛn sayn ya:

• If yu kin gɛt infɛkshɔn ɔltɛm.
• If di infekshɔn tek lɔng tɛm fɔ wɛl.
• If yu gɛt sɔm sayn dɛm fɔ infekshɔn lɛk fiva, kol, ɔr trot we de at.

If yu gɛt ɔtoimyun sik ɔ yu de tek mɛrɛsin we de mek yu nyutrofil dɛn go dɔŋ, nɔ skip yu mɛdikal chɛk-ap. We yu de chɛk yu dɔktɔ ɔltɛm, dat kin ɛp yu fɔ wach yu nyutrofil lɛvɛl ɛn ɛp fɔ mek yu nɔ gɛt infɛkshɔn.

Di impɔtant tin dɛn we wi nid fɔ mɛmba (Take-Home Message) .

Okay, so lɛ wi rikap sɔm pan di impɔtant pɔynt dɛn frɔm wetin wi dɔn tɔk bɔt:

• Agranulocytosis na siriɔs bɔt dɛn kin trit am we di wayt blɔd sɛl dɛn we dɛn kɔl nyutrofil kin go dɔŋ bad bad wan.
• If yu gɛt sɔm sayn dɛn lɛk fɔ gɛt infɛkshɔn ɔltɛm, fiva, ɔ yu trot we de at, go to dɔktɔ wantɛm wantɛm.
• Dis kin kam bikɔs ɔf sɔm mɛrɛsin dɛn, sik dɛn we dɛn kin gɛt we dɛn de fɛt dɛnsɛf, ɛn tritmɛnt dɛn we dɛn kin gi kansa.
• Di tritmɛnt kin inklud fɔ stɔp di drɔg we de mek yu fil bad, antibayɔtik, G-CSF injɛkshɔn, ɛn sɔntɛm fɔ transplant bon mɛrɔ.
• Fɔ protɛkt yusɛf frɔm infɛkshɔn rili impɔtant. Yu kin protɛkt yusɛf bay we yu de du simpul tin lɛk fɔ was yu an ɔltɛm ɛn wɛr mask we yu de na pɔblik.
• If yu de pan denja fɔ dis (e.g., if yu tek sɔm mɛrɛsin), nɔ skip fɔ go to dɔktɔ.

A op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!