Lɛ wi lan bɔt di sikrit na di bren we de mek yu maynd kol - GABA (gamma-aminobutyric acid)?

Sɔntɛnde, yu kin fil lɛk se yu at pwɛl, yu kin wɔri, ɔ yu kin jɔs fred? Ɔ yu kin sɔfa wit inshɔmnia na nɛt? Biɛn dɛn tin ya kin gɛt smɔl kemikal mɛsenja na wi bren. Na dat wi go tok abaut tide. Na GABA na. I de wok lɛk di ‘kul’ bɔtin na wi bren.

Wetin na GABA (gama-aminobutyric acid)?

Fɔ tɔk am simpul wan, GABA na kemikal we de transmit mɛsej bitwin di nerve cells (nyuron) na wi bren. I tan lɛk smat postman na wi bɔdi. bכt wetin spεshal bכt am na dat i mεnli "kכl dכn" di bren in aktiviti we nכ nid. Dat min se i de stɔp di bren in nɛv sɛl dɛn fɔ mek dɛn nɔ de wok pasmak ɛn mek dɛn nɔ de shem. Sayɛnsman dɛn kin kɔl dɛn kayn kemikal ya nyurotransmitta. Tink bɔt GABA as "brek" we de kɔntrol di spid we wi sɛntral nɛv sistɛm de spid, we inklud wi bren ɛn spɛshal kɔd. Na wetin de ɛp wi fɔ mek wi nɔ gladi pasmak ɔ fred.

Aw GABA de wok? Wetin kin apin insay wi bren?

Naw luk aw dis GABA de wok insay wi bren. Na wan we we rili wɔndaful. Wi gɛt bɔku bɔku nerv sɛl dɛn na wi bren. Wi nid fɔ sɛn mɛsej frɔm wan nɛv sɛl to ɔda wan. Fɔ tru, smɔl gap de bitwin dɛn tu nɛv sɛl dɛn ya. dat dεn kכl am `(Synapse)` כ nεv jכnkshכn.

wan `(Nyurotransmitta)` lεk GABA de du dis bay we i de tek di mεsej kכros dis jכnkshכn εn atak spεsifi k `(Rεsεptor)` pan di nεks nεv sεl. I tan lɛk ki we fit insay lɔk. Jɔs lɛk aw nɔto ɔl ki kin opin ɛvri lɔk, nɔto ɔl `(Nyurotransmita)` kin ataya to ɛvri `(Rɛsɛptɔ)`. GABA gεt tu spεsifi k `(Rεsεptor)` dεm bak we de rεkכgnεz am – `(GABA-A)` εn `(GABA-B)`.

so, we GABA go εn tay pan dεn rεsεpכta dεm ya, i de ridyus di abiliti fכ di nεks nεv sεl fכ rεspכnd. Dat min se i de ridyus di chans fɔ mek da sɛl de mek mɛsej we nɔ nid ɔ sɛn am to ɔda pɔsin. dis na di rizin we mek dεn kכl GABA "inhibitory" כ calming neurotransmitter.

Us wɛlbɔdi bɛnifit dɛn GABA de gi?

So, us wɛlbɔdi bɛnifit wi kin gɛt frɔm GABA, we kin mek di bren kol dis we? Fɔ tru, bɔku pipul dɛn de. Imajin, yu de rili ``stress'', dat na, we yu de ɔnda bɔku strɛs, yu maynd nɔ de na wan ples, yu de wɔri bad bad wan, ɛn yu chɛst de fil lɛk se i de paund. Na dis kayn tɛm, if di GABA lɛvɛl na yu bɔdi rayt, i go mek yu maynd kol ɛn ɛp yu fɔ ridyus dis strɛs .

GABA gɛt wan wɔndaful pawa bak fɔ kɔntrol di wɔri we pɔsin de wɔri . E kin ɛp fɔ ridyus frayd ɛn wɔri bɔt ɔltin wae nɔr nid.

Wan ɔda tin na dat, sɔm pipul dɛn nɔ kin ebul fɔ slip na nɛt. Dɛn kin jɔs tos ɛn tɔn we dɛn de go slip, bɔt i tan lɛk se dɛn nɔ de slip atɔl. Risach we dɛn de du naw sho se GABA kin ɛp bak fɔ slip fayn ɛn rɛst .

GABA ɛn Glutamate: Di Bren in ‘On-Off’ Switch

along wit GABA, wan כda rili imכtant `(Nyurotransmitta)` de na wi bren. Na `(Glutamate)`. Dɛn tu ya de wok lɛk tu say dɛn na kɔyn, ɔ lɛk tu ‘ɔn’ ɛn ‘ɔf’ switch dɛn. Dat min se, na difrɛn say dɛn to dɛnsɛf.

• GABA: ‘Turn off’ di bren aktiviti εn kכl am dכn (inhibitory).
• Glutamate: ‘I de tכn on’ εn i de mek di bren wok (stimulant).

so, fכ mek wi bren fכ wok fayn fayn wan εn fayn fayn wan, i nid fכ bi wan dilikεt bεlε bitwin di kכlכm pawa fכ GABA εn di stimulating pawa fכ `(Glutamate) . Jɔs lɛk di aksilarayt ɛn di brek na motoka. Na we wi ɔl tu wok fayn ɛn di rayt tɛm nɔmɔ wi go ebul fɔ travul fayn fayn wan ɛn sef wan. If dis balans lɔs, difrɛn prɔblɛm dɛn kin kam. i sכprayz se dis kכlmin ejen we dεn kכl GABA de prodyuz bak frכm di stimulant `(Glutamate). wan spεshal `(εnzym)` de involv insay am, dat na wan εnzym (`glutamic acid decarboxylase`).

GABA de wok togɛda bak wit ɔda nyurotransmitta, sɛrotonin. Infakt, bɔku nyurotransmitta dɛn kin wok togɛda, sɔntɛnde dɛn kin agens dɛnsɛf, fɔ mek wi bɔdi ɛn bren wok fayn fayn wan.

Sik dɛm we kin kam bikɔs di GABA lɛvɛl smɔl

Imajin wetin go apin if dis GABA mɛsej ɛkshɛnj nɔ bin de wok fayn, we min se di GABA lɛvɛl na di bren bin smɔl? Dis kin mek yu gɛt difrɛn kayn nyurolɔjik ɛn maynd wɛlbɔdi prɔblɛm. Risach dɔn sho se di ridyus GABA aktiviti kin kɔntribyut to kɔndishɔn dɛn lɛk:

• Wae yu de wɔri ɛn nɔr de fil fayn: Fɔ fil lɛk yu de fred ɔltɛm, de wɔri, yu nɔr de gɛt gladi at, ɛn yu nɔr de ebul fɔ pe atɛnshɔn.
Schizophrenia : Na kɔmpleks mɛntɛl sik wae kin kam wae pɔrsin nɔr kin gɛt kɔnekshɔn wit rial tin ɛn si, yɛri, ɛn tink tin dɛm wae nɔr rial.
• Autism spectrum disorder: Na divεlכpmεnt dizכrd wae de kכl dεm wae de mek dεn nכ de wok fayn na di soshal intarakshכn εn kכmyunikeshn.
• Pwɛl hat: Na fɔ fil bad fɔ lɔng tɛm, nɔr de intres pan ɛnitin, ɛn fil lɛk se yu de bost wit layf.
• Epilepsy ɛn seizure: Kɔndishɔn lɛk kɔnvulshɔn ɛn sik we kin apin na di bɔdi bikɔs ɔf di wan we di nɛv sɛl dɛn na di bren kin wok wantɛm wantɛm, we dɛn nɔ kin kɔntrol.

Apat frɔm dɛn big big tin ya, sɔm ɔda sik dɛn de we dɛn tink se gɛt fɔ du wit GABA imbalans:

• Piridoksin we nɔ de: .Dis na sik we nɔ kin apin so ɔltɛm. i de kכz fכ we yu nכ gεt vaytam in B6 (pyridoxine), we implεnt fכ mek GABA. Dis kin mek yɔŋ pikin dɛn gɛt sik ɔltɛm. Dɛn sik ya at fɔ kɔntrol wit standad anti-ɛpileptik drɔgs, bɔt dɛn kin mɛn am wit vaytamɛn sɔpɔtmɛnt.
• Hepatic encephalopathy: Na siriɔs liva sik we de afɛkt di bren wok.
• Huntington’s disease: Na sik we wi kin gɛt frɔm wi mama ɛn papa ɛn we kin pwɛl di bren sɛl dɛn smɔl smɔl.
• Distonia ɛn spasticity: Kɔndishɔn dɛn we de sho se di mɔsul dɛn nɔ de stiff ɛn i de twit.
• Hypersomnia: Fɔ fil se yu de slip pasmak ɔ yu de slip tumɔs insay di de.

Yu tink se wɛlbɔdi bɛnifit dɛn de we pɔsin kin gɛt we i de mek di GABA lɛvɛl go ɔp?

Risach pipul dεm stil de stכdi di ifekt dεm we di GABA lεvεl dεm de inkrεs. Pan ɔl we di pruf nɔ klia yet, dɛn de chɛk if GABA kin ɛp fɔ trit ɔ fɔ mek dɛn nɔ gɛt sɔm wɛlbɔdi prɔblɛm dɛn. Fɔ ɛgzampul:

• Di ay blɔd prɛshɔn
• Nɔ ebul slip
• Shuga

Dɛn nid fɔ du mɔ risach bɔt dɛn tin ya.

Di kayn drɔgs dɛn we de tɔch GABA

biכs fכ dis imכpכtants fכ GABA, di wan dεm we de mek dכg dεn dכn divεlכp bכku dכg dεm we de tכk bכt GABA ``rεsεpכta dεm''. dis dεm de wok bay we dεn de εp כ εnhans GABA in nεchכral kכlmεnt ifekt dεm. Sɔntɛm yu dɔn yɛri bɔt dɛn tin ya:

• Benzodiazepines: Dis klas ɔf drɔgs inklud dayazepam (we dɛn kin kɔl bak Valium) ɛn alprazolam (we dɛn kin kɔl bak Xanax) ɛn dɛn kin yuz am fɔ trit wɔri, nɔr kin slip, fɔ gɛt sik, ɛn fɔ lɛf fɔ drink rɔm. Dɛn kin yuz dɛn bak as anestezi we dɛn de du ɔpreshɔn.
• Barbiturates: Dɛn tin ya na wan kayn mɛrɛsin bak we de mek pɔsin slip we kin mek pɔsin slip. Bɔt naw, pipul dɛn nɔ de yuz dɛn igen.
• Vigabatrin (Sabril®): Na mεdikal we dεn kin yus fכ trit di sik we dεn kin sכk εn di mכsul dεm we kin spam pan yכŋ pikin dεm.
• Flumazenil (Romazicon®): Dɛn kin yuz am fɔ trit bɛnzodiazepine ɔvados. Dɛn kin yuz am bak fɔ mek yu maynd bɛtɛ pan ɛpatik ɛnsɛfalopathy, we na wan sik we kin kam wit liva sik.
• Valproic acid: Dis na wan mɛrɛsin wae de mek pɔrsin nɔr de fil fayn ɛn wae de kɔntrol aw pɔrsin kin gɛt ɛpilepshɔn.
• Zolpidem (dεn kin kכl am bak Ambien® כ Edluar®): Dis na big mεdikeshכn fכ inshכn.
• Propofol (we dɛn kin kɔl bak Diprivan®): Na drɔg we dɛn kin yuz fɔ mek pɔsin fil fayn ɛn mek i slip we dɛn de gi am jenɛral anestezi.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): Na tin we de mek di mɔsul dɛn rilaks.

Mɛmba se: Dɛn fɔ yuz dɛn mɛrɛsin ya ɛn ɔda kayn mɛrɛsin dɛn ya ɔnda dɔktɔ in sɔpɔtishɔn nɔmɔ. If yu yuz dɛn fɔ yusɛf, ɔ jɔs bikɔs pɔsin we de nia yu tɛl yu fɔ du dat, dat kin mek yu gɛt siriɔs prɔblɛm. So tek tɛm.

Yu tink se GABA supamakit dɛn yusful?

Naw sɔm pipul dɛn kin aks se, ‘Dɔn wetin mek wi nɔ go ebul fɔ bay GABA as sɔpɔt?’ Yes, GABA de as di it supliment. Bɔt wan smɔl prɔblɛm de ya. I stil nɔ klia bɛtɛ bɛtɛ wan aw bɔku pan di GABA we wi kin tek bay mɔt kin rili go insay wi bren.

biכs, wi bren de rawnd wan rili spεshal protεktiv mεmbran we dεn kכl "blכd-bren barεri". Dis tan lɛk get, we nɔ de alaw ɔl di kemikal dɛn fɔ go insay di bren izi wan, na di wan dɛn nɔmɔ we dɛn dɔn pik de alaw. So, stil nɔr gɛt inof strɔng sayɛns pruf fɔ se if dɛn GABA supamakit ya rili gɛt ifɛkt pan di bren ɔ nɔ gɛt. So, dɛn nid fɔ du mɔ risach bɔt dis we dɛn de yuz big grup fɔ pipul dɛn. We yu tink bɔt di tin dɛn we de apin naw, i nɔ fayn fɔ yuz GABA sɔpɔtmɛnt dɛn we yu nɔ tɔk to dɔktɔ.

Ɛni it de we gɛt GABA?

GABA de insay sɔm it dɛn bak bay insɛf. Fɔ ɛgzampul:

• Fɔd dɛn we dɛn dɔn fɛmɛnt: tin dɛn lɛk kimchi (wan Korian pikɛl), miso (wan Japan soya paste), ɛn tempeh (wan Indonishian soya prodak).
• Di kayn ti: Grin ti, blak ti, ɛn oolong ti gɛt GABA bak.
• Ɔda it dɛn: Fɔd dɛn lɛk brawn rays, soya bin, pis, chɛstnɛt (wan kayn pinat), mɔs, tomato, spinach, brɔkoli, kabij, kɔliflawa, Brussels sprouts (wan kayn smɔl kabij), grens we dɔn gro (e.g., grɛn bins we i sprout), ɛn swit pata sɛf gɛt GABA ɔ ɛp di bɔdi fɔ mek GABA.

Bɔt as wi bin dɔn tɔk bɔt sɔpɔtmɛnt, stil nɔ klia ɛksplen fɔ aw bɔku GABA frɔm dɛn it ya kin rili rich di bren. I fayn fɔ put dɛn as pat pan wɛlbɔdi it, bɔt i nɔ fayn fɔ abop pan dɛn it ya nɔmɔ as patikyula tritmɛnt fɔ wan patikyula sik. Dɔn bak, go to dɔktɔ bɔt dis.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

So, yu go dɔn ɔndastand naw se GABA (gamma-aminobutyric acid) we wi bin de tɔk bɔt tide na nyurotransmitta we de mek wi bren kol ɛn i rili impɔtant fɔ wi maynd wɛlbɔdi, slip, ɛn di wok we wi bɔdi de du injɔnal wan.

I kin ɛp fɔ kɔntrol di wɔri, strɛs, ɛn nɔ ebul fɔ slip. di lכw GABA lεvεl kin mek yu gεt difrεn nyurolכjik εn saykayatrik dizכrd dεm. Sɔm mɛrɛsin dɛn kin wok bay we dɛn de tɔch di GABA sistɛm.

Fɔda sayɛns risach nid fɔ de pan di bɛnifit dɛn we GABA sɔpɔtmɛnt ɛn it dɛn we gɛt GABA gɛt. So, if yu gɛt ɛnitin fɔ wɔri bɔt, dawt, ɔ kwɛstyɔn bɔt GABA, di bɛst ɛn sef tin fɔ du na fɔ go to yu famili dɔktɔ, tɔk bɔt yu sityueshɔn, ɛn gɛt di rayt advays.Nɔ go wok bay we yu gɛs ɔ we yu yɛri. Yu wɛlbɔdi valyu to yu.

` GABA, gamma-aminobutyric acid, nyurotransmitta, bren, mental hεlth, wɔri, slip