Yu pikin de gro tu kwik? Lɛ wi lan bɔt gigantism!

Sɔntɛnde, wi pikin dɛn kin gro kwik kwik wan, nɔto so? Bɔt i nɔ nɔmal fɔ mek dɛn gro wantɛm wantɛm fɔ lɔng pas ɔda pikin dɛn, ɛn dɛn an ɛn fut dɛn big. De rizin fɔ dis kin bi wan sik wae nɔr kin bɔrku. Tide wi go tok abaut dis kain kondishon, dat na, ‘Gigantism’.

Wetin na ‘Gigantism’?

Fɔ tɔk am simpul wan, gigantism na tin we nɔ kin apin so ɔltɛm we pikin ɔ yɔŋ pɔsin kin mek tumɔs ɔmon we de mek pɔsin gro (GH) . Dis na di rizin we mek dɛn pikin ya kin gro lɔng pas ɔda wan dɛn. nכmal wan, dis gכt כmon (GH) de kכmכt frכm wan sכmכl gland we saiz fכ pis we de na di bכs pat na wi bren. Dɛn kɔl am di pituitary gland. כltu, if sכm tכmכro de divεlכp na dis pituitary gland, i kin mek mכr gכt כmon (GH) pas aw i nid. Na da tɛm de gigantism kin apin.

di Pituitary Gland na wan sכmכl gland we de na di bכs pat na di bren, dכn di Hypothalamus. I kin rili pul lɛk 8 ɔmon dɛn. Growth Hormone (GH) na wan pan dɛn.

Growth Hormone, we dɛn kin kɔl bak Human Growth Hormone (hGH), impɔtant fɔ mek pikin dɛn gro. I kin afɛkt bɔku pat dɛn na di bɔdi ɛn ɛp di pikin fɔ gro fayn fayn wan. כltu, sכm kayn gכt plet dεm de na wi bon dεm we dεn kכl Epiphyses/Growth Plates, εn wans dεn kכmplit wan (i.e. afta di puberty), di growth כmon (GH) nכ de inkrεs di ayt. wetin i de du na fכ mek di bon dεm, di katilej dεm, εn כda כgan dεm strכkchכ εn mεtabolism. dis gכt כmon (GH) gεt kכl כmon we dεn kכl Insulin-like Growth Factor 1 (IGF1), we wi liva de mek. Tugeda, dεn tu de εp fכ gro εn mεtabolism.

Gigantism na wan sik we di bɔdi de mek tumɔs growth ɔmon (GH), we de mek di mɔsul dɛn, bon dɛn, ɛn kɔnektiv tisu gro kwik kwik wan. dis kin mek di ayt we nכ nכmal εn di sכft tisu dεm na di bכdi kin chenj sכm tεm. If dɛn nɔ trit sɔm pipul dɛn we gɛt big big bɔdi kin gro pas 8 fit.

So, i rili impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik kwik wan if yu gɛt big big bɔdi.

Wetin na di difrɛns bitwin ‘Gigantism’ ɛn ‘Acromegaly’?

Gigantism ɛn acromegaly na ɔl tu di kɔndishɔn dɛn we di ɔmon we de gro pasmak (GH) kin mek. Di difrɛns na udat de divɛlɔp am. Akromegali de divεlכp pan big pipul dεm. Gigantism kin kam pan pikin ɛn yɔŋ pipul dɛn we stil de gro, dat na, we nɔ rich dɛn yɔŋ pipul dɛn yet.

fכ sכmtεm, gigantism de apin we di gכt hכmon (GH) lεvεl dεm de inkrεs bifo di growth plet dεm na di pikin dεm bon dεm dכn kכloz (i.e., bifo di puberty dεn dכn).

If yu growth hormone (GH) lεvεl dεm de inkrεs afta yu growth plet dεm dכn klos, i kin mek yu gεt akromegali. Yu nɔ go gro lɔng, bɔt di GH we pasmak kin afɛkt di shep we yu bon dɛn gɛt, di sayz fɔ yu ɔgan dɛn, ɛn ɔda wɛlbɔdi prɔblɛm dɛn.

Gigantism na wan sik we nɔ kin apin so ɔltɛm pas akromegali.

Udat kin gɛt gigantism? Aw i kɔmɔn?

pan ɔl we dis na tin we nɔ kin apin so ɔltɛm, di gigantism kin kam pan ɛni pikin we in growth plet dɛn nɔ dɔn lɔk yet (i.e., dɛn nɔ dɔn kɔmplit di puberty). I kin apin mɔ pan bɔy pikin dɛn pas gyal pikin dɛn.

Gigantism na rili wan tin we nɔ kin apin so ɔltɛm. Fɔ ɛgzampul, na lɛk 100 pipul dɛn nɔmɔ dɛn dɔn ripɔt na Amɛrika te naw. So yu kin imajin aw i nɔ kin bɔku.

Aw pikin dɛn kin gro we nɔmal fɔ gro? Wetin na di difrɛns wit gigantism?

di כmon we de mek di pikin gro (GH) na in de kכntro di gro we i de gro we i sכm pikin. Dat min se i de kɔntrol di mɛtabolism we i de mek di bon dɛn, di mɔsul dɛn, ɛn di tisu dɛn gro we pɔsin kin mɛzhɔ. nכmal wan, di growth na fכs stebul prכsεs te di pikin rich puberty.

di tεm we uman de bכn, di sεks כmon dεm (εstrojen εn tεstostεron) de kכmכt bכku bכku wan. dis kin mek di epiphyses (growth plates) we de na di εnd dεm fכ di pikin in lכng bon dεm de kכloz sכmtεm. we di epiphyses dεm kכlכs kכmplit wan, dat min se we di puberty kכmplit, di ayt growth de stכp.

Aw pikin de gro kwik ɛn aw in las ayt go bi afta i dɔn rich fɔ bɔn, na bay we dɛn jɔyn difrɛn jin dɛn we dɛn gɛt frɔm dɛn mama ɛn papa, di tin dɛn we de arawnd dɛn, ɛn di we aw dɛn man ɔ uman.

If na big big pɔsin, di pikin kin gro kwik kwik wan, ɛn i kin lɔng pas ɔda pikin dɛn we gɛt di sem ej ɛn di sem sɛks. Bɔt, di sayn dɛm fɔ gigantism kin tan lɛk nɔmal growth spurt we pikin kin gɛt fɔs, we kin mek i nɔ izi fɔ mama ɛn papa fɔ no.

If yu gɛt ɛni kwɛstyɔn ɔ dawt bɔt aw yu pikin de gro, mek shɔ se yu tɔk to in dɔktɔ.

Wetin na di sayn dɛm fɔ gigantism?

Gigantism na bikɔs ɔf di ɔmon we de gro pasmak (GH). Dɔn bak, wan tumbu na di pituitary gland kin put prɛshɔn pan di bren ɛn di nervɔs tisu we de nia de, ɛn dis kin mek sɔm sayn dɛn de. Di men sayn fɔ gigantism na fɔ gro pasmak.Pikin dɛn we gɛt gigantism kin gro kwik kwik wan pan dɛn ayt.

Apat frɔm we i rili lɔng/big pas pɔsin in ej, di bɔdi kwaliti dɛn we dɛn kin si pan gigantism na:

• Fɔrɛst we rili impɔtant ɛn wan jawlayn we de sho klia wan.
• Fɔ gɛt gap bitwin di tit dɛn.
• Di tin dɛn we de na di fes tik.
• Big big an ɛn fut, ɛn tik tik finga dɛn.

Ɔda sayn dɛm wae yu kin si na:

• di כgan dεm we de insay di pikin big, spεshal wan di pikin in at.
• Fɔ swet pasmak (hayparaydrosis).
• Dabl vishɔn ɔ difikulti wit periferik vishɔn.
• Ed de at.
• Pen na di jɔyn dɛn.
• Dilay we pɔsin kin rich fɔ bɔn pikin.
• Menstrueshɔn we nɔ de ɔltɛm.
• Slip prɔblɛm, fɔ ɛgzampul, slip apnea.
• Di mɔsul dɛn we wik.

If yu pikin gɛt dɛn sik ya, i rili impɔtant fɔ tɔk to dɔktɔ kwik kwik wan.

Wetin na di tin dɛn we kin mek pɔsin gɛt big big bɔdi?

Bɔku tɛm, na wan fayn tɔŋ (pituitary adenoma) we de na di pikin in pituitary gland kin mek di gigantism. dis kin mek di gכt כmon (GH) rilis pasmak. we dεn no se pikin dεm we gεt gigantism, kכlכsכl כltεm dεn kin gεt big pituitary adenoma (tכmכro we 10 mm כ big pas dat), we dεn kכl makroadenoma. Gigantism kin bi bak we di pituitary gland big, we dɛn kɔl pituitary hyperplasia.

Bɔrku pikin dɛm wae gɛt gigantism gɛt wan jenɛtik muteshɔn wae kin mek dɛn gɛt pituitary tumor. di mכst kכmכn jεnεtik mכtεshכn we de asai wit gigantism na mכtεshכn כ dilit insay di AIP jin. Dis kin afɛkt lɛk 29% pan pipul dɛm wae gɛt gigantism.

Gigantism kin apin bak as pat pan wan nכmba fכ jεnεtik dizכrd dεm we rili rεs we de inkrεs di risk fכ divεlכp wan pituitary tכmכro we de sekret growth כmon (GH). Sɔm pan dɛn sik ya na:

• Carney complex: Dis na jεnεtik kכndyushכn we de afekt di skin pigmεnt εn mek bεnign tכmכro dεm na di skin, at, εn εndokrin sistεm. כlmost 10% to 13% pan di pipul dεm we gεt Carney komplεks de divεlכp di growth hכmon (GH)-secreting pituitary adenomas, we kin gro sloslo.
• Di sik we dɛn kɔl McCune-Albright:Dis na jεnεtik kכndyushכn we de afekt di bon dεm, di skin, εn di εndokrin sistεm. I kin mek pɔsin gɛt kafe-au-lait spat na di skin, skata na di bon dɛn, ɛn i kin mek pɔsin bɔn kwik kwik wan. 20% to 30% pan di pipul dεm we gεt McCune-Albright syndrome gεt εksyכs growth כmon (GH). Bɔku tɛm dis kin apin we di pituitary gland big (hyperplasia), ɔ di pituitary adenoma.
• mכltipכl εndokrin Nioplasia (MEN) tכp 1 כ 4: Dis na jεnεtik kכndishכn dεm. If na so i bi, wan ɔ mɔ pan yu ɛndɔkrin gland dɛn kin wok pasmak, ɔ wan tumbu kin kam. dis kin inklud wan pituitary tumor we de sekret growth hormone (GH).
• Nyurofibromatosis: Dis na wan jεnεtik kכndyushכn we dεn kכl nyurokutan dizכrd. Dɛn tin ya kin afɛkt di skin ɛn di nervɔs sistɛm. dis kכndyushכn dεm de kכz fכ di abnכmal inkrεs pan di sεl dεm we de gro. dis kin mek di tכmכro dεm de fכm כlsay na di bכdi. dis kin inklud wan tכmכro we de kכl gכt כmon (GH).
• Familial Isolated Pituitary Adenomas (FIPA): Dis na wan sik we pɔsin kin gɛt frɔm in mama ɛn papa. i involv di divεlכpmεnt fכ di pituitary adenomas. dis kin inklud di adenoma dεm we de kכmכt na di gכt hכmon (GH).

Aw dɛn kin no se pɔsin gɛt big big pɔsin?

Gigantism kin tranga smɔl fɔ no bikɔs na wan sik we nɔ kin apin so ɔltɛm, ɛn bikɔs di rit we pikin dɛn kin gro kin difrɛn bad bad wan bikɔs ɔf di jɛnɛtik ɛn di envayrɔmɛnt tin dɛn.

Tipikli, dɔktɔ dɛn kin sɔprayz se di pikin in ayt na tri standad dɛvyayshɔn pas di avɛrej ayt fɔ dɛn sɛks ɛn ej, ɔ tu standad dɛvyayshɔn pas di avrej ayt we dɛn kɔl frɔm di pikin in mama ɛn papa dɛn ayt.

If yu pikin in dɔktɔ tink se yu pikin gɛt gigantism, i go mɔs sɛn yu to ɛndokrinɔlɔjis (dɔktɔ we spɛshal pan sik dɛn we gɛt fɔ du wit ɔmon). Di dɔktɔ go mek di diagnosis bay yu pikin in mɛdikal istri, famili mɛdikal istri, fɔ chɛk in bɔdi gud gud wan, ɛn spɛshal tɛst dɛn lɛk blɔd tɛst ɛn imej tɛst.

Us tɛst dɛn kin yuz fɔ no if pɔsin gɛt big big pɔsin?

If yu pikin in dɔktɔ tink se i gɛt big big bɔdi, dɛn kin du dɛn tɛst ya fɔ no if i gɛt dis sik:

• Growth Hormone and IGF-1 (Insulin-like Growth Factor 1) blɔd tɛst: Dɛn tɛst ya de mɛzhɔ di lɛvɛl dɛn we difrɛn ɔmon dɛn de na di blɔd sɛmpul we dɛn tek frɔm di pikin in vein. If di lεvεl dεm hכy pas nכmal, i kin bi sayn fכ gigantism.
• Glucose Tolerance Test: Dis tεst de mכsu aw di pikin in growth כmon lεvεl dεm de rεspכnd to glukose. Fɔ dis tɛst, dɔktɔ kin tek blɔd sɛmpul frɔm wan vein difrɛn tɛm afta di pikin dɔn drink glukɔs (shuga) sɔlvushɔn.
• Imej tɛst: If blɔd tɛst kɔnfirm se yu pikin gɛt gigantism, bɔku tɛm yu dɔktɔ go tɛl yu fɔ du MRI (Magnetic Resonance Imaging) skan ɔ CT (Computed Tomography) skan. dis dεm kin si klia wan di sayz εn di say we di pituitary tumor de. Dɛn kin ɛp bak fɔ no di rayt tritmɛnt we dɛn nid.

If dɛn no se yu pikin gɛt big big sik, di dɔktɔ kin du sɔm ɔda tɛst dɛn fɔ si if di sik dɔn afɛkt ɔda pat dɛn na in bɔdi. Dɛn tɛst ya kin bi:

• Wan echocardiogram fɔ chɛk if yu gɛt at prɔblɛm.
• Slip stɔdi tɛst fɔ si if yu gɛt slip apnea.
• X-ray ɔ DEXA/DXA skan fɔ chɛk di wɛlbɔdi fɔ yu bon dɛn.

Aw dɛn kin trit gigantism?

Di men gol dɛm fɔ trit gigantism na:

• fכ kכntro di ‘grכw כmon' (GH) εn ‘insulin-layk growth fכktכ 1’ (IGF1) lεvεl dεm sef wan.
• mεnej di growth fכ wan ‘pituitary tumor’.
• fכ ridyus di impak we wan pituitary tכmכro gεt pan di bren tisu we de nia εn di optik nεv.
• Fɔ trit ɔ ridyus di ifɛkt dɛm we di growth ɔmon (GH) gɛt pan ɔda bɔdi sistɛm dɛm.

Dɔktɔ dɛn kin yuz kɔmbayn tritmɛnt fɔ gigantism , ɛn ɔpreshɔn ɛn redyushɔn tɛrapi na di men tritmɛnt.

Pan ɔl we fayn mɛrɛsin dɛn de fɔ trit di growth ɔmon (GH) we pasmak pan big pipul dɛn (acromegaly), dɛn nɔ dɔn stɔdi gud gud wan yet bɔt aw dɛn mɛrɛsin ya kin afɛkt pikin dɛn.

Ɔpreshɔn fɔ Gigantism

Ɔpreshɔn na di tritmɛnt we dɛn kin yuz mɔ fɔ gigantism. di gol na fכ pul di pituitary tumor כ ridyus in saiz. Bikɔs di pituitary tumor we de mek di gigantism kin big bɔku tɛm, di pikin kin nid fɔ du bɔku ɔpreshɔn fɔ kɔntrol di growth ɔmon (GH) lɛvɛl fayn fayn wan.

Yu pikin in dɔktɔ kin yuz wan ɔpreshɔn we dɛn kɔl transsphenoidal ɔpreshɔn fɔ pul wan pituitary tumor. dis involv fכ du di כpεrayshכn tru yu pikin in nos εn tru di sphenoid sinus (wan kכva na di sכkul bihayn di nos kכva, dכn di bren).

Radieshɔn Tɛrapi fɔ Gigantism

If di ɔpreshɔn nɔ ebul fɔ ridyus di ɔmon we de mek pɔsin gro, di tritmɛnt we dɛn kin gi pɔsin wit raytin kin ɛp. Dis involv fɔ yuz spɛshal ikwipmɛnt fɔ aim redyushɔn bim dɛn na di tɔŋ. Dis tritmɛnt de wok sloslo. I kin nid fɔ gɛt bɔku tritmɛnt dɛn, wit lɔng tɛm fɔ rɛst bitwin dɛn. I kin tek sɔm ia bak fɔ si ful rizɔlt.

Wetin na di prɔblɛm dɛn we kin apin we pɔsin gɛt tritmɛnt?

Bikɔs ɔf ɔpreshɔn ɛn/ɔ redyushɔn tɛrapi, lɛk 60% pan di pipul dɛm we gɛt gigantism kin gɛt wan kɔndishɔn we dɛn kɔl haypopituitarism afta dɛn dɔn trit am. Dis na we wan, sɔm, ɔ ɔl di ɔmon dɛn we di pituitary gland de mek nɔ de prodyuz bɛtɛ. Dɛn kin trit di haypopituitarism wit mɛrɛsin dɛn we de chenj di ɔmon.

Di prɔblɛm dɛn we kin apin we dɛn du ɔpreshɔn fɔ pul wan pituitary tumor na:

• Blɔd we de kɔmɔt.
• Sεribrospεnal Fluid (CSF) de lik.
• Meningitis (bren fiva).
• di lכs fכ sכdiכm (sכlt) εn wata bεlε na di bכdi.

Di bad tin dɛn we kin apin we pɔsin gɛt redyushɔn tɛrapi kin bi:

• Di Fɛtiliti we nɔ de wok fayn.
• Vision loss ɛn bren damej (rare).
• tכmכro fכmeshכn sεvεra ia afta tritmεnt (rare).

Yu tink se dɛn go ebul fɔ stɔp big big pipul dɛn? Wetin na di prɔgnosis?

Bɔt i sɔri fɔ no se natin nɔ de we yu go du fɔ mek yu nɔ gɛt big big pipul dɛn. Bɔt fɔ no di pɔsin kwik kwik wan rili impɔtant. If yu trit yu pikin kwik kwik wan, dat kin ɛp fɔ mek yu nɔ gɛt ɔ chenj di chenj dɛn we de mek yu pikin tu lɔng.

Di prɔgnosis fɔ pikin ɛn yɔŋ pipul dɛm we dɛn no se gɛt gigantism de dipen pan sɔm tin dɛm:

• Aw ali ɔ let dɛn bin no di sik.
• Aw di tritmɛnt dɛn kin wok fɔ kɔntrol di ɔmon we de gro?
• If kɔmplikeshɔn dɛn de we gɛt fɔ du wit gigantism.

In jɛnɛral, pipul dɛm wae dɔn ol we dɛn no se dɛn gɛt dis sik kin gɛt mɔ prɔblɛm pas di wan dɛm wae dɛn kin no se dɛn gɛt di sik we dɛn yɔŋ. dis kin bi bikoz fכ lכng tεm we dεn de εkspos to di gכt כmon εn insulin lεk growth fכktכ 1 (IGF1).

So, if yu notis chenj dɛn we nɔ kɔmɔn, we yu nɔ bin de ɛkspɛkt pan yu pikin in gro ɛn/ɔ in bɔdi, i impɔtant fɔ tɔk to dɛn dɔktɔ kwik kwik wan.

Wetin pɔsin we gɛt big big bɔdi kin liv? Wetin na di prɔblɛm dɛn we kin apin fɔ lɔng tɛm?

Fɔ no ɛn trit gigantism kwik kwik wan impɔtant fɔ mek yu nɔ gɛt bɔku ayt ɛn di prɔblɛm dɛn we kin apin to am ɛn fɔ mek yu nɔ liv lɔng.

If dɛn nɔ trit am, gigantism kin gɛt fɔ du wit bɔku prɔblɛm dɛn ɛn di rit we pipul dɛn kin day kin rich tu tɛm pas di nɔmal wan.

Lכng tεm kכmplikεshכn dεm we sכm pipul dεm we gεt gigantism kin gεt biכs fכ dεn ayt pasmak εn di כvala ifekt we dεn gεt tu mכch gכt כmon inklud:

• Difεlεns fכ muv arawnd (Mobility) bikoz fכ di mכsul dεm wik.
• Ɔstiɔ-arayt (jɔyn inflamɛns).
• Pεrifεral Nyuropati (pεrifεral nεv dizכrd).
• 'Slip Apnea'.
• At we big (cardiomegaly) ɛn at valv prɔblɛm.
• Mεtabolik komplikashכn dεm lεk Tayp 2 Dayabitis.

Apat frɔm dat, di kwaliti fɔ layf fɔ pipul dɛn we gɛt gigantism we dɛn nɔ trit kin ridyus bikɔs ɔf prɔblɛm wit di tin dɛn we dɛn kin du ɛvride lɛk fɔ go bay klos ɛn fɔ travul bikɔs dɛn tu lɔng.

Ustɛm yu fɔ go to yu pikin in dɔktɔ bɔt gigantism?

If dɛn dɔn no se yu pikin gɛt big big sik, i go nid fɔ go to in dɔktɔ ɛn/ɔ ɛndokrinɔlɔjis ɔltɛm fɔ wach aw di tritmɛnt de go bifo ɛn fɔ mek shɔ se in ɔmon lɛvɛl de fayn.

If yu notis ɛni chenj na yu pikin in growth rit ɛn/ɔ in bɔdi, i impɔtant fɔ tɔk to yu pikin in dɔktɔ kwik kwik wan. Pan ɔl we i nɔ go izi fɔ mek big big pipul dɛn de du dis, i fayn fɔ mek dɛn chɛk ɛni chenj we yu tink se go apin. I fayn fɔ no bɔt big big sik kwik kwik wan, ɛn pipul dɛn we gɛt big big sik kin liv fayn layf. If yu gɛt ɛni kwɛstyɔn bɔt aw yu pikin de gro, nɔ fred fɔ aks yu dɔktɔ. Dɛn de de fɔ ɛp yu.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Gigantism na wan sik we nɔ kin apin so ɔltɛm bɔt i kin rili siriɔs. Di tin we impɔtant pas ɔl na fɔ go to dɔktɔ wantɛm wantɛm if yu notis ɛnitin we nɔ kɔmɔn ɔ we yu de dawt bɔt aw yu pikin de gro, lɛk fɔ gro fast fast pas aw yu bin de tink ɔ fɔ gɛt big big an ɛn fut dɛn.

Mɛmba se if yu no di sik kwik kwik wan ɛn trit yu pikin, dat kin mek yu pikin liv fayn ɛn nɔmal layf. Nɔ wɔri, dɔktɔ dɛn de fɔ ɛp yu ɛn yu pikin. Tɔk to dɛn bɔt ɛnitin we de mɔna yu.

` Gigantism, Grɔw Hɔmɔn, Pituitary Gland, Grɔw na Pikin, Ayt Inkris, Akromegaly