Yu gɛt dɛn sayn ya? Lɛ wi lan bɔt bren kansa we dɛn kɔl Glioblastoma (GBM)!

Sɔntɛnde, wi kin gɛt ed we kin at wantɛm wantɛm, ɔ wi kin fil se wi yay chenj, nɔto so? Sɔntɛm wi mɛmori dɔn lɔs smɔl. Dɛn tin ya kin bi nɔrmal, bɔt sɔmtɛm dɛn kin bi sayn fɔ siriɔs sik. Tide wi go tɔk bɔt wan siriɔs kayn bren kansa we rili impɔtant fɔ no bɔt.

Wetin na Glioblastoma (GBM)?

Fɔ tɔk am simpul wan, Glioblastoma (GBM) na wan kayn bad bad bren kansa we kin bɔku pan big pipul dɛn. imajin, spεshal sεl dεm de na wi bren we de εp di nεv sεl dεm fכ wok fayn fayn wan, we dεn kכl ‘glial sεl dεm’. pan dεn glial sεl dεm ya, wan tכp de we dεn kכl ‘astrocytes’. na frכm dεn sεl dεm ya we dεn kכl astrosayt dεn de bigin dis glioblastoma kεnsar.

Dɛn kansa sɛl ya kin gro ɛn bɔku kwik kwik wan. Dɛn kin skata lɛk gras na di bren. Pan ɔl we i nɔ kin apin so ɔltɛm, sɔntɛnde dis kansa nɔ kin pas to ɔda pat dɛn na di bren nɔmɔ, bɔt i kin go bak to di spɛshal kɔd we de na wi spayna. Infakt, dis na kansa we rili siriɔs. Sɔntɛnde, i kin so siriɔs dat i kin mek pɔsin day insay siks mɔnt if dɛn nɔ trit am. Na dat mek i rili impɔtant fɔ no bɔt dis.

Wetin na di sayn dɛm fɔ Glioblastoma (GBM)?

Naw lɛ wi si us sayn dɛm pɔrsin wae gɛt Glioblastoma (GBM) kin gɛt. Dɛn sayn ya kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin, ɛn dɛn kin difrɛn bak fɔ di saiz fɔ di tumbu ɛn usay i de na di bren.

• Blur vision or double vision: Yu kin fil lɛk se yu de si tin bad bad wan, ɔr yu kin fil lɛk se yu de si tin tu.
• Ed we kin at ɔltɛm: Nɔto ed we kin at ɔltɛm, bɔt na ed we kin at smɔl, we kin kɔntinyu fɔ de, ɛn sɔntɛnde i kin wɔs na mɔnin.
• Anorexia: I nɔ kin want fɔ it igen.
• Memory loss: Fɔgɛt tin ɛn i nɔ kin izi fɔ mɛmba nem.
• Chenj na yu bihayvya ɛn pɔrsin in pɔrsin: Chenj lɛk fɔ nɔr de di sem lɛk aw yu bin de tink, fɔ chenj aw yu de tink, fɔ vɛks kwik, ɔr fɔ de kwayɛt pasmak.
• Di bɔdi nɔ de balans ɛn i nɔ de fil fayn: Wan an ɔ leg kin swɛla, i nɔ kin balans igen, ɛn i nɔ kin ebul fɔ balans fayn we i de waka.
• Nɔs ɛn vɔmit: Nɔs ɛn vɔmit kin apin, mɔ na mɔnin.
• Seizure: Seizure kin apin di kayn we we nɔr dɔn ɛva apin bifo.
• Fɔ stɔp we yu de tɔk: I nɔ izi fɔ fɛn wɔd, tay yu tɔŋ we yu de tɔk.
• Chenj na di bɔdi sɛns, tingling: Sɔm pat na di bɔdi kin fil tingling ɔr kin fil lɛk se dɛn nɔr de fil ɔltin.

Bɔrku tɛm, dɛn sayn ya kin bigin fɔ sho kwik kwik wan.Bikɔs as dis tumbu de gro insay di bren, i de put prɛshɔn pan di bren, ɛn di bren tisu we gɛt wɛlbɔdi kin pwɛl bak.

Wetin mek Glioblastoma (GBM) kin kam?

Wan kwɛstyɔn we bɔku pipul dɛn kin aks na, "Wetin mek dɛn sik ya kin apin?" Risach pipul dɛm stil nɔ no di rayt tin we kin mek pɔsin gɛt Glioblastoma (GBM). Bɔt lɛk ɔda gliomas (tumɔs we de divɛlɔp na di bren ɛn spɛshal kɔd), sayɛnsman dɛn biliv se na di chenj dɛn we de apin na wi DNA kin mek i apin.

Yu no, wi jin dɛn gɛt DNA. Dɛn jin ya de gi wi ɔl di instrɔkshɔn dɛn bɔt aw di sɛl dɛn na wi bɔdi fɔ gro ɛn sheb. so, we sכm chenj dεm (mכtεshכn) de na dis DNA, di sεl dεm kin bigin fכ sheb kwik kwik wan εn we dεn nכ kin kכntro. Na so dɛn kansa sɛl ya kin mek.

Dis na sik we pɔsin kin gɛt frɔm in mama ɛn papa?

Wan ɔda impɔtant kwɛstyɔn na, "Dis na sik we pɔsin kin gɛt frɔm in mama ɛn papa?" Sɔntɛnde, wi kin gɛt difrɛn difrɛn tin dɛn we de na wi jɛnɛtiks frɔm wi mama ɛn papa. Bɔt, Glioblastoma (GBM) nɔ kin bɔku. כl di tεm dεm, dεn chenj dεm ya na DNA (mכtεshכn) kin apin randomly insay wi layf, we min se dεn nכ gεt jεnεtik link.

Udat de pan big risk fɔ gɛt Glioblastoma (GBM)?

Pan ɔl we ɛnibɔdi kin gɛt dis sik, sɔm pipul dɛn kin gɛt dis sik pasmak.

• Ej: Glioblastoma (GBM) kin apin mɔ pan pipul dɛm wae ol bitwin 45 ɛn 70. Di avɛrej ej wae dɛn no bɔt dis sik na lɛk 64 ia.
• If pɔsin gɛt sɔm kemikal dɛn: Fɔ ɛgzampul, if pɔsin de yuz tin dɛn lɛk peshɛnt sayd, petrolium, sɛntetik rɔba, ɛn vaynil klorayd fɔ lɔng tɛm, dat kin mek i gɛt prɔblɛm.
• Sכm jεnεtik, tכmכro-kכzכn kכndyushכn dεm: Pipul dεm we gεt jεnεtik kכndyushכn lεk `(Neurofibromatosis)`, `(Li-Fraumeni syndrome)`, εn `(Turcot syndrome)` de pan risk fכ gεt dis kεnsar.
• If yu dɔn gɛt redyushɔn tɛrapi to yu ed bifo: Fɔ dɔn gɛt redyushɔn tɛrapi to yu ed fɔ ɔda rizin na tin bak we kin mek yu gɛt prɔblɛm.

Di prɔblɛm dɛn we kin apin we pɔsin gɛt Glioblastoma (GBM) .

Glioblastoma (GBM) ɛn di tritmɛnt dɛn we i kin gɛt kin gɛt difrɛn ifɛkt pan di we aw di bren de wok.

• Sɔntɛm chenj na yu maynd ɛn prɔblɛm dɛn we yu de mɛmba kin apin.
• Bɔrku pipul dɛm wae gɛt glioblastoma (GBM) kin dɔn gɛt fɔ stɔp fɔ du tin lɛk fɔ woke ɛn fɔ drayv.
• Sɔntɛm dɛn nid fɔ kia fɔ dɛn ɔltɛm .
• Dɛn chenj ya kin mek yu gɛt sɔm kayn tin lɛk wae yu de wɔri ɔr pwɛl hat. So, e fayn fɔ tek kia ɔf yu maynd wɛl bɔdi.

Aw dɔktɔ dɛn kin no se pɔsin gɛt Glioblastoma (GBM)?

Okay, naw lɛ wi si aw dɔktɔ de no se i gɛt Glioblastoma (GBM).

We yu go to dɔktɔ, i go fɔs tek tɛm lisin to yu sayn dɛn ɛn du yu nyurolɔjik ɛgzam. Dis min se yu fɔ chɛk aw yu de si, yɛri, balans, ɛn aw yu de tink.

If dɛn tink se na bren tumbu, dɛn kin du dɛn tɛst ya:

• MRI (Magnetic Resonance Imaging) skan ɔ CT (Computed Tomography) skan: Dɛn tin ya kin tek ditayli pikchɔ dɛn bɔt di bren ɛn luk tin dɛn lɛk if tumbu dɛn de, aw dɛn big, ɛn usay dɛn de na di bren.
• Bayopsi: Dis na di difinitiv tɛst fɔ no di sik. Insay dis, dɛn kin ɔpreshɔn smɔl pan di tumbu ɛn chɛk am ɔnda maykroskɔp fɔ no if kansa sɛl dɛn de ɛn us kayn kansa i bi.

Gred dɛn fɔ Glioblastoma (GBM) .

Dɔktɔ dɛn kin klas di bren tɔŋ dɛn bay aw dɛn de biev, dɛn kin yuz wan gredin sistɛm frɔm I (wan) to IV (fo).

• Gret I tumor dεm de gro sloslo εn dεn nכ de agresiv bכku.
• Gret IV tכmכro dεm na dεn wan dεm we de gro fast fast εn we de agresiv .
• Glioblastoma (GBM) tכmכro dεm na wan tכmכro we rili agrεsiv we de insay di fכs gred (Gred IV).

Glioblastoma (GBM) kin bi praymari ɔ sɛkɔndari:

• Praymari GBM: dis dεm de kכmכt dayrekt frכm di glial sεl dεm, we min se dεn nyu εn agresiv.
• sεkכnd GBM: dεn ya de kכmכt frכm di glial tכmכro dεm we bin de lכw grεd (fכ egzampl, Gret I כ II) we, as tεm, de tכn to mכr agresiv Glioblastoma (GBM).

Aw dɛn kin trit Glioblastoma (GBM)?

Naw lɛ wi si us tritmɛnt dɛn de fɔ dis. Glioblastoma (GBM) na rili sik we at fɔ mɛn ɔltogɛda. Bɔt sɔm tritmɛnt dɛn de we kin ɛp fɔ kɔntrol di sik dɛn, mek pɔsin liv lɔng smɔl, ɛn mek in layf bɛtɛ. Di tritmɛnt plan kin difrɛn frɔm wan pɔsin to ɔda pɔsin ɛn na wan tim we gɛt dɔktɔ dɛn kin disayd.

Di men we dɛn fɔ trit am na:

• Ɔpreshɔn: Fɔ pul bɔku pan di tumbu as i pɔsibul. Sɔntɛnde, i kin at fɔ pul di wan ol tumbu we nɔ go pwɛl di bren. dis kayn כpεrayshכn dεn kin kכl am bak ``Craniotomy``.
• Radiation therapy: Dɛn kin yuz ɛkstrem rayt fɔ kil ɛni kansa sɛl we lɛf afta dɛn dɔn du di ɔpreshɔn. Yu kin nid fɔ gɛt te to 30 tritmɛnt ɛvride fɔ lɛk siks wiks.
• IMRT (Intensity-modulated radiation therapy): Dis na spɛshal we we de tɔch di raytin nɔmɔ to di tɔŋ, we de mek di bren tisu we gɛt wɛlbɔdi nɔ pwɛl.
• Stiriotaktik rediosɔjɛri `(Stiriɔtaktik rediosɔjɛri - Gama Naif)`:dis de yuz bak di bim dεm we gεt hכy εnεji we dεn de tכk to di tכmכro, we de mek di hεlty tisu dεm nכ de pwεl bכku. Bɔku tɛm dɛn kin yuz dis if GBM kam bak afta IMRT.
• Kimotɛrapi: Dɛn kin gi mɛrɛsin fɔ kil di kansa sɛl dɛn. Dɛn mɛrɛsin ya kin travul tru di bɔdi in blɔd ɛn atak di kansa sɛl dɛn. Bɔku tɛm dɛn kin gi dɛn togɛda wit redyushɔn tɛrapi ɛn afta dat dɛn kin kɔntinyu fɔ gi dɛn.
• Laser interstitial thermal therapy (LITT): na we we de yuz laser enaji fכ "bכn" εn pwεl di tכmכro. Sɔntɛnde, dɛn kin yuz dis.
• Targeted therapy: Targeted therapy de target spεshal chenj dεm na di sεl dεm we de εp kεnsar fכ gro. Dɛn kin yuz dis as ɔda we fɔ tek kimotɛrapi ɔ dɛn kin yuz am togɛda.
• di tכmכro tritmεnt fil dεm (TTF): Na we fכ mek di kεnsar sεl dεm nכ de gro bay we dεn de sεnd lכw intεnsiti ilektrikal fil dεm to di tכmכro tru εlektrod dεm we de atak di sכl. Dɛn kin yuz dis afta dɛn dɔn yuz kemo-rɛdyushɔn tɛrapi.
• Immunotherapy: Dis na fɔ yuz yu bɔdi in yon imyun sistɛm fɔ fɛt di GBM sɛl dɛm. Pan ɔl we dis stil na tritmɛnt we dɛn kin tray fɔ du, op de.
• Palliative care: Dis kin min fɔ mek yu nɔr gɛt di sik, fɔ mek yu nɔr fil pen, ɛn fɔ gi yu kɔmfɔt pan yu filin. Dɛn kin gi am ɛni stej we dɛn de trit am.

Nɔr pɔrmɛnt mɛrɛsin nɔr de fɔ Glioblastoma (GBM) yet. Bɔt dɛn tritmɛnt ya kin mek di pɔsin fil fayn ɛn ɛp fɔ mek di pɔsin liv lɔng.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt wan ɔ mɔ pan dɛn sik ya, duya nɔ ignore dɛn. Yu fɔ rili go to dɔktɔ kwik kwik wan.

• Prɔblɛm fɔ mɛmba, mɔ if i de wɔs as tɛm de go.
• Dɛn kɔl di fit ``Seizures``.
• Siriv ed pen, mɔ na mɔnin, we ɔdinari pen kil nɔ kin pul am.
• Ay prɔblɛm, dabl vishɔn, blurred vishɔn.
• Fɔ lɔs yu wet fɔ natin, ɔ fɔ gɛt nɔys ɛn vɔmit ɔltɛm.
• Wan klia difrɛns pan di kwaliti dɛn ɛn di pɔsin we pɔsin bi.
• Smɔl smɔl, i de wik, i nɔ de fil fayn, ɔ i nɔ izi fɔ tɔk.

If yu gɛt dɛn sik ya, i nɔ min se yu gɛt Glioblastoma (GBM). Bɔt, i go fayn fɔ mek yu go to dɔktɔ fɔ no wetin mek i apin.

Yu tink se dɛn kin ebul fɔ protɛkt Glioblastoma (GBM)?

כnכfכs, naw, no we nכ de fכ mek di jεnεtik mכtεshכn dεm we de mek Glioblastoma (GBM), biכs dεn tin ya kin apin randomly.

Bɔt if dɛn no di sik kwik kwik wan ɛn bigin fɔ trit am, di rit we di tumbu de skata kin slo ɛn dɛn kin kɔntrol di sayn dɛm.

If pɔsin na yu famili dɔn gɛt bren tumbu, we min se yu tink se i gɛt prɔblɛm wit yu bɔdi, yu kin tink bɔt fɔ tɛst yu jɛnɛtiks. I impɔtant fɔ tɔk to dɔktɔ ɔ pɔsin we de advays yu bɔt yu jɛnɛtiks bɔt am ɛn lan di gud ɛn bad tin dɛn.

Glioblastoma (GBM) Disiz Prɔgnosis

Glioblastoma (GBM) na kansa we kin rili bad, ɛn di prɔgnosis nɔ kin rili fayn. If dɛn nɔ trit di sik, i kin mek pɔsin day insay shɔt tɛm afta dɛn dɔn no se i gɛt am.

Bɔt di tritmɛnt dɛn we dɛn de gi am naw kin ɛp fɔ mek di sik nɔ bɔku, i kin mek di pɔsin fil fayn, ɛn sɔntɛm i kin ivin mek i liv lɔng.

• Dɛn de du klinik trial fɔ fɛn nyu tritmɛnt dɛn. Dɛn tin ya kin mek yu gɛt nyu tritmɛnt we go fayn fɔ yu.
• Di tritmɛnt dɛm we de tɔch sɔm patikyula kansa sɛl jin dɛm de gi gud rizɔlt.
• Risach pipul dɛn de fɛn we bak fɔ gi kemotɛrapi dairekt to di bren tumor.
• Tipikli, bɔrku pipul dɛn kin liv bitwin 12 ɛn 18 mɔnt afta dɛn dɔn no se dɛn gɛt Glioblastoma (GBM).
• di fayv ia rεt fכ glioblastoma (GBM) na bכt 5% . Dis min se lɛk 5 pan ɔl 100 pipul dɛm wae gɛt GBM stil de alayv fayv ia afta dɛn dɔn no se dɛn gɛt dis sik.

Fɔ no se yu gɛt glioblastoma (GBM) kin bi wan tranga disizhɔn fɔ disayd. Di tumbu kin gro kwik kwik wan, ɛn i kin tranga fɔ trit am. Bɔt di wan dɛn we de stɔdi bɔt dis de kɔntinyu fɔ fɛn nyu tritmɛnt fɔ GBM. Di tritmɛnt dɛm wae de naw kin ɛp fɔ ridyus de sik ɛn fɔ mek yu liv bɛtɛ layf. Yu dɔktɔ kin gayd yu fɔ du yu nɛks step ɛn ɛp yu fɔ gɛt di kia ɛn sɔpɔt we yu nid.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

So, pan ɔl we Glioblastoma (GBM) na siriɔs sik, i impɔtant fɔ no bɔt am ɛn go to dɔktɔ as soon as di sayn dɛn dɔn sho. Di kwik we dɛn no am, na di mɔ di tritmɛnt go bɛtɛ.

Ɔltɛm kip yu op fɔ nyu tritmɛnt ɛn klinik trial. Mɛdikal sayɛns de go bifo ɛvride.

If dis apin to yu ɔ pɔsin we yu sabi, mɛmba se nɔto yu wangren de. Di sɔpɔt ɛn lɔv we dɔktɔ dɛn, nɔs dɛn, famili, ɛn padi dɛn gɛt rili impɔtant dis tɛm. Fɔ kɔntinyu fɔ gɛt strɔng maynd na big trɛnk bak fɔ bia wit dis prɔblɛm.

` glioblastoma, gbm, bren kansa, bren tumor, astrocytoma, astrocytoma, kansa simptom, bren tumor, kansa tritmɛnt