Imajin se dɛn dɔn gi yu stem sɛl transplant frɔm pɔsin we gɛt wɛlbɔdi as tritmɛnt fɔ wan sik lɛk lukimiya. Dɛn kin op se dis go mɛn yu sik. bכt sכm tεm, dεn nyu sεl dεm ya we kam fכ εp yu, yu bכdi de mistek fכ "εnεmi" εn bigin fכ atak yu yon sεl dεm. Dat na di kɔmpleks sityueshɔn we wi kin kɔl "Graft versus Host Disease" ɔ GvHD fɔ shɔt.
Wetin na GvHD insay simpul wɔd dɛn?
Fɔ ɔndastand dis, wi nid fɔ no tu wɔd dɛn. "Graft" de tכk bכt di tin we dεn transplant, dat na di hεlty stεm sεl dεm we dεn gi yu frכm do. "Host" de tכk bכt di hos, dat na yu bכdi we de rεsכp dεn sεl dεm de. So "Graft versus Host" min "graft versus host."
כltu, dεn kin du dis kayn stεm sεl transplant, we dεn kכl allogeneic transplant, fכ trit kansa lεk lukimiya εn limfoma, כ bon mכro fεil kכndishכn lεk aplastic anemia . na dεn sεl dεm ya we dεn transplant na dεn de stat yu bכdi fכ mek nyu bכdi sεl dεm.
bכt, sכmtεm dεn nyu sεl dεm ya nכ kin no yu yon sεl dεm. Dem tink se dem na forin invaders. So, dɛn kin bigin fɔ atak yu ɔgan dɛn we gɛt wɛlbɔdi, lɛk yu skin, liva, ɛn intestinal. Na dat GvHD bi.
Tu men kayn GvHD de:
GvHD kin sheb to tu men kayn. Trade, dɛn bin de sheb dis akɔdin to di tɛm we di sik bigin. Bɔt naw, dɔktɔ dɛn kin no di rayt kayn sik bay we dɛn de luk di sayn dɛn, di tɛst rizɔlt, ɛn di tɛm we di sik bigin.
- Akyu GvHD (aGvHD): dis kin apin insay di fכs 100 de dεm afta di transplant. Bɔt sɔntɛnde i kin apin leta. Dis kayn kin afɛkt yu skin, yu bɛlɛ (intestinal system), ɛn yu liva mɔ.
- Krכnik GvHD (cGvHD): Dis kayn kin apin εni tεm afta dεn transplant am, bכt i kin kכmכn pas כl insay di fכs tu ia . I kin afɛkt ɛni pat na di bɔdi, lɛk di skin, mɔt, liva, lɔng, insay, mɔsul, jɔyn, ɛn di bɔdi we gɛt bɔdi.
Pɔsin we dɛn dɔn transplant kin gɛt wan pan dɛn tu kayn ya, ɔl tu, ɔ dɛn kin gɛt wɛlbɔdi if dɛn nɔ gɛt ɛni wan pan dɛn.
Wetin na di sayn dɛm fɔ GvHD?
GvHD simptom kin kɔmɔt frɔm rili smɔl, te to mɔdaret, to siriɔs, ɛn ivin we kin mek pɔsin in layf de pan denja. Lɛ wi tek wan luk pan de sayn dɛm wae gɛt fɔ du wit dɛn tu kayn sik ya.
| Tayp fɔ GvHD | Di kɔmɔn sayn dɛm |
|---|---|
| Akyu GvHD (aGvHD) we dɛn kɔl . (I kin afɛkt di skin, di intestinal, di liva mɔ) |
|
| GvHD we nɔ de mɛn (cGvHD) . (I kin afɛkt ɛni pat na di bɔdi) |
Wetin mek dis GvHD kin apin?
Dis na smɔl sayɛns, bɔt a go ɛksplen am simpul wan.
Nɔmal wan, di sɛl dɛn na wi imyun sistɛm de protɛkt wi frɔm sik bay we dɛn de fɛt fɔrina dɛn we de kam insay wi lɛk vayrɔs ɛn baktri dɛm. Bɔt dɛn sɛl dɛn de nɔ de ɛva atak wi yon sɛl dɛn. di rizin fכ dis na biכs wan spεshal protin de na di sכfa fכ כl wi sεl dεm. Dɛn kɔl dis Human Leukocyte Antigens (HLA) .
Tink bɔt dis HLA lɛk sɔntin lɛk ID kad. wi imyun sεl dεm de luk dis ID kad εn se, "Oh... dis na wan pan wi."
Eksept fכ twin dεm we di sem, כlman in HLA difrεn.
We yu gɛt stem sɛl transplant, di nyu blɔd sɛl dɛn we dɛn mek wit dɛn sɛl dɛn de gɛt di HLA fɔ di pɔsin we gi di sɛl dɛn to yu. If da HLA de tu difrεn frכm yu HLA, dεn nyu sεl dεm de luk di sεl dεm na yu bכdi εn tink se, "Dis na invayda, in ID nכ de mach wi yon." Na da tɛm de dɛn sɛl dɛn de bigin fɔ atak yu bɔdi.
Fɔ dis rizin, di dɔktɔ dɛn kin tek tɛm chɛk di pɔsin we gi di mɔni ɛn di pɔsin we gɛt di sik in HLA fɔ mek shɔ se dɛn de nia dɛnsɛf as dɛn ebul bifo dɛn du di transplant. bכt pas dεn tek sεl dεm frכm twin, sכm risk de כltεm fכ GvHD.
Udat de pan ay risk fɔ gɛt GvHD?
di mכst imכtant risk fכs na di HLA inkompatibiliti, bכt sεvεra כda tin dεm kin ple wan rol bak.
| Risk factor | Tɔk bɔt |
|---|---|
| HLA mismatch we nɔ gɛt wanwɔd | - transplant sεl dεm we nכ εksakכt HLA-match, ivin if dεn tek am frכm fambul. - Ivin if na frɔm pɔsin we nɔ gɛt fambul, ɛn di HLA mach fayn, sɔm risk stil de. |
| Ɔda tin dɛn we kin apin |
|
Dɔn bak, if yu dɔn ɔlrɛdi gɛt Akyu GvHD (aGvHD), yu de pan ay risk fɔ gɛt Kronik GvHD (cGvHD).
Aw dɛn kin no ɛn trit dis sik?
Diagnosis we dɛn kin gɛt
Yu dɔktɔ go no se yu gɛt GvHD bay we i du yu bɔdi ɛgzam, luk yu sayn dɛm, ɛn du blɔd tɛst ɛn bayɔpsi. Bayopsi min fɔ tek wan smɔl pat pan di skin ɔ di tisu we afɛkt ɛn chɛk am ɔnda maykroskɔp. Bikɔs sɔm pan di sayn dɛm fɔ GvHD we nɔ de mɛn tan lɛk ɔda tin dɛm, yu dɔktɔ go pul ɔda tin dɛm bifo i no se yu gɛt GvHD.
Tritmɛnt
Fɔ mek yu nɔ gɛt GvHD afta dɛn dɔn transplant yu, dɛn go gi yu mɛrɛsin dɛn we de stɔp yu imyun sistɛm we de stɔp yu imyun sistɛm. Dɛn mɛrɛsin ya kin wok bay we dɛn kin mek di fɔrina sɛl dɛn nɔ ebul fɔ atak yu bɔdi.
If GvHD apin pan ɔl we yu de tek dis mɛrɛsin, yu dɔktɔ go disayd fɔ tritmɛnt bay aw yu sik ɛn di kayn GvHD.
- Fɔ akyu GvHD (aGvHD): Bɔku tɛm, dɛn kin gi kɔtikosterɔyd as pils, injɛkshɔn, ɔ as krim we dɛn kin put pan di skin. If dɛn tin ya nɔ kɔntrol di sik, dɛn kin tink bɔt ɔda mɛrɛsin dɛn lɛk Ruxolitinib (Jakafi®) ɔ klinik trial.
- Fɔ Kronik GvHD (cGvHD): Dɛn kin gi lɔng tɛm imyunosuprɛsiv drɔgs bak fɔ dis. If dɛn nɔ kɔntrol di kɔndishɔn, dɛn kin nid fɔ tek drɔgs lɛk Ruxolitinib (Jakafi®), Belumosudil (RezurockTM), Ibrutinib (Imbruvica®) ɔ spɛshal tritmɛnt dɛn lɛk fotofɛrɛsis .
Di sayd ɛfɛkt dɛn we di tritmɛnt kin gɛt
Dɛn tritmɛnt ya kin stɔp yu imyun sistɛm, we kin mek yu bɔdi nɔ ebul fɔ fɛt di infɛkshɔn. Dis kin mek yu gɛt mɔr risk fɔ gɛt fungal, baktri, ɛn vayral infɛkshɔn. Yu dɔktɔ go gi yu mɛrɛsin bak fɔ ɛp fɔ mek yu nɔ gɛt dɛn sik ya we kin mek yu layf de pan denja.
Ɔda ifɛkt dɛn we kin apin bikɔs ɔf GvHD
Yu tink se GvHD de mek pɔsin in layf de pan denja?
Yɛs, GvHD kin mek pɔsin in layf de pan denja. Krεse GvHD, spεshal wan, na di lida kכz fכ day afta dεn transplant stεm sεl, כda pas di praymar sik. Na dat mek i impɔtant fɔ tɔk to yu dɔktɔ bɔt di prɔblɛm dɛn we kin apin to yu bifo yu du ɛni tritmɛnt.
Ɛni bɛnifit de frɔm GvHD?
I sɔprayz fɔ no se, yɛs. GvHD gɛt sɔm bɛnifit dɛn. Dɛn nyu imyun sɛl ya we de atak yu wɛlbɔdi sɛl dɛn kin luk bak ɛn pwɛl ɛni kansa sɛl we kin lɛf na yu bɔdi. dis dεn kכl dis "graft-vεrs-tכmכr ifekt." So, stɔdi dɔn sho se di wan dɛn we gɛt GvHD nɔ kin gɛt dɛn kansa bak.
Tin dɛn we yu kin du fɔ yu sef
Yu dɔktɔ go ɛksplen aw yu fɔ tek kia ɔf yusɛf afta dɛn dɔn transplant yu. Tek tɛm mɔ bɔt dɛn tin ya if yu de pan denja fɔ gɛt GvHD.
- Protekt yusɛf frɔm di san: If yu de na di san, dat kin mek GvHD wɔs. So wɛr lɔng-sliv shirt ɛn lɔng pant we yu de go na do. Yuz sanskrin we gɛt at le SPF 50.
- Yu fɔ klin yu mɔt: Brus yu tit fayn fayn wan fɔ mek yu nɔ gɛt bɔku sik na yu gɔm.
- Fɔ it ɛn drink: Nɔ it tin dɛn we gɛt spays, ɔyl, ɛn it we go mek yu gɛt ɔlsa na yu mɔt.
- Protɛkt yusɛf frɔm jem: Bikɔs yu imyun sistɛm wik, avɔyd say dɛn we sik dɛn de skata ɛn ples dɛn we pipul dɛn kin bɔku. Kip yu an dɛn klin ɔltɛm.
Ustɛm a fɔ go to di dɔktɔ?
I impɔtant fɔ tɛl yu dɔktɔ wantɛm wantɛm if yu notis ɛni chenj na yu bɔdi, mɔ di sayn dɛn we de sho se yu gɛt di sik ɔ yu gɛt fiva we gɛt 38 digri sɛlshiɔs (100.4 Fahrenheit) ɔ pas dat. Infεkshכn kin bi mכr siriכs kwik we yu de tek mεdikeshכn dεm we de sכprεs di imyun sistεm.
Yu dɔktɔ go de wach yu ɔltɛm afta yu transplant fɔ wach fɔ kɔmplikeshɔn dɛn lɛk GvHD. If yu gɛt di sik, dɛn go chenj yu mɛrɛsin ɔ gi yu nyu wan. I rili impɔtant fɔ tek ɔl di mɛrɛsin dɛn we dɛn tɛl yu fɔ tek ɛn fala wetin yu dɔktɔ tɛl yu fɔ du.
Mɛsej we dɛn kin kɛr go na os
- Graft vs. Host Disease (GvHD) na komplikashכn we kin apin afta dεn transplant stεm sεl, we di rεsεpshכn in bכdi atak di sεl dεm we dεn gi.
- Tu men kayn dis de, akyu ɛn krɛse. Di sayn dɛm kin difrɛn akɔdin to dat.
- Di bɛst we fɔ mek dɛn nɔ gɛt GvHD na fɔ mek shɔ se di pɔsin we gi di mɔni ɛn di pɔsin we gɛt di tin gɛt di bɛst HLA mats.
- Bikɔs dɛn kin yuz drɔgs we de stɔp di imyun sistɛm fɔ tritmɛnt, di risk fɔ gɛt di sik kin rili bɔku.
- Notis yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni nyu sayn, mɔ if yu gɛt fiva.
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