Yu gɛt prɔblɛm wit yu blɔd vesel dɛn? Lɛ wi tɔk bɔt GPA (Granulomatosis wit Polyangiitis)!

Sɔntɛnde yu kin fil lɛk yu bɔdi rili ebi, yu kin gɛt pen na say dɛn fɔ no rizin, ɔ yu kin fil ɔltɛm lɛk se yu gɛt kol, bɔt i nɔ tan lɛk kɔmɔn kol? Sɔmtɛm, biɛn dɛn tin ya, wan sik kin de we wi nɔ kin yɛri bɔku bɔt, bɔt i impɔtant fɔ no. Dat na wan pan dɛn kɔndishɔn dɛn de we dɛn kɔl GPA.

Wetin na GPA (Granulomatosis wit Polyangiitis)? Lɛ wi ɔndastand am simpul wan!

Okay, naw mek wi si wetin dis GPA (Granulomatosis wit Polyangiitis) bi. Nɔ wɔri, a go ɛksplen am simpul wan. Dɛn bin de kɔl am `(Wegener in Granulomatosis)`. Bɔt di nem `(Granulomatosis with Polyangiitis)` we dɛn de yuz naw de tɔk bɔku tin bɔt dis sik.

Fɔ tɔk am simpul wan, GPA na we yu blɔd vesel dɛn de inflamɛns ɔ swel. dכkta dεn kכl dis ``vasculitis.`` Tink am dis we: di bכdi vεsεl dεm na wi bכdi lεk wata paip. We sɔntin nɔ fayn wit dɛn paip dɛn ya, blɔd kin ambɔg, nɔto so? Na dat de apin ya.

Naw tu ɔda spɛshal tin dɛn de bɔt dis GPA:

• Polyangiitis: Dis min se di inflamɛns kin apin na bɔku difrɛn blɔd vesel dɛn na yu bɔdi, mɔ di smɔl wan dɛn . Nɔto jɔs wan eria nɔmɔ i de du.
• Granulomatosis: Dis kin tan lɛk se na kɔmplikɛt wɔd, bɔt i jɔs min se smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. Dɛn lumps ya kin pwɛl yu blɔd vesel ɛn ɔgan dɛn.

So, bכku tכp dεm de fכ dis ``vasculitis'' kכndyushכn, bכt di tכp we dεn kכl GPA de mεntal afekt di sכm sכm bכdi vεsul dεm na wi bכdi. Bikɔs dɛn smɔl smɔl blɔd vesel ya de ɔlsay na di bɔdi, GPA kin mek prɔblɛm na bɔku pat dɛn na di bɔdi, mɔ di ɔgan dɛn we gɛt bɔku smɔl smɔl blɔd vesel dɛn. Bɔrku tɛm, i kin afɛkt yu respiratory system (di brith system) ɛn yu kidni dɛm.

Dis inflamɛns na di blɔd vesel kin mek dɛn swel, bɔs, ɛn ivin blɔd. Dɔn bak, di blɔd vesel dɛn kin smɔl bikɔs ɔf skata. Wetin kin apin da tɛm de? Wi tisu dεm nכ de gεt di כksijεn εn di nyutriεnt dεm we dεn nid. sכmtεm, GPA kin ivin mek wan kכndyushכn we dεn kכl ``pulmonary-renal syndrome``, we bכdi de lik frכm di kidni dεm εn di lכng dεm.

Us sayn dɛn kin apin we GPA de divɛlɔp?

Naw yu go mɔs de tink se, ‘Okay, if dis na sik lɛk dis, aw wi go no am? Wetin na di sayn dɛn we de sho se i gɛt dis sik?’ Lɛ wi tɔk bɔt dat.

As wi bin dɔn tɔk, GPA kin afɛkt di we aw pɔsin de blo ɛn di kidni dɛn mɔ. Bɔt i kin afɛkt bɔku ɔda ɔgan ɛn tisu dɛn bak, ɛn bak yu jenɛral wɛlbɔdi. Dis na bikɔs i de tɔch smɔl smɔl blɔd vesel dɛn ɔlsay na di bɔdi.

Sɔntɛnde, di pen na di mɔsul ɛn di joyn pen (atraytis) kin bi bikɔs ɔf vaskulaytis na yu kɔnɛktiv tisu dɛm.Apat frɔm tin dɛn lɛk dis, yu kin fil lɛk se yu nɔ de fil fayn . Dɔn bak, we pɔsin taya ɔltɛm, we i nɔ kin want fɔ it, ɛn we i kin lɛf fɔ it bɔku bɔku bɔdi na tin dɛn we kin apin.

Di simptom dɛm fɔ di respiratory system

Bɔku pipul dɛn kin fɔs sɔprayz se dɛn gɛt GPA ɛn dɛn kin go fɔ tritmɛnt bikɔs ɔf di sayn dɛm we dɛn kin gɛt we dɛn de blo. We dɛn bigin, dɛn sayn ya kin tan lɛk kɔmɔn kol, flu, ɔ flu. Bɔt dɛn kin las fɔ lɔng tɛm pas aw dɛn kin las. Chek fɔ si if yu gɛt ɛni wan pan dɛn tin ya:

• Wan bad bad ed pen ɔ prɛshɔn na di sayn eria.
• Sayn infεkshכn kin apin bכku tεm.
• Nos de rɔn ɔltɛm, ɛn krɔst dɛn de fɔm rawnd di nos.
• Mi nos de fil lɛk se i dɔn stɔp.
• Nɔs blɔd bɔku tɛm fɔ natin.
• A gɛt wan sik we de at na mi yes.
• A kin fil pen na mi chɛst.
• A kin gɛt kɔf we nɔ de chenj.
• Fɔ fil shɔt fɔ blo (lɛk kɔf).

As GPA de kam tranga, yu kin gɛt inflamɛns (polychondritis) na di katilej na yu yes, nos, ɛn trot. Dis kin mek yu gɛt mɔ siriɔs sik, lɛk:

• di nos de swel so dat di tכp pat pan di nos de sink insay (dεn kכl dis bak sadul nos).
• di trot, כ di כp pat pan di briz paip de sכmtεm (subglottic stenosis). Dis kin mek yu vɔys de ala ɛn yu de mek yu yɛri sawnd we yu de blo (wheezing or stridor).
• If yu gɛt inflamɛns na di insay yes, i kin mek yu ed de tɔn (vertigo) ɛn yu nɔ de yɛri fayn.

Dɔn bak, yu kin de blɔd na yu lɔng. If dis apin, yu go dɔn at fɔ blo mɔ ɛn mɔ, ɔ yu kin ivin kɔf blɔd .

Di sayn dɛm we gɛt fɔ du wit di kidni

Yu nɔ go fil ɛni pen na yu kidni we yu gɛt GPA. Bɔt yu kin notis chenj dɛn na yu urine. Fɔ ɛgzampul, yu urine we gɛt fom ɔ blɔd we de na yu urine. Dɔn bak, fɔ swel na yu fes ɔ yu leg (ɛdima) na ɔda sayn fɔ sik na yu kidni.

If yu gɛt GPA, dɔktɔ dɛn go de chɛk yu kidni ɔltɛm, ilɛksɛf yu nɔ ɛva gɛt di sik. Dis na bikɔs GPA nɔ kin afɛkt yu kidni dɛn di fɔs tɛm, bɔt as tɛm de go, i go mɔs afɛkt yu kidni dɛn.

Di sayn dɛm we gɛt fɔ du wit di yay

GPA kin afɛkt yu yay bak. I kin mek di yay inflamɛns ɔ insay di yay. Dis kin mek yu yay fil pen, prɛs, rɛd, ɛn swel . If i siriɔs, i pɔsibul fɔ lɛ pɔsin nɔ si fayn igen.

Di sayn dɛn we pɔsin kin si na di skin

Vasculitis na yu skin kin mek yu gɛt sɔm kayn sik lɛk:

• di skin safa de luk lεk blu-rεd patεn (mottled skin).
• Pɔpul, rɛd, ɔ brawn spat dɛn (purpura) kin apia.
• Had lumps (nodules) ɔ smɔl blista we tan lɛk blista (papules) kin apia na di skin.
• Wund dɛn we nɔ de mɛn (ɔlsa) kin apin.

Di simptom dɛm fɔ di nervɔs sistɛm

GPA kin afɛkt yu nervɔs sistɛm bak. כltu, i kin afekt yu pεriferal nεv sεstem – di nεv dεm we de rכn frכm yu spεnal kכd to כda pat dεm na yu bכdi.

If yu inflamɛns ɛn swel kin pwɛl jɔs wan nerv, we kin mek yu gɛt sɔm sayn dɛn na wan eria (mononeuropathy). Bɔt bɔku tɛm, bɔku bɔku nɛv dɛn kin afɛkt (polyneuropathy). Di sayn dɛm kin bi:

• Mɔtal simptom dɛm: Lɛk we di mɔsul dɛn wik.
• Di sayn dɛm wae de sho se yu de fil: yu de swɛla, yu de swɛt, ɔ yu de fil pen na yu nerv.
• di כtonom nεv sεstem we de kכntro di bכdi prεshכn, di blad fכ wok, כ di swet we de wok fayn.

Wetin na di siriɔs prɔblɛm dɛn we kin apin bikɔs ɔf GPA?

If dɛn nɔ kɔntrol GPA fayn, sɔntɛnde i kin mek pɔsin in layf de pan denja ɛn i kin mek di ɔgan dɛn pwɛl bad bad wan. So i impɔtant fɔ no bɔt dis. Na sɔm pan di siriɔs prɔblɛm dɛn we kin apin:

• Pulmonary hemorrhage: Dis kin mek i nɔ izi fɔ blo ɛn i kin mek i nɔ ebul fɔ blo fayn.
• Glomerulonephritis we de go bifo kwik kwik wan: Dis kin mek yu kidni nɔ wok fayn.
• I nɔ go ebul fɔ si ɔ yɛri sote go.
• di lכs fכ di skin sens כ nכ ebul fכ kכntrol di mכsul dεm (pεrifεral nyuropathy).

Wetin kin mek GPA de divɛlɔp?

Naw yu go de wɔnda, ‘Wetin mek dis kayn sik kin apin?’ Akchuali, GPA, lek oda kayn `(vasculitis)`, na `(autoimmune disease` .Dis kin luk lek se i at likli fo andastan, bot a go ehksplehn am simpul wan.

Nɔmal wan, wi imyun sistɛm tan lɛk di pɔsin we de protɛkt wi. I de fɛt sik ɛn jem bay we i de mek pɔsin inflamɛns. Bɔt insay dɛn ɔtoimyun sik ya, wi yon imyun sistɛm kin mistek bigin fɔ atak wi yon sɛl ɛn tisu dɛn we gɛt wɛlbɔdi. Insay GPA, di imyun sistɛm kin atak wi yon blɔd vesel dɛn.

Wetin na di patikyula tin dɛn we kin mek pɔsin gɛt GPA?

Risach pipul dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek pɔsin gɛt sik dɛn we pɔsin kin gɛt we i de fɛt insɛf. Bɔt dɛn biliv se bɔku tin dɛn kin mek dɛn gɛt dɛn. Sɔntɛnde, wi imyun sistɛm kin put pan ɔva drayv bikɔs ɔf strɛs, we kin mek dɛn kayn tin ya nɔ de wok fayn. Sɔm siriɔs baktri ɛn vayral infɛkshɔnRisach dɔn sho bak se GPA kin apin afta...

GPA de pan wan grup fɔ sik dɛn we dɛn kɔl ANCA-associated vasculitis, ɔ AAV . dis na di kayn vaskulεt dεm we de involv wan spεsifi k antibodi we dεn kכl ANCA. Risach pipul dɛm biliv se dis ANCA de ple impɔtant pat fɔ mek inflamɛns pan dɛn sik ya, inklud GPA.

Aw yu go no if yu gɛt GPA?

If yu gɛt sɔm sayn dɛm fɔ GPA, yu dɔktɔ go aks yu fɔs bɔt yu simptom dɛm ɛn du yu bɔdi ɛgzam. If yu simptom ɛn mɛdikal histri sho se yu kin gɛt GPA, dɛn go ɔda sɔm tɛst fɔ chɛk mɔ.

Sɔm pan di tɛst dɛn we dɛn kin yuz fɔ no if yu gɛt GPA na:

• Blɔd tɛst: Dis kin chɛk bak fɔ si if di ANCA antibodi dɛn we wi bin dɔn tɔk bɔt de.
• Urinalysis: I de chɛk fɔ blɔd ɛn prɔtin na yu urine.
• Chɛst X-ray ɛn CT skan: Dɛn tin ya kin chɛk aw yu lɔng dɛn de.
• bayɔpsi: Dɛn kin tek smɔl pat pan di tisu frɔm di lɔng, sayn (nasal cavities), ɔ kidni ɛn chɛk am ɔnda maykroskɔp fɔ si if ɛni patikyula inflammatory kɔndishɔn de.

Wetin na di tritmɛnt dɛm fɔ GPA (Wegener’s Granulomatosis)?

Okay, naw mek wi luk aw dɛn de trit GPA. Dɔktɔ dɛn kin trit GPA bay we dɛn de yuz mɛrɛsin dɛn we de ridyus di inflamɛns ɛn stɔp di imyun sistɛm (kɔtikosterɔyd ɛn ɔda imyun suprɛsant dɛn).

Sɔm pan dɛn mɛrɛsin ya gɛt pawa pas ɔda wan dɛn. Di kɔmbayn mɛrɛsin dɛn we yu dɔktɔ go tɛl yu go dipen pan aw yu sik bad ɛn yu risk fɔ gɛt sayd ɛfɛkt.

Besik tritmɛnt fɔ aktif GPA:

• Dɛn kin gi ay dos fɔ kɔtikosterɔyd (e.g., prɛdnisɔn). Dɛn dos ya kin ridyus smɔl smɔl as tɛm de go.
• `(Rituximab)`: Dis na nyu bayolojikal mɛrɛsin. Dis na di standad tritmɛnt naw we dɛn kin yuz mɔ.
• Sayklofosfamid (fɔ di wan dɛn we gɛt siriɔs sik) ɔ mɛtɔtreksɛt (fɔ di wan dɛn we nɔ gɛt bɛtɛ trɛnk): Dɛn kin yuz dɛn mɛrɛsin ya bak fɔ mɛn kansa. Bɔt we dɛn gi am fɔ GPA (insay bɔku smɔl dos), dɛn kin wok lɛk immunosuppressant.
• Avacopan: Dɛn kin yuz dis mɛrɛsin as ɔda tritmɛnt fɔ ridyus di doz fɔ kɔtikosterɔyd.

If yu gɛt siriɔs prɔblɛm, yu kin nid ɔda tritmɛnt. Fɔ ɛgzampul:

• Dayalaysis (if di kidni dɛn nɔ wok) .
• Fɔ transplant ɔgan dɛn

GPA stetɔs we yu gɛtWae dεn dכn rich wan stej fכ ``rεmishכn'', we min se di simptom dεm dכn dכn εn di sik dכn dכn, dεn kin gi mεdikeshכn dεm we nכ sכmtεm fכ mεnten da stet de. Bɔku tɛm, dis kin gɛt fɔ du wit:

• `(Rituximab)`
• Mild imyunosuprεsiv drog dεm: fכ egzampl, `(azathioprine)`, `(mεtotreksεt)` כ `(maykofεnolet mכfεtil)`.

Tru ɔl yu tritmɛnt, yu go kɔntinyu fɔ gɛt tɛst fɔ wach yu kɔndishɔn ɛn aw yu de ansa to tritmɛnt. Yu dɔktɔ go ajɔst yu prɛskrishɔn ɛn doz bay aw yu ansa.

Mɛmba se ɔl di mɛrɛsin dɛn kin gɛt sayd ɛfɛkt. Dɛn kin apin ɛnitɛm we dɛn de trit am. So, i kin nid fɔ chenj di mɛrɛsin fɔ mek yu nɔ gɛt ɔ ridyus sɔm sayd ɛfɛkt dɛn. Ɔl dɛn tin ya fɔ disayd fɔ du we yu tɔk to yu dɔktɔ.

Wetin go apin tumara bambay fɔ dis kɔndishɔn? (Autluk) .

GPA na wan sik wae de kam wae yu de liv yu layf wae yu nid fɔ kia fɔ yu ɔl yu layf. Wit tritmɛnt, de sik kin go insay rɛmishɔn ɛn di sayn dɛm kin dɔn. Bɔt, di sayn dɛm kin kam bak bak (rilaps).

Yu kin nid fɔ tek mɛrɛsin wan wan tɛm ɔlsay na yu layf fɔ kɔntrol di sik we de kam bak. Bikɔs dɛn mɛrɛsin ya de stɔp yu imyun sistɛm, yu go nid fɔ tek tɛm bak fɔ protɛkt yusɛf frɔm ɔda sik dɛn.

I pɔsibul fɔ liv nɔmal layf wit GPA?

If yu gɛt fayn tritmɛnt, yu kin liv nɔrmal layf wit GPA. Jɔs lɛk bɔrku sik dɛm wae nɔr de dɔn, sɔm tɛm kin de wae pɔrsin nɔr kin gɛt dis sik ɛn kin kam bak. So di kɔs fɔ di sik kin bi sɔm kayn we fɔ go ɔp ɛn dɔŋ.

Wetin na di layf we pɔsin we gɛt GPA de liv?

If yu nɔ gɛt tritmɛnt, di avɛrej layf we pɔsin kin liv na lɛk fayv mɔnt, we nɔ rich 50% pan di pipul dɛn we kin liv pas wan ia. Bɔt wit tritmɛnt, stɔdi dɛn we dɛn dɔn du fɔ fala dɛn sho se pas 80% pan di pipul dɛn stil de alayv afta et ia . So yu kin si aw i impɔtant fɔ gɛt tritmɛnt, nɔto so?

Wetin na di tin we kin mek pɔsin day pas ɔl na GPA?

Bifo tritmɛnt, di ɔgan we nɔ de wok fayn na di big risk fɔ day na GPA. We yu de du tritmɛnt, we yu imyun sistɛm wik, yu kin gɛt bɔku sik dɛn we go mek yu layf de pan denja .

Aw a fɔ tek kia ɔf misɛf we a de liv wit GPA?

Wae yu de liv wit wan krεse sik wae de kam pan yu bɔdi lɛk GPA, i impɔtant fɔ gɛt sɔm awareness fɔ yu bɔdi. Ivin we yu de fil fayn fayn wan, yu nid fɔ de sef.

Tek stɛp fɔ protɛkt yusɛf frɔm kɔmɔn sik dɛn we yu de tek mɛrɛsin dɛn we de stɔp yu bɔdi. If yu notis ɛni nyu ɔ nɔ kɔmɔn sayn, .Tɛl yu dɔktɔ wantɛm wantɛm.

GPA kin afɛkt yu bɔku tin dɛn, sɔm pan dɛn tin ya kin mek yu layf de pan denja. If yu no se sɔntin nɔ rayt ɛn gɛt tritmɛnt fɔ am kwik, dat kin mek big difrɛns.

Bɔrku pipul kin liv wae nɔr gɛt sɔm kayn sik, at ɔl fɔ sɔm tɛm, wit tritmɛnt. Bɔt yu mɛdikal tim go kɔntinyu fɔ wach yu kɔndishɔn. Dɛn go bi yu layf patna fɔ mek yu gɛt wɛlbɔdi.

Di impɔtant tin dɛn we yu fɔ mɛmba frɔm dis atikul (Take-Home Message) .

Okay, mek a sɔmariz sɔm pan di tin dɛm we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• GPA (Granulomatosis with Polyangiitis) na wan sik we de ambɔg di blɔd vesel dɛm, mɔ di smɔl smɔl blɔd vesel dɛm. I kin afɛkt di we aw pɔsin de blo ɛn di kidni dɛn mɔ.
• Di sayn dɛn we pɔsin kin gɛt kin difrɛn. Di sayn dɛm kin bi wae yu kin gɛt sɔm kayn sik wae tan lɛk kol, wae yu nɔr kin ebul fɔ blo fayn, yu nos kin blɔd, yu skin kin gɛt rɔsh, yu jɔyn dɛn kin pen, yu yay kin gɛt prɔblɛm wit yu yay, ɛn yu kin chenj yu urine.
• Dis kin bi siriɔs sik, so i rili impɔtant fɔ go to dɔktɔ kwik kwik wan if yu gɛt sɔm sayn dɛn.
• Sɔm tritmɛnt dɛn de we go wok fayn. Dɛn tritmɛnt ya kin kɔntrol di sik ɛn mek i kɔntinyu fɔ de na di rɛmishɔn.
• Dis na sik we yu go gɛt fɔ yu layf ɔl, so yu nid fɔ kɔntinyu fɔ de ɔnda dɔktɔ, yuz di mɛrɛsin we dɛn gi yu di rayt we, ɛn kia fɔ yu bɔdi.
• Nɔ wɔri! If yu no ɛn gi yu fayn mɛrɛsin, yu kin liv gud layf wit dis sik. Nɔto yu wan de, ɛn dɔktɔ dɛn de fɔ ɛp yu.

` GPA, Granulomatosis wit Polyangiitis, Wegener’s Granulomatosis, Vasculitis, Blɔd vesel inflameshɔn, Ɔtoimyun sik, Kidni sik, Respiratory sik