Yu de wɔri bɔt aw yu pikin de gro? Yu tink se dis kin bi Growth Hormone Deficiency (GHD)?

Yu smɔl pikin de gro slo pas ɔda pikin dɛn we in ej? Ɔ yu tink se i luk shɔt pas in ej? Na nɔmal tin fɔ mek mama ɛn papa dɛn wɔri bɔt tin dɛn lɛk dis sɔntɛnde. Bɔt, i nɔ kin izi fɔ du am ɔltɛm. Tide wi go tɔk bɔt wan kɔndishɔn wae kin kam na wi maynd pan dɛn kayn tɛm ya, bɔt nɔr kin bɔrku. dat na `Growth Hormone Deficiency`, we dεn kכl bak `GHD` fכ sכt.

Wetin na dis `Grɔw ɔmon Dɛfisiɛns (GHD)`? Lɛ wi ɔndastand am simpul wan!

Fɔ tɔk am simpul wan, GHD na wan sik we wan smɔl gland na wi bren, di pituitary gland, nɔ de mek di ɔmon we dɛn nid fɔ mek di bɔdi gro, we impɔtant fɔ mek di bɔdi gro. Sɔm pipul dɛn kin kɔl dis bak "pituitary dwarfism." Dis sik kin afɛkt bebi, pikin, ɛn big pipul. Pikin dɛm we gɛt GHD kin shɔt pas dɛn ej, bɔt dɛn ɔda bɔdi prɔpɔshɔn kin nɔmal.

Yu no, ɔmon dɛn tan lɛk kemikal mɛsenja dɛn na wi bɔdi. Dɛn kin travul tru di blɔd ɛn tɛl wi ɔgan dɛn, mɔsul dɛn, ɛn ɔda tisu dɛn wetin fɔ du ɛn ustɛm fɔ du am.

wi `Pituitary Gland` na sכmכl, bכt i rili imכtant `Endocrine Gland`. i de na di bεs fכ wi bren, dכn di `Hypothalamus`. i gεt tu men pat dεm: di `Anterior Lobe` εn di `Posterior Lobe`. na di `Anterior Lobe` we de mek `Growth Hormone (GH)` εn lεk 8 כda כmon dεm.

Sɔmtɛm pipul dɛm wae gɛt GHD kin gɛt wan sik bak wae dɛn kɔl hypopituitarism, wae na wae dɛn nɔr gɛt ɔda ɔmon dɛm wae di pituitary gland de mek. Dɛn ɔmon dɛn ya na:

• `Antidiuretik Ɔmon (ADH ɔ Vasopresin)`
• `Fɔlikul-stimulat ɔmon`
• `Luteinizing Ɔmɔn`
• Ɔmon we de mek pɔsin gɛt tayroyd (TSH) .
• `Adrenokortikotrofik Ɔmɔn (ACTH)`

So wetin dis `Growth Hormone` de du?

di כmon we de gro (GH) rili imכtant fכ di pikin dεm we de gro. I kin afɛkt bɔku pat dɛn na di bɔdi. I impɔtant fɔ mek di bɔdi gro nɔmal wan, di mɔsul ɛn bon dɛn gɛt trɛnk, ɛn fɔ mek di bɔdi fat sheb .

afta di growth plet dεm (epiphyses) na wi bon dεm dכn klos, we min se wi stכp fכ gro lכng, GH nכ de εp wi fכ gro tכŋ igen. Bɔt, wi bɔdi stil nid GH. As wi de ol, GH de ɛp fɔ mek di bɔdi nɔmal, i de mek di mɛtabolism de rɔn fayn fayn wan, ɛn i de ɛp fɔ mek di glukɔs na di blɔd kɔntinyu fɔ de .

So, yu kin si se ilɛksɛf yu na pikin, titi, ɔ big pɔsin, if yu nɔ gɛt inof ɔmon fɔ gro na yu bɔdi, i kin afɛkt yu difrɛn we dɛn dipen pan yu ej. Na pikin ɛn yɔŋ pipul dɛm, GHD kin mek yu nɔr de gro nɔrmal wan. pan big pipul dεm, i kin mek prכblεm lεk fכ bכku bכdi fεt εn hכy bכdi shuga lεvεl.

difrεn tכp dεm de fכ `Growth Hormone Deficiency (GHD)`?

Yes, tri men kayn `GHD` de:

• GHD we dɛn bɔn wit: Dis na sik we de apin we dɛn bɔn am. I kin bi bikɔs di pikin in jɛnɛtik chenj ɔ prɔblɛm wit di we aw di pikin in bren de wok.
• Acquired GHD: Dis kin kam bikɔs di pituitary gland dɔn pwɛl leta we i dɔn liv. Pikin ɛn big pipul dɛn kin gɛt GHD dis we.
• Idiopathic GHD: Insay mɛrɛsin, "idiopathic" min se dɛn nɔ no di kɔz . Insay sɔm kes dɛm fɔ GHD, dɛn nɔ kin fɛn ɛni patikyula kɔz.

Dɛn kin sheb GHD bak bay di ej we i bigin, bikɔs di sayn dɛm ɛn di we aw dɛn kin no di sik kin difrɛn difrɛn wan if i bigin pan pikin ɔ big pɔsin.

Aw kכmכn na dis kכndyushכn we dεn kכl `GHD`?

Growth hormone deficiency (GHD) na wan tin we nɔ kin apin so ɔltɛm . Fɔ tɔk roughly, GHD kin afɛkt lɛk wan pan ɛvri 4,000 to wan pan ɛvri 10,000 pikin dɛm. GHD we kin bigin fɔ big pipul dɛn bak na wan sik we nɔ kin apin so ɔltɛm, ɛn i kin afɛkt lɛk wan pan ɛvri 10,000 pipul dɛn.

Wetin na di sayn dɛm fɔ `Growth Hormone Deficiency (GHD)`?

De sayn dɛm fɔ GHD kin difrɛn difrɛn wan fɔ di ej wae yu gɛt dis sik.

Di simptom dɛm fɔ GHD na bebi ɛn pikin dɛm

We bebi ɛn pikin dɛn gɛt GHD, dɛn nɔ kin gro fayn. Di men sayn na we di pikin de ayt sloslo ɛvri ia afta di pikin in batde fɔ di tɔd tɛm . Dis min se dɛn kin gɛt less dan 1.4 inch pan ia.

Ɔda tin dɛn we dɛn kin du na:

• Fes we luk yɔŋ pas in ej.
• Wik ia ɛn nel we de gro.
• Dilay we yu de mek yu tit.
• Dilay we pɔsin kin bɔn .
• di blכd shuga lεvεl dεm (`Hypoglycemia`) na bεlε pikin dεm εn yכŋ pikin dεm.
• di penis fכ nyu bכn man pikin dεm rili sכm (`Micropenis`).

Di sayn dɛm fɔ GHD we kin bigin we pɔsin big

Di sayn dɛm fɔ GHD we kin bigin we pɔsin big kin at fɔ si smɔl. Dɛn sayn ya na:

• Fɔ fil se yu nɔ gɛt gladi at ɛn yu nɔ gɛt bɛtɛ wɛlbɔdi.
• Wae yu de wɔri ɛn/ɔr pwɛl hat.
• Di trɛnk we di bɔdi nɔ gɛt bɛtɛ trɛnk igen.
• di fεt we de kכmכt bכku bכku wan, εspεshali rawnd di bεlε .
• Di mɔsul dɛn we de tɔn dɔŋ.
• di bon dεnsiti we de dכn kin mek i gεt kכndyushכn lεk כstioporosis.
• If yu nɔ gɛt insulin, dat kin mek yu gɛt Tayp 2 Dayabitis.
• di LDL-kכlestכl εn triglisεrayd dεm we de εlevεt, i de mek yu gεt at sik.

Wetin na di tin dɛm wae kin mek dis kayn sik wae dɛn kɔl `GHD`?

Di tin dɛm wae kin mek pɔrsin gɛt GHD kin difrɛn difrɛn wan fɔ di ej wae de sik bigin. Sɔntɛnde, sɔm kayn kes kin de wae dɛn nɔr kin fɛn ɛni kɔz (idiopathic).

Di tin dɛn we kin mek pɔsin gɛt GHD we dɛn bɔn wit

di GHD we dεn kin bכn wit de kכz bay wan jεnεtik mכtεshכn . sכmtεm dis kin kכnεkt wit prכblεm na di strכkchכ na di bren כ abnכmaliti dεm na di midlayn na di fes (e.g., cleft palate, single sentral incisor).

Sayɛnsman dɛn dɔn no bɔku chenj dɛn we de apin na di jɛnɛtiks we kin mek pɔsin gɛt GHD. Sɔm pan dɛn na:

• Isolated growth hormone deficiency type IA: dis jεnεtik mכtεshכn de mek di growth slo na di fetal stej, εn di pikin sכm bכku pas aw i de εkspεkt we dεn bכn am. Fɔs, dɛn pipul ya kin ansa fayn to tritmɛnt we dɛn kɔl sɛntetik growth ɔmon (GH), bɔt leta dɛn kin gɛt antibodies agens di ɔmon. Dis kin mek di pikin nɔ gro fayn ɛn i kin mek di big pɔsin in ayt shɔt bad bad wan.
• Isolated growth hormone deficiency type IB: dis lεk tayp IA, bכt dεn pikin ya gεt sכm nεchכral GH na dεn bכdi we dεn bכn dεm. Dɛn kin ansa bak to atifishal GH tritmɛnt ɔlsay na dɛn layf.
• Isolated growth hormone deficiency type II: Dɛn pipul ya gɛt rili lɔw GH lɛvɛl, ɛn difrɛn digri dɛn kin de we dɛn kin lɔs dɛn ayt. Bɔrku tɛm wae pɔrsin nɔr de gro fayn kin sho insɛf na di fɔs ɔr midul pikin dɛm. Na lɛk af pan dɛn pipul ya gɛt wan pituitary gland we nɔ de divɛlɔp (Pituitary Hypoplasia).
• Isolated growth hormone deficiency type III: Lɛk tayp II, dɛn pipul ya gɛt rili lɔw GH lɛvɛl ɛn dɛn kin gɛt difrɛn digri dɛn fɔ stɔp. Bɔrku tɛm wae pɔrsin nɔr de gro fayn kin sho insɛf na di fɔs ɔr midul pikin dɛm. Dɛn kin gɛt bak di imyun sistɛm we wik ɛn dɛn kin gɛt infɛkshɔn ɔltɛm.

di inhεrit patεn dεm fכ dis isol tכp fכ gכt כmon dεfichεns kin difrεn frכm jεnereshכn to jεnereshכn.

Di tin dɛn we kin mek pɔsin gɛt GHD

GHD, we kin apin leta na layf, kin kam bikɔs di pituitary gland dɔn pwɛl. Dis damej kin mek di gland nɔ ebul fɔ mek ɛn pul di ɔmon we de mek pɔsin gro. Pikin ɛn big pipul dɛn kin gɛt GHD dis we.

di pituitary gland kin pwεl bay kכndishכn כ tin dεm lεk:

• Pituitary adenoma (wan tumɔs we nɔ gɛt kansa).
• Radieshɔn tɛrapi to di pituitary gland ɔ di eria we de rawnd am.
• Sivɛri ed injuri ɔ `Traumatik Bren Injuri (TBI)`.
• Blɔd nɔ de flɔ fayn to di pituitary gland.
• Aksidɛnt ɔ damej we nɔ go ebul fɔ avɔyd we dɛn de ɔpreshɔn di bren ɔ ɔpreshɔn fɔ pul wan pituitary adenoma.
• `Sɛntral Nɛvɔs Sistɛm Infɛkshɔn`.
• Sik dɛm wae kin skata insay di bɔdi, lɛk Langerhans cell histiocytosis, sarcoidosis, ɛn tuberculosis.
• di tכmכro dεm na di haypothalamus kin mek prεshכn pan di pituitary gland.

Aw wi dɔktɔ dɛn kin no dis `GHD` kɔndishɔn?

Bɔku tɛm dɛn kin no GHD pan pikin dɛn we dɛn ol tu ia. Di fɔs wan na arawnd di ej we pikin dɛn ol 5 ia, we pikin dɛn kin bigin fɔ go skul . Dis na bikɔs i izi fɔ mek mama ɛn papa dɛn kɔmpia dɛn pikin in ayt wit ɔda pikin dɛn we de na dɛn klas. di sεkכn ej rεnj de bitwin 10-13 ia fכ gyal pikin dεm εn 12-16 fכ bכy pikin dεm . Na dɛn ej ya kin bigin fɔ bɔn pikin. We pɔsin delay fɔ bɔn pikin, i kin mek pipul dɛn tink se i gɛt GHD.

di mכst imכtant tin fכ no GHD pan pikin dεm na di growth inkrεmεnt . Dis na aw di pikin de gro. Bɔku tɛm, di we aw pɔsin de gro kin fala wan we. if dεn de mכnitor di growth fכ 6 to 12 mכnt εn i de insay di nכmal rεnj insay da tεm de, sכm chans de fכ gכt prכblεm.

GHD, wae kin bigin wae pɔrsin dɔn big, kin tranga fɔ no bikɔs in sayn dɛm nɔr kin klia ɛn i kin tan lɛk kɔmɔn tin. Dis kin mek i nɔ izi fɔ no di sik.

Us tɛst dɛn kin du pan pikin dɛn fɔ no `GHD'?

Yu pikin in dɔktɔ go tek tɛm luk in mɛdikal istri ɛn in growth chɛt fɔ luk fɔ sayn dɛm fɔ se i nɔ de gro fayn, tin dɛm we de mek i gɛt GHD, ɛn ɔda tin dɛm we kin afɛkt di growth.

Ɔda wɛlbɔdi prɔblɛm dɛn we kin afɛkt di we aw pɔsin de gro na:

• Hypothyroidism (tayroyd gland we nɔ de wok fayn).
• Dilay we pɔsin kin rich fɔ bɔn pikin.
• Siliak Sik we pɔsin kin gɛt.
• Nɔ it fayn.

Bikɔs di lɛvɛl dɛn we di ɔmon we de gro na wi blɔd kin chenj bad bad wan ɔlsay na di de, we dɛn du blɔd tɛst nɔmɔ nɔ go ebul fɔ no if GH nɔ de. So, yu pikin in dɔktɔ kin ɔda fɔ du tɛst dɛn lɛk dis fɔ kɔnfirm GHD ɛn/ɔ fɔ pul ɔda tin dɛn we kin afɛkt di we aw i de gro:

• εks-ray: dεn kin du εks-ray fכ di an fכ ases di bon divεlכpmεnt (bon εj) εn di pɔtεshכn fכ gro.
• Blɔd tɛst ɛn ɔda tɛst dɛn we dɛn kin du na lɛbɔtri:Sɔm blɔd tɛst kin ɛp fɔ pul ɔda tin dɛn we kin afɛkt di we aw pɔsin de gro ɔ ɛp fɔ no if i gɛt GHD. spεsifi k bכdi tεst dεm na insulin lεk gכt fכktכ-1 (IGF-1) εn insulin lεk gכt fכktכ binding protin-3 (IGFBP-3).
• Growth Hormone Stimulation Test: Dis na di men tɛst we dɔktɔ dɛn kin yuz fɔ no if pɔsin gɛt GHD. insay dis tεst, dεn gi yu pikin wan mεdikeshכn we de mek di pituitary gland kכmכt fכ rilis GH. Dɔn di dɔktɔ tek blɔd sɛmpul ɛn mɛzhɔ di GH lɛvɛl. if di bכdi tεst rizulεt nכ sho se di GH lεvεl dεn εlevεt to di lεvεl we dεn bin de εkspεkt, i min se di pituitary gland nכ de prodyuz inof GH.
• Magnetic Resonance Image (MRI): Yu pikin in dɔktɔ kin ɔda fɔ mek dɛn du MRI na in ed. Dis kin ɛp fɔ no wetin kin mek pɔsin gɛt GHD bay we i de luk fɔ prɔblɛm wit di pituitary gland ɔ di bren.

Us tɛst dɛn kin du pan big pipul fɔ no `GHD`?

Di tɛst we dɛn kin yuz fɔ no GHD pan big pipul dɛn na di Insulin Tolerance Test . Insulin na ɔmon we wi pankrias kin mek bay insɛf.

Insay dis tɛst, di dɔktɔ go gi yu wan injɛkshɔn fɔ atifishal insulin fɔ mek yu blɔd shuga go dɔŋ. Dɔn, dɛn go tek blɔd sɛmpul ɛn mɛzhɔ di ɔmon we de gro na yu blɔd.

We di shuga na wi blɔd nɔ bɔku (haypoglycemia), di ɔmon we de gro kin kɔmɔt nɔmal wan. If yu blɔd tɛst sho se yu growth ɔmon lɛvɛl smɔl pas aw yu bin de ɛkspɛkt pan insulin tolɛreshɔn tɛst, dis de kɔnfɔm di kɔndishɔn GHD.

Ɔda tɛst dɛn kin de:

• `Glukagon stimulashɔn tɛst`
• `Macimorelin stimulashɔn tɛst`
• `Arginin stimulashɔn tɛst`
• `Klonidin stimulashɔn tɛst`

Aw dɛn kin trit `Growth Hormone Deficiency (GHD)`?

Di tritmɛnt fɔ GHD pan pikin ɛn big pipul na injɛkshɔn fɔ sintetik growth ɔmon (Recombinant Human Growth Hormone) . Dɛn kin gi dɛn tin ya na os. Bɔku tɛm pipul dɛn we gɛt GHD kin gɛt fɔ tek injɛkshɔn ɛvride .

Sintetik growth hormone tritment na fɔ lɔng tɛm , sɔmtɛm i kin te fɔ sɔm ia. I rili impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ si if di tritmɛnt de wok fayn ɛn if yu nid fɔ ajɔst di doz.

If yu ɔ yu pikin nɔ gɛt ɔda ɔmon dɛn we de na di pituitary, yu go nid tritmɛnt bak fɔ kɔrɛkt dɛn prɔblɛm dɛn de.

Sayd ifekt dɛm fɔ `GHD` tritmɛnt

Mild ɔ mɔdaret sayd ɛfɛkt frɔm growth ɔmon injɛkshɔn fɔ GHD tritmɛnt nɔ kin bɔku. Bɔt dɛn kin gɛt:

• Ed de at.
• Mɔsul pen ɔ jɔyn pen.
• Mild haypotayroydism.
• Di an ɛn fut dɛn kin swel.
• di kכva we di spayna de kכba pan pipul dεm we gεt sכliכsis.

Rare, bɔt siriɔs sayd ɛfɛkt kin apin bak:

• Siriv ed pen we kin kam wit prɔblɛm wit yu yay.
• Hip Dysplasia (di kכrekt atachmεnt fכ di thigh bon to di hip bon).
• Pankreas (inflameshɔn na di pankrias).

If yu gɛt ɛni wan pan dɛn sik ya, i impɔtant fɔ tɔk to yu dɔktɔ wantɛm wantɛm . Sɔntɛm yu go nid fɔ chenj di we aw yu de tek di mɛrɛsin.

Wetin na di risk factor dɛm fɔ divɛlɔp `GHD`?

I sɔri fɔ no se bɔku pan di kes dɛm we gɛt GHD nɔ kin ebul fɔ stɔp. Bɔt sɔm tin dɛn we kin mek yu gɛt dis sik kin mek yu ɔ yu pikin gɛt mɔ chans fɔ gɛt GHD we i dɔn gɛt. Dɛn tin ya na:

• Fɔ gɛt kansa tritmɛnt bifo yu rich big pɔsin.
• Fɔ gɛt redyushɔn tritmɛnt to di ed ɔ di bren.
• Tɔtɔl Bɔdi Irɛdieshɔn.
• כpεrayshכn pan di bren, spεshal wan di sεntri pat pan di bren usay di pituitary gland de.

If ɛni wan pan dɛn tin ya we kin mek yu gɛt prɔblɛm wit yu pikin, i impɔtant fɔ no bɔt di sayn dɛn we de sho se yu gɛt GHD ɛn tɔk to yu dɔktɔ bɔt am.

Wetin na di prɔgnosis fɔ GHD?

Fɔ pikin dɛn we gɛt GHD, di mɔ we dɛn trit di sik kwik kwik wan, na di mɔ di pikin go gro nia di nɔmal ayt we big pɔsin gɛt . Bɔku pikin dɛn kin gɛt 4 inch ɔ mɔ insay di fɔs ia we dɛn de trit dɛn. Dɛn kin gɛt tri inch ɔ mɔ insay di nɛks tu ia. Afta dat, di growth rεt de slo dכn.

Pipul wae gɛt GHD wae kin bigin frɔm big pipul, if dɛn trit dɛn fayn, kin gɛt gud tin fɔ si ɛn kin liv wɛl layf.

Wetin na di prɔblɛm dɛn we pɔsin kin gɛt we i gɛt GHD?

If dɛn nɔ trit GHD pan pikin dɛn, i kin mek dɛn nɔ gɛt bɛtɛ ayt ɛn dɛn kin te fɔ bɔn pikin .

Ivin if dɛn gɛt di rayt tritmɛnt, pipul dɛn we gɛt GHD we kin bigin fɔ big pipul dɛn kin gɛt at sik ɛn strok . Dis risk kin ridyus if yu gɛt wɛl bɔdi abit lɛk fɔ it fayn it ɛn fɔ du ɛksɛsayz ɔltɛm.

Pipul wae gɛt GHD wae kin bigin wae dɛn big kin gɛt bɔrku risk bak fɔ gɛt ɔstioporosis. Dis min se dɛn kin brok bon frɔm smɔl injury ɔ fɔdɔm. Fɔ ridyus dɛn prɔblɛm ya, i impɔtant fɔ it it we gɛt bɔku kalsiɔm ɛn tek vaytamɛn D sɔpɔtmɛnt lɛk aw yu dɔktɔ tɛl yu.

Ustɛm a fɔ si dɔktɔ bɔt GHD?

Bɔku rizin dɛn de we mek pikin dɛn kin gro sloslo ɛn shɔt pas aw dɛn kin gro. Sɔntɛnde, fɔ gro sloslo kin bi nɔmal ɛn fɔ shɔt tɛm. Fɔ ɛgzampul, we di tɛm we dɛn de bɔn pikin de kam nia. If yu de wɔri bɔt aw yu pikin de gro, go to dɔktɔ we de mɛn pikin dɛn ɛn ɔda dɔktɔ . Dɛn kin ɛp yu fɔ no if di we aw yu pikin de gro na sɔntin we yu fɔ wɔri bɔt.

If yu na big pɔsin ɛn yu gɛt sayn dɛn fɔ GHD, tɔk to yu dɔktɔ.

If dɛn no se yu ɔ yu pikin gɛt GHD, yu fɔ go to yu dɔktɔ ɔltɛm fɔ mek shɔ se di tritmɛnt de wok fayn .

If yu notis se yu pikin de delay fɔ gro, i impɔtant fɔ tɔk to yu dɔktɔ kwik kwik wan. Pan ɔl we i nɔ go izi fɔ mek GHD na di kɔz, i fayn fɔ chɛk ɛni chenj we de mek yu wɔri. If dɛn no pipul dɛm wae gɛt GHD kwik kwik wan, dɛn kin gɛt bɛtɛ lukin-grɔn ɛn dɛn kin jɔs liv wɛl layf. If yu gɛt ɛni kwɛstyɔn bɔt aw yu pikin de gro, nɔ fred fɔ aks yu dɔktɔ. Dɛn de ya fɔ ɛp.

Faynal Mɛsej fɔ Tek-Hom

So, yu go dɔn ɔndastand wetin na `Growth Hormone Deficiency (GHD)` ɛn aw i kin afɛkt pikin ɛn big pipul dɛn. Di tin we impɔtant pas ɔl na fɔ nɔ panik bɔt am, ɛn fɔ go to dɔktɔ kwik kwik wan if yu gɛt ɛnitin fɔ wɔri bɔt . If dɛn no di sik kwik kwik wan ɛn gɛt di rayt tritmɛnt, bɔku pipul dɛn we gɛt `GHD` kin liv fayn, wɛlbɔdi layf. If yu gɛt ɛnitin fɔ wɔri bɔt aw yu pikin de gro ɔ yu yon wɛlbɔdi, i nɔ go ɛva let fɔ tɔk to dɔktɔ bɔt am.

` Grɔw Ɔmon Dɛfisiɛns, GHD, Grɔw Ɔmon Dɛfisiɛns, Pituitary Gland, Pikin Grɔw, Shot, Ɔmon Prɔblɛm, GH