Yu dɔn tɛl yu pikin bɔt Ay-Grɛd Glioma? Lɛ wi tɔk bɔt am.

I at fɔ put insay wɔd dɛn aw i kin fil lɛk mama ɔ papa fɔ yɛri se yu pikin gɛt kansa na in bren. Bɔku kwɛstyɔn dɛn de we kin kam na wi maynd pan tɛm lɛk dis. So, tide wi go tɔk bɔt High-Grade Glioma, we na wan siriɔs, we de skata kwik kwik wan pan bren tumor. Wi op se dis infɔmeshɔn go gi yu sɔm ɔndastandin ɛn trɛnk insay dis tranga waka.

Wetin na Ay-Grɛd Glioma? Lɛ wi ɔndastand am rili simpul wan.

Fɔ tɔk am simpul wan, ay-grɛd glioma na wan kayn kansa we kin gro kwik kwik wan na yu pikin in bren ɔ in spɛnal kɔd. "Glioma" min wan tumbu. dis tכmכro dεm de fכm we wan kayn sεl we dεn kכl "glial sεl dεm" bigin fכ divayd εn gro kwik kwik wan we dεn nכ kכntrכl. dis glial sel dεm na wan kayn sεl we de sכpכt εn gi di nyuron dεm כ nεv dεm na wi sεntri nεv sεstem.

"High-grade" min se dis kayn glioma de gro fast fast εn agresiv . Infakt, di ay-grɛd gliomas nɔ kin bi ɔltɛm we dɛn kin mɛn ɔl. Dis na bikɔs i nɔ kin izi fɔ trit dɛn. Dis na bikɔs dɛn kansa sɛl ya kin skata kwik kwik wan na di bren ɔ di spɛnal kɔd. Dɛn kin gro bak bay we dɛn de invayd ɛn miks wit wɛlbɔdi sɛl dɛn. Imajin aw i nɔ kin izi fɔ pul jɔs di kansa we nɔ go ambɔg di wɛlbɔdi tisu we di wɛlbɔdi sɛl dɛn ɛn di kansa sɛl dɛn miks togɛda. Na dat mek sɔntɛnde i nɔ kin izi fɔ pul dɛn kɔmɔt kpatakpata wit ɔpreshɔn.

Wetin na di "grɛd" fɔ di ay-grɛd gliomas?

Di Wol Wɛlbɔdi Ɔganayzeshɔn (WHO) kin sheb di glioma dɛn akɔdin to di rit we dɛn de gro ɛn aw dɛn kin tranga. Fɔ fala dis, tu kayn dɛn de: "lɔ-grɛd" (lɛs siriɔs, gred 1 ɛn 2) ɛn "hay-grɛd" (mɔ siriɔs, gred 3 ɛn 4). di hכy grεd glioma dεm na tכmכro dεm we de gro fast fast we na gred 3 כ 4.

sכm glioma dεm na big pipul kin stat as lכw grεd εn leta i kin bi hכy grεd. Bɔt i sɔprayz fɔ no se di ay gred gliomas na pikin dɛn kin bigin as ay gred. כltu, lכw grεd glioma dεm na pikin dεm kin trit bכku bכku wan εn nכ kin bi hכy grεd.

Usay na di bren we di ay-grɛd gliomas kin apin mɔ?

di hכy grεd glioma dεm kin divεlכp bכku tεm na di "supratentorial compartment" na di bren, כ di bren stεm.

• supratentorial compartment: dis na di εria na di bren we gεt di sεribra, thalamus, εn haypothalamus. dis tכmכro dεm kin divεlכp frכm di glial sεl dεm we de ya.
• Bren stem: .dis ay grεd glioma dεm kin divεlכp bak na di pat pan di bren we dεn kכl ``pons``. dis dεn kכl dis spεshal tכp ``Diffuse Intrinsic Pontine Gliomas'' (DIPG). Dis kayn DIPG kin rili agresiv ɛn i nɔ kin izi fɔ trit.

Di say we di tumbu de rili impɔtant, bikɔs na in go sho di tritmɛnt dɛn we yu pikin go gɛt. Fɔ ɛgzampul, bɔku tɛm dɛn nɔ kin ebul fɔ pul di tumbu dɛn we de na di bren stem fayn fayn wan bay we dɛn du ɔpreshɔn.

Udat dis tin kin afɛkt mɔ?

di ay-grɛd glioma kin apin pan bebi, pikin dɛn we dɔn big, yɔŋ pipul dɛn, ɛn ivin big pipul dɛn. Bɔt di ay gred glioma na bebi ɛn yɔŋ pikin dɛn difrɛn frɔm di ay gred glioma na yɔŋ pipul dɛn ɛn big pipul dɛn. Bikɔs ɔf dɛn difrɛns ya, di tritmɛnt fɔ bebi ɛn smɔl pikin dɛn kin difrɛn.

Aw kɔmɔn tin na di ay-grɛd glioma?

di hεy grεd glioma dεm na di sεkכn tכp we dεn kכmכn pan malign bren tכmכro na pikin dεm. dεn de mek bitwin 10% εn 20% pan כl di tכmכro dεm we de afekt di sεntri nεv sεstem na pikin dεm.

Wetin na di sayn dɛm fɔ ay-grɛd glioma?

Di sayn dɛm kin difrɛn frɔm wan pikin to ɔda pikin. Dɛn kin dipen pan us pat pan di bren (ɔ spɛshal kɔd) di tumbu dɔn afɛkt, di pikin in ej, ɛn aw di tumbu de gro fast. Dɛn sayn ya kin bi mɔ we di tumbu de put prɛshɔn pan di bren ɛn mek i swel.

De sayn wae kin kam pan pɔrsin wae gɛt ed pen. Dis kin bi mɔ if di ed we de at de kam wit nɔys ɔ vɔmit. Dis ed we de at kin rili bad na mɔnin. Sɔntɛnde, i kin so bad dat i kin wek yu na nɛt. Imajin se smɔl pikin gɛt dis kayn prɔblɛm.

Ɔda sayn dɛm wae yu kin si na:

• I nɔ izi fɔ si, yɛri, ɔ tɔk (we yu nɔ de si fayn, yu nɔ de yɛri fayn, yu nɔ de tɔk fayn).
• We yu nɔ de balans ɔ yu mɔsul dɛn wik (ataxia), lɛk we i nɔ izi fɔ waka ɔ ol tin dɛn.
• Kɔnfyushɔn ɔ we pɔsin nɔ de mɛmba fayn.
• I kin slip ɔltɛm, i kin fil lɛk se i taya.
• Seizure (lɛk fit) .

di pikin dεm we rili yכŋ (bebi dεm) kin notis se dεn de kray we nכ kɔmɔn, dεn kin vɛks, dεn kin chenj di we aw dεn de it (lεk we dεn nɔ de drink milk). sכmtεm dεn kin notis bak se dεn ed de big sכmtεm, εn di sכft spat dεm (fontanelles) כ "swamps" dεm na di tכp pan dεn ed kin bi mכr prominεnt.

Wetin mek dɛn ay-grɛd glioma ya kin divɛlɔp? Wetin na di tin dɛn we kin mek i apin?

Fɔ tɔk tru, di wan dɛn we de stɔdi bɔt dis stil nɔ no di rayt rizin fɔ dis.pan big pipul dεm, dεn fכnshכn se prεviכs rεdyushכn tεrapi na risk fכ divεlכp dεn tכmכro dεm ya. I pɔsibul se pikin dɛn bak kin gɛt di sem kayn prɔblɛm dɛn we kin apin na do ɔ na di say we dɛn de, bɔt dɛn nid fɔ du mɔ risach.

Bɔt sɔm rili rare inherited genetic syndromes kin inkrisayz di risk fɔ gɛt ay-grɛd glioma pan pikin dɛm. jεnεtik kכndishכn na difεkt כ abnכmal tin na di jin dεm, we na di "kכd" we de tεl di sεl dεm aw f כ wok.

Na sɔm kayn tin dɛn ya we kin apin:

• Nyurofibromatosis tayp-1 (`Nyurofibromatosis tayp-1 - NF1`)
• Turcot sindrom we gɛt di sik
• Li-Fraumeni sindrom we gɛt di sik

Bɔt i impɔtant fɔ mɛmba se bɔku pikin dɛn we gɛt ay gred glioma nɔ gɛt famili histri bɔt dis sik.

Aw dɛn kin no se pɔsin gɛt ay-grɛd glioma?

Yu pikin in dɔktɔ go tek tɛm luk fɔs fɔ yu pikin in sik ɛn in mɛdikal istri. afta dat, dεn kin du bren skan, כ `imaging`, fכ si if tכmכro de εn if na in de mek di sik. if tכmכro de, dεn go du `bayopsi` fכ no fכ sכri if na kεnsar (malignant) כ benign (benign).

• Imajin: MRI (Magnetic Resonance Imaging) skan ɛn CT skan (Computed Tomography scan) kin ɛp dɔktɔ dɛn fɔ si tumbu dɛn na yu pikin in bren ɔ in spɛnal kɔd. MRI, mɔ MRI we gɛt kɔntrast, kin mek klia, mɔ ditayli pikchɔ dɛn pas CT skan. MRI kin yuz magnet ɛn redio wev fɔ mek pikchɔ dɛn bɔt tin dɛn we de insay di bɔdi na kɔmpyuta skrin. Difrɛn frɔm MRI, dɛn kin put day we nɔ bad na yu pikin in an. dis kin mek di say dεm we gεt tכmכro dεm de mכr fכ si na di skrin.

• bayopsi: wan spεshal prosidכs we dεn kכl "stereotactic biopsy" kin sho usay di tכmכro de εksεkt εn tek wan sכm sכm tisu frכm de εn sεnd am to di lab. afta dat, wan spεshal savant we dεn kכl "pathologist" de egzamin di sεl dεm fכ si if na hכy grεd glioma sεl dεm. Dɛn tɛst ya kin no bak sɔm kayn tin dɛn we di kansa sɛl dɛn gɛt. Sɔntɛnde, dɛn kin yuz dɛn kwaliti ya fɔ no aw fɔ trit am. Fɔ ɛgzampul, dɛn mek sɔm nyu tritmɛnt dɛn fɔ kansa fɔ wok pan sɔm kayn kansa sɛl dɛn nɔmɔ. So, dɛn tɛst ya kin ɛp bak fɔ no if yu pikin na gud kandidet fɔ da tritmɛnt de.

Sɔntɛnde, if i pɔsibul, dɔktɔ dɛn kin pul di wan ol tumbu instead fɔ jɔs tek wan smɔl pat fɔ mek dɛn tek am bayɔpsi.Dɔn, wit di diagnosis, tritmɛnt (ɔpareshɔn) kin apin bak.

כltu, bayopsi kin nכ kin pכsibul כltεm pan hεy grεd gliomas. dipכnt pan usay di tכmכro de (fכ egzampl, na di bren stem), if yu tek wan pat pan di tisu i kin pwεl di imכtant pat dεm na di bren. We dɛn kayn tin ya kin apin, dɔktɔ dɛn kin abop pan di tɛst we dɛn kin du we dɛn de tek pikchɔ fɔ no if pɔsin gɛt di sik.

Yu tink se dɛn kin mɛn ay-grɛd glioma kpatakpata?

Dis na di big kwɛstyɔn we de na ɔlman in maynd. I at fɔ gi wan stret ansa. Bɔku tin dɛn de we kin afɛkt dis, lɛk di pikin in ej, us jɛnɛtik chenj dɛn de na di kansa sɛl dɛn, ɛn ɔmɔs pan di tumbu dɛn bin pul we dɛn bin de du di ɔpreshɔn.

Wetin na di tritmɛnt fɔ ay-grɛd glioma?

di men gol dεm fכ tritmεnt na fכ pul di tכmכro, stכp כ kכntrכl di tכmכro fכ gro, εn fכ gi di pikin rilif bay we dεn de ridyus di simptom dεm.

Dipen pan di kayn tumbu, usay i de, ɛn ɔda tin dɛn, sɔm spɛshal pipul dɛn kin de fɔ kia fɔ yu pikin. Di tim kin gɛt nyurosɔjɔn, nyuro-ɔnkɔlɔjis, redyushɔn ɔnkɔlɔjis, ɛndokrinɔlɔjis, nɔs prɛktishɔn, ɛn soshal woka.

Yu kin yuz wan ɔ mɔ pan dɛn tin ya as tritmɛnt:

• Ɔpreshɔn: Ɔpreshɔn na di men tritmɛnt fɔ ay-grɛd gliomas we dɛn kin pul sef wan. Na ya, di dɔktɔ kin tray fɔ pul bɔku pan di tumbu as i ebul ɛn nɔ pwɛl di wɛlbɔdi tisu we de rawnd am.
• Radieshɔn tɛrapi: Fɔkal redyushɔn tɛrapi na standad tritmɛnt fɔ pikin dɛn we dɔn pas 3 ia. Bɔku tɛm, dɛn nɔ kin gi pikin dɛn we rili yɔŋ, dɛn nɔ kin gi dɛn raytin tɛrapi bikɔs i kin afɛkt di we aw dɛn bren de gro. Dis tritmɛnt involv wan mashin we de yuz ay doz ɛkstrem rayt fɔ tɔch di tɔŋ, ɛn tek tɛm mek i nɔ pwɛl di wɛlbɔdi tisu we de rawnd am. Redyushɔn tɛrapi kin mek di tumbu dɛn smɔl, kil di kansa sɛl dɛn, ɛn i kin mek di sik nɔ bɔku.
• Kimotɛrapi: Bikɔs pikin dɛn we rili yɔŋ nɔ kin ebul fɔ gɛt redyushɔn tɛrapi, dɛn kin yuz kemotɛrapi fɔ kɔntrol di we aw di tumbu de gro. Kimotɛrapi de yuz drɔgs fɔ kil di kansa sɛl dɛn. Bɔt stil, dɛn stil de agyu bɔt aw di kemotɛrapi wok fayn fɔ di ay-grɛd gliomas. Pan ɔl we sɔm kemotɛrapi mɛrɛsin dɛn lɛk temozolomide, kin wok fayn fɔ sɔm kayn gliomas pan big pipul dɛn, di sem mɛrɛsin dɛn nɔ kin wok fayn fɔ pikin dɛn.
• Paliativ kia:Di pɔrsin wae de woke fɔ kia fɔ yu pikin kin ɛp yu fɔ disayd fɔ du tin wae go ɛp yu fɔ kip yu pikin in kwaliti layf wae dɛn de trit yu. Dɛn kin tɔk bak bɔt aw fɔ ɛp yu pikin fɔ bia wit di sik ɛn fɔ gɛt fridɔm frɔm di sayn dɛm.

di ay-grɛd glioma kin kam bak afta dɛn dɔn trit am. If dis apin, yu dɔktɔ kin tɛl yu fɔ du "targeted therapies." Dis na tritmεnt dεm we de tכk bכt כnli di abnכmal mכlikul dεm (we di jεnεtik mכtεshכn kכz) na yu pikin in tכmכro. dis "mכlikul tכgεt tεrapi dεm" kin de tru "klinik trial dεm." Klinik trial na stɔdi dɛm wae de tɛst di sef ɛn ifektiv fɔ nyu tritmɛnt dɛm.

Sɔntɛnde, if dɛn targeted therapy drugs ya de na di makit, ɔ if stɔdi dɛn we dɛn bin dɔn du trade dɔn sho se dɛn kin wok fɔ yu pikin in kayn glioma, yu dɔktɔ kin ebul fɔ gi yu dɛn apat frɔm klinik trial.

Wetin na di bad tin dɛn we dɛn tritmɛnt ya kin du?

Tɔk to yu dɔktɔ bɔt di sayd ɛfɛkt dɛn we difrɛn tritmɛnt dɛn kin gɛt. Pan ɔl we dɔktɔ dɛn kin tray ɔl wetin dɛn ebul fɔ avɔyd fɔ pwɛl di wɛlbɔdi tisu dɛn we dɛn de du redyushɔn tɛrapi, sɔm wɛlbɔdi tisu dɛn kin stil afɛkt. dipכnt pan us pat dεm na di bren we dεn afekt, rεdyushכn tεrapi kin afekt di bren fכ wok, di pikin in growth, εn disrupt כmon prodakshכn.

I rili impɔtant fɔ tek tɛm tɔk ɛn wej di bɛnifit ɛn prɔblɛm dɛn we pɔsin kin gɛt we i gɛt di tritmɛnt wit di mɛdikal tim we de trit di pikin.

Wetin a fɔ ɛkspɛkt if mi pikin gɛt ay-grɛd glioma?

Di prɔgnosis fɔ yu pikin kin dipen pan bɔku tin dɛm, we yu dɔktɔ kin tɔk to yu. Di kayn sɛl dɛn we dɛn afɛkt, di kayn we aw di sɛl dɛn tan, ɛn ɔmɔs pan di tumbu dɛn pul we dɛn de du di ɔpreshɔn, ɔl dis kin sho wetin go apin.

Aks yu dɔktɔ wetin fɔ ɛkspɛkt bay di patikyula kɔndishɔn we yu pikin gɛt.

Wetin na di rεt we di hεy grεd glioma de liv?

Dis kayn tumbu kin kam bak afta dɛn dɔn trit am. di fayv ia sכvayv rεt fכ hεy grεd gliomas na pikin dεm sכmtεm sכmtεm sכmtεm 20%. Bɔt i impɔtant fɔ no se dɛn tumbu ya rili difrɛn frɔm dɛnsɛf. Dɛn kin gro na difrɛn say dɛn, ɛn di kayn we aw di sɛl dɛn we de insay dɛn kin bi difrɛn. Dɛn difrɛns ya kin afɛkt yu pikin in tumara bambay.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

Bɔku bɔku kwɛstyɔn dɛn de we kin kam na mi maynd pan tɛm lɛk dis. Bɔt nɔ fɔgɛt fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Us tritmɛnt dɛn de fɔ mi pikin?
• Aw di say we di tumbu de afɛkt di tritmɛnt opshɔn dɛn?
• Wetin na di prɔblɛm dɛn we kin apin we pɔsin gɛt tritmɛnt?
• Us rizulyt wi fɔ ɛkspɛkt frɔm tritmɛnt?
• Aw a fɔ kia fɔ mi pikin we dɛn de trit mi?
• Aw ɔltɛm mi pikin go nid fɔ kam fɔ tritmɛnt ɛn fɔ fala am?

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Fɔ gɛt diagnosis fɔ ay-grɛd glioma kin bi wan tin we rili at fɔ du. Dis kansa kin skata kwik kwik wan, ɛn di tumbu kin kam bak ivin afta dɛn dɔn trit am. Bɔku tɛm yu go gɛt fɔ wej di bɛnifit dɛn we di tritmɛnt go gi yu ɛn di bad tin dɛn we yu nɔ want fɔ mek yu pikin gɛt.

Yuz ɔl di tin dɛn we de fɔ ɛp yu, yu pikin, ɛn di ɔda pipul dɛn na yu famili insay dis tɛm. Tɔk to yu dɔktɔ bɔt di tritmɛnt opshɔn dɛm ɛn klinik trial dɛm. If palliativ kia savis dɛn de, go to dɛn. Mek yu pikin biliv se yu go sɔpɔt am ɔltɛm as dɛn de fes dis diagnosis togɛda. Dis go bi big tin we go mek dɛn gɛt trɛnk.

` Glioma, Bren Kansa, Pikin Kansa, Ay-Grɛd Glioma, Nyurosɔjri, Rɛdieshɔn Tɛrapi, Kimotɛrapi