Yu gɛt wan sik na yu liva we dɛn kɔl Primary Biliary Cholangitis ( PBC )? Ɔ pɔsin we yu sabi gɛt dis sik? Fɔ tɔk am simpul wan, dis na we di bayl dakt dɛn na wi liva kin pwɛl ɛn di bayl kin gɛda na di bɔdi. Sɔmtɛm dis kin nɔr kin gɛt ɛni sayn, ɔr sɔm kayn sayn dɛm lɛk fɔ taya pasmak ɛn it kin apin. As tɛm de go, dis sik kin kam siriɔs. So tide wi de tɔk bɔt di nyu mɛrɛsin we dɛn dɔn kam wit we dɛn kɔl Iqirvo (elafibranor) fɔ mɛn dis sik.
Wetin na Iqirvo? Aw i kin wok?
Iqirvo na wan mɛrɛsin we de ɛp fɔ trit praymari biliary cholangitis (PBC). I de wok bay we i de ridyus di bayl we de gɛda na yu bɔdi. Yu no aw i de du dat? Dis drɔg de gi yu bɔdi sayn fɔ stɔp fɔ mek bayl. Dat min se i de kɔntrol di we aw di bayl asid dɛn de mek .
Dɛn kin gi Iqirvo wit ɔda mɛrɛsin. Dat mɛrɛsin na ursodeoxycholic acid. Sɔntɛm yu dɔktɔ dɔn gi yu dis mɛrɛsin.
Aw dɛn dɔn du risach bɔt dis mɛrɛsin?
Lɛk ɛni nyu drɔg, dɛn dɔn stɔdi bɔt Iqirvo bɔku bɔku wan bifo dɛn gi am to mɔtalman. Di stɔdi bin involv 161 pipul dɛn we gɛt PBC.
- Tu grup: Dɛn bin sheb dɛn pipul ya to tu grup. Wan grup bin giv wan de doz fɔ Iqirvo 80 mg. Dɛn bin gi di ɔda grup wan plesibo pil.
- Wetin na plasɛbo?: Na ɛmti pil we nɔ gɛt ɛni aktif mɛrɛsin ɛn i tan lɛk mɛrɛsin. Dɛn kin gi am fɔ no di tru tin we di mɛrɛsin de du.
- Tɛm: Dɛn bin de gi di tritmɛnt dis we fɔ at le wan ia. Dɔn, dɛn bin gi di wan dɛn we bin want fɔ du dat di chans fɔ de na di risach fɔ ɔda ia.
Di wan dɛn we du di risach bin de luk mɔ pan di liva lɛbɔraytri valyu dɛn na di blɔd fɔ si if di mɛrɛsin de wok. Fɔ ɛgzampul, dɛn bin luk if di alkaline phosphatase ɛn bilirubin lɛvɛl dɛn bɛtɛ. Dɛn bin mɛzhɔ bak aw di sik pipul dɛn bin de it yu wan skel we dɛn kɔl di Worst Itch Numeric Rating Scale (WI-NRS) we dɛn ol 24 ɛn 52 wik.
Wetin na di tin dɛn we dɛn bin du we dɛn du di risach?
We di risach dɔn, a kam fɔ no sɔm tin dɛn we rili impɔtant.
Fɔ di wan dɛn we tek Iqirvo, 51% (dat na pas af) sho se dɛn dɔn rili impɔtant pan di blɔd tɛst we gɛt fɔ du wit di liva.
Bɔt na 4% nɔmɔ pan di wan dɛn we tek di plesibo sho dis kayn impɔtant tin. Dis sho klia wan se Iqirvo gɛt aktif ifɛkt.
Fɔ tɔk bɔt it, pan ɔl we di wan dɛn we tek Iqirvo bin gɛt sɔm rilif, i bin rili fiba di rilif we di wan dɛn we tek di plasɛbo bin gɛt. So, i stil at fɔ tɔk di rayt tin we kin apin to pɔsin we de it.
Di tin we impɔtant pas ɔl: Mɛmba se dɛn tin ya na di tin dɛn we dɛn dɔn du fɔ di risach. Yu rizulyt kin difrɛn. Na dat mek yu fɔ tɔk bɔt ɔltin wit yu dɔktɔ.
Udat nɔ fɔ tek Iqirvo?
Dis mɛrɛsin nɔ fayn fɔ ɔlman. If yu gɛt ɛni wan pan dɛn kɔndishɔn ya, yu nɔ fɔ tek Iqirvo. Mek shɔ se yu tɔk to yu dɔktɔ bɔt dis.
| Pozishɔn | Tɔk bɔt |
|---|---|
| Siriɔs sik na di liva | If yu gɛt siriɔs liva sik, mɔ di kɔmpɛnsed sirosis. |
| Di gal blad we de ambɔg di bɔdi | If yu gɛt biliary obstruction na yu liva. |
| We uman gɛt bɛlɛ | If yu gɛt bɛlɛ ɔ yu de op fɔ gɛt bɛlɛ. |
| Fɔ gi pikin in mama in bɛlɛ | If yu na mama we de gi yu pikin in bɛlɛ. |
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, Iqirvo kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt.Sɔm sayd ɛfɛkt dɛn kin apin.
Bɔn dɛn we kin brok
Pan ɔl we dis nɔ kin apin, pan stɔdi dɛn, sɔm pipul dɛn we tek Iqirvo dɔn gɛt bon dɛn we brok. Tɛl yu dɔktɔ if yu bin dɔn brok yu bon bifo ɔ if yu de pan denja fɔ mek yu bon brok (lɛk ɔstioporosis ). Dɛn tin ya kin ɛp fɔ mek yu bon dɛn strɔng:
- It tin dɛn we gɛt bɔku kalsiɔm: tin dɛn lɛk yogɔt, tofu, salmɔn. If nid de, tek kalsiɔm tablɛt lɛk aw yu dɔktɔ tɛl yu.
- Gɛt Vitamin D : Dɛn kin gɛt vitamin D frɔm it dɛn lɛk fish we gɛt ɔyl, eg , ɛn di san layt.
- Ɛksesaiz ɔltɛm: Dis kin mek yu mɔsul dɛn strɔng ɛn i kin mek yu nɔ fɔdɔm.
- Nɔ smok.
- Kɔntrol di shuga ɛn rɔm.
Ɔda kɔmɔn sayd ɛfɛkt dɛn
Dis dɔŋ ya na sɔm pan de sayd ɛfɛkt dɛm wae bɔrku pipul kin gɛt ɛn simpul tin dɛm wae yu kin du bɔt dɛm. Bɔt if dɛn tin ya kɔntinyu fɔ de , mek shɔ se yu go to yu dɔktɔ .
| Sayd ɛfɛkt we pɔsin kin gɛt | Tin dɛn we yu go ebul fɔ du |
|---|---|
| Nɔs ɛn vɔmit | Drink wata lɛk jinja ale ɔ wata. Bland it dɛn lɛk krak krak ɛn tost kin ɛp. |
| Banbɛlɛ | Drink bɔku wata. It mɔ frut, vɛjitebul, ɛn fayv. Probayɔtiks lɛk yogɔt ɛn kefir na gud tin. |
| At bɔn | Nɔ it tin dɛn we de mek yu gɛt mɔ inflamɛns, lɛk chɔklɛt, it dɛn we gɛt fat, kɔfi, ɛn rɔm. It smɔl smɔl it dɛn pas fɔ it bɔku tin wan tɛm. Yu kin aks yu dɔktɔ bɔt aw fɔ tek antisid. |
| Dray mɔt | Chew gɔm ɔ kandy we nɔ gɛt shuga. Drink bɔku wata. Tray fɔ blo tru yu nos instead ɔf yu mɔt. |
Iqirvo kin intarakt wit ɔda mɛrɛsin dɛn? (Drug Intarakshɔn) .
Yɛs, dis na pɔynt we rili impɔtant. Iqirvo kin intarakt wit sɔm ɔda mɛrɛsin dɛm wae yu de tek. Dis kin mek di mɛrɛsin nɔ wok fayn ɔ i kin mek di sayd ɛfɛkt dɛn bɔku.
| Tayp fɔ mɛrɛsin | Di ifɛkt dɛn we pɔsin kin gɛt ɛn advays dɛn |
|---|---|
| Pils/mɛtɔd dɛn fɔ kɔntrol bɔn pikin | If yu tek Iqirvo, i kin ridyus di effektiv we di ɔmon bɔn kɔntrol we dɛn de yuz (pil, pat). So, i impɔtant fɔ yuz ɔda we fɔ kɔntrol bɔn pikin, lɛk kɔndɔm, apat frɔm dat. |
| Statin, na wan kayn mɛrɛsin we de mek di kɔlɔstrel nɔ bɔku | If yu tek dɛn tu mɛrɛsin ya togɛda, dat kin mek yu mɔsul dɛn pen ɔ pwɛl. If yu gɛt dis kayn pen, tɛl yu dɔktɔ wantɛm wantɛm. |
| Bayl asid sikwεstrant dεm | Dɛn tin ya na mɛrɛsin dɛn bak fɔ mek pɔsin gɛt kɔlɔstrel. Dɛn tin ya kin stɔp di bɔdi fɔ absɔb Iqirvo. So, yu fɔ tek dis mɛrɛsin 4 awa bifo ɔ afta yu tek Iqirvo. |
| Rifampin bin de du am | Dis na antibayɔtik we dɛn kin yuz fɔ mɛn TB. I kin ridyus di Iqirvo we de na yu bɔdi. If yu de tek dɛn tu mɛrɛsin ya, yu dɔktɔ go du blɔd tɛst. |
So, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛvri mɛrɛsin we yu de tek, ivin wan vaytamɛn ɔ wan Ayurveda mɛrɛsin.
Mɛsej we dɛn kin kɛr go na os
- Iqirvo na nyu mɛrɛsin we dɛn kin yuz fɔ trit praymari biliary cholangitis (PBC).
- dis kin wok mεntal bay we i de ridyus di bכdi in prodakshכn fכ bayl εn kכntrכl di damej we di liva de pwεl.
- Risach dɔn sho se dis kin rili ɛp fɔ mek di blɔd tɛst we gɛt fɔ du wit di liva bɛtɛ.
- Dis nɔ fayn fɔ uman dɛn we gɛt bɛlɛ, uman dɛn we de gi dɛn bɛlɛ, ɛn di wan dɛn we gɛt siriɔs liva sik.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔda mɛrɛsin dɛn we yu de tek, bikɔs sɔm mɛrɛsin dɛn kin miks wit Iqirvo.
- Tɔk opin wan wit yu dɔktɔ bɔt ɛni sayd ɛfɛkt ɔ tin we de mɔna yu.
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