Prɔblɛm de wit ɔksijɛn na di blɔd? Lɛ wi lan bɔt mɛthemoglobinemia!

Yu dɔn ɛva si pɔsin in skin ɛn in lip dɛn tɔn wan strenj blu kɔlɔ wantɛm wantɛm? Ɔ yu dɔn yɛri se dɛn kin bɔn sɔm bebi dɛn blu smɔl? Wan rizin fɔ dis kin bi wan sik we nɔ kin apin so ɔltɛm, bɔt we kin rili siriɔs. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya we na mɛthemoglobinemia . Sɔm pipul dɛn kin kɔl am bak "blu bebi sindrom."

Wetin rili na mɛthemoglobinemia?

Fɔ tɔk am simpul wan, mɛthemoglobinemia na wan sik we di rɛd blɔd sɛl dɛn na wi blɔd nɔ kin ebul fɔ kɛr ɔksijɛn go ɔda sɛl dɛn ɛn tisu dɛn na di bɔdi. Tink bɔt am, na rɛd blɔd sɛl dɛn de ɛp fɔ kɛr ɔksijɛn go ɔlsay na wi bɔdi, nɔto so? Dɛn rɛd blɔd sɛl dɛn ya gɛt wan spɛshal prɔtin we dɛn kɔl ɛmoglobin . I tan lɛk bɔs, ɛn dis ɛmoglobin de kɛr ɔksijɛn go ɔlsay na di bɔdi.

כltu, insay dis kכndishכn we dεn kכl ``Mεthemoglobinemia``, wetin de apin na dat wi ``Hεmoglobin`` we de kכri כksijεn de chenj εn bi difrεn kayn tin we dεn kכl ``Mεthemoglobin.`` di prכblεm na, dis ``Mεthemoglobin`` nכ kin kכri כksijεn. I tan lɛk se di bɔs we de kɛr ɔksijɛn brok ɛn nɔ ebul fɔ kɛr pasenja dɛn.

Dis kכndyushכn kin bi inhεrit (jεnεtik) pan sכm pipul dεm. Bɔt bɔku tɛm na sɔm mɛrɛsin dɛn we wi de yuz, drɔgs fɔ ɛnjɔy wisɛf, ɔ we wi gɛt sɔm kemikal dɛn . Sɔntɛnde, i kin mek pɔsin in layf de pan denja, mɔ pan di pikin dɛn we dɛn bɔn wit wan kayn bad bad sik ɛn pan pipul dɛn we de yuz drɔgs. Bɔt bɔku tɛm, dɔktɔ dɛn kin gi mɛrɛsin fɔ mek di lɛvul fɔ ``Mɛtimoglobin`` go dɔŋ ɛn fɔ pul di sayn dɛm.

Aw dis kin afɛkt mi bɔdi?

Bɔrku pipul dɛm wae gɛt mɛtimoglobinemia kin gɛt wan sik wae dɛn kɔl saynosis . Saynosis na we yu finga nel, tɔŋ, lip, ɛn skin tɔn layt blu ɔ pepul kɔlɔ. Dis kin apin we yu blɔd nɔ gɛt bɛtɛ ɔksijɛn. As a bin dɔn tɔk, na di rɛd blɔd sɛl dɛn we kin kɛr ɔksijɛn ɔlsay na di bɔdi. Wan prɔtin we dɛn kɔl ɛmoglobin de ɛp fɔ du dis.

insay mεthemoglobinemia, ``Mεthemoglobinemia`` de apin we ``Hεmoglobin`` bi ``Mεthemoglobin``, we kin bi fכ wan jεnεtik mכtεshכn כ sכm כda εksternal kכz. biכs ``Mεthemoglobin`` nכ kin kכri כksijεn, di כksijεn we de na di bכdi de dכn εn yu de divεlכp ``Cyanosis``.

Wetin na di sayn dɛm fɔ Methemoglobinemia?

De sik kin difrɛn frɔm pɔrsin to ɔda pɔrsin, ɛn i kin difrɛn bak pan di kayn sik wae yu gɛt. Lɛ wi tek wan luk pan aw dɛn sik ya kin sho.

Di simptom dɛm fɔ di sik we dɛn kɔl Acquired Methemoglobinemia

Bɔku pipul dɛn kin gɛt dis sik afta dɛn dɔn tek sɔm mɛrɛsin dɛn we de mek dɛn fil pen, drɔgs, ɔ we dɛn dɔn gɛt pɔyzin tin dɛn . Dɛn kɔl dis akwyayz mɛtimoglobinemia. Di sayn dɛm wae kin apun na:

• Pale skin (pallor) .
• Fɔ fil taya bad bad wan (fatigue) .
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Sɔntɛnde, pipul dɛm wae gɛt acquired methemoglobinemia kin gɛt siriɔs sik wae kin nid fɔ go to dɔktɔ kwik kwik wan . Dɛn tin ya na:

• Nɔs ɛn vɔmit.
• Fɔ slip pasmak, nɔr de tɔk fayn, ɛn nɔr kin ebul fɔ du tin kwik kwik wan: Dɛn tin ya kin bi sayn dɛm wae de sho se yu gɛt pwɛl hat na yu sɛntral nervous system .
• Nɔr kin no natin ɔr yu bɔdi kin muv wae yu nɔr kin ebul fɔ kɔntrol (lɛk wae yu gɛt sik): Dɛn tin ya na sayn dɛm wae de sho se yu gɛt epileptic seizure .
• Fɔ blo kwik kwik wan, yu at kin rit mɔ ɛn mɔ, ɛn yu kin kɔnfyus: Dɛn tin ya na sayn dɛm fɔ wan sik we dɛn kɔl mɛtabolik asid .

Impɔtant: If pɔrsin wae gɛt yu sho ɛni wan pan dɛn kayn sik ya wae gɛt epilepsy, `(Metabolic Acidosis)` ɔr `(Central Nervous System Depression)`, yu fɔ kɔl 1990 wantɛm wantɛm ɛn kɔl ambulans .

Di simptom dɛm fɔ di Kɔngenital Mɛthemoglobinemia

Methemoglobinemia we dɛn bɔn wit na wan sik we nɔ kin apin so ɔltɛm. Na wan wan pipul dɛn nɔmɔ dɛn dɔn ripɔt ɔlsay na di wɔl. Frɔm da infɔmeshɔn de, dɔktɔ dɛn dɔn sheb am to tri men kayn: Tayp 1, Tayp 2, ɛn Ɛmoglobin M sik (HbM) .

• Bɔku tɛm, pipul dɛn we gɛt ɛmoglobin M sik (HbM) kin gɛt saynosis (blu skin), bɔt bɔku tɛm dɛn kin gɛt wɛlbɔdi.
• Pipul wae gɛt Type 1 Methemoglobinemia (Type 1 MetHb) kin gɛt saynosis bak, bɔt ɔda big big wɛl bɔdi prɔblɛm nɔ kin bɔku.
• כltu, pikin dεm we dεn bכn wit Tayp 2 mεthemoglobinemia (Type 2 MetHb) kin gεt siriכs nyurolכjik prכblεm bay di tεm we dεn ol lεk 9 mכnt. I sɔri fɔ no se dɛn pikin ya nɔ kin liv lɔng.

Wetin mek di mɛthemoglobinemia kin apin?

Dis sik kin kɔmɔt frɔm am, ɔr lɛk aw a bin dɔn tɔk, i kin kam bak leta bikɔs ɔf sɔm mɛrɛsin, drɔgs, ɔ pɔyzin kemikal.

Di tin dɛn we kin mek pɔsin gɛt di sik we dɛn kɔl Methemoglobinemia

• Di mɛrɛsin dɛn we de mek pɔsin fil pen lɛk bɛnzokɛyn ɛn lidokɛyn (espɛshali di wan dɛn we dɛn kin si na jel ɛn sprɛy we dɛn kin put pan pɔsin in bɔdi) ɛn di antibayɔtik dapsone kin mek dis apin.
• Naytrɛt we dɛn kin yuz fɔ mek sɔm mɛrɛsin dɛn, Naytrayt, we kin de insay tin dɛn we dɛn kin yuz fɔ mek it ɛn sɔm wɛl wata, ɛn we pɔsin kin gɛt sɔm ɛbisayd dɛn we dɛn kin yuz fɔ du agrikalchɔral biznɛs, na dɛn bak kin mek i apin.
• Pipul dɛn we de yuz drɔgs fɔ ɛnjɔy dɛnsɛf lɛk amyl nitrite (dɛn kin kɔl am bak poppers), nitrous oxide (laf gas), ɛn sɔm anestetik dɛn we dɛn miks wit drɔgs lɛk kɔkɛyn kin gɛt mɔ risk fɔ gɛt mɛrɛsin prɔblɛm we kin mek dɛn layf de pan denja bikɔs dɛn gɛt bɔku bɔku mɛthemoglobin.

Di tin dɛn we kin mek pɔsin gɛt di sik we dɛn kɔl Conngenital Methemoglobinemia

di kכnεjital mεthemoglobinemia (Congenital MetHb) de kכz bay tu difrεn jεnεtik mכtεshכn dεm.

• insay tayp 1 εn 2 , wan mכtεshכn na di jin CYB5R de disrupt di bεlε bitwin εmoglobin εn mεthemoglobin insay rεd bכdi sεl dεm.
• di sik we dεn kכl εmoglobin M (HbM) de kכz bay di mכtεshכn dεm we de insay sεvεra εmoglobin M jin dεm.

di mεthemoglobinemia we dεn bכn wit na wan כtosom rεsεsiv dizכrd . Fɔ tɔk am simpul wan, fɔ mek pikin gɛt di sik, in mama ɛn papa ɔl tu fɔ gɛt di jin we de chenj ɛn di pikin fɔ gɛt di chenj frɔm dɛn ɔl tu.

Di sik we dɛn kɔl ɛmoglobin M (HbM) na wan sik we de mek pɔsin gɛt ɔtosom . Dis min se pikin kin gɛt di sik ilɛksɛf na wan mama ɔ papa nɔmɔ dɛn gɛt di jin we dɛn chenj.

Aw dɔktɔ dɛn kin no bɔt dis?

Dɔktɔ dɛn kin no dis sik bay we dɛn tek yu kɔmplit mɛdikal istri ɛn du wan ɛgzam pan yu bɔdi . If pɔsin gɛt sayn dɛn we de sho se i gɛt mɛthemoglobinemia, i kin aks bɔt ɛni drɔgs we i de yuz ɔ pɔyzin kemikal dɛn we i dɔn gɛt.

Us tɛst dɛn kin du fɔ no dis?

Bɔku tɛm, dɛn kin du dɛn tɛst ya:

• Blɔd Tɛst: Blɔd we dɛn kin tek frɔm di at dɛn we pipul dɛn we gɛt dis sik kin gɛt kin gɛt dak brawn kɔlɔ. Dis dak brawn kɔlɔ min se di at dɛn nɔ de kɛr ɔksijɛn fayn fayn wan na di blɔd.
• Methemoglobin (MetHb) level test: Dis de mek yu no aw bɔku mɛthemoglobin de na yu blɔd.
• CYB5R εnzym aktiviti: if di aktvכti fכ dis εnzym lכs pas nכmal, na sayn fכ di mεthemoglobinemia we dεn bכn wit am.
• Jɛnɛtiks: If yu sɔspɛkt se yu gɛt mɛtimoglobinemia we yu bɔn wit, dɛn go chɛk yu DNA fɔ si if yu gɛt chenj dɛn na yu jɛnɛtiks fɔ kɔnfɔm di diagnosis. Dis kin ɛp bak fɔ no di kayn sik.
• Ɛmoglobin Ilɛktrofɔrɛsis: .dis na we fכ tεst di ``Hεmoglobin`` insay rεd bכdi sεl dεm. dis tεst kin yus fכ no di hεmoglobin M sik ``(HbM).``

Aw dɛn kin trit dis?

Di tritmɛnt opshɔn dɛn kin difrɛn difrɛn wan bay di kayn mɛthemoglobinemia we yu gɛt. Fɔ ɛgzampul, di tritmɛnt fɔ pikin we dɛn jɔs bɔn wit tayp 2 rili difrɛn frɔm di tritmɛnt fɔ pɔsin we gɛt dis sik tru we i yuz pɔyzin kemikal ɔ drɔgs.

• Pipul wae gɛt Tayp 1 Methemoglobinemia ɔ Hemoglobin M sik nɔr nid tritmɛnt. If nid de, dɔktɔ dɛn kin yuz dɛn mɛrɛsin ya fɔ mek di Mɛtimoglobin lɛvɛl go dɔŋ:
• Methylene Blue: Dis na di men antidote fɔ methemoglobinemia.
• Vitamin C ɛn vaytamɛn B2.

Tritmɛnt fɔ Akwyayz Mɛtimoglobinemia

Dipכnt pan di kכndyushכn, di mεthemoglobinemia we dεn kin gεt kin bi mεdikal imejensi. If na so i bi, i kin nid fɔ mek dɛn put wata insay di bɛlɛ ɛn ɔksijɛn . Bɔku tɛm, dɛn kin gi pipul dɛn we gɛt di sik we dɛn kɔl mɛtimoglobinemia mɛtilin blu .

Wetin na di prɔblɛm dɛn we kin apin we pɔsin gɛt tritmɛnt?

if dεn gi pכsin we gεt G6PD Dεfisiεns (we na jεnεtik kכndishכn bak) mεtilen blu tritmεnt kכntinyu, wan kכndyushכn we dεn kכ l εmolaysis kin apin. Ɛmolaysis na we yu rɛd blɔd sɛl dɛn brok bifo tɛm ɔ we nɔ nid fɔ brok.

A kin ridyus di risk fɔ gɛt mɛthemoglobinemia?

• Pipul dεm we gεt wan jεnεtik vεryכnt fכ dis kכndyushכn fכ avכyd tכxik kεmεkal dεm (e.g. peshכnal), sכm mεdikeshכn dεm, εn plεnti lokal anεsthεtik dεm we kin inkrεs di mεthemoglobin lεvεl. If yu gɛt dis sik, aks yu dɔktɔ bɔt wetin yu go gɛt alɛji to.
• Pipul wae de yuse drɔgs lɛk amyl nitrite ɔr cocaine kin put dɛnsɛf pan risk fɔ gɛt methemoglobinemia. If yu de yuz dɛn mɛrɛsin ya ɛn yu nid ɛp fɔ lɛf fɔ yuz am, tɔk to dɔktɔ bɔt di tritmɛnt dɛn we de.

Wetin kin apin if a gɛt dis sik?

Bɔrku tɛm, tritmɛnt kin mek yu nɔr gɛt di sik. Bɔrku pipul dɛm wae gɛt Type 1 Congenital Methemoglobinemia, ɔ Hemoglobin M sik, nɔr kin gɛt bɛtɛ sayn dɛm. Dɛn kin liv lɔng lɛk pɔrsin wae nɔr gɛt dis sik.

Aw a kin kia fɔ misɛf?

• In jɛnɛral, pipul dɛm we dɛn bɔn wit di ``congenital`` fɔm fɔ di sik fɔ tek tɛm wit mɛrɛsin ɛn kemikal dɛm we kin mek di sik wɔs. Bikɔs ɔlman in prɔblɛm difrɛn smɔl, i go fayn fɔ mek yu go to yu dɔktɔ.
• Pipul wae gɛt acquired methemoglobinemia (Acquired MetHb) fɔ avɔyd ɔl di tin dɛm wae mek i kam – lɛk drɔgs, topical painkillers, ɔr pɔyzin kemikal.

Ustɛm a fɔ go to dɔktɔ?

• If yu gɛt wan kayn mɛthemoglobinemia we yu gɛt frɔm yu mama ɛn papa, go to dɔktɔ if yu notis chenj dɛn na yu bɔdi, lɛk fɔ taya ɔ fɔ taya. Dɛn tin ya kin bi sayn dɛn we de sho se yu rɛd blɔd sɛl dɛn nɔ ebul fɔ kɛr ɔksijɛn go ɔlsay na yu bɔdi igen.
• If yu gɛt siriɔs sik lɛk saynosis (blu skin) wit di sik we yu de si ɔ yu de slip pasmak, kɔl 911 wantɛm wantɛm ɔ go na di ɔspitul imejensi dipatmɛnt we de nia yu.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

Methemoglobinemia na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm. Sɔm pipul dɛn kin gɛt am we dɛn kin gɛt frɔm dɛn mama ɛn papa (Congenital MetHb), bɔt bɔku pipul dɛn kin gɛt am leta (Acquired MetHb). Dipen pan yu kɔndishɔn, yu kin aks yu dɔktɔ kwɛstyɔn dɛn lɛk:

Bɔt di Mɛtimoglobinemia we dɛn dɔn gɛt (Akwyayz MɛtHb):

• Wetin mek dis bin apin to mi?
• Di tritmɛnt go mek di sik dɛn we a gɛt nɔ de igen?
• Yu tink se di sayn dɛn we a kin gɛt kin kam bak?
• Wetin a fɔ du fɔ mek sɔntin lɛk dis nɔ apin igen?

Bɔt Tayp 1 Kɔnjɛnital MɛtHb:

• Saynosis (blu skin) na siriɔs mɛrɛsin prɔblɛm?
• A go gɛt fɔ tek mɛthemoglobinemia (MetHb) tritmɛnt ɔltɛm?
• A kin gɛt ɔda sayn dɛn?
• Mi pikin dɛn kin gɛt dis sik?

Tayp 2 Congenital MetHb (if na pikin):

• Aw dis sik go afɛkt mi pikin?
• Tritmɛnt dɛn de fɔ ridyus di sik dɛn we mi pikin gɛt?
• Wetin a go du fɔ ɛp mi pikin?
• If a gɛt mɔ pikin dɛn, dis go apin to dɛnsɛf?

Fɔ sɔmtin (Tek-Home Message) .

Methemoglobinemia na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm we kin afɛkt di we aw wi rɛd blɔd sɛl dɛn kin ebul fɔ kɛr ɔksijɛn rawnd di bɔdi. Fɔ sɔm pipul dɛn, dɛn kin gɛt am frɔm dɛn mama ɛn papa, bɔt fɔ bɔku pipul dɛn, na sɔm mɛrɛsin dɛn, we dɛn de yuz pɔyzin kemikal dɛn, ɔ we dɛn de yuz drɔgs fɔ ɛnjɔy dɛnsɛf. Sɔntɛnde, di mɛthemoglobinemia we dɛn bɔn wit (espɛshali tayp 2) kin mek yu gɛt siriɔs nyurolɔjik prɔblɛm, bɔt bɔku tɛm i nɔ kin mek big big wɛlbɔdi prɔblɛm. Bɔt sɔntɛnde, di sik we dɛn kin gɛt we dɛn kɔl methemoglobinemia (acquired methemoglobinemia) kin mek pɔsin in layf de pan denja.

De tin wae impɔtant pas ɔl na dat, if yu tink se yu de pan denja fɔ gɛt dis sik, nɔr frayd fɔ tɔk to dɔktɔ bɔt am. I go gladi fɔ ɛp yu.

` Methemoglobinemia, Methemoglobinemia, Blu bebi sindrom, Saynosis, Ɔksijɛn nɔ de na di blɔd, Ɛmoglobin, Blɔd sik, Jɛnɛtik sik