Yu gɛt dis strenj sik? Lɛ wi tɔk bɔt Maykroskɔpik Polyangiitis (MPA) .

Bɔku tɛm yu kin fil lɛk se yu taya, yu kin gɛt fiva we yu nɔ ebul fɔ ɛksplen, ɛn yu kin lɛf fɔ it bɔku bɔku bɔdi we yu gɛt pen na yu jɔyn dɛn? Pan ɔl we dɛn tin ya kin tan lɛk nɔmal tin, sɔntɛnde, wetin kin ayd biɛn dɛn sayn ya kin bi sik we wi nɔ yɛri bɔku bɔt ɛn we wi fɔ wɔri bɔt smɔl. Tide wi de tɔk bɔt dis kayn sik we nɔ bɔku bɔt we impɔtant, we wi fɔ no bɔt. Dɛn kɔl dis maykroskɔpik polyangiitis, ɔ MPA lɛk aw dɔktɔ dɛn kin kɔl am.

Fɔ tɔk am simpul wan, wetin na Maykroskɔpik Polyangiitis (MPA)?

Fɔ tɔk am simpul wan, MPA na wan sik we di smɔl ɛn midul saiz blɔd vesel dɛm (blɔd vesel dɛm) na wi bɔdi kin inflam, dat min se dɛn kin swel. Insay mɛrɛsin, wi kin kɔl dis swɛlin na di blɔd vesel dɛn ‘vasculitis’. Dis na sik we nɔ kin apin so ɔltɛm.

We di blɔd vesel dɛn inflam dis we, dɛn kin bigin fɔ pwɛl di ɔgan dɛn we dɛn de gi blɔd to. di men כgan dεm we kin afekt na MPA na:

• Kidni dɛn
• Lɔng
• Nɛv dɛn
• Kanda
• Jɔyn dɛn (jɔyn dɛn) .

Wetin na ‘Vasculitis’? Wetin i de kɔz?

Tink bɔt di blɔd vesel sistɛm we de ɔlsay na wi bɔdi lɛk wan sistɛm we gɛt paip dɛn we de kɛr wata. We dɛn paip ya swel ɔ inflam, bɔku prɔblɛm dɛn kin apin.

1. We di blɔd vesel wik: Bikɔs di blɔd vesel de swel, di blɔd vesel in wɔl kin wik ɛn i kin bulge lɛk balyɔn. Wi kin kɔl dis ``(Aneurysm)``. Sɔntɛnde dis say we wik kin bɔs ɛn blɔd go insay di tisu we de rawnd am.

2. Narrowing of blood vessels: Wan ɔda tin na dat di blood vessels kin smɔl bikɔs ɔf di swel insay dɛn, ɛn sɔm tɛm dɛn kin ivin blok ɔl. Dɔn di ɔgan dɛn we de gɛt blɔd ɛn ɔksijɛn frɔm dɛn blɔd vesel dɛn de kin bigin fɔ pwɛl. Jɔs lɛk aw tik kin day we dɛn nɔ gɛt wata.

Na dat de apin na MPA. Bikɔs di smɔl smɔl blɔd vesel dɛn kin afɛkt, dɛn kin pwɛl di sɛnsitiv ɔgan dɛn we de gi blɔd, lɛk di kidni ɛn di lɔng.

Udat kin gɛt dis sik? Wetin kin mek i apin?

Dis na sik we nɔ kin apin so ɔltɛm. Statistikin sho se dis sik kin ambɔg bitwin 13 ɛn 19 pan ɛvri milyɔn pipul dɛm na di wɔl. I kin kam pan ɛni ej ɛn i kin tan lɛk se i kin afɛkt man ɛn uman ikwal.

Dɛn nɔ dɔn no yet di rayt tin we kin mek pɔsin gɛt dis sik, bɔt dis bɔku tin klia:

• Dis nɔto kansa.
• I nɔto sik we pɔsin kin pas.
• Bɔku tɛm, i nɔ kin bi sik we pɔsin kin gɛt frɔm in mama ɛn papa.

Risach dɔn sho bɔku tɛm se dis na sik we kin kam bikɔs di bɔdi in yon imyun sistɛm nɔ de wok fayn. Fɔ tɔk am simpul wan, di imyun sistɛm we dɛn se go protɛkt wi bɔdi, kin mistek bigin fɔ atak wi yon blɔd vesel dɛn. Na dat kin mek dis inflamɛns.

Wetin na di sayn dɛm fɔ MPA sik?

Bikɔs MPA kin afɛkt bɔku ɔgan dɛn, di sayn dɛn kin difrɛn, ɛn dɛn kin difrɛn frɔm wan pɔsin to ɔda pɔsin.

Aw dɔktɔ kin no bɔt dis sik?

Fɔ no MPA nɔto wan step prɔses. Dɔktɔ fɔ jɔyn bɔku tin dɛn fɔ mek i ebul fɔ disayd fɔ du sɔntin.

• Dɛn go aks yu fɔ no mɔ bɔt dis: De dɔktɔ go tek tɛm lisin to yu sik, aw dɛn bigin, ɛn yu mɛdikal histri.
• Fɔ chɛk yu bɔdi: Yu dɔktɔ go chɛk yu bɔdi fɔ tray fɔ no us ɔgan dɛn gɛt di sik.
• bכdi εn urine tεst: di bכdi tεst dεm spεshal wan de luk fכ wan antibodi we dεn kכl ``(ANCA - Antineutrophil Cytoplasmic Antibodies)``. Dis kin bi pɔsitiv pan sik dɛm lɛk MPA. Dɔn bak, fɔ chɛk di urine fɔ si if i gɛt prɔtin ɛn rɛd blɔd sɛl dɛn, i impɔtant fɔ no di kayn we aw di kidni dɛn de.
• Skan: Dɛn kin yuz ɛkstrem rayt, CT skan, ɔ MRI skan fɔ chɛk fɔ si if tin nɔ de na di ɔgan dɛn lɛk di lɔng.
• Bayɔpsi: If dɛn sɔprayz se di sik de, dɛn kin tek wan smɔl pat pan di tisu frɔm di say we di sik afɛkt (e.g., kidni, skin) ɛn chɛk am ɔnda maykroskɔp. Dis na di bɛst we fɔ kɔnfɔm if yu gɛt vasculitis.

Wetin na di tritmɛnt dɛm fɔ MPA?

Di men gol fɔ trit MPA na fɔ kɔntrol di ɔva aktiviti na wi imyun sistɛm ɛn stɔp di damej pan di blɔd vesel dɛm. Dɛn kin yuz mɛrɛsin dɛn we de mek pɔsin nɔ ebul fɔ fɛt di sik fɔ dis.

We di sik bad bad wan

if di big כgan dεm lεk di kidni εn di lכng dεm afekt bad bad wan, dεn kin gi k כtikostεroyd wit כda strכng imyun supεshכn drog lεk Cyclophosphamide (Cytoxan®) כ Rituximab (Rituxan®).

If di sik nɔr so bad

Insay kes dɛm we nɔ kin rili bad, dɛn kin yuz kɔtikosterɔyd ɛn mɛtɔtreksɛt fɔs.

Di gol fɔ tritmɛnt na fɔ kɔntrol di sik ɔltogɛda ɛn briŋ am to stet we i nɔ de du ɛnitin. Dɛn kɔl dis fɔ go insay ‘rɛmishɔn’. We dɛn dɔn kɔntrol di sik, di dɔktɔ go ridyus di doz fɔ stɛroyd smɔl smɔl.

Dɛn kin gi strɔng drɔgs lɛk `Cyclophosphamide` te di sik dɔn ɔnda kɔntrol (lɛk 3-6 mɔnt). Afta dat, dɛn kin chenj yu to `Maintenance Medication`, lɛk `Azathioprine (Imuran®)` ɔ `Mycophenolate Mofetil (Cellcept®)`, fɔ kip di sik ɔnda kɔntrol ɛn mek i nɔ kam bak. Dis mentenɛns tritmɛnt kin nid fɔ tek fɔ at le wan ɔ tu ia.

Yu gɛt di fred bak fɔ se, "Dis na kansa drɔgs, nɔto so?"

Bɔku pipul dɛn gɛt kwɛstyɔn na ya. Dɛn kin gi mɛrɛsin dɛn we dɛn kɔl `Cyclophosphamide` ɛn `Methotrexate` bak fɔ kansa, so dɛn se dɛn tin ya na `Chemotherapy` mɛrɛsin. Yɛs, dɛn kin gi dɛn tin ya bak fɔ kansa. Bɔt di doz we dɛn gi fɔ `Vasculitis` na 10-100 tɛm smɔl pas di doz we dɛn gi fɔ kansa. Na ya, di wok we dɛn mɛrɛsin ya de du nɔto fɔ kil di kansa sɛl dɛn, bɔt fɔ kɔntrol di we aw di imyun sistɛm de wok.

Aw layf go tan lɛk wit dis sik?

Pan ɔl we MPA na siriɔs sik, if dɛn tek di rayt tritmɛnt, bɔku pipul dɛn kin ebul fɔ kɔntrol di sik fayn fayn wan. Di tin dɛn we kin apin kin difrɛn difrɛn wan bay aw di sik rili bad. Bɔt, in jɛnɛral, pas 80% pan pipul dɛm de alayv ɛn wɛl afta 5 ia wae dɛn dɔn no se dɛn gɛt dis sik.

If yu no am kwik ɛn trit am kwik, dat kin ɛp fɔ mek di ɔgan dɛn nɔ pwɛl. I impɔtant bak fɔ kɔntinyu fɔ tɔk to yu dɔktɔ ɔltɛm.

Afta di sik dɔn ɔnda kɔntrol, dat na afta i dɔn go insay ``Rɛmishɔn``, sɔmtɛm i kin kam bak. Wi de kol dis wan ``Rilaps``. Na lɛk 50% pan di sik pipul dɛn kin gɛt dis kayn sik we kin kam bak. So, yu fɔ tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛni nyu sayn we yu gɛt.