Wi ɔl dɔn yɛri di wɔd "mRNA" bɔku wit di COVID-19 pandemic, nɔto so? Bɔt pan di sem tɛm, bɔku pipul dɛn kin gɛt kwɛstyɔn bɔt dis, ɛn dɛn kin ivin fred smɔl. "Dis na nyu tin?", "Wetin dis go du to wi bodi?" Sɔntɛm yu go dɔn de wɔnda. So tide, lɛ wi tɔk rili simpul ɛn pɔlitiks bɔt wetin na dis mRNA vaysin ɛn aw i rili de wok insay wi bɔdi.
Lɛ wi si fɔs, wetin na dis mRNA?
di ful nem fכ mRNA na mεsenja Ribonuklik Asid. Pan ɔl we di nem kɔmplikt smɔl, di wok rili simpul. Tink bɔt di DNA we de na wi bɔdi lɛk wan big buk we de sho aw fɔ kuk. Dis buk gɛt di instrɔkshɔn dɛn fɔ mek ɔl di prɔtin dɛn we wi bɔdi nid. bכt yu nכ kin tek dis כl big buk go na di kichin (dat na, to di ribosכm dεm na wi sεl dεm we de mek protin dεm).
dis na di say we di ‘mεsenja’ we dεn kכl mRNA de kam in. wetin i de du na fכ rayt pan wan pepa di rεsipi fכ di protin we i nid fכ mek frכm da big DNA buk de, εn tek da mεsej de go na di kichin. Fɔ tɔk am simpul wan, mRNA tan lɛk shɔt mɛsej we de kɔpi di instrɔkshɔn dɛn we de na DNA ɛn sɛn dɛn to di ples usay dɛn mek di protin. Dis na tin we kin apin na wi bɔdi ɔltɛm.
So wetin kin apin wit mRNA vaysin?
Lɛk ɔl di vaysin dɛn, wan mRNA vaysin de tren wi bɔdi in imyun sistɛm fɔ fɛt wan sik. Bɔt di we aw i de du am difrɛn smɔl.
Tek di mRNA vaysin fɔ COVID-19 as ɛgzampul. Wetin dis vaksin de du na fɔ gi wi sɛl dɛn nɔmɔ di instrɔkshɔn (mRNA mɛsej) we nid fɔ mek di ‘Spike Protein’, we na pat pan di SARS-CoV-2 vayrɔs we de mek COVID-19.
Di tin we impɔtant pas ɔl na dat, dis vaysin nɔ gɛt di wan ol vayrɔs, ɔ ɛni pat we de alayv ɔ we dɔn day pan di vayrɔs . I jɔs gɛt di ‘rɛsipɛkt’ fɔ mek wan pat pan di vayrɔs.
We wi sɛl dɛn gɛt dis instrɔkshɔn, dɛn kin mek sɔm pan dis ‘protɛin we gɛt chukchuk.’ we wi imyun sistεm si dis nyu protin we dεn fכm, i de se, "Oh... dis na invayda we nכ de insay wi bכdi." Dɔn, i kin rɛdi fɔ mek wɛpɔn dɛn lɛk antibodies fɔ fɛt am.
Bikɔs dɛn tren wi dis we bifo tɛm, if di rial COVID-19 vayrɔs kam insay di bɔdi leta, wi imyun sistɛm go no am jɔs lɛk aw i si am, atak am kwik ɛn fayn fayn wan, ɛn protɛkt wi fɔ mek wi nɔ sik bad bad wan.
di mRNA mεsej frכm di vaksin de brok dכn, brok dכn, εn de disappear insay fכ de dεm na di bכdi. Jɔs lɛk di rɛsipɛkt buk wi kin kɛr go na di kichin ɛn pwɛl am we wi dɔn. I nɔ de ɛva jɔyn wit wi DNA ɔ chenj wi jin dɛn.
Wetin na di difrɛns bitwin mRNA vaysin ɛn tradishɔnal vaksin?
di men difrεns na di we aw di vayrus de prεzεnt to di imyun sistεm. Si di tebul we de dɔŋ fɔ no mɔ.
| mRNA Vaksin dɛn | Tradishɔnal Vaksin dɛn |
|---|---|
| dεn gi di bכ di di instrכkshכn dεm (mRNA) we i nid fכ mek pat pan di vayrus. | di vayrus dεm we dεn nכ aktiv ("killed") , di vayrus dεm we wik , כ di protin fragmεnt dεm fכ di vayrus insεf dεn de gi di bכdi. |
| Di vaysin nɔ gɛt ɛni pat pan di vayrɔs. | Di vaysin gɛt sɔm kayn pat pan di vayrɔs. |
| Ɛgzampul dɛn: Pfizer-BioNTech (Comirnaty®), Moderna (Spikevax®) COVID-19 vaysin dɛn. | Ɛgzampul dɛn: Novavax® COVID-19 vaysin (wan prɔtin sabyunit vaysin), mizɛl vaysin (attenuated virus). |
Wetin kin apin we yu gɛt di vaysin?
Dɔktɔ ɔ nɔs go klin di tap pat pan yu an wit rɔm ɛn gi yu di injɛkshɔn. Dɔn, dɛn go aks yu fɔ wet fɔ lɛk 15 minit so. Dis na fɔ chɛk fɔ si if yu gɛt alɛji wantɛm wantɛm to di injɛkshɔn. Sɔm pipul dɛn kin fil lɛk se dɛn nɔ gɛt bɛtɛ trɛnk we dɛn de gi dɛn injɛkshɔn, so i go fayn fɔ mek dɛn sidɔm.
Wetin na di bɛnifit ɛn risk dɛm fɔ mRNA vaysin dɛm?
Di bɛnifit dɛn we pɔsin kin gɛt
wan pan di big advantej dεm fכ mRNA tεknכlכji na spid . Tradishɔnal vaysin dɛn nid fɔ mek dɛn gro di vayrɔs na lɛbɔtri. Dat kin tek mɔnt, ivin ia. Bɔt mRNA vaysin nɔ nid dat, so dɛn kin mek dɛn kwik kwik wan, ivin if nyu pandemik apin.
We wi de tɔk bɔt COVID-19 vaysin, fɔ gɛt vaysin,
- I de ridyus di risk fɔ gɛt COVID-19 infɛkshɔn.
- Ivin if i gɛt di sik, di risk fɔ mek pɔsin sik bad bad wan, fɔ go na ɔspitul, ɛn fɔ day kin ridyus bad bad wan.
- Ridyus di risk fɔ lɔng tɛm ifɛkt (Lɔng COVID) afta yu gɛt COVID-19.
Risk ɛn Sayd Ɛfɛkt dɛn
Lɛk ɛni vaysin, mRNA vaksin kin gɛt smɔl smɔl sayd ɛfɛkt dɛn. Dɛn tin ya na rili sayn fɔ sho se yu imyun sistɛm dɔn bigin fɔ wok.
Di kɔmɔn sayd ɛfɛkt dɛn:
- Pen ɔ swɛlin na di say we dɛn injekt am
- Taya
- Ed de at
- Mɔsul dɛn kin pen
- Mild fiva
Dɛn sayn ya kin dɔn kpatakpata insay wan ɔ tu dez.
Alɛji we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs:
Na smɔl tɛm nɔmɔ, pɔsin kin gɛt alɛji fɔ sɔntin we de insay di vaysin. Di sayn dɛm na:
- Skin rash ɔ it
- I de it
- Fɔ swel na yu fes, yu lip, yu tɔŋ, ɔ yu trot (Anaphylaxis) .
If yu gɛt siriɔs alɛji lɛk fɔ blo, yu fes ɔ yu trot de swel, go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
Yu tink se dis teknɔlɔji rili nyu?
Nɔ. Risach pan mRNA teknɔlɔji dɔn de go bifo frɔm di 1970 dɛm. Na insay di 1990 dɛm bigin fɔ du risach fɔ yuz dis teknɔlɔji fɔ mek vaysin. I tek sayɛnsman dɛn pas 20 ia fɔ no aw fɔ mek dis mRNA go insay sɛl dɛn we wi imyun sistɛm nɔ go pwɛl am.
Dɛn bin de yuz dis teknɔlɔji fayn fayn wan fɔ wan drɔg (Patisiran) we de trit wan rare neurological disease ivin bifo di COVID-19 pandemic. We di COVID-19 pandemik bin kam, sayɛnsman dɛn bin ebul fɔ yuz di no we dɛn bin gɛt frɔm di risach we dɛn bin de du fɔ lɔng lɔng tɛm fɔ mek dɛn mek vaysin dɛn we sef ɛn we go wok kwik kwik wan pas aw dɛn bin de du trade.
Na nɔmal tin fɔ fred smɔl ɛn nɔ biliv nyu tin dɛn. Bɔt mRNA na big big lip fɔ go bifo pan mɛdikal sayɛns, we dɛn dɔn du risach ɛn divɛlɔp fɔ lɔng lɔng tɛm. Dis smɔl mɛsenja mɔlyul kin ɛp wi fɔ trit bɔku ɔda sik dɛn lɛk kansa tumara bambay.
Mɛsej we dɛn kin kɛr go na os
- di mRNA vaksin dεm nכ gεt di vayrus, i de liv כ dεn day. Dɛn jɔs gɛt di instrɔkshɔn fɔ mek wan pat pan di vayrɔs.
- Dɛn vaysin ya nɔ de chenj yu DNA . di mRNA mɛsej we de insay di vaksin de kɔmɔt na di bɔdi insay sɔm dez.
- Dis na fɔ tren yu imyun sistɛm bifo tɛm fɔ fɛt wan sik.
- Bɔku tɛm, di sayd ɛfɛkt dɛn nɔ kin at ɛn i kin go insay sɔm dez, we kin sho se yu imyun sistɛm de wok.
- Dis na teknɔlɔji we sef ɛn we go wok fayn ɛn we dɛn dɔn de du risach fɔ lɔng lɔng tɛm.
- If yu gɛt ɛnitin fɔ wɔri bɔt ɔ kwɛstyɔn, tɔk to yu dɔktɔ bɔt am.
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