Yu de fil strenj tin dɛn na yu bɔdi? Sɔntɛm i impɔtant fɔ no bɔt Multiple System Atrophy (MSA)!

Yu kin ɛva fil lɛk se tin dɛn na yu bɔdi de chenj di we aw yu nɔ ebul fɔ kɔntrol? Sɔntɛnde, i kin tan lɛk se yu nɔ de balans we yu de waka, ɔ yu kin fil diziz we yu tinap wantɛm wantɛm. Dis na tin wae wi nɔr kin pe atɛnshɔn to sɔmtɛm, bɔt dɛn kin bi sayn dɛm bak fɔ sɔm kayn nyurolɔjik sik dɛm wae nɔr kin bɔrku. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya we kɔmplikt smɔl, bɔt i rili impɔtant fɔ no bɔt. Dat na Mɔltipɛl Sistɛm Atrofi (MSA) .

Wetin rili na Multiple System Atrophy (MSA)?

Fɔ tɔk am simpul wan, Multiple System Atrophy (MSA) na wan sik we nɔ kin apin so ɔltɛm we di pat dɛn na wi bren kin wik smɔl smɔl, dat min se dɛn kin pwɛl. As tɛm de go, di wok ɛn di tin dɛn we wi bɔdi de du we dɛn pat ya na di bren de kɔntrol kin bigin fɔ pwɛl. Dis na rili siriɔs sik, bikɔs i nɔ kin izi fɔ mek pɔsin wɛl ɔltogɛda frɔm am.

Trade, dɛn bin de kɔl MSA wit bɔku difrɛn nem dɛn. yu kin yeri bכt nem dεm lεk `Shy-Drager syndrome`, `Sporadic olivopontocerebellar atrophy`, `Striatonigral dijenεreshכn`. Na leta nɔmɔ dɔktɔ dɛn kam fɔ no se ɔl dɛn sik ya gɛt sɔm tin dɛn we dɛn kin du. Na dat mek dɛn jɔyn dɛn ɔl ɛn gi dɛn nyu nem, `Multiple System Atrophy` (MSA). Di sayn dɛm kin difrɛn difrɛn wan bay us pat pan di bren dɔn pwɛl. Na dat mek ɔlman kin gɛt difrɛn kɔmbaynshɔn pan di sayn dɛm.

Tu kayn MSA de, nɔto so? Wetin na dɛn?

Yɛs, fɔ no mɔ klia wan di sik we MSA gɛt, dɔktɔ dɛn dɔn sheb am to tu men kayn, i go dipen pan di sayn dɛn we de sho:

1. MSA-C : di 'C' we de ya de tinap fכ `sεribεl'. Dis kayn kin afɛkt di we aw yu ebul fɔ kɔdinɛt yu muvmɛnt dɛn mɔ. Dat min se yu de lɔs yu balans , we dɔktɔ dɛn kin kɔl bak `ataxia'. Dis na di men sayn fɔ dis kayn tin. di sem tεm, yu kin si prכblεm bak wit di bכdi in כtomatכk kכntrכl sistεm dεm (`autonomic dysfunction`) εn fכ fכl fכ fכl.

2. MSA-P : Di 'P' we de ya de tinap fɔ `parkinsonism'. Na dis kayn sik, dɛn kin si sɔm kayn sayn dɛm wae fiba dis sik wae de mɛk pɔrsin gɛt dis sik. pan ɔl we dɛn sik ya kin sho mɔ pan di fɔs tɛm, as tɛm de go, prɔblɛm wit di ɔtonomik nɛvɔ sistɛm ɛn di simptom dɛm fɔ `ataxia' kin apin bak.

Udat dɛn kin afɛkt mɔ pan dis MSA kɔndishɔn? Aw i kɔmɔn?

MSA kin afɛkt big pipul dɛn we dɔn pas 30. Di sayn dɛm kin mɔs apin bitwin di ej dɛm we ol 50 ɛn 59. I kin afɛkt ɛnibɔdi, ilɛksɛf na man ɔ uman.

Bɔt MSA na wan sik we nɔ kin apin so ɔltɛm . Masta sabi bukman dɛn se na 0.6 ɔ 0.7 nyu wan dɛn nɔmɔ de gɛt di sik pan ɛvri 100,000 pipul dɛn ɛvri ia. Dɛn se di ɔl di kes dɛm de bitwin 3.4 ɛn 4.9 pan ɛvri 100,000. So yu kin si aw dis nɔ kin apin so ɔltɛm.

Wetin kin apin to di bɔdi we gɛt MSA? Us pat dɛn na di bren kin afɛkt?

MSA na wan sik we de go bifo we de afɛkt difrɛn pat dɛn na di bren. Di sayn dɛm de dipen pan di pat na di bren we di sik afɛkt. di men εria dεm na di bren we MSA de afekt na:

• Basal ganglia : Dɛn wan ya de rayt na di midul pan di bren. Dɛn kin kɔnɛkt difrɛn pat dɛn na di bren ɛn ɛp dɛn fɔ wok togɛda. I tan lɛk di men kɔntrol rum na di bren .
• Brainstem : Dis na wetin de kɔntrol bɔku pan di ɔtomɛtik prɔses dɛm na wi bɔdi. Dat min se, tin dɛn we kin apin ɔtomɛtik wan we wi nɔ tink bɔt dɛn, fɔ ɛgzampul, aw wi de blo, aw wi at de bit, ɛn aw wi blɔd prɛshɔn. Dɛn tin ya rili impɔtant fɔ mek wi kɔntinyu fɔ liv.
• Sεribεl : Dis de na di bak pat pan di ed, na di bεs. I men wan fɔ kɔntrol di muvmɛnt ɛn fɔ mek i balans. I de wok bak wit ɔda pat dɛn na di bren. Risach pipul dɛn stil de lan bɔt di ful wok we i de du, bɔt sɔm pruf dɛn sho se i de insay wi filin ɛn disayd bak.

So, we dɛn pat dɛn ya na di bren dɔn pwɛl, di wok dɛn we dɛn pat dɛn de kin kɔntrol nɔ kin ebul fɔ du fayn. fכ egzampl, if di `Brainstem` dכn pwεl, prכblεm wit כtomat tin dεm lεk bכdi prεshכn kin apin.

Wetin na di sayn dɛm fɔ MSA? Aw wi kin no dɛn?

Sɔm sayn dɛm fɔ MSA kin kɔmɔn fɔ ɔl tu di kayn dɛm, ɛn sɔm kin spɛshal fɔ ɛni kayn. Bɔt wan tin we kɔmɔn fɔ ɔl tu di kayn tin dɛn na di ɔtonomik disfɔkshɔn. Fɔ tɔk am simpul wan, di ɔtomɛtik kɔntrol sistem dɛn we yu bɔdi gɛt kin go haywire.

di simptom dεm we de kכz fכ prכblεm wit di כtonom nεv sεstem:

• Ɔtostatik haypɔtɛnshɔn : Dis na we yu blɔd prɛshɔn go dɔŋ wantɛm wantɛm, we kin mek yu ed de tɔn , we yu chenj yu pozishɔn, fɔ ɛgzampul, we yu tinap wantɛm wantɛm frɔm we yu sidɔm.
• I nɔ ebul fɔ kɔntrol di urine (`urinary incontinence`) ɛn i nɔ ebul fɔ kɔntrol di stɔl (`fecal incontinence`).
• Sεkswal disfכnkshכn, spεshal wan pan man dεm, na difεlεnt fכ gεt erection (erectile dysfunction).
• Rapid eye movement (REM) sleep behavior disorder : Semweso lɛk di sik we dɛn kɔl Parkinson, we yu de drim, yu kin rili akt di tin dɛn we yu bin du na yu drim. Yu kin ala ɔ flay yu an.
• Di swet we de go dɔŋ (anhidrosis).
• Prɔblɛm dɛn we pɔsin kin gɛt we i de si.
• Dray mɔt.
• Slip apnɛa fɔ slip.
• Slow digestion ɛn kɔnstipɛshɔn.

Tink bɔt se bɔku pan dɛn ɔtonomik simptom ya kin apin mɔnt, ivin ia bifo di motoka simptom dɛn apia. Dis kin apin bitwin 20% ɛn 75% pan di MSA pasɛnt dɛn.

Di kayn we aw pɔsin de tink ɛn di we aw i de fil

Na lɛk wan pat pan tri pipul dɛm wae gɛt MSA kin gɛt prɔblɛm wit dɛn ebul fɔ tink ɛn kɔnsɛntret. I nɔ kin izi bak fɔ dɛn fɔ kɔntrol di we aw dɛn de fil. Dis kin mek yu gɛt prɔblɛm wit yu maynd lɛk:

• Wɔri.
• Pwɛl at.
• Imotional instability: Dat na fɔ kray ɛn laf we nɔ fayn.
• Panik atak dɛn.
• Tin fɔ tink bɔt fɔ du bad ɔ kil yusɛf.

Di tin dɛn we gɛt fɔ du wit muvmɛnt

di kכntribyushכn dεm fכ MSA-C (sεribεl tכyp):

dis kayn we de mεntal involv `ataxia` (lכs כf bεlε). di `sεribεl` na pat pan di bren we de ple big rol fכ kכntro di mכsul dεm we de muv. So, we da kɔdineshɔn de lɔs, tin dɛn lɛk dis kin apin:

• Di muvmɛnt dɛn we di an ɛn fut dɛn kin muv we dɛn nɔ kin kɔntrol ɛn we kin mek dɛn nɔ gɛt wanwɔd.
• Akshɔn trem : Dis min se we yu tray fɔ du sɔntin, di trem we de na yu an ɛn fut dɛn kin bɔku.
• We yu de waka wit fut we wayd we nɔ kɔmɔn .
• Ay twit we yu nɔ kin kɔntrol (nystagmus).

Karakta dεm fכ MSA-P (Parkinsonism tayp):

Dis kayn sik kin bigin na wan say na di bɔdi ɛn afta dat i kin go na ɔl tu di say dɛm. Dɛn sayn ya kin tan lɛk dis:

• Slow muvmɛnt (bradykinesia), fil lɛk se di bɔdi nɔ gɛt layf .
• Fɔ fil se yu bɔdi stif ɛn stif, we kin mek yu tinap we tan lɛk se yu de ledɔm bifo.
• Fɔ stɔp bɔku tɛm we yu de waka.
• Fɔ tɔk smɔl smɔl we yu de tɔk, fɔ tɔk klia wan .

Wetin mek dis MSA kin apin? Wetin na di rizin?

dεn nכ no yet di εksakεt kכz fכ MSA , bכt masta sabi pipul dεn sכspεkt se i riliyt to wan spεshal protin we dεn kכl `alpha-synuclein`, we kin kכmכt na difrεn pat dεm na wi bren. Dɛn kin tink bak se dis sem prɔtin na di men tin we kin mek pɔsin gɛt di sik we dɛn kɔl Pakinsin.

Protein na impɔtant kemikal dɛn fɔ mek wi bɔdi wok. dεn de εp wit bכku tin dεm, lεk fכ kכmכnik bitwin difrεn sistεm dεm na di bכdi εn fכ transpot kεmikכl kכmpawnd dεm rawnd. Bɔt if dɛn prɔtin ya gɛda na di rɔng ples, dɛn kin pwɛl. Masta sabi bukman dɛn biliv se dis damej na in de mek di bren tisu de day smɔl smɔl pan MSA.

sayɛnsman dεm stil de rεsכch wetin mek dis `alpha-synuclein` protin de kכmכt na sכm pat dεm na di bren. dεn de sכspεkt bak se sכm jεnεtik mכtεshכn dεm kin chenj di we aw sכm sεl dεm de yuz dis `alpha-synuclein`. Pruf de bak fɔ se di kayn MSA-C de rɔn na famili. כltu, dεn nכ fכnshכn dis kayn jεnεtik link yet fכ di MSA-P tכyp.

Di tin we impɔtant pas ɔl na dat MSA nɔto sik we pɔsin kin gɛt . Yu nɔ go ebul fɔ kech am frɔm ɔda pɔsin, ɛn yu nɔ go ebul fɔ spre am to ɔda pɔsin.

Aw yu go no fɔ tru if yu gɛt MSA? Us tɛst dɛn dɛn kin du?

Dat na MSA dedi onli we fכ bi 100% sכri na fכ egzamin di bren tisu afta pכsin day, biכs nכ we de fכ si kכrekt wan if `alpha-synuclein` dכn akumulet na di εria dεm na di bren we pכsin de alayv.

We pɔsin de alayv, dɔktɔ dɛn kin sɔprayz se MSA de bikɔs ɔf di sayn dɛn, di mɛdikal istri, in famili istri, ɛn if i de du sɔm tritmɛnt dɛn ɔ nɔ de du am. Bɔrku tɛm, di fɔs tin wae dɛn kin no na Pakinson sik ɔr ɔda kayn muvmɛnt prɔblɛm, ɛn dɛn kin chenj di sik to MSA leta we nyu sayn dɛn kin kam ɔ sɔm mɛrɛsin dɛn kin stɔp fɔ wok.

Bɔku impɔtant tin dɛn de we kin mek MSA difrɛn frɔm di sik we dɛn kɔl Pakinsin:

• MSA de go bifo kwik kwik wan : I kin tek sɔm ia fɔ mek pɔsin we gɛt Pakinsin sik gɛt prɔblɛm wit di ɔtonomik nɛvɔ sistɛm. Bɔt na MSA, dɛn prɔblɛm ya kin bigin insay wan ia.
• Sɔm sayn dɛm kin apia difrɛn we : Ɔtonomik nɛvɔ sistɛm simptom dɛm, mɔ, kin rili bad na MSA. Bɔt tin lɛk fɔ shek shek kin nɔr kin tranga, ɔr kin nɔr de atɔl. Di we aw di sik kin pas ɔlsay na di bɔdi kin difrɛn bak.
• Tritmɛnt nɔ de wok : Levodopa na di men mɛrɛsin fɔ di sik we dɛn kɔl Parkinson. Bɔt, lɛvodopa nɔ kin wok bɛtɛ na MSA. Bɔrku tɛm dis na di men rizin wae mek dɔktɔ dɛn kin tink se na MSA ɛn nɔr kin bi Pakinsin.

Us tɛst dɛn de du fɔ dis?

Na smɔl tɛst dɛn de we de ɛp fɔ no MSA dairekt wan. Bɔku pan di tɛst dɛn kin du fɔ mek dɛn nɔ gɛt ɔda sik dɛn ɛn fɔ gɛda mɔ pruf fɔ sɔpɔt di saspek se i kin bi MSA. Sɔm pan dɛn tin ya na:

• Magnetic resonance imaging (MRI) scan : Sɔntɛnde dis kin sho sɔm say dɛn na di bren we dɔn pwɛl. Dis kin ɛp fɔ mek dɛn no di sik kɔrɛkt wan. i yusful bak fכ no MSA-C, biכs i kin sho wan kכros-strip patεn na wan pat pan di bren (di "hכt kכros bכn" sayn). Bɔt yu kin si dis sayn bak pan ɔda sik dɛn, so i nɔ go du fɔ no bɔt MSA fɔ insɛf.
• Jεnεtik tεst : Dis kin chεk fכ jεnεtik mכtεshכn we de afekt di we aw pכsin in bכdi de proכses alfa-synuclein. dis tεst dεm kin mכr fכ no di jεnεtik mכtεshכn dεm we de asai wit MSA-C bitwin Japan pipul dεm.
• Skin biopsy : Sכm kayn skin bayopsi kin no sayn dεm fכ alfa-synuclein akyumyuleshכn na di nεv tisu. Bɔt dɛn nid fɔ du mɔ risach fɔ no if dis yusful fɔ bi standad pat pan di diagnostik prɔses.

Yu dɔktɔ go tɛl yu bɔt ɔda tɛst dɛn we fayn ɛn aw dɛn go ɛp yu. Dɛn go tink bɔt yu wɛlbɔdi istri, yu famili istri, ɛn ɔda tin dɛn fɔ mek dɛn disayd fɔ du di bɛst tin fɔ yu.

Tritmɛnt de fɔ MSA? Yu tink se dɛn kin mɛn am?

So fa, dɛn nɔ dɔn fɛn ɛni difinitiv mɛrɛsin fɔ MSA.So, di tritmɛnt na fɔ kɔntrol di sik fɔ lɔng tɛm. Di tritmɛnt fɔ di MSA simptom dɛm de dipen pan bɔku tin dɛm, lɛk di sikman in simptom dɛm ɛn aw dɛn siriɔs.

Us mɛrɛsin ɔ tritmɛnt dɛn dɛn kin yuz?

Bɔrku kayn mɛrɛsin de wae kin ɛp fɔ kɔntrol di sayn dɛm fɔ MSA. De kayn mɛrɛsin wae yu go gɛt go dipen pan yu sik ɛn ɔda tin dɛm. Yu dɔktɔ na di bɛst pɔsin fɔ tɛl yu di bɛst mɛrɛsin fɔ yu, bikɔs na dɛn go no mɔ bɔt yu sik. Dɛn go ɛksplen to yu bak di prɔblɛm dɛn we di tritmɛnt dɛn kin gɛt.

Impɔtant: MSA na wan sik we na dɔktɔ we tren ɛn kwalifay nɔmɔ go ebul fɔ no. So, nɔr tray fɔ no ɔ trit di sayn dɛm yusɛf if yu nɔ tɔk to dɔktɔ.

I gɛt we fɔ mek MSA nɔ divɛlɔp?

Di masta sabi pipul dɛn nɔ no yet wetin kin mek pɔsin gɛt MSA ɔ wetin kin mek i gɛt am. So, naw, no we nɔ de fɔ mek i nɔ apin ɔ fɔ ridyus di prɔblɛm .

Us kayn fiuja pɔsin we gɛt MSA kin ɛkspɛkt?

Pipul wae gɛt MSA kin fɔs gɛt sɔm kayn sik wae gɛt fɔ du wit muvmɛnt. Dis sik kin wɔs smɔl smɔl as tɛm de go. Na lɛk af pan di sik pipul dɛn nid ɛp fɔ waka insay dis tɛm. Dis min se yu fɔ yuz ken ɔ tin fɔ waka. Na lɛk fayv ia afta we MSA bigin, lɛk 60% pan di sik pipul dɛn nid fɔ yuz wilchia. Insay siks to et ia, at le af pan di sik pipul dɛn kin de na bed.

As di sik de go bifo, dɛn kin nid fɔ du ɔda tin dɛn ɔ fɔ du tin dɛn fɔ mek di bɔdi kɔntinyu fɔ wok ɛn fɔ mek dɛn nɔ gɛt prɔblɛm dɛn we denja. Sɔm pan dɛn tin ya na:

• Tracheostomy fɔ mek yu kɔntinyu fɔ blo.
• fכ it tru wan tiub (`Tiub fכ it` / `enteral nyutrishכn`).
• Indwelling catheters ɔ urostomy fɔ urinary incontinence.
• Kolostomi fɔ di prɔblɛm dɛn we kin mek pɔsin muv di bɔdi.

Aw lɔng MSA kin las?

MSA na wan sik we pɔsin kin gɛt fɔ ɔl in layf, we kin de sote go. Di avrej layf we pɔsin kin liv wit dis sik na siks to tɛn ia . If i nɔr tranga, i kin te fɔ 15 ia. Bɔt if i rili bad, di layf we pɔsin kin liv kin shɔt pasmak. Dɛn kayn bad bad sik ya kin gɛt dɛn sayn ya:

• di כtonom nεv sεstem simptom dεm kin bi siriכs bifo di simptom dεm we de fכ muvmεnt bigin.
• Ol ej we dɛn no di sik.
• Fɔ gɛt muvmɛnt simptom dɛm wae kin mek yu fɔdɔm ɔltɛm.

Wetin pipul dɛn de tink bɔt dis tin we de apin?

Di luk fɔ MSA nɔ rili fayn. Di sayn dɛm fɔ dis sik kin wɔs smɔl smɔl, bɔku tɛm i kin ambɔg di wok we di bɔdi de du ɛn i kin mek i gɛt prɔblɛm dɛn we kin mek i day. Di prɔblɛm dɛn we kin mek pɔsin day na:

• Nyumonia.
• Urinary tract infection (UTI) kin mek yu gɛt sepsis (blɔd pɔyzin).
• Day wantɛm wantɛm (bɔku tɛm na nɛt, bikɔs ɔf di distɔblɛshɔn na di we aw di bren de kɔntrol di we aw pɔsin de blo we i de slip).

Aw a go tek kia ɔf misɛf/di pɔsin we a lɛk? Wetin a fɔ wɔri bɔt?

Pipul wae gɛt MSA kin gɛt sɔm kayn sik wae de go bifo. Dis min se wans di sayn dɛm dɔn rich wan patikyula lɛvɛl, dɛn nɔ kin ebul fɔ liv fɔ dɛnsɛf igen. Dis sik kin afɛkt bak aw yu kin ebul fɔ tink, tɔk, ɛn disayd fɔ yusɛf. Bikɔs ɔf ɔl dɛn tin ya, i impɔtant fɔ tɔk to di wan dɛn we yu lɛk bɔt wetin yu want fɔ du tumara bambay ɛn fɔ mek plan fɔ kia fɔ yu if yu nɔ ebul fɔ disayd fɔ du sɔntin .

Ustɛm yu fɔ go to dɔktɔ?

Bɔrku pan de fɔs sayn dɛm fɔ MSA na tin dɛm wae yu fɔ tɔk bɔt wit dɔktɔ. Dɛn tin ya na:

• Mami ɛn dadi biznɛs di we aw Gɔd nɔ want.
• Ɔtostatik haypɔtɛnshɔn (we yu de diziz ɔltɛm ɔ yu de fɔdɔm fɔ no rizin).
• Prɔblɛm fɔ slip ɛn slip apnɛa (we yu de swɛla we yu de slip).

If dɔktɔ no se yu gɛt wan sik we de mek yu muv lɛk Pakinsin sik, i impɔtant fɔ tɔk to dɛn bɔt ɛni chenj we yu gɛt pan yu sik. Yu dɔktɔ go sɛdyul fɔ fala yu mɛrɛsin fɔ wach yu kɔndishɔn ɛn ajɔst yu mɛrɛsin. Yu kin tɔk bɔt ɛni chenj we yu notis we yu de du dɛn visit ya. Na kɔmɔn tin fɔ mek pipul dɛm wae dɛn dɔn no se gɛt Pakinson sik chenj dɛn sik leta, ɔr wae nyu sayn dɛm de kam ɔr wae lɛvodopa dɔn stɔp fɔ wok fayn fayn wan.

Bɔrku tɛm, pipul dɛm wae gɛt MSA kin gɛt ɔda sayn dɛm, mɔr lɛk dɛn maynd wɛl bɔdi prɔblɛm. I impɔtant fɔ go fɛn tritmɛnt fɔ mental wɛlbɔdi prɔblɛm dɛn we gɛt fɔ du wit MSA, ɛn bak fɔ di sik dɛn we pɔsin kin gɛt na in bɔdi. Yu dɔktɔ kin tɛl yu fɔ trit yu ɔr kin sɛn yu to dɔktɔ we de mɛn yu maynd.

Fɔ sɔmtin (Tek-Home Message) .

Multiple System Atrophy (MSA) na wan siriɔs sik we kin kil pɔsin. Bɔt i sɔri fɔ no se, nɔr dairekt mɛrɛsin ɔ tritmɛnt nɔr de yet fɔ dis sik.

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Bɔt, dɛn kin trit bɔku pan di sik dɛn we i kin gɛt , ɛn we dɛn de fɔ mek i nɔ gɛt bɔku prɔblɛm dɛn ɛn di sayn dɛn we i kin gɛt. If dɛn gɛt tritmɛnt, bɔku pipul dɛn kin ebul fɔ kip dɛn kwaliti layf fɔ lɔng lɔng tɛm, spɛn valyu tɛm wit di wan dɛn we dɛn lɛk, ɛn yuz dɛn tɛm fayn fayn wan. So, i impɔtant fɔ kɔntrol di sik dɛn wit di rayt dɔktɔ advays, we nɔ go mek yu at pwɛl.

`Mכltipכl Sistem Atrofi, MSA, Nyurolכjik Disiz, Bren Sik, Pakinsin Simptom, Muvmεnt Dizכrd, Awtכnomik Nεv Sistem Prכblεm