Yusɛf de fil wik? Sɔntɛm dis na wan sik we dɛn kɔl mayopati!

Sɔntɛnde, yu kin fil lɛk se yu an ɛn fut dɛn wik ɛn taya? Yu tink se i nɔ kin izi fɔ yu fɔ du ivin simpul tin dɛn lɛk fɔ grap na chia, es ebi ebi tin, ɔ kɔm yu ia? If yu fil se yu mɔsul dɛn de wik fɔ no rizin, nɔ jɔs dismis am as nɔmal tin. Sɔntɛm di tin we kin mek dɛn gɛt dɛn sik ya na wan sik we dɛn kɔl ‘myopathy’, we wi go tɔk bɔt tide. Nɔ wɔri, wi go tɔk bɔt dis simpul we we yu go ɔndastand.

Wetin na mayopati? Fɔ tɔk am simpul wan...

Mayopathy, fɔ tɔk am simpul wan, na wan grup fɔ sik dɛn we de afɛkt di mɔsul dɛn we de atak wi bon dɛn. Dɛn sik ya kin pwɛl wi mɔsul fayv dɛn ɛn mek dɛn wik. Jɔs lɛk aw motoka in injin kin wik, i kin at fɔ drayv, we di mɔsul dɛn kin wik, i kin at fɔ mek wi bɔdi ebul fɔ du di wok dɛn we wi kin du ɛvride.

Difrɛn kayn mayopathy de?

Yɛs, dɛn kin sheb di mayopathies difrɛn we dɛn. Dɛn kin sheb dɛn mɔ to tu kayn: mayopathies we dɛn kin gɛt frɔm dɛn mama ɛn papa ɛn we dɛn kin gɛt . Lɛ wi tek wan luk pan ɛni wan pan dɛn kayn dɛn ya.

Wetin na di Inherited Myopathies?

Dis na di kayn mayopati we kin kam bikɔs wi kin gɛt wan abnɔmal jin muteshɔn we kin de na wi bɔdi we wi bɔn wi, bɔku tɛm na frɔm wi mama ɔ papa.

• Mayopathies we dɛn bɔn wit:

Bɔrku tɛm, di sayn dɛm kin bigin we dɛn bɔn am ɔr we dɛn smɔl. Bɔt sɔntɛnde, dɛn kin apia we dɛn yɔŋ ɔ ivin leta. Wan difrɛn tin bɔt dis kayn tin na dat di wikɛdnɛs nɔ kin jɔs de pan di mɔsul dɛm we de nia di sɛntrɔm na di bɔdi, bɔt i kin afɛkt di mɔsul dɛm na di wan ol bɔdi, ɛn bɔku tɛm di sik nɔ kin go bifo.

• Mitochondrial mayopati dɛn: .

Wi sɛl dɛn gɛt smɔl smɔl faktri dɛn we dɛn kɔl mitochondria we de mek ɛnaji. dis kayn mayopati de kכz fכ wan difεkt na dεn maytochכndria dεm ya. Apat frɔm we di mɔsul dɛn wik, dɛn tin ya kin afɛkt ɔda ɔgan sistɛm dɛn bak, lɛk di at, bren, ɛn di bɛlɛ. Dɛn kin divɛlɔp bikɔs ɔf di jɛnɛtik muteshon, ilɛksɛf famili histri de ɔ nɔ de.

• Mεtabolik mayopati dεm:

dis mayopati de kכz fכ difεkt dεm na di jin dεm we de mek εnzym dεm we de εp di mכsul dεm fכ wok εn muv fayn fayn wan. I kin mek yu taya we yu de du ɛksɛsayz, yu kin fil pen na yu sholda ɛn yu shɔl we yu de du ɛksɛsayz, ɔ i kin mek yu gɛt wan sik we dɛn kɔl rabdomyolysis, we di mɔsul fayv dɛn kin brok ɛn nɔ wund. Sɔmtɛm de sik kin kam ɛn go, wit di mɔsul dɛm we wik ɛn afta dat i kin kam bak to nɔmal.

• Distrofi dɛn we kin apin na di mɔsul dɛn:

insay dεn kes dεm ya, di mכsul dεm de wik sכmtεm εn atrofi bikoz fכ wan abnכmaliti כ dεfisit fכ strכkchכral sכpכt protin dεm we di mכsul tisu nid. insay ɛni wan pan dɛn, di an ɛn/ɔ di leg dɛn kin afɛkt difrɛn difrɛn digri dɛn. Sɔntɛnde, di mɔsul dɛn na di yay ɔ di fes kin afɛkt bak.

Wetin na di akwyayz mayopathies?

Dis na kayn mayopathie wae de kam leta na layf. Dɛn kin kam bikɔs ɔf difrɛn tin dɛn lɛk ɔda sik dɛn, infɛkshɔn, we pɔsin de tek sɔm mɛrɛsin dɛn, ɛn we di ilɛktrɔlayt nɔ balans na di bɔdi.

• Awtoimyun/inflammatory mayopati: .

Wetin kin apin pan dis na we wi bɔdi in yon imyun sistɛm kin atak wi yon mɔsul dɛm. Dis kin mek di mɔsul dɛn nɔ kin wok fayn. I tan lɛk se wi yon difens dɛn de atak dɛnsɛf.

• Tɔksik mayopati: .

Dis kכndyushכn kin apin we wan tכxin כ dכg de ambɔg di strכkchכ כ fכnshכn fכ di mכsul dεm.

• Pɔyzin: Alkol, toluene (na wan tin we kin rɔtin we kin de na tin dɛn lɛk pent we sɔm pipul dɛn kin blo fɔ mek i gɛt ay).
• Mεdikeshכn dεm: Chεkpכynt inhibito imyuno tεrapi dεm (e.g., pembrolizumab, nivolumab), kכtikostεroyd (e.g., prednisone), kכlestכl-lכwεr dεm (statins), amiodarone, kolchicine, klorokin, antivayral εn protease inhibito fכ HIV infεkshכn, omeprazole.

• Ɛndokrin mayopathies:

Dis kכndyushכn kin apin we di akshכn fכ di כmon dεm na wi bכdi de afekt di mכsul dεm.

• Tayroyd gland: Pan ɔl we di tayroyd ɔmon lɛvɛl we smɔl (haypothyroidism) kin bɔku, prɔblɛm kin apin bak bikɔs di tayroyd ɔmon lɛvɛl bɔku (haypa tayroydism).
• Paratayroyd gland: Di haypaparatayroyd de mek di kalsiɔm we de na di blɔd go ɔp.
• Adrenal gland: `Addison in sik` ɛn `Cushing in sindrom`.

• Mayopathies we kin mek pɔsin gɛt sik:

Difrɛn infɛkshɔn kin afɛkt di we aw di mɔsul dɛn de wok.

• Vayral infεkshכn dεm: `HIV`, `influεnza`, `Epstein-Barr`.
• Baktri infεkshכn: `bakterial pyomyositis`.
• `Laym sik`.
• Parasayt infεkshכn dεm: `trichinosis`, `toxoplasmosis`, `cysticercosis`.
• Fɔngal infɛkshɔn: Kandida, Kɔksidiomaykɔsis.

• Ilɛktrɔlayt imbalans:

we di lεvεl dεm fכ sכm imכtant εlektrolayt dεm na wi bכdi inkrεs כ dכn kin afekt di mכsul dεm fכ wok.

• Potashכm: dεn dכn dכn (`hypokalemia`), dεn dכn inkrεs (`hyperkalemia`).
• Magnesium: I de go ɔp (`Hypermagnesemia`).

• Kritikal sik mayopati na di intensiv kia yunit:

Dis na wan sik wae de afekt di limb dεm εn di mכsul dεm we de fכ blo na pipul dεm we sik bad bad wan εn we de gεt tritmεnt na intensiv kεriכn yunit (ICU) . I kin kam bikɔs yu nɔ de muv fɔ lɔng tɛm ɔ yu de yuz tin dɛn we de mek yu mɔsul rilaks, kɔtikosterɔyd, ɛn slip pils we yu de yuz we yu de trit yu.

Udat kin gɛt mɔ sik we dɛn kɔl myopathy? Aw dis sik kin kɔmɔn?

Mayopathy kin rili kam pan ɛnibɔdi, bɔt sɔm pipul dɛn kin gɛt smɔl prɔblɛm.

Tin dɛm wae kin mek di risk bɔku:

• If pɔsin na di famili gɛt mayopati, den chans de fɔ mek i gɛt dis sik frɔm in jɛnɛtiks.
• Fɔ bi man. Sɔm kayn mayopati kin pas tru di X kromozom, so dɛn kin afɛkt man dɛn pas uman dɛn. כltu, di kayn mayopathy dεm we dεn kin pas tru כda kromozom dεm kin afekt כlman ikwal wan.
• Fɔ gɛt ɔtoimyun, mɛtabolik, ɔ ɛndokrin sik.
• Fɔ gɛt sɔm drɔgs ɔ pɔyzin (luk di say we de tɔk bɔt pɔyzin mayopati we wi bin dɔn tɔk bɔt).

Di prɛvalɛns fɔ mayopathy kin difrɛn difrɛn wan bay di kayn. Fɔ ɛgzampul, mayopathy we kin kam leta na layf:

• Inflammatory ɛn endocrine myopathies kin bɔku pas ɔda kayn, ɛn dɛn kin bɔku pan uman dɛn pas man dɛn.
• Bitwin 9 ɛn 32 pan ɛvri 100,000 pipul dɛn kin sɔfa wit inflammatory myopathies.
• Bitwin 25% ɛn 79% pan di big pipul dɛm we gɛt haypothayroydizm kin gɛt sɔm kayn sik dɛm we gɛt fɔ du wit di mɔsul dɛm, bɔt di insidɛns fɔ ɔvat mayopathy kin smɔl lɛk 10%.

di mכst kכmכn kכnεkshכn mayopathies na di mכskul dεstrofi, we kin kכmכn mכr pan man dεm.

• Duchenne ɛn Becker’s muscular dystrophies na di kayn wae wae kin pasmak, wae kin afɛkt lɛk 7 pan ɛvri 100,000 pipul dɛm ɔlsay na di wɔl.
• Mitochondrial sik dɛn kin afɛkt wan pan ɛvri 5,000 pipul dɛn, ɛn bɔku pan dɛn sik ya kin afɛkt di skel mɔsul.
• Ɔda kayn mayopathies we dɛn kin bɔn wit nɔ kin bɔku.

So, wetin na di sayn dɛm fɔ mayopathy?

Bɔrku kayn mayopathy gɛt sɔm kɔmɔn sayn dɛm. Dɛn tin ya na:

• Di mɔsul dɛn we wik.εspεshali di mכsul dεm na di sכlda dεm, di כp an dεm, εn di tכŋ dεm (dεn wan dεm de afekt pas כl εn di wan dεm we de afekt pas כl).
• Mɔsul dɛn kin kramp, stiff, ɛn spasm.
• Fɔ fil taya kwik kwik wan we yu de du ɛksɛsayz ɔ du ivin smɔl wok.
• Fɔ fil se yu nɔ gɛt layf ɛn yu nɔ gɛt trɛnk.

Aw mayopati kin rili fil?

pan bכku mayopati dεm, di mכsul dεm na di tu say dεm na di bכdi (simetrik) de wik ikwal wan. di mכsul dεm we de nia di midul pat na di bכdi (proksimal mכsul dεm), lεk di sכlda dεm, di כp an dεm, di hip dεm, εn di tכŋ dεm, dεn kin afekt am mכtalman. Dis kin mek yu gɛt sɔm sayn dɛn lɛk:

• I nɔ kin izi fɔ du di wok dɛn we yu kin du ɛvride, lɛk fɔ was, drɛs, ɛn fɔ kɔm yu ia.
• I nɔ izi fɔ grap frɔm chia, fɔ klaym stej, ɔ fɔ du wok dɛn we nid fɔ rich ɔp yu ed (e.g., fɔ chenj layt bɔl na di siling).
• Fɔ fil lɛk se di mɔsul dɛn de shek shek ɛn de shek shek.
• Di mɔsul dɛn kin taya kwik kwik wan we dɛn de du sɔntin.
• I nɔ kin izi fɔ yu fɔ blo we yu de du ɛksɛsayz.

Bɔku tɛm, i nɔ kin afɛkt di mɔsul dɛn na di an ɛn di fut.

Ɔda sayn dɛm kin difrɛn difrɛn wan bay di kayn mayopathy.

• di wik we di mכsul dεm wik kin bi kכnstant (nכ de go bifo) כ sכmtεm de go bifo. Insay sɔm sik dɛn, di mɔsul dɛn kin wik ɛn go, ɛn ɔda tɛm dɛn kin gɛt nɔmal trɛnk.
• dilay divεlכpmεnt fכ mכtalman skil dεm (e.g. fכ waka, jomp, klaym stej, ol spun כ pensil) na yכŋ pikin dεm.
• Nɔ ebul fɔ kip kɔmpin wit ɔda pikin dɛn we dɛn de ple spɔt ɔ ple na do (e.g., ple katch).
• Prɔblɛm wit di mɔsul dɛm we de ɛp fɔ swɛla ɛn tɔk. Dis kin mek it stɔp ɛn tɔk nɔ kin tɔk bad.

Wetin a fɔ du if a tink se a gɛt mayopati?

If yu gɛt dɛn sik ya, yu fɔ tɔk to yu praymari dɔktɔ fɔs. Dipen pan yu sayn dɛm, i kin rifer yu to spɛshal dɔktɔ, lɛk nyurolɔjis ɔr rεumatɔlɔjis.

Aw dɛn kin no se pɔsin gɛt mayopathy?

Yu dɔktɔ go aks yu bɔt yu mɛdikal histri, if ɛnibɔdi na yu famili dɔn gɛt dis kayn sik, us mɛrɛsin yu de tek, ɛn yu sayn dɛm. Dɔn dɛn go du ɛgzam fɔ dɛn bɔdi. Dɛn go chɛk yu skin, yu riflɛks, yu mɔsul dɛn trɛnk, yu balans, ɛn aw yu de fil.

Di kayn tɛst dɛn we di dɔktɔ kin ɔda:

• Blɔd tɛst dɛn:
• insay sכm mayopati dεm, di mכsul εnzym lεvεl dεm lεk kriaytin kinaz (CK) כ aldolase kin inkrεs bikoz fכ di mכsul fayb dεm we de brok.
• di ilektrolayt lεvεl dεm lεk sכdiכm, magnεsiכm, potashכm, kalsiכm, εn fכsfכr.
• tεst fכ כtoimyun sik dεm: fכ egzampl, `Antinuclear Antibodies (ANA), `Rheumatoid Factor', `Sedimentation Rate' εn `C-reactive protein'.
• εndokrin gland tεst dεm: fכ egzampl, di tayroyd כmon lεvεl dεm.
• εlektromayografi (EMG) εn nεv kכndukshכn stכdi dεm: dεn tεst dεm ya de mכsu di kayn εn di mכsul dεm we dεn dכn pwεl bay we dεn de mכsu aw ilektrikal de travul tru di nεv dεm εn put sכm sכm nidul dεm insay di mכsul dεm.
• Wan magnɛtik rɛsɔnans imej (MRI) tɛst fɔ di mɔsul dɛn .
• Tɛst dɛn we dɛn kin du fɔ tɛst dɛn jɛnɛtiks.
• Muscle biopsy: Dis min se dɛn kin du ɔpreshɔn fɔ pul wan smɔl pat pan di mɔsul tisu fɔ mek dɛn chɛk am.

Aw dɛn kin trit mayopathy?

Wae dɛn dɔn no di rayt kayn mayopathy wae yu gɛt, yu dɔktɔ go mek wan tritmɛnt plan we dɛn mek fɔ yu simptom dɛm.

Bɔku pan di tritmɛnt dɛn na fɔ trit yu bɔdi, fɔ trit yu wok, ɛn fɔ du sɔm kayn ɛksesaiz . Ɔda tritmɛnt dɛn kin spɛshal fɔ di kayn mayopathy. in jεnarכl, mכst akwyayz mayopathi dεm kin mεnεj fayn fayn wan, we de minimiz wikεd εn simptom dεm. Sɔm mayopathies wae dɛn kin bɔn wit kin gɛt sɔm kayn tritmɛnt wae kin mek di sik slo. Naw, no patikyula tritmɛnt nɔ de fɔ bɔku pan di mayopathi dɛm we dɛn bɔn wit, bɔt fɔ trit pɔsin in bɔdi ɛn sɔm kayn ɛksɛsayz kin ɛp.

Inflammatory ɛn ɔtoimyun-rilayt mayopathies

Di gol fɔ tritmɛnt fɔ dɛn tin ya na fɔ ridyus inflamɛns ɛn di bɔdi in ɔtoimyun rispɔns. Di kɔmɔn tritmɛnt fɔ dɛn mayopathi ya na:

• Imyunmodulatɔri/imyunosuprɛsant drɔgs: Fɔ ɛgzampul, mɛtɔtreksɛt, sayklɔspɔrin, takrolimus, azathioprine, maykofɛnɔlɔt, rituximab, ɛn intravenɔs (IVIg) ɔ sabkyutan (SubQIg) imyunoglobulin.
• `Kɔtikosterɔyd`: Fɔ ɛgzampul `prednisɔn` ɔ `mɛtilprɛdnisolon`.

Mayopathies we dɛn kin gɛt frɔm dɛn mama ɛn papa we dɛn kin gɛt frɔm dɛn mama ɛn papa

Bɔku pan di mayopathi dɛm we dɛn bɔn wit ɛn di jenɛtiks nɔ gɛt ɛni patikyula tritmɛnt ɔ kɔmplit mɛrɛsin.di mεnejmεnt na fכs tru di simptom kכntrכl εn difrεn tεrapi mכdal dεm. Bɔku klinik trial dɛn de go bifo pan difrɛn risach eria dɛn bɔt tritmɛnt ɛn jin tɛrapi.

Dɛn kin trit di sik dɛn we dɛn kɔl Duchenne muscular dystrophy ɛn Pompe disease wit sɔm patikyula mɛrɛsin dɛn.

Ɔda mayopathies we dɛn kin gɛt

Dɔktɔ dɛn kin trit di mayopathies we kin kam wit ɛndokrin, pɔyzin, ɛn infɛkshɔn kɔz bay we dɛn kin trit di ɔndalayn sik we mek di mayopathy. Dɛn kin trit pɔyzin mayopati bay we dɛn de stɔp di tin we de mek pɔsin fil bad (e.g., alkol, toluene) ɔ drɔg (e.g., statin). Di simptom dɛm na di mɔsul dɛm we baktri, vayrɔs, ɔ ɔda tin dɛm we kin mek pɔsin gɛt sik kin bɛtɛ we dɛn trit di infekshɔn dairekt wit antibayɔtik.

Aw a go kia fɔ mi wɛlbɔdi biznɛs?

Ilɛksɛf na mayɔpati we pɔsin bɔn wit, we pɔsin kin gɛt, ɔ we kin tek lɔng tɛm (we kin te), tin dɛn de we yu kin du fɔ mek yu gɛt wɛlbɔdi ɛn fɔ mek yu ebul fɔ kɔntrol di sik. Dɛn tin ya na:

• It gud it we gɛt balans. Put bɔku difrɛn frut ɛn vɛjitebul dɛn insay yu it.
• Stay aktif wit mild kadiovaskular eksasaiz. Dipen pan yu kayn mayopathy, dɛn kin advays yu fɔ nɔ du sɔm kayn weit liftin. So tɔk to yu dɔktɔ bifo yu bigin ɛni ɛksesaiz program.
• Mek yu gɛt wɛlbɔdi wet.
• If yu gɛt skin rash we de kam wit dɛmatomyositis, protɛkt yu skin frɔm di san. Dis kin mek di rash wɔs. Wear klos fɔ protɛkt yusɛf ɛn hat ɛnitɛm we i pɔsibul. Nɔ fɔgɛt fɔ put sanskrin wit at le SPF 30 bifo yu go na do.
• If i nɔ izi fɔ yu fɔ swɛla, it tin dɛn we saf ɔ we nɔ strɔng. Yu kin puree yu it bak. If yu na pɔsin we de na bed, it we yu sidɔm ɔp na bed.
• Tek ɔl di mɛrɛsin dɛn we dɛn tɛl yu fɔ tek di rayt tɛm.
• If dɛn se yu fɔ tek tritmɛnt dɛn lɛk fyzikal tritmɛnt, wok tɛrapi, ɔ fɔ tɔk, tek pat pan dɛn.

Mɛmba se bikɔs bɔku kayn mayopathy de, yu dɔktɔ go gɛt fɔ mek wan tritmɛnt plan we go spɛshal fɔ yu kayn mayopathy ɛn yu sayn dɛm. So i impɔtant fɔ fala wetin i tɛl wi fɔ du di rayt tin. Dɔn bak, pe atɛnshɔn to yu bɔdi. Notis ɛni chenj na yu kɔndishɔn ɔ aw yu sik dɛn kin tranga. Si yu dɔktɔ ɔltɛm (ɔ kwik if yu notis ɛni chenj). Dis we ya, yu kin chenj yu tritmɛnt plan jɔs lɛk aw di sik dɔn sho.

Fɔ dɔn, di tin dɛn we impɔtant pas ɔl we wi fɔ mɛmba

Mayopathy nɔto sɔntin fɔ fred, bɔt nɔto kɔndishɔn fɔ ignore sɛf.

• If yu de fil se yu mɔsul dɛn de wik ɔltɛm, yu de fil pen, ɔ yu taya, mek shɔ se yu go to dɔktɔ.
• Bɔrku kayn mayopathy de, so fɔ no di sik kɔrɛkt wan rili impɔtant.
• Tritmɛnt ɛn we fɔ manej bɔku kayn mayopati de.
• If yu fala yu dɔktɔ in instrɔkshɔn, tek di mɛrɛsin we dɛn gi yu, ɛn liv fayn layf, yu kin liv gud layf wit dis sik.

A op se yu go si se dis infɔmeshɔn go ɛp yu. If yu gɛt ɛni ɔda kwɛstyɔn, nɔ fred fɔ tɔk to di dɔktɔ ɛnitɛm.

` Mayopati, mכsul wik, mכsul pen, jεnεtik sik, כtoimyun sik, mכsul simptom, mayopati tritmεnt