we wi de chεk wi kכlestכl, wi kin כnli luk pan di "gud kכlestכl" (HDL) εn "bad kכlestכl" (LDL), nכto? Bɔt yu no se wan kayn kɔlɔstrel de we rili impɔtant we bɔku pipul dɛn nɔ kin tɔk bɔt, bɔt i kin ayd bitwin dɛn? Dis na Lipoprotein(a), ɔ Lp(a) fɔ shɔt. Di spɛshal tin bɔt dis na dat na wi jin dɛn de disayd am, we min se i de pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn, pas wetin wi de it ɛn drink ɔ ɛksesaiz. Yu kin bi pɔrsin wae gɛt wɛl bɔdi, bɔt yu Lp(a) lɛvɛl kin rili ay.
Wetin rili na Lipoprotein(a)?
Fɔ tɔk am simpul wan, dis na tin bak we gɛt kɔlɔstrel na wi blɔd. Bɔt di prɔblɛm wit dis na dat di lɛvul we i gɛt na wi jin dɛn de sho am mɔ. Dis min se if yu mama, papa, ɔr sɔmbɔdi na yu famili gɛt dis sik, yusɛf go gɛt dis sik. Dɛn se lɛk wan pan ɛvri fayv pipul dɛn na di wɔl gɛt ay Lp(a) lɛvɛl.
di denja fכ dis na dat fכ gεt hכy Lp(a) lεvεl de bכku bכku wan inkrεs di risk fכ hat atak εn strכk we yu yכng. Bɔrku tɛm, pipul dɛn kin no bɔt dis afta dɛn dɔn gɛt hat atak ɔr strok. dis na biכs wan standad lipid panεl nכ de sho dis Lp(a) valyu. I nid fɔ mek dɛn du wan sɛpret tɛst.
Fɔ ɛgzampul, tek di stori bɔt Bɛnadɛt, wan uman we ol 66 ia, we kin waka lɛk 10 mayl so ɛvride ɛn it tin dɛn we dɛn mek wit plant, lɛk vɛjitebul ɛn tofu. In kɔlɔstrel lɛvɛl bin jɔs de na di gud rɛnj, bɔt in Lp(a) lɛvɛl bin fayv tɛm pas di risk lɛvɛl. Dis na bikɔs ɔf in jenɛtiks. In mama ɛn in grani ɔl tu bin dɔn day bikɔs ɔf at sik.
"Di big chalenj fɔ mi na di strɛs we a de gɛt we a de liv wit dis. Pan ɔl we a de fil sik smɔl, a de tink se, 'Na dis na di at atak we a go gɛt?'" Bɛnadɛt se.
Di prɔblɛm ɛn di nyu op
Te naw, nכ spεshal drog dεn bin apruv fכ lכs Lp(a) lεvεl. Dis min se pan ɔl we dɛn no se i de, bɔku pipul dɛn dɔn gɛt fɔ liv wit fred, ɛn dɛn nɔ gɛt natin fɔ du bɔt am. I tan lɛk se dɛn gɛt tɛm bɔm na dɛn bɔdi we kin bɔn ɛnitɛm.
Bɔt, naw da tin de go chenj!
Naw, di mεdikal risach dεm de invεstigat fayv nyu dεm we dεn sho insay di fכs stכdi dεm fכ sכmtεm lכw Lp(a) lεvεl. Dis na big op fɔ di milyan pipul dɛm wae gɛt ay Lp(a) lɛvɛl. As di lida risachman Dr. Steven Nissen se, " Nɔ wɔri, sɔlvishɔn de kam. "
Di laytst drɔgs dɛm we de na di risach stej
Dɛn nyu mɛrɛsin ya stil de na di las stej fɔ risach (klinik trial). If dɛn gɛt sakrifays, dɛn kin de na di makit insay di nɛks tɛm. Lɛ wi si wetin dɛn drɔgs dɛn de ɛn aw dɛn kin wok fayn.
| Di Nem fɔ Drug | Ficha / Aw fɔ gi | Rizult we dɛn de ɛkspɛkt |
|---|---|---|
| Pelakarsen bin de tɔk bɔt am | Wan injɛkshɔn we dɛn kin gi wan tɛm insay di mɔnt | di Lp(a) lεvεl dεm kin rεdכks bay lεk 80%. |
| Olpasiran we dɛn kɔl | Wan vaysin we dɛn kin gi ɛvri 3 mɔnt | di Lp(a) lεvεl dεm kin ridyus pas 95%. |
| Lepodisiran we dɛn kɔl Lepodisiran | Wan vaysin we de kɔntinyu fɔ wok fɔ lɛk wan ia so | di Lp(a) lεvεl dεm kin ridyus bay lεk 94% εn i kin mεnten fכ lכng tεm. |
| Zerlasiran we de na di wɔl | Wan vaysin we dɛn nɔ kin gi bɔku tɛm | di Lp(a) lεvεl dεm kin rεdכks bay lεk 86%. |
| Muvalaplin we dɛn kɔl Muvalaplin | Wan pil we dɛn kin gi ɛvride | di Lp(a) lεvεl dεm kin rεdכks bay lεk 86%. |
Wetin spɛshal bɔt wan Muvalaplin tablɛt?
Fɔ dɛn wan ya, di wan dɛn we de du risach gɛt bɔku op fɔ wan mɛrɛsin we dɛn kɔl ``(Muvalaplin)'' bikɔs pan ɔl we dɛn fɔ gi di ɔda 4 mɛrɛsin dɛn as injɛkshɔn, dɛn kin tek dis wan as pil we dɛn kin tek ɛvride . So, i kin izi fɔ di wan dɛn we sik, ɛn i kin nɔ dia bak.
כda dכg dεm de wok bay we dεn de silεns di jin we de rispansabl fכ Lp(a) prodakshכn. Bɔt dis pil de wok difrɛn we. i de stכp di prodyushכn fכ Lp(a) patikyula dεm na di midul. Dis kin mek i wok ɛn nɔ afɛkt di liva ɛn i kin kɔmɔt na di bɔdi kwik kwik wan if ɛni sayd ɛfɛkt apin.
Wetin mek wi nid fɔ tɛst Lp(a)?
As yu de rid dis atikul, yu go de wɔnda, ‘A fɔ mek dɛn chɛk dis bak?’ Di ansa na, yɛs! Yu fɔ rili tink bɔt dis, mɔ if pɔsin na yu famili dɔn gɛt at sik ɔ strok we i yɔŋ .
Di Nashɔnal Lipid Asɛmbli naw se ɔlman fɔ chɛk dɛn Lp(a) lɛvɛl wan tɛm insay dɛn layf . Bikɔs na jɛnɛtik tin, di lɛvɛl nɔ de chenj bɔku ɔlsay na layf. Jɔs fɔ mek dɛn chɛk am wan tɛm, na in nɔmɔ go du fɔ am.
Dis na wan rili simpul blɔd tɛst. Bɔt bikɔs i nɔ de insay wan standad kɔlɔstrel ripɔt, yu fɔ aks yu dɔktɔ spɛshal wan bɔt dis bifo yu du dis tɛst.
Fɔ no yu Lp(a) lɛvɛl na di fɔs tin we yu fɔ du. If i ay, nɔ panik. Wit dis nyu mɛrɛsin wae de kam jisnɔ, yu go ebul fɔ kɔntrol yu risk fɔ gɛt hat atak ɛn strok. Te da tɛm de, i impɔtant fɔ kɔntrol ɔda tin dɛn we kin mek yu gɛt dis sik, lɛk ay blɔd prɛshɔn, dayabitis, smok, ɛn LDL kɔlɔstrel lɛvɛl, fayn fayn wan.
Mɛsej we dɛn kin kɛr go na os
- Lipoprotein(a), ɔ Lp(a), na wan kayn kɔlɔstrel we dɛn kin kɔntrol frɔm in jɛnɛtiks ɛn i kin mek pɔsin gɛt at sik.
- Dis nɔ de insay di kɔlestɔl tɛst we dɛn kin du ɔltɛm (lipid profayl), so yu fɔ aks yu dɔktɔ bɔt dis ɛn mek dɛn chɛk am spɛshal wan.
- If ɛnibɔdi na yu famili dɔn gɛt at sik we i yɔŋ, i rili impɔtant fɔ mek dɛn du dis tɛst.
- Pan ɔl we naw nɔ patikyula drɔg nɔ de fɔ Lp(a), sɔm drɔgs dɛn we de sho rili prɔmis rizɔlt de na di las stej dɛn fɔ di risach. Dis na tin we rili prɔmis.
- If yu kam fɔ no se yu Lp(a) lɛvɛl ay, nɔ panik, tɔk bɔt am wit yu dɔktɔ, ɛn kɔntrol ɔda tin dɛn we kin mek yu gɛt at sik.
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