Yu go mɔs dɔn yɛri di wɔd ‘Opioid’. Dɛn tin ya na pawaful mɛrɛsin dɛn we de mek pɔsin fil pen we dɔktɔ dɛn kin gi am fɔ kɔntrol di bad bad pen we i de fil. Dɛn kin yuz dɛn fɔ kɔndishɔn lɛk kansa pen, afta sɔm ɔpreshɔn, ɛn ɔda tin dɛn Bɔt bikɔs ɔf dɛn pawaful ifɛkt, if dɛn yuz dɛn di rɔŋ we, if ɔvados apin, ɔ if pɔsin gɛt adikshɔn to dɛn, i kin bi big trɛt fɔ layf. So tide wi go tɔk bɔt wan spɛshal klas ɔf drɔgs we dɛn kin yuz fɔ sev layf na dɛn kayn denja sityueshɔn ya, we de akt lɛk ‘antagonist’. Dat na di Opioid Antagonist dɛn.
Fɔ tɔk am simpul wan, wetin na dis Opioid Antagonist?
Fɔ ɔndastand dis, lɛ wi fɔs tek wan luk pan aw opioid pen kil de wok na wi bɔdi. Tink bɔt wi nεv sεstem, spεshal wan di bren εn di spεnal kכd, lεk se dεn gεt sכm sכm sכm ‘get dεm’. Insay mɛrɛsin, wi kin kɔl dɛn tin ya ‘rɛsɛptɔ’. We wan opioid pen kil go insay di bɔdi, i de tay pan dɛn get ya ɛn ‘opin’ dɛn, we de ridyus di pen ɛn mek pɔsin fil fayn (euphoria).
Opioid Antagonist dεm lεk difrεn ki we fit di sem lכk. Bɔt we yu put dis ki na di lɔk, i nɔ de opin di domɔt. Bifo dat, i kin stɔp insay di lɔk, i kin blok di we fɔ di opioid ki fɔ kam insay kpatakpata. Na dat mek dɛn kin rivɛns di denja ifɛkt dɛm we opioid ɔvados kin gɛt.
Di impɔtant tin na dat, if yu nɔ gɛt ɛni Opioid na yu bɔdi, dis Opioid Antagonist drɔg kin ɔltɛm nɔ gɛt ɛni ɛfɛkt. I de wok nɔmɔ we Opioid de na yu bɔdi.
Wetin na dɛn drɔgs ya ɛn wetin dɛn kin yuz fɔ?
Bɔku kayn drɔgs de we de insay di Opioid Antagonist klas. Dɛn kin yuz ɛni wan pan dɛn fɔ wan patikyula tin. Lɛ wi luk di men kayn dɛn.
| Nem fɔ di drɔg | Wetin dɛn kin yuz am mɔ fɔ? | Aw fɔ gi |
|---|---|---|
| Nalɔkson we dɛn kɔl | Na di imejensi tritmɛnt fɔ wan opioid ɔvados. Dɛn kin yuse am fɔ rivɛns di pwɛl hat we pɔsin kin gɛt we i de blo we opioid kin kam wit. Na mɛrɛsin we de sev pɔsin in layf. | As injεkshכn (intravenous כ intramuscularly) כ as nasal spray (e.g. Narcan®, Kloxxado®) |
| Naltrekson we gɛt di sik | Wan mentenɛns tritmɛnt fɔ opioid ɛn rɔm yus dizayd. I de blok di euphoria frɔm drɔgs ɛn ɛp fɔ ridyus di rilaps. | As injɛkshɔn ɔ as pil we dɛn kin tek wit mɔt. (fɔ ɛgzampul, Vivitrol®, ReVia®) |
| Methylnaltrexone we gɛt di sik | Dɛn kin yuse am fɔ trit opioid-induced constipation pan pipul dɛm wae de tek opioid penkiller fɔ lɔng tɛm. i de כnli blכk di rεsεpכta dεm na di intestinal, we nכ de afekt di bren. | As injɛkshɔn ɔ as pil we dɛn kin tek wit mɔt. (ɛgz. Rilistor®) |
| Nalmefene we dɛn kɔl | Wan drɔg we fiba Naloxone. Dɛn kin yuz am fɔ trit opioid ɔvados, i kin de na di bɔdi fɔ lɔng tɛm. Bɔt dɛn nɔ kin yuz am lɛk Naloxone. | As injɛkshɔn. (e.g. Rivɛks®) |
Di spɛshal impɔtant tin we Naloxone gɛt
Bikɔs ɔf di opioid epidemic, dɛn tren di imejensi savis pipul dɛm lɛk polis ɔfisa ɛn ambulans wokman dɛm na bɔku kɔntri dɛm ɔlsay na di wɔl fɔ kɛr ɛn gi Naloxone. If pɔsin stɔp fɔ blo bikɔs i tek di opioid ɔvados, if i gi am Naloxone insay 2 to 5 minit, i kin sev in layf bay we i de blo fayn bak.
Wetin na di bad tin dɛn we dɛn mɛrɛsin ya kin du?
Di men ɛn kwik ifɛkt we Naloxone, Naltrexone, ɛn Nalmefene gɛt na di simptom dɛm fɔ lɛf fɔ yuz opioid.Di tin we kin apin.
Imajin pɔsin we rili adikshɔn to opioid. Dɛn bɔdi dɔn yus to dɛn opioid dɛn de kɔmplit wan. We yu gi pɔsin lɛk dat wan drɔg lɛk Naloxone wantɛm wantɛm, ɔl di opioid dɛn we de na dɛn bɔdi kin deaktiv wantɛm wantɛm. Dɔn dis na di we aw di bɔdi de ansa to dat.
Di men sayn dɛm wae de sho se yu gɛt dis sik na:
- Mucus (mukus we de kɔmɔt na di bɔdi) .
- Di wata we de kɔmɔt na di yay pasmak
- Fɔ pis bɔku tɛm (urinary incontinence) .
- Inkris rεt fכ brith (Hyperventilation) .
- Hyperthermia we pɔsin kin gɛt
- Di at rit we de go ɔp (Tachycardia) .
- Sɔm mɔsul dɛn kin pen bad bad wan
- Nɔs ɛn vɔmit
- Blɔt (dayarɛa) .
- I nɔ kin rɛst ɛn wɔri bad bad wan
Di kayn we aw dɛn sik ya kin tranga kin difrɛn frɔm wan pɔsin to ɔda pɔsin, i kin dipen pan aw lɔng dɛn dɔn de yuz opioid ɛn us kayn dɛn de yuz.
Bɔt i impɔtant fɔ mɛmba dis. Fɔ ɛgzampul, na ɔspitul na di Imejɛnsi Dipatmɛnt (ETU) , dɔktɔ dɛn kin ebul fɔ kɔntrol dɛn sik ya we pɔsin kin gɛt we i de lɛf fɔ drink. Dis kin bi bay we yu gi yu salin, ɛn ɔda mɛrɛsin dɛn lɛk Mɛtadɔn ɛn Buprenɔfin.
Sayd ifekt dɛm fɔ methylnaltrexone
Bikɔs dis kin mɔs afɛkt di intestinal, di sayd ɛfɛkt dɛn gɛt fɔ du wit dat.
- Bɛlɛ de pen
- Fɔ ful-ɔp di bɛlɛ
- Sɔm kayn nɔys ɔ dayarɛa
- Ed de at
- Mɔsul dɛn we de rɔl
- Diziz we pɔsin kin gɛt
So wetin na di bɛnifit dɛn we dɛn mɛrɛsin ya de gi?
Pan ɔl di bad tin dɛn we kin apin to dɛn, di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi kin pas dɛn fa fawe.
Naloxone ɛn Nalmefene na drɔgs we de sev pɔsin in layf. If dɛn trit wan opioid ɔvados kwik ɛn kɔrɛkt wan, i kin sev pɔsin in layf. Dat na di tin we impɔtant pas ɔl. If yu si pɔsin we nɔ no natin ɛn we nɔ de blo fayn bikɔs ɔf di opioid ɔvados, yu fɔ kɛr am go na ɔspitul in Imejɛnsi Tritmɛnt Yunit (ETU) wantɛm wantɛm . Dɔn bak, if yu nid infɔmeshɔn bɔt ɛni pɔyzin, yu kin kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital fɔ advays.
Naltrexone na wan rili impɔtant tul we dɛn kin yuz fɔ trit di kɔmpleks kɔndishɔn fɔ sɔbstans yus disɔda. Bɔt dis mɛrɛsin nɔmɔ nɔ go ebul fɔ mɛn dis sik. I nid fɔ gɛt saykotɛrapi, rihabiliteshɔn, ɛn ɔda sɔpɔt savis dɛm.
So, Opioid Antagonist na wan klas we rili yusful fɔ drɔgs. If yu gɛt ɛnitin fɔ wɔri ɔr de fred bɔt dɛn mɛrɛsin ya ɔr dɛn sayd ɛfɛkt, tɔk to yu dɔktɔ bɔt dɛn opin wan. I kin gi yu di rayt advays ɛn sɔpɔt we yu nid.
Mɛsej we dɛn kin kɛr go na os
- Wan opioid antagonist na wan kayn drɔg we de blok di akshɔn fɔ opioid pen kil dɛm.
- Naloxone na imejensi tritmɛnt we dɛn kin gi fɔ mek pɔsin ebul fɔ blo bak ɛn sev pɔsin layf if i tek di opioid ɔvados.
- Naltrexone na mentenɛns tritmɛnt fɔ opioid ɔ alcohol adikshɔn. I de blok di gladi at we pɔsin kin gɛt we i de tek drɔgs.
- We dɛn gi dɛn mɛrɛsin ya to pɔsin we gɛt adikshɔn to opioid, dɛn kin mek i gɛt siriɔs sayn fɔ lɛf fɔ tek di mɛrɛsin, bɔt dɛn kin ebul fɔ kɔntrol dɛn tin ya na ɔspitul.
- Pan ɔl we dɛn mɛrɛsin ya rili impɔtant, fɔ mɛn pipul dɛn we gɛt adikshɔn to drɔgs, dɛn nid fɔ gɛt bɔku program, ɛn dɛn nid fɔ gɛt advays bɔt dɛn maynd.
- Ɔltɛm tɔk bɔt dɛn mɛrɛsin ya wit yu dɔktɔ ɛn gɛt di rayt advays.
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