Yu de strɛs bak wit kɔlɔstrel ? Sɔntɛm yu de tek di mɛrɛsin we yu dɔktɔ tɛl yu fɔ du, yu de kɔntrol di tin dɛn we yu de it , ɛn yu de du ɛksɛsayz. Bɔt i stil at fɔ mek yu kɔlɔstrel go dɔŋ, nɔto so? Sɔntɛnde, ilɛk aw yu tray tranga wan, di bad bad kɔlɔstrel lɛvɛl na yu bɔdi kin kɔntinyu fɔ bɔku. Insay dis atikul, wi go tɔk bɔt wan nyu klas fɔ drɔgs we kin ɛp dɛn kayn pipul dɛn ya.
Fɔ tɔk am simpul wan, wetin na dɛn PCSK9 Inhibitors ya?
Dis kin tan lɛk se na kɔmplikɛt nem, bɔt i kin wok rili simpul. PCSK9 inhibito dεm na wan klas כf drog dεm we de lכs kכlestכl. Spɛshal wan, dɛn kin tɔch LDL (Low-Density Lipoprotein) kɔlɔstrel , we na di “bad kɔlɔstrel” we de ambɔg wi bɔdi. Sɔm pipul dɛn kin gɛt bɔku bɔku kɔlɔstrel ɔlsay na dɛn layf. Fɔ dɛn pipul dɛn de, dis kayn mɛrɛsin kin rili ɛp.
Okay, naw mek wi si wetin di nem `PCSK9` min. `PCSK9` na spεshal kayn protin we wi liva de mek. di nem fכ dis protin na `proprotein convertase subtilisin/kεksin tayp 9`. wetin i de du na fכ kכntro tin dεm we dεn kכl `LDL rεsεpכta dεm` na wi bכdi. mεdikal stכdi dεn sho se if pכsin in bכdi nכmal wan de prodyuz mכr `PCSK9` protin, dat pכsin go gεt hכy kכlestכl .
Udat nid dis mɛrɛsin?
Dis na kwɛstyɔn we rili impɔtant. Na bikɔs dɛn nɔ kin gi dis mɛrɛsin to ɔlman we gɛt ay kɔlɔstrel. Jɛnɛral wan tu men sityueshɔn dɛn de we yu dɔktɔ kin gi dis `PCSK9 inhibitor` drɔg:
1. We ɔda mɛrɛsin nɔ de kɔntrol kɔlɔstrel: If yu dɔn ɔlrɛdi de yuz ɔda mɛrɛsin dɛn we de mek yu nɔ gɛt kɔlɔstrel, lɛk `(statins),` bɔt yu kɔlɔstrel lɛvɛl stil bɔku, yu kin tek dis mɛrɛsin as di nɛks tin we yu fɔ du.
2. Insay sɔm jɛnɛtik kɔndishɔn: Sɔm pipul dɛn kin gɛt wan sik we dɛn kin gɛt frɔm dɛn mama ɛn papa we dɛn bɔn wit, we gɛt ay kɔlɔstrel. dis dεn kכl am ``familial hypercholesterolemia`` insay mεdikal sayns.Dis mɛrɛsin kin ɛp bak fɔ pipul dɛm wae gɛt dis sik.
Mɛmba se di men tin we dis mɛrɛsin gɛt na fɔ mek yu kɔlɔstrel go dɔŋ, ɛn dis go mek yu nɔ gɛt siriɔs prɔblɛm wit yu at ɛn blɔd vesel lɛk at atak ɛn strok .
Aw dis mɛrɛsin de wok insay di bɔdi?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul.
Imajin se yu bɔdi gɛt “an dɛn we de kech kɔlɔstrel.” Wi kin kɔl dɛn tin ya “LDL rεsεpכta dεm.” Dɛn “rɛsɛptɔ” ya kin de mɔ na di say we wi liva sɛl dɛn de. Dɛn “an” ya kin ol di bad kɔlɔstrel we de flɔt na di blɔd (LDL kɔlɔstrel) ɛn kɛr am go na di liva. Dɔn di liva kin brok da kɔlɔstrel de ɛn pul am na di bɔdi. Dis na nɔmal tin we kin apin.
Bɔt na smɔl vilɛn de ya. na di `(PCSK9)` protin we wi bin tכk bכt bifo. dis `PCSK9` protin de wok lεk wan `siza`. wetin i de du na fכ pwεl dεn an dεm we de kech kכlestכl, dat na, `LDL rεsεpכta dεm`, εn ridyus dεn aktiviti. we di `PCSK9` protin de inkrεs na di bכdi, di nכmba fכ di `han` dεm we de kech kכlestכl de dכn. Dɔn di bad kɔlɔstrel we de na di blɔd nɔ go ebul fɔ pul di liva ɛn i kin gɛda na di blɔd.
Naw yu go mɔs ɔndastand wetin di `PCSK9 inhibitor` drɔg de du. fכ bi prεsis, dis dכg de inhεbit di `PCSK9` protin we de wok lεk siza. dat min se we dεn tek dis dכg, di `PCSK9` protin nכ kin ebul fכ pwεl dεn an dεm we de grap kכlestכl (LDL rεsεpכta dεm).
Wetin kin apin da tɛm de?
- mכr aktif LDL rεsεpכta dεm de.
- dis aktif ‘han dεm’ de kech bכku pan di bad kכlestכl we de na di bכdi εn deliv am to di liva.
- Di liva de pul da kɔlɔstrel de na di bɔdi.
Di ɛnd risal na we di bad bad kɔlɔstrel we de na yu blɔd go ridyus bad bad wan.
Aw dis mɛrɛsin de wok? Ɛn wetin na di kayn dɛn?
PCSK9 inhibito dεm na wan klas כf drog dεm we dεn sho se dεn kin rili wok fכ sכm pipul dεm. Sɔm stɔdi dɔn sho se dɛn mɛrɛsin ya kin ridyus di bad kɔlɔstrel (LDL kɔlɔstrel) lɛvɛl te to 70% ɛn dɛn kin ridyus di risk fɔ gɛt at atak bak bay lɛk wan pat pan tri.
Tu kayn `PCSK9 inhibitors` de we dɛn kin yuz mɔ naw na Sri Lanka ɛn di wɔl:
- `Alirocumab` (nem fɔ di brand: Praluent®)
- `Evolocumab` (na di nem fɔ di brand: Repatha®)
Aw yu kin tek di mɛrɛsin?
Dis nɔto pil fɔ tek ɛvride. `PCSK9 inhibitors` dεn gi am as injεkshכn.Yu go nid fɔ gɛt dis vaysin ɛvri sɔm wik ɔ ɛvri sɔm mɔnt, lɛk aw yu dɔktɔ dɔn disayd.
We yu de tek dis tritmɛnt, yu dɔktɔ go du blɔd tɛst ɔltɛm fɔ chɛk aw di mɛrɛsin de wok fayn. Sɔmtɛm dɛn kin gi dis mɛrɛsin in wan, ɛn ɔda tɛm dɛn kin gi am togɛda wit wan mɛrɛsin we yu dɔn ɔlrɛdi de tek, lɛk wan statin.
Wetin na di bɛnifit ɛn di sayd ɛfɛkt dɛn we pɔsin kin gɛt?
Lɛk ɛni mɛrɛsin, dis mɛrɛsin kin gɛt bɛnifit ɛn smɔl smɔl sayd ɛfɛkt dɛn. Bɔt bɔku pipul dɛn nɔ kin gɛt siriɔs sayd ɛfɛkt.
| Tɔk bɔt | Ɛgzampul dɛn |
|---|---|
| Men advantej dɛn |
|
| Kɔmɔn sayd ɛfɛkt dɛn | |
| Sɔm sayd ɛfɛkt dɛn we nɔ kin apin so ɔltɛm |
Yu tink se di mɛrɛsin nɔmɔ go du fɔ am? Nɔ, dis na pat pan wan big plan.
Dis rili impɔtant. If yu tek PCSK9 inhibitor ɔ ɔda mɛrɛsin we de mek yu nɔ gɛt bɔku kɔlɔstrel, na wan pat nɔmɔ pan yu ɔl tritmɛnt plan. Bɔku ɔda tin dɛn de we yu kin du fɔ protɛkt yu at wɛlbɔdi, ɛn yu nɔ fɔ abop pan mɛrɛsin nɔmɔ.
- Gud it: Nɔ it bɔku ɔyl, shuga, ɛn sɔl, ɛn it mɔ vɛjitebul, frut, grɛn, ɛn it dɛn we gɛt bɔku fayv.
- Ɛksesaiz: Du ɛksesaiz we go ɛp yu at, lɛk fɔ waka kwik kwik wan, fɔ rɔn, ɔ fɔ rayd baysikul, fɔ lɛk sɔm dez insay di wik.
- Stress management: Fɔ rilaks yu maynd tru tin dɛm lɛk meditashɔn ɛn yoga.
- Gud slip: Gɛt at le 7-8 awa slip ɛvri nɛt.
- Nɔ smok: If yu de smok, stɔp am kpatakpata.
Yu go gɛt di bɛst rizɔlt we yu miks dɛn chenj ya na yu layf wit mɛrɛsin.
Na yu dɔktɔ nɔmɔ go disayd aw lɔng yu fɔ tek dis mɛrɛsin, ɛn if yu fɔ stɔp ɔ kɔntinyu fɔ tek am. So, i impɔtant fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we.
Mɛsej we dɛn kin kɛr go na os
- `PCSK9 inhibitors` na wan kayn mεdikeshכn we rili ifektiv, we dεn gi as injεkshכn, fכ hεy kכlestכl kכndishכn dεm we at fכ kכntrכl wit kכvεshכnal mεdikeshכn dεm.
- dis dεm de εp di liva fכ pul "bad kכlestכl" (LDL) frכm di bכdi.
- Dɛn nɔ kin gi dis as fɔs tritmɛnt. Yu dɔktɔ go jɔs tink bɔt am we ɔda tritmɛnt dɛn nɔ wok.
- We yu de tek dis mɛrɛsin, i rili impɔtant fɔ mek yu gɛt gud layf we gɛt fɔ du wit wɛlbɔdi it ɛn ɛksesaiz.
- Tɔk opin wan wit yu dɔktɔ bɔt if dis mɛrɛsin fayn fɔ yu ɔ nɔ rayt fɔ yu ɛn ɔl di tin dɛn we gɛt fɔ du wit am.
PCSK9 inhibito dεm, kכlestכl, kכlestכl, LDL kכlestכl, at atak, strכk, famili haypa kכlestכlεmia, statin, Alirocumab, Evolocumab
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