Yu dɔktɔ dɔn tɛl yu se yu kɔlɔstrel lɛvɛl bɔku? If na so, yu go dɔn bigin fɔ tek wan statin. Dat na di fɔs layn fɔ tritmɛnt. Bɔt sɔntɛnde, da mɛrɛsin de nɔmɔ nɔ kin du. Ɔ sɔm pipul dɛn nɔ kin ebul fɔ bia wit di sayd ɛfɛkt dɛn we di mɛrɛsin kin gɛt. Na dat mek dɔktɔ dɛn de tɔk naw bɔt wan nyu klas fɔ drɔgs we na ‘game-changer’. Dɛn kɔl dɛn tin ya PCSK9 Inhibitors. Lɛ wi tɔk bɔt dɛn insay simpul wɔd dɛn tide.
Fɔ tɔk am simpul wan, wetin na dɛn PCSK9 Inhibitors ya?
Dis na nyu klas fɔ drɔgs we kin rili ridyus di ‘bad’ kɔlɔstrel, ɔ LDL kɔlɔstrel , we de na wi blɔd. Naw, tu men kayn mɛrɛsin dɛn de we dɛn dɔn gri fɔ tek na di wɔl. Dɛn na `alirocumab (Praluent)` ɛn `evolocumab (Repatha)`.
Risach dɔn sho se dɛn mɛrɛsin ya we dɛn kɔl PCSK9 inhibitors, kin wok fayn fayn wan. Sɔntɛnde, dɛn kin ivin mek pɔsin nɔ gɛt at atak ɛn strok . Yu kin tek dɛn mɛrɛsin ya yu wan, ɔ yu kin tek am wit wan statin drɔg we yu dɔn ɔlrɛdi tek. Bɔt wan tin we wi fɔ mɛmba na dat dɛn dia pas ɔda mɛrɛsin dɛn we gɛt kɔlɔstrel.
Okay, naw lɛ wi si aw dis mɛrɛsin de wok insay di bɔdi.
Fɔ ɔndastand dis, lɛ wi tink bɔt wan smɔl stori. Di men ɔgan we de kɔntrol di kɔlɔstrel na wi bɔdi na di liva.
imajin se wi liva sεl dεm gεt sכm sכm "scavengers" (rεsεptor) dεm we de kech εn pul kכlestכl we wi nכ want frכm di bכdi. Na dɛn wan ya de mek wi blɔd vesel dɛn klin.
bכt, כda protin de we dεn kכl PCSK9 we wi bכdi de prodyuz. I wok na fɔ fɛn ɛn pwɛl dɛn gud "klin" dɛn de. Dɔn, bikɔs nɔbɔdi nɔ de fɔ pul di kɔlɔstrel, i kin gɛda na di blɔd ɛn go de na di wɔl dɛn na di at.
Dis na di say we wi spika, di PCSK9 inhibitor drɔg, de kam fɔ ɛp wi. wetin dis dכg de du na fכ grap da bad PCSK9 protin de εn stכp am fכ wok. I tan lɛk se yu ol natin pikin ɛn put am na chia. Den wi "klin" dem kin du dem wok witout eni hindrance. Di rizɔlt? di lεvεl fכ LDL kכlestכl na di bכdi de dכn kwik kwik wan.
Aw dɛn tin ya difrɛn frɔm ‘statin’?
Statin dεm εn PCSK9 inhibito dεm na tu kayn dεm we de lכs kכlestכl, bכt dεn de wok tu difrεn we dεm. Dis tebul go ɛp yu fɔ ɔndastand dis.
| Difrɛn | Statin we dɛn kɔl Statin | PCSK9 Inhibitɔ dɛn |
|---|---|---|
| Di we aw pɔsin de wok | I de mek di kɔlɔstrel nɔ de na di liva. | I de mek di risεptor dεm we de pul kכlestכl kכmכt na di liva nכ de pwεl. |
| Aw fɔ tek | Wan pil we dɛn kin tek ɛvride. | Wan injɛkshɔn we dɛn kin gi ɛvri 2 ɔ 4 wik. |
| Aw fɔ yuz am | Bɔku tɛm dɛn kin yuz am in wan, na di fɔs tin we dɛn kin pik fɔ kɔntrol kɔlɔstrel. | Yu kin yuz am in wan ɔ yu kin yuz am wit statin. Di tin dɛn we kin apin kin strɔng pas dat. |
So udat want fɔ tek dis mɛrɛsin?
Dis na impɔtant kwɛstyɔn bikɔs nɔto ɔlman we gɛt ay kɔlɔstrel nid dis mɛrɛsin. Yu dɔktɔ go tray fɔs fɔ kɔntrol yu kɔlɔstrel wit statin. Bɔt yu dɔktɔ kin tink bɔt PCSK9 inhibitor pan dɛn kayn tin ya:
- Jεnεtik hεy kכlestכl kכndyushכn: sכm pipul dεn gεt jεnεtik kכndyushכn we dεn kכl ``Familial Hypercholesterolemia.'' Dɛn pipul ya gεt difεkt pan di we aw dεn bכdi de kכntro kכlestכl. Ivin wit di maksimal doz fɔ statin, i rili at fɔ mek dɛn pipul ya briŋ LDL kɔlɔstrel dɔŋ to wan wɛlbɔdi lɛvɛl.
- Fɔ pipul dɛm wae gɛt bɔrku risk fɔ gɛt hat atak ɔr strok: If yu dɔn ɔlrɛdi gɛt hat sik, ɛn yu nɔr dɔn kɔntrol yu kɔlɔstrel lɛvɛl fayn fayn wan wit mɛrɛsin lɛk statin, yu dɔktɔ kin tink bɔt dis mɛrɛsin.
- Fɔ di wan dɛn we nɔ ebul fɔ telɛ ‘statin’: Na lɛk 10%-20% pan di pipul dɛn we de tek statin kin gɛt sayd ɛfɛkt lɛk pen we dɛn nɔ kin ebul fɔ bia wit di mɔsul dɛn, wik, ɛn bɔdi we kin at . Fɔ dɛn pipul dɛn de, dis kin bi fayn tin fɔ du.
Ustɛm di dɔktɔ kin gi dis mɛrɛsin?
Dɔktɔ nɔ go ɛva gi dis mɛrɛsin wan tɛm. Wan prosidur de fɔ am.
1. Fɔs, chenj di we aw yu de liv yu layf: Di dɔktɔ fɔs se yu fɔ du ɛksɛsayz fayn ɛn it tin dɛn we gɛt bɔku ɔyl, shuga, ɛn flawa .
2. Neks, wan ‘Statin’: If chenj na layf stayl nɔ inof, dɛn kin stat wan statin. If di kɔlɔstrel nɔ go dɔŋ, dɛn kin ad di doz smɔl smɔl.
3. As las tin: If dɛn nɔ kɔntrol yu kɔlɔstrel ivin wit di maksimam doz fɔ statin, ɔ if di sayd ɛfɛkt dɛn bad, den yu dɔktɔ kin tink bɔt PCSK9 inhibitor. Dis disizhɔn kin bi bay we yu du wan tɛst, lɛk korona kalsiɔm skɔ, fɔ no if yu gɛt at sik.
Aw dɛn kin yuz dis mɛrɛsin ɛn wetin na di sayd ɛfɛkt dɛm?
I kin kam lɛk injɛkshɔn we yu kin gi ɔnda di skin ɛvri tu ɔ 4 wik . Yu kin gɛt am na di skin na yu bɛlɛ, di ɔp pat na yu shɔl, ɔ di ɔp pat na yu an. Yu dɔktɔ ɔ nɔs we tren go sho yu aw fɔ gi am di rayt we. Bɔku tɛm, i nɔ kin mek pɔsin fil pen ɛn i kin izi.
We i kam pan di bad tin dɛn we kin apin to pɔsin, di wan dɛn we kin apin mɔ na smɔl smɔl tin dɛn.
- Bak we de at
- Di sayn dɛm wae kin tan lɛk kol (trot kin it, fɔ mek yu gɛt mɔkus) .
- Rɛd, brus, ɔ smɔl pen na di say we dɛn injekt
I rili impɔtant: Na smɔl tɛm nɔmɔ, bad bad alɛji kin apin. If yu gɛt siriɔs ayv wantɛm wantɛm, yu fes ɔ yu lip swel, ɔ yu nɔ ebul fɔ blo , dis na imejensi. If dis apin, yu fɔ go na di ɔspitul imejensi dipatmɛnt (ETU) we de nia yu wantɛm wantɛm .
Fɔ dɔn, we i kam pan di kɔst fɔ dɛn mɛrɛsin ya, dɛn nɔ tan lɛk di mɛrɛsin dɛn we dɛn kin tek ɔltɛm, ɛn dɛn rili dia . So, dis tritmɛnt nɔr kin fayn fɔ ɔlman. I bɛtɛ fɔ tɔk opin wan wit yu dɔktɔ bɔt dis ɛn tɔk bɔt if yu nid am, if i fayn fɔ yu, ɛn wetin yu go ebul fɔ pe fɔ.
Mɛsej we dɛn kin kɛr go na os
- PCSK9 inhibito dεm na wan rili pawaful, nyu klas fכ drog dεm we de lכs di hεy LDL (‘bad’) kכlestכl lεvεl.
- Dɛn tin ya nɔ kin kam as pils fɔ tek ɛvride, bɔt na injɛkshɔn we dɛn kin gi ɛvri 2 ɔ 4 wik.
- Dɛn kin advays dɛn tin ya fɔ pipul dɛn we gɛt di sik we dɛn kɔl jenɛtik kɔlɔstrel, di wan dɛn we rili gɛt at sik, ɔ di wan dɛn we nɔ ebul fɔ tek di mɛrɛsin dɛn we dɛn kɔl statin.
- Dis mɛrɛsin rili dia, so yu fɔ disayd if dis fayn fɔ yu afta yu dɔn tek tɛm tɔk to yu dɔktɔ.
- Nɔ ɛva disayd bɔt mɛrɛsin bay wetin yu yɛri ɔ wetin yu si na di intanɛt. Ɔltɛm fala yu dɔktɔ in advays.
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